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Accurately modelling wind turbine wakes is essential for optimising wind farm performance but remains a persistent challenge. While the dynamic wake meandering (DWM) model captures unsteady wake behaviour, it suffers from near-wake inaccuracies due to empirical closures. We propose a symbolic regression-enhanced DWM (SRDWM) framework that achieves equation-level closure by embedding symbolic expressions for volumetric forcing and boundary terms explicitly into governing equations. These physically consistent expressions are discovered from large-eddy simulations (LES) data using symbolic regression guided by a hierarchical, domain-informed decomposition strategy. A revised wake-added turbulence formulation is further introduced to enhance turbulence intensity predictions. Extensive verification across varying inflows shows that SRDWM accurately reproduces both mean wake characteristics and turbulent dynamics, achieving full spatiotemporal resolution with over three orders of magnitude speed-up compared to LES. The results highlight symbolic regression as a bridge between data and physics, enabling interpretable and generalisable modelling.
Individuals with mental health difficulties (MHD) have a substantial reduction in life expectancy compared to the general population. It is increasingly recognised that mental health services need to improve physical healthcare as a priority. Sexual health, including consideration of high-risk sexual behaviours, medication side effects, and challenges in romantic relationships, is a further important but under-recognised aspect of overall health. We discuss some of the current issues relating to physical and sexual health, with a particular focus on youth with MHD and how we might implement holistic care in Ireland. Prioritising the resourcing of these issues could facilitate the implementation of a Shared Model of Care as recommended in Ireland’s National Mental Health Policy, Sharing the Vision.
This study aimed to evaluate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and inactivated virus vaccination on intracytoplasmic sperm injection (ICSI) outcomes in infertile couples. A retrospective case–control study was conducted at the Royan Institute from August 2020 to March 2022. The study included 90 couples in the COVID-19 infection phase and 31 in the vaccination phase. A total of 30 infected but unvaccinated couples were compared to a control group of 60 couples with no COVID-19 infection or vaccination history. Additionally, 31 couples underwent treatment before and after receiving the Sinopharm inactivated vaccine. Key variables analysed included sperm parameters (concentration, motility, progressive motility and morphology), ovarian parameters (antral follicle count, oocyte retrieval), embryological outcomes and pregnancy outcomes. SARS-CoV-2 infection significantly reduced sperm motility (P = 0.02) and progressive motility (P = 0.01) compared to controls. Sperm concentration and morphology showed non-significant declines. Post-vaccination analysis revealed similar but statistically insignificant changes in sperm parameters. Ovarian stimulation parameters and embryological outcomes remained unaffected by both infection and vaccination. Although biochemical, clinical pregnancy and live birth rates were lower among the infected group, these differences did not reach statistical significance (p = 0.16, 0.08 and 0.09). SARS-CoV-2 infection has been associated with impaired sperm progressive motility, which may negatively influence ICSI outcomes. In contrast, vaccination with an inactivated virus does not appear to impact fertility outcomes. These findings provide crucial guidance for physicians and infertile couples managing treatments during and after the pandemic, suggesting the need for extended recovery periods before ART procedures following COVID-19 infection.
Deterministic and stochastic processes are of great importance in influencing the composition of communities. Here, we tested if deterministic and stochastic processes have the same force of influence on functional traits of tiger moth communities. Specifically, we hypothesised that the functional traits of the tribe Arctiini would be more strongly influenced by stochastic processes (associated with spatial variables), given that these moths are primarily diet and habitat generalists within a highly diverse clade. They also exhibit high morphological trait dissimilarity and are capable of occupying a wide range of vegetation habitats. On the other hand, we hypothesised that the functional traits of the tribe Lithosiini would be more influenced by deterministic processes (associated with environmental variables), given that these moths are primarily diet and habitat specialist moths and tend to occur in more specific vegetation types. In agreement with our hypotheses, the functional traits of Arctiini species were better explained by variables related to stochasticity, while the functional traits of Lithosiini were explained by deterministic processes only. Thus, the processes shaping moth distributions across communities may vary according to species’ functional traits and interspecific relationships.
Stroke remains a major public health issue globally. Tele-rehabilitation, incorporating internet-based interventions and wearable devices, offers an accessible strategy for post-discharge rehabilitation. This study evaluates their effectiveness in stroke patients.
Methods:
A total of 160 subacute stroke patients hospitalized between November 2022 and September 2023 were enrolled and randomly allocated to four groups at discharge (n = 40 per group): a control group receiving conventional rehabilitation, an internet-based tele-rehabilitation (ITR) group, a wearable-device-assisted (WDA) group and a combined intervention (IWT) group, which received both ITR and WDA training. The primary outcome was assessed by the Modified Barthel Index (MBI) at discharge, 4 weeks and 12 weeks post-discharge, with the 12-week score prespecified as the primary endpoint. Secondary outcomes included Berg Balance Scale (BBS), simplified Fugl-Meyer Assessment (sFMA), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE) and Zarit Burden Interview (ZBI), all assessed at discharge, 4 weeks and 12 weeks post-discharge.
