In this paper, we study asymmetric Ramsey properties of the random graph $G_{n,p}$. Let $r \in \mathbb{N}$ and $H_1, \ldots, H_r$ be graphs. We write $G_{n,p} \to (H_1, \ldots, H_r)$ to denote the property that whenever we colour the edges of $G_{n,p}$ with colours from the set $[r] \,{:\!=}\, \{1, \ldots, r\}$ there exists $i \in [r]$ and a copy of $H_i$ in $G_{n,p}$ monochromatic in colour $i$. There has been much interest in determining the asymptotic threshold function for this property. In several papers, Rödl and Ruciński determined a threshold function for the general symmetric case; that is, when $H_1 = \cdots = H_r$. A conjecture of Kohayakawa and Kreuter from 1997, if true, would fully resolve the asymmetric problem. Recently, the $1$-statement of this conjecture was confirmed by Mousset, Nenadov and Samotij.

Building on work of Marciniszyn, Skokan, Spöhel and Steger from 2009, we reduce the $0$-statement of Kohayakawa and Kreuter’s conjecture to a certain deterministic subproblem. To demonstrate the potential of this approach, we show this subproblem can be resolved for almost all pairs of regular graphs. This therefore resolves the $0$-statement for all such pairs of graphs.

“Return-to-player” information is used in several jurisdictions to display the long-run cost of gambling, but previous evidence suggests that these messages are frequently misunderstood by gamblers. Two ways of improving the communication of return-to-player information have been suggested: switching to an equivalent “house-edge” format, or via the use of a “volatility warning,” clarifying that the information applies only in the statistical long run. In this study, Australian participants (N = 603) were presented with either a standard return-to-player message, the same message supplemented with a volatility warning, or a house-edge message. The return-to-player plus volatility warning message was understood correctly more frequently than the return-to-player message, but the house-edge message was understood best of all. Participants perceived the lowest chance of winning in the return-to-player plus volatility warning condition. These findings contribute data on the relative merits of two proposed approaches in the design of improved gambling information.

We use probabilistic methods to study properties of mean-field models, which arise as large-scale limits of certain particle systems with mean-field interaction. The underlying particle system is such that n particles move forward on the real line. Specifically, each particle ‘jumps forward’ at some time points, with the instantaneous rate of jumps given by a decreasing function of the particle’s location quantile within the overall distribution of particle locations. A mean-field model describes the evolution of the particles’ distribution when n is large. It is essentially a solution to an integro-differential equation within a certain class. Our main results concern the existence and uniqueness of—and attraction to—mean-field models which are traveling waves, under general conditions on the jump-rate function and the jump-size distribution.

The unfolded protein response has recently been implicated as a mechanism by which 1,10-phenanthroline-containing coordination compounds trigger cell death. We explored the interaction of two such compounds—one containing copper and one containing manganese—with endoplasmic reticulum (ER) stress. Pretreatment with anisomycin significantly enhanced the cytotoxic activity of both metal-based compounds in A2780, but only the copper-based compound in A549 cells. The effects of pretreatment with tunicamycin were dependent on the nature of the metal center in the compounds. In A2780 cells, the cytotoxic action of the copper compound was reduced by tunicamycin only at high concentration. In contrast, in A549 cells the efficacy of the manganese compound cells was reduced at all tested concentrations. Intriguingly, some impact of free 1,10-phenanthroline was also observed in A549 cells. These results are discussed in the context of the emerging evidence that the ER plays a role in the cytotoxic action of 1,10-phenanthroline-based compounds.

The loss count distributions whose probabilities ultimately satisfy Panjer’s recursion were classified between 1981 and 2002; they split into six types, which look quite diverse. Yet, the distributions are closely related – we show that their probabilities emerge out of one formula: the binomial series. We propose a parameter change that leads to a unified, practical and intuitive, representation of the Panjer distributions and their parameter space. We determine the subsets of the parameter space where the probabilities are continuous functions of the parameters. Finally, we give an inventory of parameterisations used for Panjer distributions.

In this paper we estimate the expected error of a stochastic approximation algorithm where the maximum of a function is found using finite differences of a stochastic representation of that function. An error estimate of the order $n^{-1/5}$ for the nth iteration is achieved using suitable parameters. The novelty with respect to previous studies is that we allow the stochastic representation to be discontinuous and to consist of possibly dependent random variables (satisfying a mixing condition).

