Acute infection with Toxoplasma gondii in pregnant people can lead to vertical transmission to the foetus and congenital toxoplasmosis. As part of risk assessment, the epidemiology of toxoplasmosis among pregnant people must be quantitatively elucidated. Herein, we investigated the risk of primary T. gondii infection during pregnancy in Japan, estimating the incidence of T. gondii infection among pregnant people as well as that of congenital toxoplasmosis. We used a compartment model that captured the infection dynamics in pregnant people, analysing prescription data for spiramycin in Japan, together with local serological testing results and the screening rate of primary T. gondii infection during pregnancy. The nationwide risk of T. gondii infection pregnant people in Japan was estimated to be 0.016% per month. Among prefectures investigated, the risk estimate was highest in Tokyo with 0.030% per month. Nationally, the number of T. gondii infections among pregnant people in the years 2019, 2020, and 2021 was estimated to be 1507, 1440, and 1388 infections, respectively. The nationwide number of cases of congenital toxoplasmosis in each year was estimated at 613, 588, and 567 cases, respectively. Our study indicated that T. gondii infection continues to place a substantial burden on public health in Japan.

Recent academic contributions explore the integration of Digital Twins (DTs) within smart Product-Service System (sPSS). This integration aims to innovate business propositions, hardware and services. However, gaps persist in developing DT environments to support early-stage collaborative innovation for sPSS, and limited studies explore how real-time synchronized digital replicas enhance value co-creation in this area. This paper addresses this gap by presenting a framework and practical example of integrating value-driven decision support into early sPSS conceptual design. A case study on the development of the Smart Electric Vehicle (SEV) conducted with a global automotive Original Equipment Manufacturer (OEM) demonstrates the framework’s efficacy. Through qualitative data analyses based on experimental validation in a case company, the DT proves effective in aiding decision makers in selecting value-adding configurations within specific scenarios. Furthermore, the DT serves as a visual decision-making tool, fostering collaboration across diverse teams within the automotive company. This collaboration facilitates value creation across practitioners with varied backgrounds, emphasizing the DT’s role in enhancing early-stage innovation and co-creation processes in the sPSS domain.

This article examines the social and political impacts of President Nayib Bukele’s 2023 opening of a megaprison in El Salvador by analyzing his government-funded international public relations campaign. We chronicle how the design of the prison, along with policies for arresting, detaining, and prosecuting Salvadorans for alleged gang-related crimes, offers a mirage of transparency that obstructs the visibility needed to protect the human rights of Salvadorans. Our analysis places empirical accounts of conditions in El Salvador in conversation with the largely Twitter/X-based public relations campaign announcing the new prison. We show how the campaign works to justify an alarming degradation of democratic principles and practices during the current régimen de excepción (state of exception). Bukele rationalizes an iron-fist-style approach to gang violence while simultaneously silencing political opposition and obfuscating the expanding scope of state human rights violations. We argue that the trade-offs being made in El Salvador between increased safety for some and human rights violations for others ultimately contribute to the corrosion of democracy. Moreover, we discuss how Bukele’s tough-on-crime populism simultaneously produces and exports an “authoritarian playbook” for wider regional democratic erosion in line with Bukele’s model.

In Where Do We Go from Here: Chaos or Community? the Reverend Dr. Martin Luther King, Jr. speaks with conviction on the need for and importance of community. King depicts American society and modern civilization as a great “world house” that is inhabited, inherited—and imperiled. Behind the metaphor of the world house is a prophetic vision and dream—the realization of what he called the “beloved community.” In this article, the author considers King’s beloved community ideal through a housing lens. Engaging with King’s metaphor, the author frames the beloved community as an apologetic for integrated community. The author views the metaphor of the world house as a significant means to expand understanding of beloved community, elevate housing as a moral-ethical concern, and engender radical structural solutions that can be realized through racial justice in the housing sector.

