To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In the present work, we experimentally investigate the transverse injection of elliptic liquid jets into a supersonic cross-flow ($M_\infty$ = 2.5). The primary focus is to understand the effect of injection orifice aspect ratio ($\textit{AR}$ = spanwise/streamwise dimension), on the liquid jet breakup mechanism, the flow field around the liquid jet and the resulting droplet sizes formed downstream, for three $\textit{AR}$ cases ($\textit{AR}$ = 0.3, 1, 3.3). We find that the $\textit{AR}$ = 0.3 case has large unsteadiness in the spray core due to relatively large wavelength Rayleigh–Taylor (RT) waves formed on the liquid jet surface. However, the primary jet breakup occurs through Kelvin–Helmholtz (KH) instabilities formed on the large lateral surfaces, as in coaxial liquid jet breakup. This leads to a higher Sauter mean diameter (SMD) of the droplets in the spray core with a wider range of droplet sizes compared with the circular case ($\textit{AR}$ = 1.0). However, in the case of $\textit{AR}$ = 3.3, the RT waves are more intense and of smaller wavelength due to the large drag on the liquid jet, which results in a direct catastrophic breakup of the liquid jet by the RT waves. This results in a relatively steady liquid jet and shock structure with the formation of a fine spray and smaller droplets in the spray core than for the $\textit{AR}=1.0$ case. The study shows the importance of the orifice $\textit{AR}$ on the flow around, and the spray downstream of, the liquid jet injection into supersonic cross-flow.
Forced labour in the Middle Congo was characterized in the interwar period by, on the one hand, a declining role of the notorious French concession companies, and, on the other hand, the growing importance of forced recruitment and forced labour orchestrated by the colonial state. The article attempts to analyse and understand the overall setup of overburdening created by these conditions. Based on new French and Congolese archival resources, it discusses the effects of this overburdening, linking it to the responses shown by local populations, notably through flight and evasion. In a last step, the discussion focuses on the role of intermediaries and their impact on the violence that was locally experienced. The analysis includes a wider perspective into the changes and continuities during the years of World War II, and on the challenges for the forced labour system due to its official abolition in 1946 and the decline of clandestine practices of continuity until 1948.
Recent years have seen increasing focus, including by the National Institutes for Health (NIH), on developing the field of translational science (TS). TS focuses on improving the process of translational research (TR), including generating knowledge that can facilitate TR across specific diseases or translational stages. With TS as an emerging field, research organizations have an increasing need to understand how to develop capacity for and support the advancement of TS. To support such institutional and infrastructural change, this paper outlines a Translational Science Promotion and Research Capacity (T-SPARC) Framework. The T-SPARC Framework provides a foundation to 1) inform the development of TS-creating and science-supporting interventions and programs, and 2) examine the effectiveness of said interventions and programs. The framework outlines organizational levels that T-SPARC programs can target; mechanisms, or intervention activities, that can foster change; and outcomes, including specific attitudinal or behavioral changes, institutional changes, and domains on which TS changes can focus. T-SPARC’s capacity-building focus builds upon earlier efforts focused on conceptualizing and defining TS. T-SPARC supports movement towards TS goals of reducing longstanding challenges in the TR process, thus accelerating the health impact of TR, and ultimately improving health outcomes.
Virtual reality (VR) may improve psychological treatments for psychotic disorders. We investigated the effects of VR-based cognitive behavior therapy for paranoid ideation (VR-CBTp) compared to standard CBTp.
Methods
We conducted a pragmatic, single-blind, randomized clinical trial in seven mental health centers across the Netherlands and Belgium. A total of 98 participants with a psychotic spectrum disorder and paranoid ideation were randomized to a maximum of 16 sessions of VR-CBTp (n = 48) or CBTp (n = 50). The primary outcome was momentary paranoia, measured with the experience sampling method (ESM) at posttreatment. Secondary measures, assessed at baseline, posttreatment, and 3-month follow-up, included symptoms (paranoia, hallucination, depression, cognition, and anxiety related), social functioning, self-esteem, and schemes.
