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Modeling detailed chemical kinetics is a primary challenge in combustion simulations. We present a novel framework to enforce physical constraints, specifically total mass and elemental conservation, during the reaction of ML models’ training for the reduced composition space chemical kinetics of large chemical mechanisms in combustion. In these models, the transport equations for a subset of representative species are solved with the ML approaches, while the remaining nonrepresentative species are “recovered” with a separate artificial neural network trained on data. Given the strong correlation between full and reduced solution vectors, our method utilizes a small neural network to establish an accurate and physically consistent mapping. By leveraging this mapping, we enforce physical constraints in the training process of the ML model for reduced composition space chemical kinetics. The framework is demonstrated here for methane, CH4, and oxidation. The resulting solution vectors from our deep operator networks (DeepONet)-based approach are accurate and align more consistently with physical laws.
Chapter 6, Branding Birth Control, examines how birth-controllers used claims about medical works’ vulnerability to destruction under the Hicklin test to distance contraception from immorality, frame its advocacy as a free speech issue, and generate publicity for the cause. Contraception pamphlets first published by radicals in the 1820s and 1830s had long been sold by both social reformers and pornographers. In 1876, a figure with feet in both domains was arrested for selling Charles Knowlton’s Fruits of Philosophy (1832). The following year, Annie Besant and Charles Bradlaugh engineered their own arrest for selling it. The chapter examines the selective publication history that Bradlaugh and Besant constructed to divorce Fruits from its associations with promoscuity and promote contraception advocacy as a respectable, progressive cause, and shows that birth-controllers went on to sell huge volumes of literature on contraception. Although they encountered relatively little legal opposition, they often claimed that selling such works was very risky. These claims operated as a way of generating further publicity for the cause, and branding it as brave, modern, and progressive.
This study investigates the integration of literal completions of idiomatic multiword expressions (MWEs) into two linguistic contexts: one promoting a literal interpretation and the other a figurative one, requiring reinterpretation to align with figurative bias. Sixteen Italian idioms were distributed in two groups by their Potential Idiomatic Ambiguity (PIA) score, an index of literal plausibility, decomposability and transparency. Using experimental dialogues, the study tested whether high-PIA idioms receive higher acceptability ratings across both contexts than low-PIA idioms. Eighty-four Italian-speaking participants rated idiom literal completions within literal and figurative contexts. Results show that literal completions of high-PIA idioms integrate better across contexts, while those of low-PIA idioms receive lower ratings and have longer combined reading and rating times. This supports hybrid models of idiom processing, emphasizing the role of idiomatic features and context in balancing figurative and compositional interpretations. This study also marks an initial effort to experimentally trace systematicity within idiomatic wordplay, challenging the idea that it lacks relevance for linguistic research while outlining limitations and directions for future work.
To examine how aligned the UK food supply is with the Eatwell Guide and identify discrepancies that should be addressed to support the availability of healthy diets for the population.
Design:
A dietary gap assessment was carried out on the 2022 UK food supply with FAOSTAT Food Balance Sheets (FAO-FBS) data, including domestic production, imports and exports and excluding animal feed, seeds and non-food uses. Foods were grouped into potatoes and cereals, oils and spreads, dairy products, protein, fruit and vegetables and sugar. The percentage contribution of each food group to the food supply was compared with the Eatwell Guide. An overview of the food supply from 2010 to 2022 was also created. To triangulate the data, FAO-FBS data were compared with the 2022 data from the Department for Environment, Food and Rural Affairs (DEFRA).
Setting:
UK, 2010–2022
Participants:
N/A
Results:
The proportion of fruit and vegetables, potatoes and cereals in the UK food supply was lower than the Eatwell Guide, while dairy products and oil were higher. Only 7 % of the food produced in the UK in 2022 was fruit and vegetables. This was the second smallest proportion, after oils and spreads (6 %), and about half the amount of sugar beet produced (13 %).
Conclusion:
Although the relationship between food supply and consumption is complex, taking a more coherent approach by integrating dietary recommendations with the food supply could help increase the availability of the recommended healthy diet. Going forward, DEFRA should include dietary gap assessments in future Food Security Reports.
This study investigates the links between dietary diversity, food insecurity and mental health (depression and anxiety) in adolescents from rural Pakistan. Adolescence is a critical time for developing mental health disorders, yet limited research exists on these issues in low- and middle-income countries (LMICs).
Methods
The study included 1,396 adolescents (ages 9–15) and assessed their mental health, nutrition and maternal well-being. Depression and anxiety were measured using standardized questionnaires, while dietary diversity and food insecurity were evaluated through household assessments. Incidence rate ratios assessed the relationship between nutrition and mental health.
Results
Results showed that 8.1% of boys and 10.2% of girls experienced depression, with anxiety rates ranging from 5.8% to 39.1%. Adolescents from households with higher dietary diversity had lower symptoms of depression and anxiety (IRRs:0.91–0.96), while those with higher food insecurity had increased symptoms (IRRs:1.24–1.86). Folate deficiency was associated with depressive symptoms, particularly in boys. Maternal mental health was observed to mediate the relationship between food insecurity and adolescent depression and anxiety.
