To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
It is now acknowledged that possible negative effects of cancer therapies on future reproductive autonomy are a major concern. In the bioethics literature, some advocate that the child’s right to fertility preservation (FP) should be recognized as a right to an open future.
Research objectives
The aim of this qualitative study is to (1) explore pediatric oncologists’ perceptions regarding barriers and facilitators of OTC in prepubertal girls and (2) analyze the ethical, legal, social, and policy implications of these barriers and facilitators in Canada and France.
Participants and research design
Between November 2022 and August 2023, 10 French and 6 Canadian oncopediatricians took part in semi-directed interviews. The content of the interviews was analyzed using thematic content analysis.
Findings
All the participants emphasized the importance of FP, describing it as a fundamental right and central part of care. However, they identified ethical issues associated with the cost and the uncertainties of ovarian tissue cryopreservation (OTC). The majority thought that OTC should be covered by the public healthcare system to promote equity of access. French oncopediatricians of this study considered OTC to be standard of care, while the majority of Canadian oncopediatricians still considered it experimental, due to the risk of reintroducing malignant cells.
Discussion/conclusions
The results highlight the importance of FP for prepubertal girls as a right, linked to the child’s right to an open future, as described in bioethics literature. According to these findings, the fact that OTC is not systematically discussed, offered, or not covered by the healthcare system constitutes a barrier and fails to protect patients, who may experience future infertility as a consequence of their treatment, thus curtailing their reproductive autonomy.
Australian workers mobilised precociously to win the eight-hour day. Building workers in Melbourne secured the standard in 1856. They inspired and helped to lead a wider movement that shared in the victory over subsequent decades. By the early 1890s the “eight-hour day” was widely embraced as a social norm. Australian successes were contemplated in a range of international publications.
Australian employees in several trades secured an eight-hour day from the middle 1850s. By the 1890s, Australian advances had attracted considerable international attention. But these precocious Australian successes have not yet been satisfactorily explained. The dominant explanations focus especially on a propitious environment in the middle 1850s, buoyed by the wealth of a gold rush and characterised by labour shortages. These accounts overestimate the persistence of favourable market conditions and underestimate the import of the political context and of creative and determined collective struggle.
This article offers a new interpretation. It suggests that the Australian campaign for eight-hours is best understood as a social movement. It then applies five key concepts drawn from the field of social-movement studies to examine the campaign and to explain its successes: political opportunities; framing; strategy; repertoire; and mobilising structures.
The article aims not only to explain the Australian eight-hours campaign, but also to demonstrate the value of concepts and approaches drawn from “social-movement studies” to the study of labour history. It is based on a substantial source base, including union records, scores of newspapers, parliamentary debates, contemporary pamphlets, and government reports.
We pose some conjectures about the existence of certain complete, one-dimensional families of degree $d$, genus $g$ branched covers of an elliptic curve. The conjectures would imply that the slope of the corresponding Hurwitz space is precisely $5+6/d$, and that the slope of the moduli space of stable genus $g$ curves is bounded below by $5$. We provide evidence for the conjectures when $g=2$ or when $d \leq 5$ and $g \gg 0$.
The Earth is approaching irreversible tipping points. Markets, democracy, and technology alone cannot address these complex crises. Future Design (FD) tackles these challenges by activating human ability to prioritise future generations’ happiness over immediate gains. This research expands the FD framework and reviews a decade’s worth of studies, deepening our understanding of FD’s potential in creating mechanisms for long-term societal well-being and environmental sustainability.
Technical summary
The Earth is approaching irreversible tipping points across multiple domains. Despite advances in markets, democracy, and science, these systems systematically fail to prioritise future generations’ well-being – creating what we term ‘future failures’. New mechanisms are needed, such as FD. Originating in Japan in the early 2010s, FD aims to design, experiment with, and implement mechanisms that activate our futurability – the ability to prioritise the happiness of future generations over immediate gains – to tackle future failures. This paper introduces presentability and pastability alongside futurability, extending the FD framework. Placing various FD studies from the past decade within this framework, this study reviews mechanisms for activating these abilities and examines how activating one ability affects the others. These abilities are ‘leverage points’, as defined by Meadows. We explore the path to a paradigm shift by designing and using mechanisms that activate these points. This paper also highlights unknowns about FD and potential directions for its development, providing a comprehensive overview of its current state and future prospects in addressing global challenges.
Social media summary
Future Design: A new approach to global crises, prioritising future generations over immediate gains.
