Woodrats of the genus Neotoma are an important study system for ecological and paleoecological research. However, paleontological studies are often hindered by the difficulty of identifying woodrat remains to species. We address this limitation by using 2D landmark-based geometric morphometrics to classify 199 lower first molars (m1s) of five extant western North American Neotoma species (N. albigula, N. cinerea, N. fuscipes, N. lepida, and N. macrotis) collected throughout California. We then use discriminant analysis of principal components (DAPC) models to identify Late Pleistocene fossils of unknown species from the Rancho La Brea Tar Pits in Los Angeles, California. DAPC correctly identifies ∼85–90% of extant individuals to species, with most misclassifications occurring between sister taxa N. fuscipes and N. macrotis. Most fossil m1s are classified as N. macrotis by DAPC, which may be the first confirmation of N. macrotis in the fossil record. We show that landmark-based geometric morphometric analyses are generally effective at differentiating m1s of extant Neotoma species in California and they are an auspicious method for unknown fossil identification. Further applications of this method across a broader range of geographic locations and species will better contextualize its utility.

In the early 2000s, Ramakrishna asked the question: for the elliptic curve

\[E\;:\; y^2 = x^3 - x,\]

$a_p(E)$

$E/\mathbb{Q}$

We prove a Poisson process approximation result for stabilising functionals of a determinantal point process. Our results use concrete couplings of determinantal processes with different Palm measures and exploit their association properties. Second, we focus on the Ginibre process and show in the asymptotic scenario of an increasing observation window that the process of points with a large nearest neighbour distance converges after a suitable scaling to a Poisson point process. As a corollary, we obtain the scaling of the maximum nearest neighbour distance in the Ginibre process, which turns out to be different from its analogue for independent points.

Bornite (Cu5FeS4) and digenite (Cu9–xFexS5; x = 0.4) have closely related cubic structures and are known for their range of superstructures derived from metal vacancies leading to larger unit cells expressed as n × a, where a = ∼5.5 Å and n is an integer. Such polymorphs can form during cooling from higher temperature bornite (Bn)–digenite (Dg) 1a solid solution (ss). The alleged basket-weave textures in natural bornite are investigated using high-angle annular dark field (HAADF) scanning transmission electron microscopy (STEM) imaging and energy-dispersive X-ray spectrometry. These techniques, combined with crystal modelling and STEM simulations, are suitable for depicting changes in phases related to crystal-structural modularity as they collectively better reproduce atomic distributions in real space. Bornite associated with either chalcocite or chalcopyrite from the Olympic Dam Cu-U-Au-Ag deposit, South Australia has non-stoichiometric Cu/Fe ratios and displays nanoscale basket-weave textures between the main components Bn2a and anilite (Cu7S4); Dg1a is preserved throughout, albeit as a minor phase. Anilite is a derivative of digenite, whereby a = b = √2aDg and c = 2aDg. Two intermediate phases, Dg3a and Bn2a4a, are documented and an additional phase, Bn2a6a, is tentatively suggested to occur in Fe-rich nanodomains within Bn2a. Considering the epitaxial relationships between all phases, we infer that basket-weave textures record phase transitions via polymorphic transformations of parent Bn2a and Dg1a during cooling. Observed phase assemblages are thus linked to cooling of Bn–Dgss in the range 70–87 mol.% Bn along a Cu6.18Fe1.26S5 – Cu9.12Fe0.89S5 tie-line defined from measured compositions. We depict three associations: Bn2a + Dg1a, Bn2a4a + Dg3a, and Bn2a4a/Bn2a6a + anilite, formed during cooling. Polymorph associations like these are relevant for enrichment of critical/precious metals in copper ores because Bi, Pb, Ag, Te and, probably also Au, if dissolved in Bn–Dgss, could be incorporated into superstructures during Cu-Fe-sulfide phase transitions.