Bacterial antibiotic resistance (AMR) is a significant threat to public health, with the sentinel ‘ESKAPEE’ pathogens, being of particular concern. A cohort study spanning 5.5 years (2016–2021) was conducted at a provincial general hospital in Crete, Greece, to describe the epidemiology of ESKAPEE-associated bacteraemia regarding levels of AMR and their impact on patient outcomes. In total, 239 bloodstream isolates were examined from 226 patients (0.7% of 32 996 admissions) with a median age of 75 years, 28% of whom had severe comorbidity and 46% with prior stay in ICU. Multidrug resistance (MDR) was lowest for Pseudomonas aeruginosa (30%) and Escherichia coli (33%), and highest among Acinetobacter baumannii (97%); the latter included 8 (22%) with extensive drug-resistance (XDR), half of which were resistant to all antibiotics tested. MDR bacteraemia was more likely to be healthcare-associated than community-onset (RR 1.67, 95% CI 1.04–2.65). Inpatient mortality was 22%, 35% and 63% for non-MDR, MDR and XDR episodes, respectively (P = 0.004). Competing risks survival analysis revealed increasing mortality linked to longer hospitalisation with increasing AMR levels, as well as differential pathogen-specific effects. A. baumannii bacteraemia was the most fatal (14-day death hazard ratio 3.39, 95% CI 1.74–6.63). Differences in microbiology, AMR profile and associated mortality compared to national and international data emphasise the importance of similar investigations of local epidemiology.

We suggest two related conjectures dealing with the existence of spanning irregular subgraphs of graphs. The first asserts that any $d$-regular graph on $n$ vertices contains a spanning subgraph in which the number of vertices of each degree between $0$ and $d$ deviates from $\frac{n}{d+1}$ by at most $2$. The second is that every graph on $n$ vertices with minimum degree $\delta$ contains a spanning subgraph in which the number of vertices of each degree does not exceed $\frac{n}{\delta +1}+2$. Both conjectures remain open, but we prove several asymptotic relaxations for graphs with a large number of vertices $n$. In particular we show that if $d^3 \log n \leq o(n)$ then every $d$-regular graph with $n$ vertices contains a spanning subgraph in which the number of vertices of each degree between $0$ and $d$ is $(1+o(1))\frac{n}{d+1}$. We also prove that any graph with $n$ vertices and minimum degree $\delta$ contains a spanning subgraph in which no degree is repeated more than $(1+o(1))\frac{n}{\delta +1}+2$ times.

For a bivariate random vector $(X, Y)$, suppose $X$ is some interesting loss variable and $Y$ is a benchmark variable. This paper proposes a new variability measure called the joint tail-Gini functional, which considers not only the tail event of benchmark variable $Y$, but also the tail information of $X$ itself. It can be viewed as a class of tail Gini-type variability measures, which also include the recently proposed tail-Gini functional. It is a challenging and interesting task to measure the tail variability of $X$ under some extreme scenarios of the variables by extending the Gini's methodology, and the two tail variability measures can serve such a purpose. We study the asymptotic behaviors of these tail Gini-type variability measures, including tail-Gini and joint tail-Gini functionals. The paper conducts this study under both tail dependent and tail independent cases, which are modeled by copulas with so-called tail order property. Some examples are also shown to illuminate our results. In particular, a generalization of the joint tail-Gini functional is considered to provide a more flexible version.

We introduce a general two-colour interacting urn model on a finite directed graph, where each urn at a node reinforces all the urns in its out-neighbours according to a fixed, non-negative, and balanced reinforcement matrix. We show that the fraction of balls of either colour converges almost surely to a deterministic limit if either the reinforcement is not of Pólya type or the graph is such that every vertex with non-zero in-degree can be reached from some vertex with zero in-degree. We also obtain joint central limit theorems with appropriate scalings. Furthermore, in the remaining case when there are no vertices with zero in-degree and the reinforcement is of Pólya type, we restrict our analysis to a regular graph and show that the fraction of balls of either colour converges almost surely to a finite random limit, which is the same across all the urns.

This paper examines the preservation of several aging classes of lifetime distributions in the formation of coherent and mixed systems with independent and identically distributed (i.i.d.) or identically distributed (i.d.) component lifetimes. The increasing mean inactivity time class and the decreasing mean time to failure class are developed for the lifetime of systems with possibly dependent and i.d. component lifetimes. The increasing likelihood ratio property is also discussed for the lifetime of a coherent system with i.i.d. component lifetimes. We present sufficient conditions satisfied by the signature of a coherent system with i.i.d. components with exponential distribution, under which the decreasing mean remaining lifetime, the increasing mean inactivity time, and the decreasing mean time to failure are all satisfied by the lifetime of the system. Illustrative examples are presented to support the established results.