Results
Both groups showed reductions in momentary paranoia between baseline and posttreatment (n = 56, b = −15.0, effect size [ES] = 0.65), but those were greater for VR-CBT (interaction b = 8.3, ES = 0.62). Reductions remained at follow-up (n = 50, b = −10.7, ES = 0.57) but not the interaction. Limited ESM compliance resulted in data loss; however, secondary paranoia measures did confirm improvements (ES range = 0.66–1.15, n = 78–81), but not the interaction. Both groups improved in symptoms, self-esteem, and social functioning. Interaction effects in favor of VR-CBTp were found for safety behavior, depression, and self-esteem at posttreatment, and self-esteem and anxiety at follow-up. For VR-CBTp, 37.5% did not complete treatment; for CBTp, this was 24.0%. Completers, on average, received 12.7 (VR-CBTp: standard deviation [SD] = 3.9) and 15.1 (CBTp: SD = 2.5) sessions.
Conclusions
Both CBTp and VR-CBTp are efficacious treatments for paranoid ideation, but VR-CBTp may be somewhat more effective. Limitations concern missing primary outcome data and a lower sample size than anticipated.
Rutgers Health, Clinical Research Management (CRM) program with support from New Jersey Alliance for Clinical and Translational Science (NJ ACTS) provide scholarships to establish a “Clinical Research Experience” (CRE). The CRE focuses on building an entry-level Clinical Research Coordinator (CRC) workforce. The six-month precepted CRE is embedded in an accelerated master’s degree and demonstrates a skill-based approach to developing CRC resources. The CRE structure affiliated site collaboration; competency based curriculum objectives; standardized competency aligned on-boarding; and preceptor-evaluated performance. The experiential education is designed for academic medical centers (AMCs) to foster the development of qualified research coordinators. The CRE model supports “teach one, see one, do one” coupled with preceptor-evaluated feedback to cultivate clinical research competency.
In this article, we show that the Russian invasion of Ukraine triggered a pro-democratic reaction from citizens in liberal democracies, which we term the “rally for democracy.” Unlike the conventional “rally ‘round the flag” effect that boosts government popularity, this involves citizens rallying behind democracy as an international ideal. It includes expressing stronger proximity to democratic powers, stronger approval for democratic leaders abroad, and greater aversion to authoritarian regimes. Through a survey quasi-experiment conducted in six countries between February and May of 2022, we provide evidence that the “rally for democracy” emerged immediately following Russia’s invasion. Exploring this observation further via analysis of data from 55 countries between 2014 and 2023, we find this to be the intensification of a longer-term trend in response to the rise of authoritarian great powers. A new cleavage exists in geopolitical loyalties, based on the degree to which citizens feel attachment to democracy, and this divide runs both between and within countries.
This study aims to ascertain the effect of baseline IL-1Ra and IL-8 in the treatment response of patients with major depressive disorder (MDD) and to clarify the relationship between inflammation markers and depression.
Methods:
We recruited 242 patients with a Beck Depression Inventory (BDI) score ≥ 17 referred to secondary care in Finland. The patients’ serum IL-1Ra and IL-8 concentrations were measured at baseline. Montgomery-Åsberg Depression Rating Scale (MADRS) tests and Alcohol Use Disorders Identification Tests (AUDIT) were administered at baseline and six weeks. The antidepressant treatments varied: somewere started, others changed or continued their previous medication, and others had their doses adjusted. Patients started behavioral activation therapy. Linear regression was used with a relative MADRS score change during six weeks as the dependent variable and patient age, AUDIT score, BMI, daily number of cigarettes smoked, sex, and serum IL-1Ra and IL-8 concentrations as independent variables.
Results:
Higher baseline serum IL-1Ra and IL-8 levels were associated with a smaller relative change in the MADRS-score within the first six weeks of treatment in linear regression analysis (p < 0.001 and p = 0.007, respectively). In further analysis comparing groups with ≤ 24 and>24 MADRS score only the ≤ 24 MADRS score group showed a similar association.
