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There is a growing need to enhance healthcare providers’ spiritual care competence, including for people receiving palliative care. A preceding study of predictors of spiritual care competence in a general group of nurses found that more competent nurses rated significantly higher in spiritual training adequacy, frequency of spiritual care provision, and personal spirituality than other nurses; like the demographic variables of level of education, length of nursing experience, and sex, confidence and comfort in providing spiritual care were not related to spiritual care competence. The current study aimed to replicate these relationships in a sample of palliative care nurses. This sample also allowed the testing of a hypothesis that palliative care nurses will tend to subscribe to more competent understandings of spiritual care.
Methods
Data were collected from a convenience sample of Australian palliative care nurses who completed an anonymous, online survey. The survey provided qualitative data about what spiritual care means for them and quantitative data regarding nurse characteristics. The qualitative data were used to create sub-groups of nurses based on their understanding of spiritual care and the quantitative data were used to construct a profile of nurse characteristics for each sub-group. The replication analysis determined whether a statistical difference in nurse characteristics existed across sub-groups. The hypothesis testing compared levels of spiritual care understanding across the general and palliative care samples of nurses.
Results
While the results of the palliative care sample are largely concordant with those obtained in the general sample, the current study amends “training adequacy” as a predictor of spiritual care competence to “experience (whether on-the-job or training) in caring for the dying.” The study hypothesis was supported.
Significance of results
The results can be used to assess and develop competence in spiritual care for palliative care nurses.
This study examines how China’s former one-child policy has shaped fertility attitudes among the Chinese diaspora in the United States. Through semi-structured qualitative interviews with thirty reproductive-age women of Chinese descent, either born in China or first-generation immigrants to the United States, this study explored opinions towards the policy, self-reported impact on reproductive decision-making, and attitudes towards family size. Participants were recruited from an internet-based survey distributed through cultural groups on social media, paper flyers, and email listservs. Interviews were analysed using the principle of thematic analysis by three authors, who met after coding to resolve disagreements. The mean age of participants was 33. Six participants (20%) used an interpreter. Eighteen participants (60%) were born in China. The range of pregnancies was 0–5, and the range of births was 0–2. Authors found that while participants were no longer directly constrained by the one-child policy, many continued to demonstrate preferences for fewer children. Financial strains, resource allocation, societal shame, and internalised social norms emerged as key themes. These themes echo messages promoted during the one-child policy era through propaganda and enforcement measures, such as audits of family registrations, rewards for compliant families, fines, mandatory IUDs, or sterilisations for noncompliant ones, and even forced abortions for ‘unauthorized’ pregnancies. These messages reinforced that small families were more appropriate. These findings suggest a lasting cultural shift towards fewer children as a result of the policy, even after emigration. They also carry theoretical implications towards understanding the long-term social and psychological consequences of reproductive mandates and the generational transmission of policy-shaped fertility norms. This study offers a perspective for nations currently implementing pronatalist fertility regulations. These findings highlight the role of historical policies in shaping contemporary reproductive perspectives, family dynamics, and potentially, engagement with medicine beyond geographic, political, and temporal boundaries.
Global food systems have a key influence on both health and sustainability. Dietary shifts that promote health and sustainability are regarded as a critical synergistic pathway for advancing human and planetary health. In response, consumer interest in the sustainability of food systems has prompted the use of claims highlighting positive sustainability attributes displayed on-pack. This study assessed the prevalence and types of sustainability claims displayed on packaged food in Australia.
Design:
Claims data on packaged food were collected at five supermarkets in Sydney in 2024. We determined the prevalence of sustainability claims overall, by claim category and format (text or logo).
Setting:
Australia
Participants:
None
Results:
Over a third of products displayed at least one sustainability claim, the most prevalent being natural and vegan. Text claims were far more prevalent than logos (84% v 16% of total claims identified on pack, respectively).
Conclusions:
Frequent use of broad and unspecific sustainability claims raises challenges for substantiation, and there is a risk that consumers are being misled. Our findings support the need for stronger regulation, including criteria for terms used in claims, to improve consumer trust and comparability across products.