Intercropping annual cash crops with grasses is a strategy that promotes both diversification and intensification of production in the same area, contributing to sustainable food systems. This study evaluated the impact of intercropping maize with different Urochloa species on maize and subsequent soybean yields over three years in the Brazilian Savannah. The treatments included: (1) maize monoculture; (2) maize intercropped with Urochloa ruziziensis; (3) maize intercropped with U. brizantha cv. Marandu; and (4) maize intercropped with U. brizantha cv. BRS Paiaguás. The evaluations included maize grain yield, land equivalent ratio (LER), forage biomass and soybean yield in succession. The results confirmed that maize intercropped with U. brizantha cv. Marandu and U. brizantha cv. BRS Paiaguás achieved grain yields comparable to monoculture. Demonstrating that these forage species do not significantly compete with maize in 2018 and 2019 in Montividiu and 2018 and 2020 in Rio Verde. In Montividiu, intercropping with U. brizantha cv. BRS Paiaguás resulted in an average LER of 1.13 over three years, highlighting its advantage in optimising land use. In addition, the intercropping system was particularly beneficial in sandy soils, where faster biomass decomposition accelerated improvements in soil structure, moisture retention, and nutrient availability, leading to earlier benefits in soybeans grain yield compared to clay soils. These findings emphasise the potential of maize-forage intercropping to enhance land-use efficiency and soil health while maintaining crop yields in tropical agroecosystems. However, site-specific management is essential to maximise benefits and minimise trade-offs. Future research should focus on long-term soil health dynamics and refining intercropping strategies to improve sustainability in different environmental conditions.

This project aims to identify and explain a phenomenon I call pain-related motivational deficit, which occurs when there is proper uptake of the epistemic contributions of a pain utterance, but defective uptake of the motivational contributions of a pain utterance. I argue that the normalization of fibroid pain in Black women, and of menstrual pain more broadly, causes a pain-related motivational deficit to be unfairly assigned to utterances about these pain experiences. I show that current ways of thinking about epistemic injustice cannot adequately explain these cases.

After dispensing major precedents affecting the public’s health in each of its prior three terms, the 2024-2025 term of the US Supreme Court was arguably less impactful amid several unanimous decisions preserving existing jurisprudence (at least in part). However, this is an understatement. While the Court issued key decisions arguably favorable to communal health this prior year it also denied minors access to medical procedures sought by their doctors, diminished diversity, equity, and inclusion (DEI) initiatives in employment, allowed states to deny health providers access to Medicaid because they also provided abortions, disallowed rural hospitals from collecting specific costs for treating low-income patients, and provided a “script” of sorts for executive control of federal health advisory committees.

Branched broomrape [Phelipanche ramosa (L.) Pomel], a parasitic weed with a broad host range, is a quarantine pest in California. Phelipanche ramosa plants can produce thousands of tiny seeds that are easily spread by farm equipment. Best management practices for reducing dispersal risk include physical cleaning and disinfestation of farm equipment, but data on the efficacy of sanitizers on weed seeds are limited. A three-phase study was undertaken during 2022 to 2023 to evaluate quaternary ammonium compound (QAC) sanitizer efficacy on P. ramosa seed germinability. First, several QAC ingredients were evaluated at various concentrations (0 to 2.5 g per 100 ml) and exposure durations (1, 3, and 5 min) to develop initial germination curves. Second, the experiments were conducted with three commercial QAC sanitizers (MG4-Quat [Mg4], Flo-Quat, and Cleaner QT-185) at the recommended dose (1% v/v) and a field-relevant exposure duration (1 min). The final experiments evaluated commercial QAC sanitizer efficacy in the presence of various debris types. The initial experiments showed that alkyl dimethyl benzyl ammonium chloride (ADAC), didecyl dimethyl ammonium bromide (DDAB), and didecyl dimethyl ammonium chloride (DDAC) effectively prevented P. ramosa germination, but the effective dose for a 50% reduction in P. ramosa seed germination ranged from 0.001% (g per 100 ml) at 10 min with DDAC to 0.35% (g per 100 ml) at 1 min with ADAC. While all three QAC sanitizers reduced seed germination 75% to 100% after a 1-min exposure to the recommended dose (1% v/v), this treatment did not affect seed germination in the presence of soil (100 mg ml−1) or fruit/plant tissue (40 mg ml−1). At higher concentrations of Mg4 (8% v/v), P. ramosa seed germination was reduced by 90% to 100%, even in the presence of soil and plant debris. This study demonstrates that while QAC sanitizers can reduce P. ramosa seed germinability, their efficacy is compromised in the presence of debris. Therefore, physical cleaning to reduce debris loads before QAC application is essential for reducing the risk of P. ramosa seed movement among fields on equipment.