Conclusion:
Higher baseline IL-1Ra and IL-8 concentrations were associated with a lesser relative response to depression treatment, particularly in patients with mild depression. Results on IL-8 concur with earlier findings, whereas the association between higher IL-1Ra serum concentrations reduced treatment response is a novel finding.
Non-pharmacological interventions (NPIs) are recognised for their potential in treating dementia symptoms. However, little is known about the extent of their use. In this study, we conducted structured interviews with people with dementia and their family caregivers (n = 50), professional caregivers (n = 42) and dementia care coordinators (n = 42) on the use of 14 NPIs.
Results
Cognitive stimulation/training, physical activity and occupational therapy were implemented by most participants, whereas neurofeedback, drama therapy and phototherapy were rarely used. Most NPIs were carried out weekly. People with dementia and their caregivers reported using significantly fewer NPIs than other participants (P < 0.001). Participants perceived effects for, on average, 90.3% (s.d. = 31.3%) of the NPIs that they used.
Clinical implications
Providing targeted support and funding might help to increase the use of NPIs by family caregivers as well as in institutional care settings.
Health Technology Assessment international (HTAi) supports global collaboration and innovation in HTA through its dynamic network of Interest Groups (IGs). These thematic communities provide a dedicated platform for members to engage in focused, collaborative efforts that drive professional exchange, advance methodologies, and develop best practices in HTA. This commentary offers a panoramic overview of all IGs, their evolution, aim, and initiatives. By drawing on diverse stakeholder perspectives, spanning academia, clinical practice, industry, and patient communities, the IGs foster inclusiveness and extend HTAi’s influence to significantly contribute to the broader HTA community. Through activities such as workshops, conference sessions, webinars, publications, and research projects, they offer opportunities for professional development and thought leadership. The IGs’ cross-cutting contributions position them as engines of innovation to ensure HTAi remains at the forefront of shaping a globally relevant, responsive, and ethically grounded HTA ecosystem.
This article sheds light on a series of Xinjiang maps created by order of imperial Japan’s General Staff Headquarters in 1943. These maps, seventeen in all, offered panoramic views on Xinjiang’s topography, geological and meteorological conditions, ethnic composition, major cities, riverine systems, aviation ports, roads for motorized vehicles, wireless and postal systems, and various resources. Those maps invite the heretofore little-studied question of how Xinjiang figured in imperial Japan’s geostrategy. This article contextualizes imperial Japan’s heightened strategic interest in Xinjiang during World War II, particularly after the closure of the Burma Road, which paradoxically revitalized Chongqing’s Republican regime. These sources inform the argument that the place of Xinjiang in imperial Japan’s geostrategic thinking must be understood beyond the narrow lens of Sino-Japanese enmity. It warrants a world historical perspective. The article examines said maps and uncovers the multiplicity of Xinjiang’s toponyms and ethnonyms that encapsulated parallel and oftentimes contested temporalities. Tokyo’s attentiveness to ethnological understandings of the region’s indigenous populations reflects an aspiration to construct a political demography that tethered indigenous sovereignty to the authority of the colonial state, bypassing the domination of the Chinese Republic in Chongqing.
Ce texte explore le rôle du sujet dans la théorie des savoirs situés de Donna J.Haraway et de Lorraine Code. Il examine la tension entre l’approche individualiste et l’approche collective dans les épistémologies féministes. Nous y soutenons que les savoirs situés permettent de concilier la dimension individuelle du sujet avec une perspective politique et collective, tout en évitant une critique anti-individualiste qui nierait l’agentivité personnelle. Cette approche offre des critères de responsabilité épistémique individuelle et s’intéresse plus aux actions du sujet qu’à son essence.
Diagnostic accuracy is an unmet need for major depressive disorder (MDD) and major depressive episode (MDE) in bipolar disorder. Very limited research has evaluated bipolar disorder/MDE and MDD using ecological momentary assessment (EMA) time-series data.
Aims
We aimed to examine differentiating phenomenological characteristics in positive affect dynamics, and temporal relationships with pleasure towards current activity and meaning in life (MIL), among MDD, MDE/bipolar disorder and healthy controls using EMA.