This article contributes to the ongoing debate on reactionary internationalism by linking it with scholarly discussions on civilisation and civilisationism, which have mostly been running in parallel trajectories. By doing so, it attempts to address the question of how the radical right, rooted in numerous particularisms, such as cultural, national, and religious, has managed to foster a global movement with an internationalist ideology that poses a significant challenge to the liberal international order. Through an analysis of the relevant literature and a case study of the Serbian radical right, this article tries to elucidate this question and bridge the gap between the two debates by demonstrating that civilisationism forms the core of reactionary internationalism, unifying the radical right from the West to the East. This article examines the Serbian case and its history of civilisational and geopolitical reactions as a possible paradigm for the contemporary radical right in general. Furthermore, it explores the role of Russian revisionism and war in Ukraine in shaping this civilisational discourse, specifically considering the narratives built around the Serbian foreign fighters’ network in Ukraine. An additional contribution of this article is that it provides a non-Western perspective on civilisation, religion, and nationalism.

La labor periodística de Francisco Castañeda reconoce antecedentes formales tanto con los espectadores de la prensa moral europea, como con ciertas estrategias de la prensa porteña. Sus colaboraciones en los periódicos de Antonio Valdés permiten identificar un proceso de intervención en lo público signado por la sátira y la ficción que se desarrolla de manera progresiva a lo largo de la década de 1810. Su actuación en la prensa alcanza su máxima expresión en el período entre 1820 y 1823, con una producción propia en la que se destaca el lugar central de la ficción como modo de comprender la realidad política, la sátira como herramienta pedagógica y el montaje de fragmentos como método de resignificación crítica tanto de los textos como de la realidad.

Brun’s constant is the summation of the reciprocals of all twin primes, given by

$$ \begin{align*}B=\sum_{p \in P_2}{\bigg( \frac{1}{p} + \frac{1}{p+2}\bigg)}.\end{align*} $$

While rigorous unconditional bounds on B are known, we present the first rigorous bound on Brun’s constant under the assumption of GRH, yielding $B < 2.1594$.

This article documents the legal and social history of “distress for rent” (also known as rent distraint) in early Republic New York, a legal tool that allowed landlords whose tenants were in arrears to seize tenants’ belongings and sell them to offset the cost of the unpaid rent. Rent distraint was a practice and topic around which New Yorkers contested ideological and practical conceptions of class, the rights of property, the role of law, and welfare. In 1811, New York City officials began tracking tenants in arrears of rent, creating a deep archive of documents that reveal the nuances of landlord-tenant relations and subsistence in this period. This article follows that paper trail, exploring distraint in this context as a legal remedy, as an experience with major impacts on individuals’ lives, and of efforts to reform the law and the lived experience of law. In the first decades of the nineteenth century, poor, middling, and wealthy New Yorkers were engaged in knowledge exchange around distraint and the social categories and experiences associated with it. Their stories document a materialist sensibility that crossed class lines and was attuned to the practical dimensions of working people’s living conditions.

There is a tendency in academia to expect humanities graduates to have an innate understanding of the significance of their educational training, even in the midst of a diminishing regard for their chosen subjects within educational policy and public discourse. This pedagogical reflection explores the experience of two tutors and eight students on a final-year module called “The Public Role of the Humanities.” Grounded in the pedagogical principle that the Liberal Arts offers interdisciplinary education for engaged citizenship, its remit is to explore the ways in which arts and humanities perspectives play a vital role in all walks of public life. The module is designed to help students understand how they can bring their educational training to bear not just on future careers but also on the kinds of paid jobs and volunteering roles in which they are already engaged. The students each create a podcast reflecting on this topic. In this article, we discuss the shared experience of thinking about the public humanities, including situations where issues and disagreements arose. We draw conclusions about how to move beyond defensive discourse about value and instead integrate interdisciplinary insights and approaches with daily living and working practices.

The scale function plays a significant role in the fluctuation theory of Lévy processes, particularly in addressing exit problems. However, its definition is established through the Laplace transform, which generally lacks an explicit representation. This paper introduces a novel series representation for the scale function, utilizing Laguerre polynomials to construct a uniformly convergent approximation sequence. Additionally, we conduct statistical inference based on specific discrete observations and propose estimators for the scale function that are asymptotically normal.