A local food-based approach, including school lunch with multiple-micronutrient fortified biscuits (MMB) as supplementary snacks, may enhance dietary adequacy, although current evidence remains limited. This study assessed nutrient inadequacies and developed food-based dietary recommendations (FBR) incorporating school lunch from the Ghana School Feeding Programme (GSFP) and MMB. Data from 292 girls aged 10–17 years, enrolled in the Ten2Twenty-Ghana study was analysed. Dietary intake was assessed via a quantitative 24-h dietary recall. Usual intakes were estimated using the National Cancer Institute method. Linear programming with Optifood was used to develop FBRs based on commonly consumed foods (≥5% of participants) and their median serving sizes, intake frequency, nutrient content, and cost per 100 g. Constraints included estimated energy needs and harmonised average nutrient requirements. The mean usual energy intake was 2351 (sd 66) kcal/d. Ca (99·8 %), vitamin B12 (99·8 %), riboflavin (96·2 %), vitamin A (91·5 %), vitamin C (87·6 %), Fe (73·7 %), folate (49·3 %) and Zn (8·5 %) inadequacies were prevalent. Optimised diets achieved adequacy for protein and most micronutrients, except Ca and vitamin B12, besides vitamin A for 15–17-year-old girls. School lunch from the GSFP did not enhance micronutrient levels when added to the daily diet. Adding MMB to the daily diet ensured adequacy for vitamin C, riboflavin and Fe, although marginal for Fe. Ca and vitamin A improved substantially with MMB for girls aged 15–17 but remained below the harmonised average requirements. Integrating regular school lunch with specialised fortified foods may be a cost-effective strategy to enhance dietary adequacy for adolescent girls in rural areas.

Design computing refers to the usage of computer frameworks, models or systems in design-related activities. Design computing research, in turn, refers to the development of these frameworks/models/systems, and so forth. As design practice increasingly relies on computer tools, the demand for research in design computing grows. While this opens innumerable venues for research, the profusion of information in the field poses significant challenges for researchers. Therefore, meta-level surveys of the field are called for. To provide researchers with a useful overview of design computing research, we set out to identify some of the main clusters of activity in the field. By “clusters of activity”, we refer to groups of researchers pursuing similar or identical research questions. Our PRISMA-style review focuses on the identification of such clusters, based on the complete proceedings (N = 404) of a long-standing conference (Design Computing and Cognition, DCC, 2004–2024), which captures the richness and diversity of the field. The primary contribution of this work is a map that organizes the main questions explored and the approaches taken in exploring them, which are informative for researchers and educators alike. This map may also help to execute large-scale surveys via automation, toward obtaining a comprehensive view of the field.

Early career researchers have unique demands, many of which contribute to increased stress, decreased professional fulfillment, and burnout. Consequently, academic institutions and government organizations, such as the National Institutes of Health, are beginning to embrace structured coaching as a tool to support physician wellbeing. To date, such coaching programs have demonstrated promising results, but little is known about whether early career research faculty find coaching feasible, accessible, or helpful. To explore this question further, we developed a novel group coaching intervention for clinician researchers and scientific faculty at the University of Texas Southwestern Medical Center based on the concept of appreciative inquiry, grounding the program in a positive and hopeful approach to the challenges faced by clinicians and researchers. Results from our program indicate this intervention is feasible, satisfactory, and helpful, with participants reporting enhanced self-reflection and empowerment. Effective for a wide array of research faculty, our program brought together diverse faculty, fostered connections, and encouraged future collaborations among this translational group. This suggests that our program provides a foundational blueprint that can be used by other academic medical centers who aim to develop group coaching efforts.