Results:
At baseline, no significant differences were observed among groups (P > 0.05). Over 12 weeks, all intervention groups demonstrated significant improvements in MBI, BBS and sFMA compared to the control group (P < 0.05), with the IWT group achieving the greatest gains (P < 0.01). Anxiety, depression and caregiver burden significantly decreased across intervention groups, with the IWT group showing the most pronounced reductions (P < 0.01). Cognitive function also improved significantly, particularly in the IWT group (P < 0.01).
Conclusion:
ITR and WDA training enhances functional and psychological recovery in stroke patients, highlighting its potential clinical significance in managing stroke recovery.
In a normal pregnancy, glucocorticoids (GC), such as cortisol, play an essential role in early heart development. GC concentrations surge in late gestation to facilitate the maturation of fetal systems in preparation for birth. However, pregnancy complications related to stress, lifestyle factors, disease, and commonly used antenatal care treatments (GC therapy and artificial reproductive technology) can lead to prematurely increased GC concentrations that are detrimental to the heart before it is mature enough to benefit. These findings underpin the hypothesis that GC play a double-edged role that benefits normal heart development but is potentially harmful when dysregulated. However, the mechanisms by which both physiological and pathological elevations in GC concentrations influence the fetal cardiometabolic pathways that lead to detrimental long-term cardiovascular outcomes remain unclear. This review will, firstly, describe how cortisol regulates different aspects of cardiac development and, secondly, compare findings from different animal models that have provided mechanistic insight into how excess cortisol/GC during pregnancy impacts cardiac health across the life course.
There is substantial international variation in recommended vitamin C intake levels. In the USA, the recommendation is 90 mg/d for men and 75 mg/d for women, while in the UK, the current recommendation – established in 1991 – is only 40 mg/d for adults. This UK level was based on the 1953 Sheffield study, which found that 10 mg/d prevents scurvy, with 40 mg/d chosen as the recommended level for yielding somewhat higher plasma levels. In this commentary, we argue that the UK recommendation overlooked key evidence available at the time. Specifically, at least six controlled trials published before 1991 reported benefits from vitamin C supplementation in participants whose baseline vitamin C intake was already 40 mg/d or higher. One randomised controlled trial, published in 1993, found benefits from vitamin C supplementation even at a baseline intake of about 500 mg/d; however, this trial involved ultramarathon runners, and the findings should not be broadly generalised. Nonetheless, such results challenge the assumption that 40 mg/d is universally adequate to maintain full health. We also highlight that the UK recommendations were narrowly focused on preventing dermatological symptoms of scurvy, despite strong evidence – even at the time – that vitamin C deficiency can also cause cardiac dysfunction and greater morbidity due to respiratory infections. We conclude that the current UK vitamin C recommendation should be re-evaluated in light of controlled trial evidence and broader clinical outcomes.
The dating of the qameṣ shift (*/aː/ > [ɔː]) in the Tiberian tradition of Biblical Hebrew has long been a scholarly puzzle. In this article I present possible evidence for this shift in the Greek transcriptions of Origen’s Hexapla, datable to the first half of the third century ce in Palestine. While the evidence is limited both in attested tokens and in grammatical scope, it is suggested that lexical diffusion may account for the gradual spread of this shift, as recorded in different stages of the transmission of Biblical Hebrew.
This paper studies the effect of gender imbalance on assortative matching and household income inequality. Using data across prefectures in China, we show that a higher sex ratio in the marriage market is negatively associated with both assortative marriage and household income inequality. Motivated by empirical evidence, we develop a heterogeneous-agent model to study the mechanism behind the pattern. The quantitative results of the model match the empirical evidence: a higher sex ratio is associated with a lower degree of assortative matching, which leads to a decrease in household income inequality. When we allow men and women to choose their level of education endogenously before entering the marriage market, we find that a higher sex ratio leads to a higher level of education investment among both men and women, with men investing more significantly than women.
Results are presented of an experimental investigation into the levitation of spheres on thin layers of viscous fluid. In one set of experiments the layer is formed on a planar vertical wall and in a second investigation the sphere sits on a fluid layer on the inside of a rotating horizontal cylinder. The motion takes place at a set of fixed locations in the latter case whereas the sphere generally translates up or down the plane wall of the belt. Lubrication layers formed between the surfaces of the spheres and the walls induce slip. Two distinct states are identified, and excellent accord is found between experimental results and those from a recently developed theory for the single-track state which is only observed in the rotating horizontal cylinder. The two-track state exists in both sets of experiments, but theoretical progress with this remains an outstanding challenge.