Nonlinear Markov chains with finite state space were introduced by Kolokoltsov (Nonlinear Markov Processes and Kinetic Equations, 2010). The characteristic property of these processes is that the transition probabilities depend not only on the state, but also on the distribution of the process. Here we provide first results regarding their invariant distributions and long-term behaviour: we show that under a continuity assumption an invariant distribution exists and provide a sufficient criterion for the uniqueness of the invariant distribution. Moreover, we present examples of peculiar limit behaviour that cannot occur for classical linear Markov chains. Finally, we present for the case of small state spaces sufficient (and easy-to-verify) criteria for the ergodicity of the process.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the novel global coronavirus disease 2019 (COVID-19) disease outbreak. Its pathogenesis is mostly located in the respiratory tract. However, other organs are also affected. Hence, realising how such a complex disturbance affects patients after recovery is crucial. Regarding the significance of control of COVID-19-related complications after recovery, the current study was designed to review the cellular and molecular mechanisms linking COVID-19 to significant long-term signs including renal and cardiac complications, cutaneous and neurological manifestations, as well as blood coagulation disorders. This virus can directly influence on the cells through Angiotensin converting enzyme 2 (ACE-2) to induce cytokine storm. Acute release of Interleukin-1 (IL1), IL6 and plasminogen activator inhibitor 1 (PAI-1) have been related to elevating risk of heart failure. Also, inflammatory cytokines like IL-8 and Tumour necrosis factor-α cause the secretion of von Willebrand factor (VWF) from human endothelial cells and then VWF binds to Neutrophil extracellular traps to induce thrombosis. On the other hand, the virus can damage the blood–brain barrier by increasing its permeability and subsequently enters into the central nervous system and the systemic circulation. Furthermore, SARS-induced ACE2-deficiency decreases [des-Arg9]-bradykinin (desArg9-BK) degradation in kidneys to induce inflammation, thrombotic problems, fibrosis and necrosis. Notably, the angiotensin II-angiotensin II type 1 receptor binding causes an increase in aldosterone and mineralocorticoid receptors on the surface of dendritic cells cells, leading to recalling macrophage and monocyte into inflammatory sites of skin. In conclusions, all the pathways play a key role in the pathogenesis of these disturbances. Nevertheless, more investigations are necessary to determine more pathogenetic mechanisms of the virus.

Let f be the density function associated to a matrix-exponential distribution of parameters $(\boldsymbol{\alpha}, T,\boldsymbol{{s}})$. By exponentially tilting f, we find a probabilistic interpretation which generalizes the one associated to phase-type distributions. More specifically, we show that for any sufficiently large $\lambda\ge 0$, the function $x\mapsto \left(\int_0^\infty e^{-\lambda s}f(s)\textrm{d} s\right)^{-1}e^{-\lambda x}f(x)$ can be described in terms of a finite-state Markov jump process whose generator is tied to T. Finally, we show how to revert the exponential tilting in order to assign a probabilistic interpretation to f itself.

This study provides an econometric methodology to test a linear structural relationship among economic variables. We propose the so-called distance-difference (DD) test and show that it has omnibus power against arbitrary nonlinear structural relationships. If the DD-test rejects the linear model hypothesis, a sequential testing procedure assisted by the DD-test can consistently estimate the degree of a polynomial function that arbitrarily approximates the nonlinear structural equation. Using extensive Monte Carlo simulations, we confirm the DD-test’s finite sample properties and compare its performance with the sequential testing procedure assisted by the J-test and moment selection criteria. Finally, through investigation, we empirically illustrate the relationship between the value-added and its production factors using firm-level data from the United States. We demonstrate that the production function has exhibited a factor-biased technological change instead of Hicks-neutral technology presumed by the Cobb–Douglas production function.

We have previously shown that the geographic routing’s greedy packet forwarding distance (PFD), in dissimilarity values of its average measures, characterizes a mobile ad hoc network’s (MANET) topology by node size. In this article, we demonstrate a distribution-based analysis of the PFD measures that were generated by two representative greedy algorithms, namely GREEDY and ELLIPSOID. The result shows the potential of the distribution-based dissimilarity learning of the PFD in topology characterizing. Characterizing dynamic MANET topology supports context-aware performance optimization in position-based or geographic packet routing.

It was recently proven that the correlation function of the stationary version of a reflected Lévy process is nonnegative, nonincreasing, and convex. In another branch of the literature it was established that the mean value of the reflected process starting from zero is nondecreasing and concave. In the present paper it is shown, by putting them in a common framework, that these results extend to substantially more general settings. Indeed, instead of reflected Lévy processes, we consider a class of more general stochastically monotone Markov processes. In this setup we show monotonicity results associated with a supermodular function of two coordinates of our Markov process, from which the above-mentioned monotonicity and convexity/concavity results directly follow, but now for the class of Markov processes considered rather than just reflected Lévy processes. In addition, various results for the transient case (when the Markov process is not in stationarity) are provided. The conditions imposed are natural, in that they are satisfied by various frequently used Markovian models, as illustrated by a series of examples.

Combining cross-sectional and time-series data is a long and well-established practice in empirical economics. We develop a central limit theory that explicitly accounts for possible dependence between the two datasets. We focus on common factors as the mechanism behind this dependence. Using our central limit theorem (CLT), we establish the asymptotic properties of parameter estimates of a general class of models based on a combination of cross-sectional and time-series data, recognizing the interdependence between the two data sources in the presence of aggregate shocks. Despite the complicated nature of the analysis required to formulate the joint CLT, it is straightforward to implement the resulting parameter limiting distributions due to a formal similarity of our approximations with Murphy and Topel’s (1985, Journal of Business and Economic Statistics 3, 370–379) formula.