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Intercropping annual cash crops with grasses is a strategy that promotes both diversification and intensification of production in the same area, contributing to sustainable food systems. This study evaluated the impact of intercropping maize with different Urochloa species on maize and subsequent soybean yields over three years in the Brazilian Savannah. The treatments included: (1) maize monoculture; (2) maize intercropped with Urochloa ruziziensis; (3) maize intercropped with U. brizantha cv. Marandu; and (4) maize intercropped with U. brizantha cv. BRS Paiaguás. The evaluations included maize grain yield, land equivalent ratio (LER), forage biomass and soybean yield in succession. The results confirmed that maize intercropped with U. brizantha cv. Marandu and U. brizantha cv. BRS Paiaguás achieved grain yields comparable to monoculture. Demonstrating that these forage species do not significantly compete with maize in 2018 and 2019 in Montividiu and 2018 and 2020 in Rio Verde. In Montividiu, intercropping with U. brizantha cv. BRS Paiaguás resulted in an average LER of 1.13 over three years, highlighting its advantage in optimising land use. In addition, the intercropping system was particularly beneficial in sandy soils, where faster biomass decomposition accelerated improvements in soil structure, moisture retention, and nutrient availability, leading to earlier benefits in soybeans grain yield compared to clay soils. These findings emphasise the potential of maize-forage intercropping to enhance land-use efficiency and soil health while maintaining crop yields in tropical agroecosystems. However, site-specific management is essential to maximise benefits and minimise trade-offs. Future research should focus on long-term soil health dynamics and refining intercropping strategies to improve sustainability in different environmental conditions.
This project aims to identify and explain a phenomenon I call pain-related motivational deficit, which occurs when there is proper uptake of the epistemic contributions of a pain utterance, but defective uptake of the motivational contributions of a pain utterance. I argue that the normalization of fibroid pain in Black women, and of menstrual pain more broadly, causes a pain-related motivational deficit to be unfairly assigned to utterances about these pain experiences. I show that current ways of thinking about epistemic injustice cannot adequately explain these cases.
After dispensing major precedents affecting the public’s health in each of its prior three terms, the 2024-2025 term of the US Supreme Court was arguably less impactful amid several unanimous decisions preserving existing jurisprudence (at least in part). However, this is an understatement. While the Court issued key decisions arguably favorable to communal health this prior year it also denied minors access to medical procedures sought by their doctors, diminished diversity, equity, and inclusion (DEI) initiatives in employment, allowed states to deny health providers access to Medicaid because they also provided abortions, disallowed rural hospitals from collecting specific costs for treating low-income patients, and provided a “script” of sorts for executive control of federal health advisory committees.
Branched broomrape [Phelipanche ramosa (L.) Pomel], a parasitic weed with a broad host range, is a quarantine pest in California. Phelipanche ramosa plants can produce thousands of tiny seeds that are easily spread by farm equipment. Best management practices for reducing dispersal risk include physical cleaning and disinfestation of farm equipment, but data on the efficacy of sanitizers on weed seeds are limited. A three-phase study was undertaken during 2022 to 2023 to evaluate quaternary ammonium compound (QAC) sanitizer efficacy on P. ramosa seed germinability. First, several QAC ingredients were evaluated at various concentrations (0 to 2.5 g per 100 ml) and exposure durations (1, 3, and 5 min) to develop initial germination curves. Second, the experiments were conducted with three commercial QAC sanitizers (MG4-Quat [Mg4], Flo-Quat, and Cleaner QT-185) at the recommended dose (1% v/v) and a field-relevant exposure duration (1 min). The final experiments evaluated commercial QAC sanitizer efficacy in the presence of various debris types. The initial experiments showed that alkyl dimethyl benzyl ammonium chloride (ADAC), didecyl dimethyl ammonium bromide (DDAB), and didecyl dimethyl ammonium chloride (DDAC) effectively prevented P. ramosa germination, but the effective dose for a 50% reduction in P. ramosa seed germination ranged from 0.001% (g per 100 ml) at 10 min with DDAC to 0.35% (g per 100 ml) at 1 min with ADAC. While all three QAC sanitizers reduced seed germination 75% to 100% after a 1-min exposure to the recommended dose (1% v/v), this treatment did not affect seed germination in the presence of soil (100 mg ml−1) or fruit/plant tissue (40 mg ml−1). At higher concentrations of Mg4 (8% v/v), P. ramosa seed germination was reduced by 90% to 100%, even in the presence of soil and plant debris. This study demonstrates that while QAC sanitizers can reduce P. ramosa seed germinability, their efficacy is compromised in the presence of debris. Therefore, physical cleaning to reduce debris loads before QAC application is essential for reducing the risk of P. ramosa seed movement among fields on equipment.