Method
Participants (N = 88, mean age 28.7 years, 69% female), including individuals with MDD (n = 29) and MDE/bipolar disorder (n = 29) and healthy controls (n = 30), were assessed for positive affect, pleasure and MIL 5 times daily over a 2-week period. Multilevel modelling analysis was conducted, with estimation of first-order autoregressive model structure and time-lagged relationship between pleasure and positive affect.
Results
From 4632 EMA observations, positive affect dynamics (inertia, variability and instability) did not differ significantly across groups (all P > 0.05). Although all groups demonstrated a bidirectional relationship between positive affect and pleasure, for MDE/bipolar disorder, both pleasuret − 1 (β = −0.11, t[51.09] = −2.31, P = 0.025) and positive affectt − 1 (β = −0.13, t[56.54] = −2.30, P = 0.025) predicted subsequent MIL less significantly than for MDD and healthy controls.
Conclusion
Individuals with MDE/bipolar disorder, but not MDD, had less self-reported MIL from positive affect and pleasure. There is little evidence that emotional experience alone characterises the pathophysiology between MDD and MDE/bipolar disorder; such investigation may be limited by within-group heterogeneity. Our findings provide a new perspective on using a time-series approach beyond bimodal measures in EMA to differentiate bipolar disorder/MDE and MDD.
We present a new Eulerian framework for the computation of turbulent compressible multiphase channel flows, specifically to assess turbulence modulation by dispersed particulate matter in dilute concentrations but with significant mass loadings. By combining a modified low-dissipation numerical scheme for the carrier gas phase and a quadrature-based moment method for the solid particle phase, turbulent statistics of the fluid phase and fluctuations of the particle phase may be obtained as both are resolved as coupled fields. Using direct numerical simulations, we demonstrate how this method effectively resolves the turbulent statistics, kinetic energy, skin friction drag, particle mass flow rate and interphase drag for moderate-Reynolds-number channel flows for the first time. Validation of our approach to the turbulent particle-free flow and the turbulent particle-laden flow proves the applicability of the carrier flow low-dissipation scheme to simulate relatively low-Mach-number compressible flows and of the quadrature-based moment method to simulate the particle phase as an Eulerian field. This study also rationalises the computed interphase drag modulation and total Reynolds shear stress results using a simplified analytical approach, revealing how the particle migration towards the wall can affect the drag between the two phases at different Stokes numbers and particle loadings. Furthermore, we show the effect of near-wall particle accumulation on the particle mass flow rate. Using our Eulerian approach, we also explore the complex interplay between the particles and turbulent fluctuations by capturing the preferential clustering of particles in turbulence streaks. This interplay leads to turbulence modulations similar to recent observations reported in prior computational works using Lagrangian simulations. Our study extends the applicability of the Eulerian approach to accurately study particle–fluid interactions in compressible turbulent flows by explicitly calculating the energy equations for both the particle phase and the carrier fluid motion. Since the formulation is compressible and includes energy equations for both the particle and carrier flow fields, future studies for compressible flows involving heat and mass transfer may be simulated using this methodology.
Partnerships between public, private and civil society actors can potentially address food systems challenges. However, such cross-sector partnerships may require the management of potential tensions and conflicts of interest. This article presents the development and content of a framework for engagement between food systems actors involved in NewTools, a cross-sector research partnership involving twenty-eight partners from research institutions, government, food industry and civil society. The purpose of the framework is to facilitate engagement of partners and maintain research integrity.
Design:
This two-phased, iterative study was conducted in 2022. It was guided by recommendations for methodological framework development and was informed by existing frameworks and recommendations as well as two rounds of consultations with partners.
Setting:
The Norwegian cross-sector research partnership NewTools that aims to develop two food profiling models: one for dietary quality and one for environmental and social impact.
Participants:
Food systems actors involved in the NewTools project.
Results:
The NewTools framework consists of four main parts: (1) definition of overarching principles for collaboration (transparency, regular information, adhering to defined roles and responsibilities), (2) descriptions of roles and responsibilities of the partners involved, (3) procedures to ensure involvement and transparency and (4) identification and mediation of potential conflict areas.
