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The rise of digital money may bring about privately issued money that circulates across borders and coexists with public money. This paper uses an open-economy search model with multiple currencies to study the impact of such global money on monetary autonomy – the capacity of central banks to set a policy instrument. I show that the circulation of global money can entail a loss of monetary autonomy, but it can be preserved if government policy that limits the amount or use of global money for transactions is introduced or if the global currency is subject to the threat of counterfeiting. The result suggests that global digital money and monetary autonomy can be compatible.
This article addresses the questions of when mental health advance planning documents are created, the points when circumstances which they are intended to address arise and what consequences should flow when such a situation does arise. It addresses these points primarily from the perspective of what the law could/should be at a conceptual level. It looks at three stages: (a) creation of the document; (b) the period between the creation of the document and the point at which the intended circumstances arise; and (c) the point at which the intended circumstances arise. It does not purport to provide solutions at each stage, but rather to frame the dilemmas to aid discussion. In similar vein, it draws upon case studies from England & Wales, not to purport to dictate similarities of approach, but to flesh out dilemmas that have arisen to stimulate consideration.
The famous Sidorenko’s conjecture asserts that for every bipartite graph $H$, the number of homomorphisms from $H$ to a graph $G$ with given edge density is minimised when $G$ is pseudorandom. We prove that for any graph $H$, a graph obtained from replacing edges of $H$ by generalised theta graphs consisting of even paths satisfies Sidorenko’s conjecture, provided a certain divisibility condition on the number of paths. To achieve this, we prove unconditionally that bipartite graphs obtained from replacing each edge of a complete graph with a generalised theta graph satisfy Sidorenko’s conjecture, which extends a result of Conlon, Kim, Lee and Lee [J. Lond. Math. Soc., 2018].
Neurocognitive assessment is an essential research instrument for autism spectrum disorder (ASD), as the clinical manifestations are rooted in diverse neurocognitive processes that cause variation in clinical presentation. Few instruments comprehensively capture relevant neurocognitive domains, and most require professional assessors. The Penn Computerized Neurocognitive Battery (CNB) is widely used in child and adolescent psychiatry research across cultures. This study adapted and validated the CNB for a clinical ASD cohort in Hong Kong.
Method:
In this Hong Kong version of the CNB (CNB-HK), thirteen cognitive tasks were translated and adapted, with one task for sensorimotor speed and twelve belonging to four specific domains (episodic memory, social cognition, complex cognition, and executive function). The CNB-HK was administered to 636 normal-IQ children with ASD (mean age: 8.4 years, 87.1% male) and 412 children without ASD (mean age: 8.6 years, 55.1% male). Factor structure was examined using factor analyses.
Results:
The CNB-HK had high feasibility for children with ASD, with <7% invalid data across all tasks. The original four-factor and bi-factor structures were replicated with good model fit, and partial scalar invariance was achieved between children with and without ASD. The factor scores correlated positively with estimated IQ in the ASD group. The ASD group had worse performance across all four cognitive domains and the g factor compared to the group without ASD.
Conclusions:
The CNB-HK is a valid, multi-domain cognitive assessment tool for children with ASD in Hong Kong, offering a feasible and reliable approach for research and clinical settings.
The notions of “emergence” and “becoming” have become widely adopted in relational studies in archaeology, but their definition and application remain nebulous. We advocate a middle-range approach to the incorporation of these related concepts into the study of migration and pronounced cultural shifts. Our study relies on the Bayesian modeling of a significant corpus of radiocarbon dates from Mississippian sites in the Tombigbee Valley of southeastern North America. This investigation has identified the likelihood of two broad migration episodes that we hypothesize are related to cultural rephrasings of landscape and temporality.
Due to the high prevalence of depression and anxiety in people with epilepsy, the International League Against Epilepsy Commission on the Neuropsychiatric Aspects of Epilepsy recommends implementing routine screening for depression and anxiety symptoms. Our epilepsy group began administering three screening questionnaires to all clinic patients in 2016: the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Beck Anxiety Inventory (BAI) and the Generalized Anxiety Disorder-7 (GAD-7).
Objective:
We aim to review our experience with this screening approach.