A local food-based approach, including school lunch with multiple-micronutrient fortified biscuits (MMB) as supplementary snacks, may enhance dietary adequacy, although current evidence remains limited. This study assessed nutrient inadequacies and developed food-based dietary recommendations (FBR) incorporating school lunch from the Ghana School Feeding Programme (GSFP) and MMB. Data from 292 girls aged 10–17 years, enrolled in the Ten2Twenty-Ghana study was analysed. Dietary intake was assessed via a quantitative 24-h dietary recall. Usual intakes were estimated using the National Cancer Institute method. Linear programming with Optifood was used to develop FBRs based on commonly consumed foods (≥5% of participants) and their median serving sizes, intake frequency, nutrient content, and cost per 100 g. Constraints included estimated energy needs and harmonised average nutrient requirements. The mean usual energy intake was 2351 (sd 66) kcal/d. Ca (99·8 %), vitamin B12 (99·8 %), riboflavin (96·2 %), vitamin A (91·5 %), vitamin C (87·6 %), Fe (73·7 %), folate (49·3 %) and Zn (8·5 %) inadequacies were prevalent. Optimised diets achieved adequacy for protein and most micronutrients, except Ca and vitamin B12, besides vitamin A for 15–17-year-old girls. School lunch from the GSFP did not enhance micronutrient levels when added to the daily diet. Adding MMB to the daily diet ensured adequacy for vitamin C, riboflavin and Fe, although marginal for Fe. Ca and vitamin A improved substantially with MMB for girls aged 15–17 but remained below the harmonised average requirements. Integrating regular school lunch with specialised fortified foods may be a cost-effective strategy to enhance dietary adequacy for adolescent girls in rural areas.
Design computing refers to the usage of computer frameworks, models or systems in design-related activities. Design computing research, in turn, refers to the development of these frameworks/models/systems, and so forth. As design practice increasingly relies on computer tools, the demand for research in design computing grows. While this opens innumerable venues for research, the profusion of information in the field poses significant challenges for researchers. Therefore, meta-level surveys of the field are called for. To provide researchers with a useful overview of design computing research, we set out to identify some of the main clusters of activity in the field. By “clusters of activity”, we refer to groups of researchers pursuing similar or identical research questions. Our PRISMA-style review focuses on the identification of such clusters, based on the complete proceedings (N = 404) of a long-standing conference (Design Computing and Cognition, DCC, 2004–2024), which captures the richness and diversity of the field. The primary contribution of this work is a map that organizes the main questions explored and the approaches taken in exploring them, which are informative for researchers and educators alike. This map may also help to execute large-scale surveys via automation, toward obtaining a comprehensive view of the field.
Early career researchers have unique demands, many of which contribute to increased stress, decreased professional fulfillment, and burnout. Consequently, academic institutions and government organizations, such as the National Institutes of Health, are beginning to embrace structured coaching as a tool to support physician wellbeing. To date, such coaching programs have demonstrated promising results, but little is known about whether early career research faculty find coaching feasible, accessible, or helpful. To explore this question further, we developed a novel group coaching intervention for clinician researchers and scientific faculty at the University of Texas Southwestern Medical Center based on the concept of appreciative inquiry, grounding the program in a positive and hopeful approach to the challenges faced by clinicians and researchers. Results from our program indicate this intervention is feasible, satisfactory, and helpful, with participants reporting enhanced self-reflection and empowerment. Effective for a wide array of research faculty, our program brought together diverse faculty, fostered connections, and encouraged future collaborations among this translational group. This suggests that our program provides a foundational blueprint that can be used by other academic medical centers who aim to develop group coaching efforts.
Based on present knowledge of atmospheric composition, a mechanism for the natural formation of vesicles in the lakes of Titan is proposed. It involves precipitation-induced spray droplets coated by a monolayer of amphiphiles. On interaction with the monolayer on the lake’s surface, bilayer membranes are being formed that encapsulate the liquid phase of the original droplet. The resulting vesicles develop thermodynamic stability by continuous compositional selection of various types of amphiphiles in a dynamic equilibrium, leading to an optimized vesicle stability. Different populations of stable vesicles may compete, initiating a long-term evolution process that could eventually result in primitive protocells. The existence of any type of vesicles on Titan would prove that early steps towards increasing order and complexity have taken place, which represent the necessary precondition for abiogenesis. A valid analytical approach could involve a laser device with combined light scattering analysis and surface enhanced Raman spectroscopy. It would allow for very sensitive detection of amphiphiles as well as for the observation of dispersed vesicles.