This article examines the evolution of Soviet operatic conventions during Khrushchev’s Thaw. The first opera to be prematurely cancelled from the Bolshoi Theatre since Stalin was Rodion Shchedrin’s 1961 opera Not Love Alone, and as such, it set the standard for what would be deemed unacceptable in Thaw-era opera. Using this opera as a case study, I employ extensive archival material, including never-before-accessed audience surveys and internal Bolshoi Theatre meeting minutes, to analyse the opera’s path to official acceptance – and then official rejection. I thus illuminate the competing demands that composers, Party bureaucrats, and audiences expected of the Soviet opera project, and the convergences and divergences with the Stalin-era. Finally, I demonstrate why the project of creating a robust repertoire of contemporary-themed Soviet opera failed during the Thaw, never to be revived with such fervour, and demonstrate why Shchedrin’s opera was the attempt closest to achieving enduring success.

Norm contestation has become an established research programme in International Relations. However, scholars have yet to scrutinise the form and effect of radical contestation. I argue that radical contestation is a disruptive form of contestation, distinguished by (1) the extensive scope that attacks a specific norm and wider normative order, institutions, and actors sympathetic to the norm, and (2) high emotional intensity in animating contestation. To bring these features of radical contestation together, I use insights from the study of emotions and backlash movements to advance a new ‘emotional backlash’ framework and explain the construction, mobilisation, and outcome of radical contestation. I subsequently apply this framework to analyse the emotional backlash against Rohingya refugees during Covid-19. Cultivated by resentment, the emotional backlash against the Rohingya contests refugee protection norms and extends to radically challenge human rights advocates, United Nations agencies, and the larger humanitarian and cosmopolitan principles. In doing so, backlash supporters aim to restore a society without refugees and their sympathisers, and instead to promote racism as a ‘normal’ organising principle. By capturing radical contestation, this contribution steers norms scholarship towards a new research terrain and highlights the implications that the backlash has for the international refugee regime.

My research on dietary protein and the regulation of proteostasis in muscle and the whole body during growth and adult maintenance is reviewed. Growth control involves both permissive and regulatory roles of protein acting with genetic determinants and functional demand, to mediate substrate flow into metabolic consumption, energy storage and growth. In 1995 a Protein-Stat hierarchical model for control of the fat-free mass was proposed and is updated here with special emphasis on the skeletal muscle mass. Control is exerted in large part through a central aminostatic appetite mechanism sensing changes in free amino-acid patterns in response to the balance between their supply in relation to their demand. This acts primarily to maintain skeletal muscle mass at a level set by the linear dimensions of the organism, which in turn is controlled by genetic programming and mediated by the developmental hormones acting together with an appropriate anabolic drive deriving from dietary protein. This, together with other important nutrients like zinc, calcium and vitamin D, provides the regulatory stimulus for growth and protein deposition in all tissues. The applicability of this model to childhood growth and development will be described as well as the maintenance of the adult phenotypic muscle mass within populations with protein intakes varying over a wide range, work which resulted in an adaptive metabolic demand model for protein and amino acid requirements and values for apparent adult protein and lysine requirements. Finally current understanding of aminostatic mechanisms of amino-acid sensing in the brain will be reviewed.

Flight Data Monitoring (FDM) programmes have become a key part of every major airline’s safety management system. They are primarily based on learning from unwanted deviations in flight parameters encountered during normal flight operations. Owing to its unique nature, anomaly detection of FDM presents distinct problem complexities from the majority of analytical and learning tasks. This methodology, while useful, concentrates only on a small part of the operation, leaving most of the data unprocessed, and does not allow for analysing events that had the potential to go wrong but were recovered in time by the crews. This research focused on analysing an FDM dataset of 1332 approaches between January 2018 and July 2022 at Tenerife South Airport (Spain), where there is a known phenomenon of increasing headwinds during the final approach. The flights were clustered using self-organising maps (SOM) by patterns of increasing headwinds, and the clusters were assessed in terms of clustering performance. The clusters were well differentiated. A further comparison between the results from the airline showed that 88 flights were affected by wind shifts, while 27 flights were picked up by the airline. The results demonstrate that SOMs are a meaningful tool for clustering flight data and can complement the current FDM analysis methodology. Combining both methodologies could shift FDM data analysis to look beyond exceedances into what went well, thus shifting the FDM paradigm towards a more safety-II-based method.