Field sampling was conducted in the Chiffa tunnel area of the El Hamdania sector within Chrea National Park (CNP), Algeria. A total of 20 bats were captured and examined for ectoparasite infestations. Additionally, coprological analysis of guano was performed to investigate the possible presence of traces of internal parasites, subject to the methodological limitations described herein. The captured bats belonged to 2 distinct families. The family Rhinolophidae included Rhinolophus blasii Peters, 1866, represented by 18 individuals, and the greater horseshoe bat, Rhinolophus ferrumequinum (Schreber, 1774), represented by a single individual. The family Vespertilionidae was represented by Nyctalus leisleri (Kühl, 1817), also by a single individual; this constitutes the first documented record of this species in CNP. Examination of ectoparasites from 19 rhinolophid bats identified 3 dipteran ectoparasite species. Brachytarsina (Brachytarsina) flavipennis Macquart, 1851 (Streblidae) was the most prevalent (66.7%), followed by Phthiridium biarticulatum Hermann, 1804 and Nycteribia schmidlii Schiner, 1853 (Nycteribiidae), each at 16.7%. The study documents, for the first time in Algeria, N. schmidlii parasitizing R. blasii. Coprological analysis of guano revealed the presence of structures belonging to 3 phyla; these data are preliminary and should be interpreted with caution. The findings contribute to knowledge of chiropteran ectoparasite–host associations in North Africa and highlight CNP as a significant locality for bat biodiversity.
I aim to make progress on the following question: When is it morally wrong to risk harming another being? I will pay special attention to the use of the roundworm Caenorhabditis elegans (C. elegans), but my points are relevant to other situations and beings. I focus on the motive or purpose for exposing a being to risk of harm. I argue that it is morally wrong to potentially harm a being for the sake of others’ positive well-being or for a purported good such as knowledge (that is, knowledge for its own sake). The practical ramifications include that there is a moral hurdle of justification for potentially harming another being, and the justification cannot be others’ positive well-being or a good such as knowledge. Essentially, if the use of a being can be morally justified, it needs to be justified based on reducing enough ill-being or unpleasantness. One should recognise the creation and use of beings as a moral issue and view any warranted potential harm as a regrettable lesser evil. If feasible, it is desirable to use alternative methods that carry less risk and do not involve potentially sentient beings.
We evaluated Clostridioides difficile admission screening in a cancer unit. Admission screening was associated with a non-significant decrease in hospital-onset C. difficile infection (CDI) incidence and a significant decrease in community-onset CDI incidence, which may reflect, in part, the artifactual impact of screening on subsequent provider testing behavior.
In this article, it is argued that in the actual world, even if not in all possible worlds, sentience is both a necessary and sufficient condition for having moral standing. In arguing for this conclusion, the concepts of sentience and moral standing are explained. Five kinds of interest are then differentiated—functional, biotic, sentient, sapient, and self-conscious. It is argued that having sentient interests, rather than merely any interests, is what grounds moral standing. However, determining who has moral standing is only a beginning. Once we know whose interests we need to consider, we still need to know what interests need to be considered. We also need to know what considering those interests implies. Those questions are engaged in the remainder of this article.
Subcortical nuclei – including the thalamus, basal ganglia, and hippocampus-amygdala complex – are key regions in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). While cortical–subcortical connectivity is well studied, fine intra- and inter-subcortical patterns are less known. This study aimed to identify shared and distinct functional connectivity alterations across SZ, BD, and MDD using a high-resolution subcortical atlas.
Methods
Resting-state functional magnetic resonance imaging data from 800 participants (200 per group: SZ, BD, MDD, and healthy controls) in a single-site cohort were analyzed. Subcortical structures were parcellated into 27 regions per hemisphere – thalamus (8 regions), hippocampus (5 regions), amygdala (2 regions), and striatum (12 regions) – based on the a priori atlas. Pairwise functional connectivity among the 54 regions was computed for each participant, and group differences were assessed using general linear models.