Conclusions
The study highlights that improving maternal mental health and addressing nutritional deficiencies, particularly folate, may benefit adolescent well-being. Further research in other LMICs is needed to explore these associations and their mechanisms.
Eddy currents play a significant role in the evolution of tokamak plasmas and must therefore be correctly taken into account in time-dependent simulations. In this paper, a computational method for solving the evolution of tokamak plasma considering eddy currents utilising VMEC (Hirshman & Whitson, Phys. Fluids, vol. 26, 1983, pp. 3553–3568), a commonly used static magnetohydrodynamic equilibrium solver, is proposed. This method is convenient since it does not modify the equilibrium solver internally and achieves convergence calculation through external processing. By allowing the components of the magnetic field to be treated separately, this method provides convergence for cases with displacements in arbitrary directions, which has been difficult to achieve with the previous methods.
Macro- and microbotanical remains recovered from post-Teotihuacan occupations in quarry tunnels east of the Sun Pyramid, Teotihuacan, contribute to understanding lifeways in the surrounding valley after the partial abandonment of the city. Plant remains associated with domestic and ritual contexts from the excavations directed by Linda Manzanilla (1993–1996) are relevant to subsistence questions, aspects of surrounding vegetation, landscape exploitation, and the possibility of less-intensive agricultural production during the Epiclassic and Early Postclassic occupations.
To investigate the impact of the widespread availability and use of the semi-synthetic cannabinoid hexahydrocannabinol (HHC) on hospital admissions owing to psychosis. Medical records of patients admitted for psychotic illness to University Hospital Galway were examined to assess HHC or other illicit drug use before admission.
Results
Of the 214 total admissions for psychotic illness, 28 admissions (13.1%) were preceded by use of HHC, nine of whom used only HHC. Sixteen (34%) admissions of first-episode psychosis were preceded by HHC use, with seven of these using only HHC.
Clinical implications
Clinicians should explicitly enquire about the use of HHC in patients presenting with first-episode and relapse of psychotic illness. Sufficient evidence has now accumulated from research of a link between HHC and psychosis. Such psychoses appear to be more prominent in young people with early-phase psychosis, and highlights the need for authorities to change legislation to avoid further harm.
Predicting radiotherapy (RT) tooth dose guides pre-RT dental management, reducing osteoradionecrosis (ORN) risk through informed extraction or treatment adjustments. This study evaluated the mean radiation dose to individual teeth for head and neck cancer (HNC) patients receiving external beam RT at the South West Wales Cancer Centre (SWWCC), to guide pre-emptive tooth extraction.
Methods:
A retrospective analysis was conducted on 158 HNC RT patients treated over a 2-year period. Patients with subsites containing ≤10 patients were excluded, and larynx cases were analysed separately before exclusion due to low ORN risk, leaving 107 patients in the final analysis. Teeth were outlined using MedCom ProSoma v4.2, and treatment plans were generated with Philips Pinnacle v16.2 using volumetric arc therapy (VMAT), without dental dose optimisation. Mean doses were reported per tooth and categorised by site, staging and tooth position, with mean and standard deviations calculated. ORN risk was defined as medium (≥40Gy) and high (≥50Gy).
Results:
Larynx patients received low mean doses (<25Gy), supporting their exclusion. Base of tongue (BoT) cases showed a dose ≥40Gy for lower ipsilateral molars in T4. Oral cavity diagnosis had the highest ORN risk, with most teeth ≥40Gy in T2+ cases and ≥50Gy in later cancer staging. The oropharynx showed some higher risk doses for T4-staging. T-tests confirmed significant dose differences between upper and lower teeth.
Conclusion:
This study provides a site-specific indicative guide for pre-RT tooth extraction based on likely dose exposure, to guide pre-radiation dental management strategies and plan optimisation decisions to reduce ORN risk.
Yield is impacted by the environmental conditions that plants are exposed to. Controlled environmental agriculture provides growers with an opportunity to fine-tune environmental conditions for optimising yield and crop quality. However, space and time constraints will limit the number of experimental conditions that can be tested, which will, in turn, limit the resolution to which environmental conditions can be optimised. Here we present an innovative experimental approach that utilises the existing heterogeneity in light quantity and quality across a vertical farm to evaluate hundreds of environmental conditions concurrently. Using an observational study design, we identify features in light quality that are most predictive of biomass in different kinds of microgreens (kale, radish and sunflower) that may inform future iterations of lighting technology development for vertical farms.