This article explores the role of representative assemblies in the diverse territories of the early modern Spanish and Portuguese empires spanning the Americas, parts of Asia, and Africa. It begins with a concise overview of the Portuguese and Spanish representative assemblies, commonly referred to as the Cortes. The second section raises some preliminary questions about how the parliamentary culture brought by the Spanish and Portuguese to their overseas possessions shaped, and was shaped by, local understandings of political participation in institutions with a representational character. The third section examines the complex debate over the integration of representatives from overseas municipalities into the Castilian and Portuguese Cortes. The fourth and final section analyses the interaction between Iberian parliamentary culture and a range of Asian, Indigenous American, and African perspectives on participation in representative gatherings. The principal argument is that representative assemblies, the debates they generated, and their varying degrees of prominence, reflect the fundamental changes observed in the political and legal structure of the Portuguese and Spanish empires.
Network meta-analysis (NMA) is becoming increasingly important, especially in the field of medicine, as it allows for comparisons across multiple trials with different interventions. For time-to-event data, that is, survival data, traditional NMA based on the proportional hazards (PH) assumption simply synthesizes reported hazard ratios (HRs). Novel methods for NMA based on the non-PH assumption have been proposed and implemented using R software. However, these methods often involve complex methodologies and require advanced programming skills, creating a barrier for many researchers. Therefore, we developed an R Shiny tool, NMAsurv (https://psurvivala.shinyapps.io/NMAsurv/). NMAsurv allows users with little or zero background in R to conduct survival-data-based NMA effortlessly. The tool supports various functions such as drawing network plots, testing the PH assumption, and building NMA models. Users can input either reconstructed pseudo-individual participant data or aggregated data. NMAsurv offers a user-friendly interface for extracting parameter estimations from various NMA models, including fractional polynomial, piecewise exponential models, parametric survival models, Cox PH model, and generalized gamma model. Additionally, it enables users to effortlessly create survival and HR plots. All operations can be performed by an intuitive “point-and-click” interface. In this study, we introduce all the functionalities and features of NMAsurv and demonstrate its application using a real-world NMA example.
We construct explicit generating series of arithmetic extensions of Kudla’s special divisors on integral models of unitary Shimura varieties over CM fields with arbitrary split levels and prove that they are modular forms valued in the arithmetic Chow groups. This provides a partial solution to Kudla’s modularity problem. The main ingredient in our construction is S. Zhang’s theory of admissible arithmetic divisors. The main ingredient in the proof is an arithmetic mixed Siegel-Weil formula.
Health economic evaluations are important for healthcare resource allocation. Reviews of health economic evaluations for medical devices have highlighted concerns about the quality of these studies. The complexity of medical devices, including learning curve effects, organizational impact, dynamic pricing, low evidence, and incremental innovation presents unique challenges compared with pharmaceuticals. To support developing a methodological quality assessment instrument for medical device economic evaluations, we conducted a systematic review to identify and evaluate existing economic evaluation quality assessment instruments for suitability in medical device evaluations.
Methods
A comprehensive search of databases (MEDLINE, EMBASE, EconLit, CINAHL, and Web of Science) and grey literature was conducted. Two reviewers screened titles and abstracts. Full-text, peer-reviewed primary studies introducing original instruments were included. Only methodological quality assessment instruments were considered for data extraction. Each item was assessed for its suitability in evaluating medical device economic evaluations and inclusion of medical device-specific features.
Results
The search identified 4203 citations and 77 grey literature sources. Fifteen results underwent full-text assessment, with five relevant instruments identified. A previous systematic review identified 10 additional instruments, which we also considered. Of these 25 articles, 13 were included in the review. These instruments lack specificity for medical devices, particularly in addressing features like learning curve effects, organizational impact, and incremental innovation. Instruments should include items specific to these unique characteristics.
Conclusions
Existing instruments contain general items related to health economic evaluation studies, highlighting the need for an instrument specifically tailored to evaluate the methodological quality of medical device economic evaluation studies.