Results
Patients with SZ exhibited significantly reduced intra-thalamic connectivity and increased intra-striatal connectivity, as well as enhanced connectivity between the thalamus, striatum, and limbic regions. Patients with BD showed reduced intra-thalamic and intra-striatal connectivity, along with decreased thalamus–amygdala and thalamus–striatum connectivity. In MDD, the predominant finding was reduced intra-limbic connectivity, accompanied by mild reductions in intra-thalamic and striatum–limbic connectivity.
Conclusion
The results suggest that intra-thalamic hypoconnectivity appears common to SZ, BD, and MDD, with graded degrees of severity. In contrast, distinct alterations in intra-striatal and striatum–limbic connectivity may differentiate mood disorders from SZ. These shared and disorder-specific subcortical connectivity patterns enhance the understanding of psychiatric neurobiology and may guide the development of targeted, disorder-tailored interventions.
The present review aims to provide a comprehensive overview of parasitic diseases impacting the nervous systems of small companion animals. Toxoplasma gondii and Neospora caninum are well-documented pathogens linked to neurological disorders; however, a variety of other parasitic agents, ranging from unicellular protozoa to complex helminths, also exhibit a tropism for the nervous system in these animals. Parasites can exert a direct influence on the nervous system through mechanisms that reflect their inherent neurotropism (e.g., Encephalitozoon cunicoli and Gurltia paralysans). Additionally, they may indirectly compromise neurological function through several distinct mechanisms: (i) ectopic dislocation of larvae, eggs or adult parasites/fungi (e.g., Baylisascaris procyonis, Angiostrongylus cantonensis, Dirofilaria immitis, Spirocerca lupi, Cryptococcus spp., Cuterebra spp.); (ii) immune-mediated reactions (e.g., Leishmania infantum); (iii) coagulation disorders (e.g., Angiostrongylus vasorum); (iv) electrolyte imbalances (e.g., Toxocara canis); and (v) effects of neurotoxins (e.g., Ixodes holocyclus bite). Furthermore, neurological complications have been documented following antiparasitic interventions, ranging from direct drug toxicity in D. immitis and Babesia spp. infections to the potential post-treatment neuroinflammatory responses in Angiostrongylus cantonensis cases. Collectively, these mechanisms can lead to substantial neurological dysfunction as a consequence of both primary parasitic invasion and secondary pathological processes within nervous tissues. In addition, parasitic diseases injuring the nervous system usually cause neurological sequelae that could reduce life expectancy and quality of life, leading owners to elect euthanasia of their pets. In conclusion, parasitic diseases affecting the nervous system may represent a relevant health concern in companion animals and warrant further attention.
One factor that has been shown to mediate and protect against psychopathology is the ability to engage in meaning making in adverse situations during the COVID-19 pandemic. To date, the models that have attempted to explain the relationship between traumatic, stressful events’ meaning and clinical symptoms have been conducted in a piecemeal fashion. The objective of this study is to analyze which model (two-pathway model vs three-pathway model) has a better fit in explaining the association between the violation of global meaning and clinical symptoms such as somatization, anxiety, and depression in participants during the COVID-19 pandemic. The study sample consisted of N = 1106 adults. The results suggest that the violation of schemas affects depression and anxiety symptoms through three pathways: (a) Path one, directly, schema violation explains clinical symptoms; (b) Path two, indirectly, schema violation explains clinical symptoms through the search for meaning and negative effect; and (c) Path three, the presence of meaning explains positive affect and buffers clinical symptoms. The three-pathway model explains 90% of the variance in clinical symptoms. The three-pathway model has clinical implications for the assessment, prevention, and treatment of people who are coping with unforeseen negative situations.
Ventricular fibrillation in paediatric recipients of left ventricular assist devices is rare but potentially fatal; however, because systemic perfusion may be temporarily maintained by the mechanical support, haemodynamic deterioration may be delayed, leading to underrecognition and presentation in the outpatient setting rather than as an immediate in-hospital emergency.