Standard approaches to neoclassical theory do not extend into regions of strong gradients in tokamaks such as the pedestal and internal transport barriers. Here, we calculate the modifications to neoclassical electron physics inside strong gradient regions of large aspect ratio tokamaks in the banana regime. We show that these modifications are due to the different ion flow and the strong poloidal variation of the potential. We also provide a physical interpretation of the mechanisms that drive poloidal asymmetries and hence a poloidal electric field. We apply our model to two specific example cases of pedestal profiles, calculating the neoclassical electron flux and the bootstrap current. We find that, depending on the ion flow, weak gradient neoclassical theory overestimates or underestimates the neoclassical electron transport and the bootstrap current in regions with strong gradients. We show that the determination of the mean parallel flow is more complex than in weak gradient neoclassical theory. For vanishing turbulence, we can determine the radial electric field for a given flow profile in the pedestal.
Poorly managed inpatient flow can lead to adverse health outcomes, including increased mortality and readmission rates. In neurosurgery, optimizing inpatient flow is crucial to improving patient experience and outcomes, but the factors influencing it are unclear. A preliminary analysis revealed suboptimal average length of stay (ALOS) and expected length of stay (ELOS) rates – key metrics used to assess inpatient flow – across Alberta, Canada. The purpose of this study was to evaluate the current state of inpatient flow in Alberta’s neurosurgical care and explore strategies for enhancement.
Methods:
This study used mixed methods: a rapid scoping review and a retrospective cohort study. The rapid scoping review synthesized peer-reviewed and gray literature (after a three-stage screening process) to identify factors impacting neurosurgery inpatient flow across jurisdictions. The cohort study analyzed Alberta’s adult neurosurgical patient data from 2009 to 2019 to explore how patient- and system-level factors relate to ALOS/ELOS rates.
Results:
Nine of the 391 screened articles were included in the review. Three main themes emerged influencing neurosurgery inpatient flow: interdisciplinary care pathways, introducing new roles and identification of risk factors. Building on these themes, patient- and system-level factors impacting ALOS/ELOS were explored. ALOS/ELOS rates varied among the five Alberta Health Services zones, with Rural Zone 1 having the highest and significantly different rate. Age, sex, zone and comorbidities significantly accounted for differences in ALOS/ELOS rates (p < 0.001).
Conclusions:
Neurosurgery patients in Alberta are experiencing longer hospital stays than expected. Several areas requiring further research have been identified, along with potential strategies to enhance patient care and outcomes.
Homophonous morphs have been reported to show differences in acoustic duration in languages such as English and German. How common these differences are across languages, and what factors influence the extent of temporal differences, is still an open question, however. This paper investigates the role of morphological disambiguation in predicting the acoustic duration of homophones using data from a diverse sample of 37 languages. Results indicate a low overall contribution of morphological affiliation compared to other well-studied effects on duration such as speech rate and Final Lengthening. It is proposed that two factors increase the importance of homophony avoidance for the acoustic shape of morphs: crowdedness (i.e. the number of competing homophones) and segmental make-up, in particular the presence of an alveolar fricative. These findings offer an empirically broad perspective on the interplay between morphology and phonetics and align with the view of language as an adaptive and efficient system.
The present study examines whether presenting words in song versus spoken sentences can lead to differences in word learning in 47–50-month-old children. This work extends previous findings on this topic and evaluates whether the location of pitch changes within the song may contribute to how well the words are learned. Using a Preferential Looking Paradigm, 32 children were taught the names of objects, either in spoken sentences or in a song that followed an unfamiliar melody. In both conditions, the novel word was emphasized by a pitch change. Looking patterns indicated that children learned the names of the novel items better when the words were trained in the spoken sentence compared to the song condition. The findings are discussed in relation to theories of word learning, and how differences in the characteristics between speech and song may relate to variability in how well new words are acquired.
In the past decade, researchers have been increasingly interested in understanding the process of language learning, in addition to the effect of instructional interventions on L2 performance gains (i.e., learning products). One goal of such investigations is to reveal the interplay between learning conditions, processes, and outcomes where, for example, certain conditions can promote attention to the learning targets, which in turn facilitates learning. However, the statistical modeling approach taken often does not align with the conceptualization of the complex relationships between these variables. Thus, in this paper, we introduce mediation analysis to SLA research. We offer a step-by-step, contextualized tutorial on the practical application of mediation analysis in three different research scenarios, each addressing a different research design using either simulated or open-source datasets. Our overall goal is to promote the use of statistical techniques that are consistent with the theorization of language learning processes as mediators.
Random-effects meta-analyses with only a few studies often face challenges in accurately estimating between-study heterogeneity, leading to biased effect estimates and confidence intervals with poor coverage. This issue is especially the case when dealing with rare diseases. To address this problem for normally distributed outcomes, two new approaches have been proposed to provide confidence limits of the global mean: one based on fiducial inference, and the other involving two modifications of the signed log-likelihood ratio test statistic in order to have improved performance with small numbers of studies. The performance of the proposed methods was evaluated numerically and compared with the Hartung–Knapp–Sidik–Jonkman approach and its modification to handle small numbers of studies. The simulation results indicated that the proposed methods achieved coverage probabilities closer to the nominal level and produced shorter confidence intervals compared to those based on existing methods. Two real examples are used to illustrate the proposed methods.