Flax plays an important role in art, especially for painters. Flax seeds are ground into linseed oil, which is used as binder for oil paints, and fibers are used to make linen canvas as a support for paintings. Because of the rapid growth of flax, linen canvas fiber and linseed oil are considered good candidates for the radiocarbon (14C) dating of paintings. However, the time necessary to transform flax into a linen canvas must be estimated in order to determine the completion date of paintings. Based on the paintings of the French painter Pierre Soulages (1919–2022), who titled his works with the day on which he considered them finished, the time elapsed between completion of the painting and harvesting of the flax was determined for 25 canvases and 13 oil binders. For the canvases, three periods can be distinguished between 1956 and 1981 with durations of 5±1 years in the 1950s, 3±2 years in the 1960s and 11±3 years for the paintings from the 1970s–1980s. For the oil, the time elapsed between the date indicated by the artist and the 14C calibrated date has a mean value of 3±2 years in the 1950s and 1960s and more than 15 years in the 1970s. These long time lags could be due to the massive change in flax processing, which was relocated, resulting in longer times between flax harvesting and canvas marketing. The determination of these time lags enables us to better interpret the 14C dating results for the paintings.
The Cahn–Hilliard model with reaction terms can lead to situations in which no coarsening is taking place and, in contrast, growth and division of droplets occur which all do not grow larger than a certain size. This phenomenon has been suggested as a model for protocells, and a model based on the modified Cahn–Hilliard equation has been formulated. We introduce this equation and show the existence and uniqueness of solutions. Then, formally matched asymptotic expansions are used to identify a sharp interface limit using a scaling of the reaction term, which becomes singular when the interfacial thickness tends to zero. We compute planar solutions and study their stability under non-planar perturbations. Numerical computations for the suggested model are used to validate the sharp interface asymptotics. In addition, the numerical simulations show that the reaction terms lead to diverse phenomena such as growth and division of droplets in the obtained solutions, as well as the formation of shell-like structures.
To date, the direct effects of complete glacier disappearance on the specialized fauna associated with this habitat have never been investigated in situ. The Trobio glacier, once the largest in the Bergamo Alps (Italy), completely vanished in 2023 due to climate-induced retreat. This study reconstructs Trobio glacier’s evolution from the Little Ice Age to its disappearance and assesses the impact of glacier extinction on two cryophilic endemic terrestrial arthropod species: the ground beetle Nebria tresignore and the springtail Desoria orobica. Historical maps, literature and recent field data were used to trace glacier changes, while biological surveys evaluated species occurrence to be compared with past (last 10 years) records. These data reveal a direct link between the recorded glacier retreat and species elevational shift: Nebria tresignore shifted upslope about 30 m a-1 following glacial retreat. Desoria orobica showed a dramatic population collapse, with average densities dropping from 80 to < 4 individuals per sample since 2020, likely due to the deeply modified glacial environment. These findings highlight the vulnerability of glacier-dependent biodiversity and the urgent need to document glacier extinction and to identify and protect microrefugia for cold-adapted species in rapidly changing alpine environments.
Embolization of the middle meningeal artery (EMMA) is an emerging neuroendovascular therapy for chronic subdural hematoma (CSDH). Recently, three landmark randomized trials (MAGIC-MT, EMBOLISE, STEM) were published. We performed a systematic review and meta-analysis of randomized trials for EMMA.
Methods:
The authors systematically searched MEDLINE, EMBASE, Cochrane and ClinicalTrials.gov (National Library of Medicine) through March 6, 2025. Prospective randomized controlled trials comparing EMMA and standard care versus standard care alone were included. Primary (symptomatic recurrence, symptomatic progression, major adverse event, neurological deterioration, stroke, myocardial infarction and/or death) and secondary endpoints (serious adverse events, stroke, death from any cause and death from neurological causes) were analyzed. The review was registered on PROSPERO (CRD42024512049).
Results:
Four randomized trials (Lam et al., MAGIC-MT, EMBOLISE, STEM) were meta-analyzed. A total of 1468 patients were included. The primary endpoint was met in 50 patients (7.5%) in the EMMA group compared to 106 patients (15.5%) in the control group (RR 0.49 [95% CI, 0.36–0.67]; P < 0.001, I2 = 0.0%), with a number needed to treat of 13. There was no difference in serious adverse events (RR 0.88 [95% CI 0.68–1.13]; P = 0.31, I2 = 50.2%), stroke (RR 1.51 [95% CI 0.46–5.01]; P = 0.50, I2 = 0.0%), death from any cause (RR 1.03 [95% CI 0.37–2.85]; P = 0.95, I2 = 58.1%) or death from neurological causes (RR 1.29 [95% CI 0.53–3.09]; P = 0.58, I2 = 25.4%).
Conclusions:
EMMA is effective in reducing symptomatic recurrence, progression and/or reoperation among patients with CSDH and is not associated with a greater incidence of serious adverse events, stroke or death.