Methods:
We report three paediatric left ventricular assist device recipients who developed outpatient malignant ventricular arrhythmias, each representing a distinct mechanistic category: structural, mechanical, and endocrine. Clinical presentation, diagnostic findings, and therapeutic responses were reviewed to highlight pathophysiologic heterogeneity and inform individualised management.
Results:
The first patient, with biopsy-proven arrhythmogenic right ventricular dysplasia, experienced recurrent ventricular fibrillation refractory to multiple antiarrhythmic agents, ultimately requiring heart transplantation. The second patient presented with ventricular fibrillation secondary to mechanical suction and interventricular septal contact; defibrillation and left ventricular assist device speed reduction restored a stable rhythm with no recurrence. The third patient developed polymorphic ventricular arrhythmias during amiodarone-induced thyrotoxicosis and succumbed to refractory electrical storm and multi-organ failure despite intensive endocrine and antiarrhythmic therapy.
Conclusions:
Outpatient ventricular fibrillation in paediatric left ventricular assist device recipients may result from diverse mechanisms, including myocardial structural disease, mechanical pump heart interaction, and systemic endocrine disturbances. Mechanism-guided management combining antiarrhythmic, mechanical, and metabolic interventions is essential for optimal outcomes. Continuous rhythm surveillance and readiness for immediate defibrillation are key to improving survival in this vulnerable group.
Insomnia is commonly seen in opioid use disorder (OUD) patients receiving methadone maintenance treatment (MMT) and might be related to high heroin relapse risk. This study aims to identify potential mediation pathways among peripheral cytokines, neuroimaging characteristics, and insomnia in MMT patients, and explore diagnostic markers and therapeutic targets for MMT-related insomnia.
Methods
A total of 121 OUD individuals (OUDs) and 109 healthy controls were recruited, including MMT individuals (MMT group, N = 53), short-term abstinent (median: 30 days) heroin users at baseline (OUD1, N = 68), and around 10-month follow-up (OUD2, N = 61) without MMT, healthy controls-cohort 1 (HC1, N = 53, age/gender/education match MMT), and healthy controls-cohort 2 (HC2, N = 56, age/gender match OUD1). Multimodal datasets, including cerebral diffusion tensor imaging (DTI), peripheral hematologic indicators, and neuropsychological assessments, were collected from the MMT group and HC1. Within the MMT group, we revealed relationships among cytokines, DTI metrics, and neuropsychological assessments via partial correlation and mediation analyses. Mendelian randomization (MR) analyses between OUD and white matter (WM)-related imaging-derived phenotypes were used to further confirm Tract-Based Spatial Statistics (TBSS) results. Besides, the results of TBSS among OUD1, OUD2, and HC2 hypothetically served as baseline WM alteration before MMT.
Results
Through comparisons among OUD1, OUD2, and HC2, WM aberrances could return to normal after 10-month abstinence, and we used the results as baseline alterations before MMT. MMT patients exhibited a broad imbalance in peripheral immune cells and cytokines, as well as presented insomnia, anxiety, and depression symptoms. After Bonferroni correction, mean diffusivity and radial diffusivity in extensive WM regions were higher in MMT patients than those of HC1. Ultimately, through multimodal correlation analysis, the ‘Interferon-γ (IFN-γ)-WM aberrance-insomnia’ axis was discovered in the MMT group.
Conclusions
Together, these results primarily link cytokines and WM injury for OUDs with MMT to insomnia, implicating pharmacological IFN-γ target as a latent strategy to improve the insomnia of MMT patients.