This work tackles a significant challenge in dynamo theory: the possibility of long-term amplification and maintenance of an axisymmetric magnetic field. We introduce a novel model that allows for non-trivial axially symmetric steady-state solutions for the magnetic field, particularly when the dynamo operates primarily within a ‘nearly spherical’ toroidal volume inside a fluid shell surrounding a solid core. In this model, Ohm’s law is generalised to include the dissipative force, arising from electron collisions, that tends to align the velocity of the shell with the rotational speed of the inner core and outer mantle. Our findings reveal that, in this context, Cowling’s theorem and the neutral point argument are modified, leading to magnetic energy growth for a suitable choice of toroidal flow. The global equilibrium magnetic field that emerges from our model exhibits a dipolar character. The central insight of the model developed here is that if an additional force is incorporated into Ohm’s law, symmetric dynamos become possible.

The Lower Jurassic (Toarcian) Posidonienschiefer Formation of southwestern Germany is a classic konservat lagerstätte, yielding some of the world’s best-preserved fossils of marine vertebrates, including ichthyosaurs, thalattosuchian crocodylomorphs, plesiosaurs and fishes. Despite numerous studies concentrating on the taphonomy of ichthyosaurs in this formation, less taphonomic work has focussed on the thalattosuchians of the assemblage. Multiple thalattosuchian species displaying a wide range of body sizes have been recovered. We investigated indicators for seafloor arrival position in thirteen Macrospondylus bollensis and one Platysuchus multiscrobiculatus specimens representing various body sizes using three-dimensional (3D) photogrammetric models. False-colour depth maps were used to interpret the relative topography (depth level) of bone penetration into the sediment and were aligned on the XY plane, making them parallel to the stratigraphic plane. Our results show both headfirst and non-headfirst seafloor arrivals in observed specimens, with headfirst seafloor arrivals exhibiting deeply buried skulls, displacement of select cervical vertebrae and/or characteristic fractures in the cranium and mandible. We (1) interpret seafloor landing types in teleosauroids; (2) recognize and list specific characteristics that are consistently attributed to either a headfirst or non-headfirst seafloor arrival; (3) discuss possible factors that may have contributed to these features, such as body shape and size, substrate and velocity; and (4) provide a new definition for headfirst seafloor arrival that can be readily attributed to other marine vertebrates from various formations. Lastly, our results show that observers must carefully consider how historical specimens might have been prepared, as this may influence taphonomic interpretations.

Past research indicates that support for conservatism increases when individuals perceive threat to their group’s social status – i.e., prestige and respect. However, the causal link between status threat and increased electoral support for conservative candidates has not been established. Most prior studies rely on observational data, and it remains unclear how the effect of status threat on candidate support varies depending on the specific conservative policies adopted by candidates. Additionally, previous research has not fully addressed whether and how these effects are constrained by voters’ party loyalty. This article investigates these questions by conducting a joint experiment combining vignette and conjoint designs. White Americans were randomly exposed to status threat communication, and then choose between different hypothetical candidates with varying degrees of conservatism on various issues. The results show large effects of candidates’ issue positions and partisanship, but very little effect of status threat.

This article examines cross-border inheritance transfers between the United States, Germany, and Russia between the 1840s and the late 1980s. These transfers were not only characterized by private considerations and kinship networks but were also strongly intertwined with national and international political developments. This article argues that the history of transnational inheritance transfers since the 19th century can be subdivided into three distinct periods. The first period, from the mid-19th century to 1914, witnessed the gradual development and expansion of professional networks and legal agreements designed to facilitate cross-border estate transfers. By contrast, the second period, from World War I and the October Revolution of 1917 through the late 1960s, was a time of unprecedented global disruption. Unlike the half-century before World War I, governments and probate courts complicated, delayed, and prevented inheritance transfers across state borders due to military and ideological conflicts. During the third period, beginning in the 1960s, governments, international organizations, lawyers, and families resumed efforts to create structures that would legally protect and enable cross-border estate transfers in an increasingly globalized world.