A partial differential equation governing the evolution of the joint probability distribution of multicomponent flow observations, drawn randomly from one or more control volumes, is derived and applied to examples involving irreversible mixing. Unlike local probability density methods, this work adopts an integral perspective by regarding a control volume as a sample space with an associated probability distribution. A natural and general definition for the boundary of such control volumes comes from the magnitude of the gradient of the sample space distribution, which can accommodate Eulerian or Lagrangian frames of reference as particular cases. The formulation exposes contributions made by uncertain or stochastic boundary fluxes and internal cross-gradient mixing in the equation governing the observables’ joint probability distribution. Advection and diffusion over a control volume’s boundary result in source and drift terms, respectively, whereas internal mixing, in general, corresponds to the sign-indefinite diffusion of probability density. Several typical circumstances for which the corresponding diffusion coefficient is negative semidefinite are identified and discussed in detail. The framework is a natural setting for examining available potential energy, the incorporation of uncertainty into bulk models, and establishing a link with the Feynman–Kac formula and Kolmogorov equations that are used to analyse stochastic processes.
We present a comprehensive spectro-temporal analysis of GRS $1915+105$ observed with AstroSat during June, 2017. A detailed study of the temporal properties reveals the appearance of an ‘unknown’ variability class ($\tau$) during $\unicode{x03C1} \rightarrow \unicode{x03BA}$ class transition of the source. This new ‘unknown’ class ($\tau$) is characterised by the irregular repetition of low count ‘dips’ along with the adjacent ‘flare’ like features in between two successive steady count rate durations, resulting in uniform ‘C’ shaped distribution in the colour-colour diagram. A detailed comparative study of the variability properties between the $\tau$ class and other known variability classes of GRS $1915+105$ indicates it as a distinct variability class of the source. Further, we find evidence of the presence of possible HFQPO features at ${\sim} 71$ Hz with quality factor ${\sim} 13$, rms amplitude ${\sim} 4.69\%$, and significance $3\sigma$, respectively. In addition, a harmonic-like feature at ${\sim} 152$ Hz is also seen with quality factor ${\sim} 21$, rms amplitude ${\sim} 5.75\%$, and significance ${\sim} 4.7\sigma$. The energy-dependent power spectral study reveals that the fundamental HFQPO and its harmonic are present in 3–15 keV and 3–6 keV energy ranges, respectively. Moreover, the wide-band (0.7–50 keV) spectral modelling comprising of thermal Comptonization component indicates the presence of a cool ($kT_\textrm{e}\sim 1.7$ keV) and optically thick (optical depth ${\sim} 14$) Comptonizing ‘corona’, which seems to be responsible in regulating the HFQPO features in GRS 1915+105. Finally, we find the bolometric luminosity ($L_\textrm{bol}$) to be about $42\% L_\textrm{Edd}$ within 1–100 keV, indicating the sub-Eddington accretion regime of the source.
In-person, therapist-supported interventions targeting emotion regulation have been shown to improve the mental health of adolescents. Increasingly, self-directed digital interventions (e.g. mobile apps) are being developed as a cost-effective, scalable solution to widen access to support. However, evidence of the acceptability and feasibility of these interventions has yet to be synthesised.
Aims
To identify existing evidence on the benefits, acceptability and feasibility of self-directed digital interventions that target emotion regulation in adolescents (aged 11–18 years).
Method
A Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guided systematic review was conducted to identify studies published from 1 January 2010 to 13 November 2024 investigating self-directed digital emotion regulation interventions for adolescents. A total of ten electronic databases were searched (e.g. PsycInfo). Data on the effects, and perceived acceptability, of the interventions were extracted, with results narratively synthesised. Methodological quality was assessed using the Effective Public Health Practice Project Quality Assessment tool.
Results
Six out of 9049 studies met the eligibility criteria and included preliminary evidence on self-directed digital interventions that target emotion regulation, in a pooled sample of 1271 adolescents. All interventions identified were brief (most <1 month) and included different components to target emotion regulation (e.g. mindfulness, mood monitoring). Most interventions demonstrated benefits for emotion regulation and were acceptable for use by an adolescent population.
Conclusions
Although the evidence base was small, the included studies demonstrate preliminary evidence of the benefits and acceptability of self-directed, digital interventions for emotion regulation in adolescents. Future research should focus on approaches beyond mindfulness, including components to target the related skills required to access emotion regulation strategies (e.g. emotional awareness) and use them flexibly.
Negative symptoms in schizophrenia, particularly motivational deficits, pose significant challenges to treatment and recovery. Despite their profound impact on functional outcomes, these symptoms remain poorly understood and inadequately addressed by current interventions.