Low protein intake is prevalent in people with CHD and is inadequately addressed in UK-based cardiac rehabilitation. This pilot feasibility study aimed to identify whether targeted education increases protein intake in patients with CHD and low protein intake, compared with standard cardiac rehabilitation dietary education. People referred to cardiac rehabilitation with CHD (≥ 50 years) underwent anthropometric assessment and completed a food diary, sit-to-stand test and three questionnaires (physical activity, sarcopenia screening and nutrition knowledge). Participants with low protein intake (≤ 1·2 g/kg per d) were randomised to receive either extra protein education (intervention; protein group) or standard education (control; control group), embedded within their usual 6-week cardiac rehabilitation programme. At 6 and 12 weeks, outcome measures were repeated; thirty-four participants provided baseline data. Protein intake was inversely associated with waist circumference (r = −0·348). Twenty-seven participants (79 %) with low protein intake were randomised to the protein group (n 15) or control group (n 12). At week 6, the median (interquartile range) change in protein intake was 0·0 (−0·0–0·3) and 0·4 (0·2–0·5) g/kg per d in the protein group and control group, respectively (effect size 0·5). At week 12, the change in protein intake was 0·0 (−0·0–0·1) and −0·0 (−0·2–0·2) g/kg per d in the protein group and control group, respectively (effect size 0·3). Effect sizes for all other variables were ≤ 0·4. The intervention appeared well-received by those who completed the study; however, changes to primary and secondary outcomes were minimal. Uptake of the study was low, and attrition was high, limiting the interpretation of efficacy and the implementation of a definitive trial.
The cognitive-behavioral model of body dysmorphic disorder (BDD) implicates impaired cognition; yet existing evidence of cognitive impairment in the disorder is often inconsistent. To date, cognitive performance in BDD has not been measured utilizing the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV), a gold standard cognitive assessment in clinical settings. Accordingly, this study compared WAIS-IV performance between individuals with BDD and healthy controls.
Methods:
Participants included 59 BDD patients and 56 controls. Cognitive performance was evaluated via the WAIS-IV, and clinical characteristics of the BDD group were examined via multiple clinician and self-report questionnaires.
Results:
The BDD group demonstrated significantly poorer performance compared to the control group in the WAIS-IV index and subtests that reflect processing speed abilities (Processing Speed Index: d = −0.55, 95% CI [−0.92, −0.18], Symbol Search: d = −0.70, 95% CI [−1.07, −0.32], Coding: d = −0.79, 95% CI [−1.17, −0.41]), yet other indices were not significantly different. These impairments were not correlated with anxiety or BDD-YBOCS symptom severity. Reduced overall cognitive performance was primarily driven by impairments in processing speed.
Conclusions:
The study suggests that in BDD, processing speed is notably lower than other index scores, falling in the low average range. This may reflect difficulties with rapid visual processing, attention to detail, or motor speed. Performance in domains reflective of reasoning and verbal functioning were unimpaired relative to controls. This selective cognitive pattern in BDD may be driven by increased cognitive load associated with perfectionistic traits. This has clinical implications for cognitive-behavioral treatment.
This brief report examines physical and mental health symptom profiles among older adults approximately 5 months after Hurricane Helene–related flooding in Southern Appalachia.
Methods
Survey data were collected from 233 older adults and assessed physical health symptoms, posttraumatic stress disorder, depressive symptoms, flood event exposure, environmental contaminant exposure, and post-flood stressors. Cluster analysis was conducted to identify post-disaster physical and mental health symptom profiles, and analysis of variance and chi-square tests were conducted to examine differences in disaster exposure, post-flood stressors, and sociodemographic characteristics across profiles.
Results
Three distinct post-disaster health symptom profiles were identified: a lower symptom profile, an elevated mental health symptom profile, and a combined elevated physical and mental health symptom profile. Disaster exposure, contaminant exposure, and post-flood stressors increased in a graded manner across profiles, indicating a dose–response framework of disaster-related health impacts. Higher symptom burden profiles were disproportionately represented among older adults with disabilities/chronic illness and among older age groups.
Conclusions
Findings highlight heterogeneity in post-disaster health experiences among older adults and underscore the value of identifying high-risk subgroups and implementing recovery strategies that address co-occurring physical and mental health needs among older adults following flood events.