Solar radiation modification (SRM) presents important challenges to risk regulation and governance, arising from the array of multiple risks that SRM may influence. SRM would not simply reverse climate change, but could pose further ancillary impacts, depending on the method of SRM, such as stratospheric aerosol injection (SAI), marine cloud brightening (MCB), or a space-based planetary sunshade system (PSS). We identify multiple risks that SRM may influence, both biophysical and sociopolitical, to be compared to the multiple risks that may be affected by greenhouse gas (GHG) mitigation and climate adaptation. This multi-risk framework helps analysts and decision makers identify, evaluate, and compare multiple risks holistically; helps identify affected groups to overcome problems of disregard and omitted voice; helps compare policy options and map the array of risks to corresponding (or missing) governance mechanisms; and seeks risk-superior policies that would reduce multiple risks in concert. We then examine governance frameworks: uncoordinated, coordinated and comprehensive. We suggest two key mechanisms that can help build up from uncoordinated toward more coordinated or even comprehensive approaches, and that can gain support from SRM advocates, observers and critics alike: a series of international assessments of SRM, and a transparent international monitoring system for SRM.
The Corn Belt is famously responsible for the bulk of U.S. corn production, and over half of its production comes from counties that rely on artificial drainage. We trace the history of this extensive investment in farmland and document the importance of a key institutional innovation, the drainage management district, which increased the land value of naturally wet eastern U.S. counties by 20–37 percent ($16.8–18.7 billion in 2020 dollars). While dramatically increasing agricultural productivity, drainage converted more than half of the 215 million acres of wetlands estimated to have existed in the United States at the time of colonization to agriculture.
The Galapagos sea lion (Zalophus wollebaeki) is an endemic and endangered species that plays a vital role in the ecosystem dynamics of the archipelago. In recent decades, they have faced a significant population decline, related to the effects of climate variability and anthropogenic influences. Thus, the co-occurrence of sea lion resting areas with mosquito breeding sites and the presence of free-roaming domestic dogs present significant health risks related to parasite transmission. This research demonstrates the occurrence of Dirofilaria immitis (canine heartworm) in Z. wollebaeki, indicating their possible function as a definitive host for this parasite. Blood samples collected in August 2023 from 50 individuals (juveniles and adults) in 2 rookeries of San Cristóbal Island, revealed a 2% prevalence of D. immitis in juvenile females, as confirmed by Knott’s test and polymerase chain reaction analysis. Results of this work emphasize the critical necessity for effective monitoring and conservation strategies to address the threat posed by D. immitis and to safeguard this endangered species.
The transition from primary to secondary school, encompassing the pre-, during-, and post-transition stages, often poses significant challenges for students on the autism spectrum. This critical period has garnered growing research attention; however, the perspectives of Australian parents on the support their autistic children receive post-transition remain largely unexplored. Underpinned by a transcendental phenomenological epistemology and Kohler’s Taxonomy for Transition Programming, we explored Australian parents’ perspectives on the support being provided to their children on the autism spectrum and how these students experience this post-transition period. Four parents of high-school-aged children on the autism spectrum participated in interviews, conducted online via Zoom. A deductive content analysis of parents’ insights revealed overwhelming dissatisfaction with the post-transition support provided to their children on the autism spectrum, particularly surrounding home–school collaboration practices and the utilisation of personalised learning. The findings contribute a much-needed Australian perspective to the limited body of research focused on sustaining support for students on the autism spectrum beyond the initial transition to secondary school.
Let $\mathcal {D}$ be a Hom-finite, Krull-Schmidt, 2-Calabi-Yau triangulated category with a rigid object R. Let $\Lambda =\operatorname {End}_{\mathcal {D}}R$ be the endomorphism algebra of R. We introduce the notion of mutation of maximal rigid objects in the two-term subcategory $R\ast R[1]$ via exchange triangles, which is shown to be compatible with the mutation of support $\tau $-tilting $\Lambda $-modules. In the case that $\mathcal {D}$ is the cluster category arising from a punctured marked surface, it is shown that the graph of mutations of support $\tau $-tilting $\Lambda $-modules is isomorphic to the graph of flips of certain collections of tagged arcs on the surface, which is moreover proved to be connected. Consequently, the mutation graph of support $\tau $-tilting modules over a skew-gentle algebra is connected. This generalizes one main result in [49].
Putnam’s Twin-Earth thought experiment has been hugely influential as an argument in favor of semantic externalism. In this article, I argue that the Twin-Earth thought experiment relies on some previously unnoticed metaphysical assumptions about how to individuate words. My aim is not to argue that semantic externalism is false. Rather I aim to show that Putnam’s thought experiment is only effective as an argument for semantic externalism if we also are committed to certain additional highly controversial and/or implausible claims within the metaphysics of words. I close by arguing that a similar argument for semantic externalism by Burge also relies on unnoticed metaphysical assumptions in the metaphysics of words.