Aims
The CHANSS (Characterising Negative Symptoms in Schizophrenia) study aims to dissect the cognitive mechanisms underlying motivational impairments by focusing on three interconnected domains: executive cognition, motivational cognition and meta-cognition.
Method
This large, international, cross-sectional study recruits a heterogeneous sample of patients across illness stages – from first-episode psychosis to treatment-resistant schizophrenia – and uses a comprehensive cognitive battery, clinical scales, self-report measures and computerised cognitive tasks. Four novel tasks assess key processes in motivated behaviour: option generation, reward-based decision-making, risk sensitivity and performance self-evaluation. By incorporating control for secondary influences like depression, psychosis, sedation and illness chronicity, the study seeks to identify distinct cognitive and behavioural subtypes within motivational dysfunction.
Results
CHANSS tests the hypothesis that specific patient profiles exhibit predominant impairments in one or more cognitive domains, which may differentially affect goal-directed behaviour. The study’s design allows exploration of hierarchical relationships between cognitive processes, such as how neurocognitive deficits may cascade to impair motivation and self-evaluation.
Conclusions
Ultimately, CHANSS aims to advance mechanistic understanding of motivational deficits in schizophrenia and pave the way for personalised, targeted interventions. Its findings may inform future clinical trials and contribute to a shift away from one-size-fits-all approaches towards more effective, stratified treatment strategies in schizophrenia.
Do employment opportunities for women reduce intimate partner violence (IPV)? We address this question using harmonized field experiments in Egypt and Tunisia. In Egypt, we evaluate a public works program that disproportionately benefited women; in Tunisia, the program we evaluate benefited men and women equally. Consistent with a household bargaining model in which men perpetrate IPV to maintain dominance over their spouses, we find that the Egyptian program exacerbated IPV and heightened psychological distress, even among eligible women who were not randomly selected to participate, while the Tunisian program did not. Also consistent with this model, the Egyptian program increased women’s control over spending – a measure of bargaining power – while the Tunisian program did not. We rule out several alternative explanations for these results. Finally, we show that the Egyptian program’s adverse effects on IPV persisted over time, but did not spill over onto women in the community writ large.
We define and study a generalization of the Beilinson–Drinfeld Grassmannian to the case where the curve is replaced by a smooth projective surface $X$, and the trivialization data are given on loci associated with a nonlinear flag of closed subschemes. We first establish some general formal gluing results for moduli of (almost) perfect complexes and torsors. We construct a simplicial object $\operatorname {\underline {\mathsf{Fl}}}_X$ of flags of closed subschemes of a smooth projective surface $X$, associated with the operation of taking union of flags. We prove that this simplicial object has the $2$-Segal property. For an affine complex algebraic group $G$, we define a derived, flag analogue $\mathcal{G}r_X$ of the Beilinson–Drinfeld Grassmannian of $G$-bundles on the surface $X$, and show that most of the properties of the Beilinson–Drinfeld Grassmannian for curves can be extended to our flag generalization: we prove a factorization formula, the existence of a canonical flat connection and define a chiral product on suitable sheaves on $\operatorname {\underline {\mathsf{Fl}}}_X$ and on $\mathcal{G}r_X$. We sketch the construction of actions of flags analogues of the loop group and of the positive loop group on $\mathcal{G}r_X$. To fixed ‘large’ flags on $X$, we associate ‘exotic’ derived structures on the stack of $G$-bundles on $X$.
Methylation alterations of the glucocorticoid receptor gene (NR3C1) may help explain why not all individuals experiencing insensitive parenting develop behavior problems, yet evidence from human cohorts remains limited. This longitudinal study examined associations among NR3C1 methylation, caregiver parenting, and child internalizing and externalizing behaviors. A total of 224 Han Chinese preschoolers (Mage = 47.33 ± 9.60 months; 42.5% girls) were recruited from Jinan, China, in 2021 (T1). Parenting quality and child behavior problems were reported by both parents, and NR3C1 methylation across 46 cytosine–phosphate–guanine sites in the exon 1F promoter region was sequenced from buccal cells. Follow-up assessments were conducted 1.5 years later among 113 children who stayed in the same kindergarten (Mage = 63.60 ± 7.68 months; 45.7% girls). NR3C1 methylation at baseline moderated the association between parenting and baseline, but not follow-up, behavior problems, consistent with differential susceptibility. Children with lower methylation exhibited more behavior problems under low-quality parenting but fewer under high-quality parenting. This interaction did not vary between parental and child sex, or NR3C1 BclI (rs41423247) and Tth111I (rs10052957) polymorphisms. Findings highlight the dynamic nature of Epigenome × Environment interactions and suggest that lower NR3C1 methylation may act as a plasticity factor in preschool children.