Many archaeology graduate students pursue advanced degrees in the hope of undertaking an academic career. Job-listing websites often serve as the first port-of-call for students seeking academic positions. We examined tenure-track job advertisements over the past decade to gain insights into the academic job market for archaeologists. Using data from the community-edited Academic Jobs Wiki for Archaeology, we examined changes in the academic job market over time. We investigated the editing dynamics of the Wiki to understand its users and their biases. We then analyzed the text of 431 job ads posted from 2013 to 2023. Our analysis addresses the question of how archaeological topics, methods, and geographic regions specified in archaeological job ads have shifted over time. We also explored whether the labor burden for applicants has changed over time: do institutions request more information and documents from applicants at the initial stages of application, compared to a decade ago? Finally, we assessed the influence of sociopolitical factors on the changing focus of research topics in the field. We conclude with implications for archaeology students, graduates, and advisors seeking to understand the dynamics of the academic job market and the requirements of employers.
La reciente excavación arqueológica efectuada en el centro provincial inka de Tambo Viejo, en el valle de Acarí, Perú, resultó en el hallazgo de una pequeña construcción de forma rectangular y semisubterránea. En su interior encontramos hojas y semillas de coca en asociación con arena limpia. Esta evidencia sugiere que la pequeña construcción sirvió para el almacenamiento de las hojas de coca, las que habían sido cubiertas con arena limpia para garantizar su preservación. La arena tiene propiedades térmicas que crean condiciones relativamente frías y que son óptimas para la preservación de productos orgánicos.
Estimate bacterial pathogen contamination of healthcare workers’ (HCW) long-sleeved attire.
Design:
Prospective observational study.
Setting:
Tertiary care hospital.
Participants:
HCWs wearing long-sleeved attire providing direct inpatient care.
Intervention:
Sampling of both sleeves of HCWs wearing long-sleeved attire was performed using a swab and cultured for aerobic bacterial growth classified as potential pathogens or presumptive skin commensals. Potential predictors of sleeve contamination, including participant survey responses related to attire and infection prevention practices, were analyzed using univariate analyses. Whole genome sequencing compared isolates to a genomic surveillance database of patient clinical isolates.
Results:
Among 280 samples, 81.1% (n = 227) demonstrated any bacterial growth and 20.7% (n = 58) grew ≥1 potential pathogen. Speciated organisms included alpha-hemolytic streptococci (n = 28), Bacillus sp. (n = 20), and Pantoea/Mixta sp. (n = 8), gram-negative bacilli (n = 6), and Staphylococcus aureus (n = 2). Univariate analysis demonstrated that sleeves sampled on non-intensive care units (P = .038) were significantly associated with any bacterial growth, and attire type (P = .002) and sleeve material (P = .004) were associated with growth of ≥1 potential pathogen. Fleece attire and material were more likely to be contaminated than other attire and material types. Sequenced isolates from sleeve samples were not genetically related to any patient isolates.
Conclusions:
HCW long sleeve contamination occurs frequently, including with potential pathogens. Changing trends in attire type may have an impact on bacterial transmissibility. While this study could not infer transmission events associated with clinically diagnosed patient infections, the potential benefit of a “bare below the elbows” attire policy warrants further investigation.
We report the first detections of Otiorhynchus albidus Stierlin (Coleoptera: Curculionidae) in North America. The first specimens of O. albidus were found inside a home in Kelowna, British Columbia, Canada, in June 2022, and additional specimens from the same location were collected throughout 2023 and 2024. Otiorhynchus albidus is of European origin. It is known to attack tree fruits and ornamental plants. Otiorhynchus albidus sometimes co-occurred with O. raucus (Fabricius), an already established weevil species in British Columbia that is a pest of tree fruits, grapes, vegetables, and ornamental plants. To test different surveillance methods and understand the seasonal occurrence of O. albidus, surveys for adult weevils were conducted in 2023 and 2024 with pitfall traps (outside the home) and sticky traps (inside and outside the home) in 2023. Both O. albidus and O. raucus were recovered with pitfall and sticky traps and were found in both years. We provide a key and reference DNA barcodes (from the cytochrome c oxidase subunit 1 region) to distinguish O. albidus from similar species present in Canada. Otiorhynchus albidus has the potential to become a pest of tree fruits and ornamental plants in North America, as well as a nuisance pest for homeowners.
This study aimed to systematically review the evidence on functional outcomes following dorsal preservation rhinoplasty, with a focus on nasal obstruction.
Methods
A systematic review was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. PubMed, Embase, Scopus and Cochrane databases were searched up to March 2025. Studies reporting nasal airway outcomes following dorsal preservation rhinoplasty using subjective or objective measures were included.
Results
Six studies comprising 662 patients were included. Patient-reported outcomes (Nasal Obstruction Symptom Evaluation, Standardized Cosmesis and Health Nasal Outcomes Survey and Visual Analogue Scale) consistently demonstrated significant post-operative improvement. Objective measures (acoustic rhinometry, rhinomanometry and cone-beam computed tomography) showed maintained or improved airway dimensions. dorsal preservation rhinoplasty was functionally equivalent to traditional structural techniques, with low complication (<5 per cent) and revision rates (<2 per cent).
Conclusion
Dorsal preservation rhinoplasty maintains or improves nasal airway function while preserving structural integrity and reducing the need for grafting. It is a safe and effective alternative to traditional dorsal reduction techniques.