Based on present knowledge of atmospheric composition, a mechanism for the natural formation of vesicles in the lakes of Titan is proposed. It involves precipitation-induced spray droplets coated by a monolayer of amphiphiles. On interaction with the monolayer on the lake’s surface, bilayer membranes are being formed that encapsulate the liquid phase of the original droplet. The resulting vesicles develop thermodynamic stability by continuous compositional selection of various types of amphiphiles in a dynamic equilibrium, leading to an optimized vesicle stability. Different populations of stable vesicles may compete, initiating a long-term evolution process that could eventually result in primitive protocells. The existence of any type of vesicles on Titan would prove that early steps towards increasing order and complexity have taken place, which represent the necessary precondition for abiogenesis. A valid analytical approach could involve a laser device with combined light scattering analysis and surface enhanced Raman spectroscopy. It would allow for very sensitive detection of amphiphiles as well as for the observation of dispersed vesicles.

This article explores the role of representative assemblies in the diverse territories of the early modern Spanish and Portuguese empires spanning the Americas, parts of Asia, and Africa. It begins with a concise overview of the Portuguese and Spanish representative assemblies, commonly referred to as the Cortes. The second section raises some preliminary questions about how the parliamentary culture brought by the Spanish and Portuguese to their overseas possessions shaped, and was shaped by, local understandings of political participation in institutions with a representational character. The third section examines the complex debate over the integration of representatives from overseas municipalities into the Castilian and Portuguese Cortes. The fourth and final section analyses the interaction between Iberian parliamentary culture and a range of Asian, Indigenous American, and African perspectives on participation in representative gatherings. The principal argument is that representative assemblies, the debates they generated, and their varying degrees of prominence, reflect the fundamental changes observed in the political and legal structure of the Portuguese and Spanish empires.

Network meta-analysis (NMA) is becoming increasingly important, especially in the field of medicine, as it allows for comparisons across multiple trials with different interventions. For time-to-event data, that is, survival data, traditional NMA based on the proportional hazards (PH) assumption simply synthesizes reported hazard ratios (HRs). Novel methods for NMA based on the non-PH assumption have been proposed and implemented using R software. However, these methods often involve complex methodologies and require advanced programming skills, creating a barrier for many researchers. Therefore, we developed an R Shiny tool, NMAsurv (https://psurvivala.shinyapps.io/NMAsurv/). NMAsurv allows users with little or zero background in R to conduct survival-data-based NMA effortlessly. The tool supports various functions such as drawing network plots, testing the PH assumption, and building NMA models. Users can input either reconstructed pseudo-individual participant data or aggregated data. NMAsurv offers a user-friendly interface for extracting parameter estimations from various NMA models, including fractional polynomial, piecewise exponential models, parametric survival models, Cox PH model, and generalized gamma model. Additionally, it enables users to effortlessly create survival and HR plots. All operations can be performed by an intuitive “point-and-click” interface. In this study, we introduce all the functionalities and features of NMAsurv and demonstrate its application using a real-world NMA example.

We construct explicit generating series of arithmetic extensions of Kudla’s special divisors on integral models of unitary Shimura varieties over CM fields with arbitrary split levels and prove that they are modular forms valued in the arithmetic Chow groups. This provides a partial solution to Kudla’s modularity problem. The main ingredient in our construction is S. Zhang’s theory of admissible arithmetic divisors. The main ingredient in the proof is an arithmetic mixed Siegel-Weil formula.