Conclusions:
This article provides an example of how a cross-sector research partnership developed a framework to facilitate engagement between partners with different interest within a food system. Future studies are needed to assess the potential value of frameworks for cross-sector research partnerships towards healthier and more sustainable food systems.
Predictive biomarkers can identify patients who are more likely to respond to immunotherapy, which can guide treatment decisions. The objective of this study was to assess the potential value of predictive biomarkers in advanced NSCLC patients to guide the development of cost-effective biomarkers in this field.
Methods
A decision analytical model was constructed to compare theoretical new strategies with biomarkers to the current standard of care. The analysis was performed for three different patient groups based on PD-L1 status. Differences in health outcomes (QALYs) and costs were assessed between the current practice and these biomarker strategies.
Results
Omitting immunotherapy in NSCLC patients with a PD-L1 score < 1 percent or between 1 and 49 percent, and a negative biomarker test, could potentially reduce healthcare costs significantly a small loss in QALYs. In these groups, a biomarker test is potentially cost-effective as the incremental cost-effectiveness ratio largely exceeds a willingness-to-accept threshold of €80,000 saved per QALY lost. For patients with a PD-L1 score > 50 percent, a considerable QALY gain can potentially be realized by adding chemotherapy to patients with a negative biomarker test. However, this comes at a significant increase in costs and appears not to be cost-effective.
Conclusions
In general, predictive biomarkers seem to have the potential to increase the cost-effectiveness of treatment with immunotherapy in patients with advanced NSCLC. Optimal positioning of a biomarker depends on the weighing between health impact and costs.
Workplace exclusion – often subtle and difficult to detect – significantly contributes to employee disengagement and turnover, costing US organizations over $1 trillion annually. This study examines how exclusionary behaviors (EBs) influence turnover intentions (TOIs) through disruption of psychological needs, using Rock’s SCARF model (Status, Certainty, Autonomy, Relatedness, Fairness) and self-determination theory. A two-wave survey of full-time US employees (N = 277) assessed EB, SCARF-based need satisfaction, and TOI. Partial least squares structural equation modeling revealed that EB significantly undermines all five SCARF domains, but only fairness and status mediated the EB–TOI link. Certainty, autonomy, and relatedness did not have significant effects. These findings suggest turnover risk intensifies when employees feel unfairly treated or socially devalued, rather than merely disempowered or disconnected. The study advances theoretical integration between SCARF and SDT and offers practical guidance for managers seeking to reduce attrition by fostering inclusive, respectful, and psychologically safe workplace environments.
Everyday understanding takes empathy to be not just emotional mirroring with a specific etiology, but also a form of feeling for, or on behalf of, another. This article proposes an analysis of that for-relation. The analysis begins with the phenomenon of acting on behalf, which is then used as a template for an analysis of generic on behalfness, applicable to both action and emotion. The key to the relation turns out to be an agent’s espousal of a target’s goal, in light of which the agent acquires reasons for acting or feeling.
Women remain underrepresented in National Institutes of Health (NIH) study sections, panels of scientists who review grant applications to inform national research priorities and funding allocations. This longitudinal, retrospective study examined the representation of women on study sections before and during the COVID-19 pandemic. Overall, 16,902 reviewers served on 1,045 study sections across 2019, 2020, and 2021, of which 40.1% (n = 6,786) were women. The likelihood of reviewers being women significantly increased from 2019 to 2021, except among chairpersons. Understanding the representation of scientists influencing NIH grant decisions is important to ensuring scientific discovery that meets the nation’s pluralistic needs.
Decades of systemic oppression in Syria, from the 1963 state of emergency to the 2011–2024 conflict, have caused widespread psychological devastation. Arbitrary imprisonment, torture and sexual violence have been systematically weaponised. Following the fall of the Syrian regime in December 2024, freed political prisoners face severe mental health challenges due to years of inhumane conditions and trauma. This paper emphasises the urgent need for specialised mental health interventions and outlines evidence-based pathways to healing. A coordinated, multi-tiered response, integrating local and international efforts, is essential to prioritise mental health aid, restore dignity and support survivors in rebuilding their futures.