Methods:
We reviewed 2253 sets of questionnaires completed from January 2018 to March 2020 and studied the actions taken by epileptologists in response to a positive screening.
Results:
Thirty-six percent of all assessed patients screened positive on at least one questionnaire: 13.6% screened positive for depression symptoms (NDDI-E ≥ 16), 12.3% for anxiety symptoms (BAI ≥ 22) and 30.3% for GAD symptoms (GAD-7 > 7). Among patients with a positive screening, 36% received a care intervention, 59% did not and 5% declined the neurologist’s recommendation. Among patients for whom an intervention was implemented, 58% were referred to a mental health professional (generally a neuropsychiatrist), 29% had their antiseizure medication adjusted to alleviate their symptoms and 13% received another intervention.
Conclusion:
In our clinic, an important proportion of patients screened positive for depression and/or anxiety symptoms. Fewer than half received a management option to alleviate their symptoms. We conclude that while routine screening increases the detection of depression and anxiety among epilepsy patients, it must be accompanied by effective interventions and access to mental-health professionals.
This study explores how loneliness affects earthquake risk perception and preparedness behaviors among older adults in Japan. Aging is often accompanied by increased vulnerability to natural disasters, and loneliness is hypothesized to compromise effective preparedness. Using the Japanese Older Adult Preparedness Model (JOAPM), which integrates the Protective Action Decision Model (PADM) and cultural context, we examine how loneliness influences both perceived earthquake risk and protective behaviors.
Methods
An online survey conducted in April 2024 gathered responses from adults aged 55 and older across 4 earthquake-prone Japanese prefectures. Measures included demographics, disaster experience, loneliness (UCLA Loneliness Scale), risk perception, and preparedness actions such as household adjustments. Regression and mediation analyses assessed the direct and indirect effects of loneliness on preparedness.
Results
Findings show that loneliness has a significant negative direct effect on disaster preparedness. However, it also slightly increases risk perception, which in turn has a positive relationship with preparedness behaviors, suggesting a modest indirect pathway. Overall, the direct negative effect of loneliness outweighs the indirect benefit.
Conclusion
The results highlight the complex role of psychosocial factors in disaster readiness, suggesting that interventions should address information dissemination, self-efficacy, and the emotional isolation experienced by older adults in high-risk areas.
The prevalence of mental ill health is increasing in young people worldwide, with rising referrals to child and adolescent mental health services (CAMHS). The numbers and proportions of the youth population who present to CAMHS, however, including how those figures are changing over time, are unclear. Understanding trends in mental health service contacts for young people over time is crucial mental health surveillance data.
Aims
Our aim was to calculate both the lifetime and annual prevalence of CAMHS contact in Wales for young people up to age 18 years.
Method
Using linked Welsh administrative healthcare records, we calculated the annual prevalence of CAMHS contacts between 2004 and 2023. We also calculated the lifetime prevalence of CAMHS contacts for sequential annual birth cohorts born between 1991 and 2005 and followed to age 18 (between 2009 and 2023).
Results
In 2004, 0.8% (n = 4665) of the total child and adolescent population were in contact with CAMHS. By 2022, this had risen nearly five-fold to 3.9% (n = 19 870) of the total child and adolescent population. Among the 1991 birth cohort who turned 18 in 2009, 5.8% had contact with CAMHS at some stage in childhood or adolescence. For individuals born in 2005 who turned 18 in 2023, this figure had risen to 20.2%.
Conclusions
The number of the young people in contact with CAMHS has increased dramatically over the past 15 years, from 1 in 17 young people who turned 18 in 2009 to 1 in 5 young people who turned 18 in 2023.
While the effects of multidisciplinary weight loss (WL) on resting energy expenditure remain unclear in adolescents with obesity, the potential presence of adaptive thermogenesis (AT) has never been explored, which was the objective of the present work. Twenty-six adolescents (14·1 (sd 1·5) years) with severe obesity completed a 9-month inpatient multidisciplinary intervention followed by a 4-month follow-up. Anthropometric measurements, body composition (dual X-ray absorptiometry) and resting energy expenditure (REE, indirect calorimetry) were assessed before (T0) and after 9 months of WL intervention (T1) and after a 4-month follow-up (T2). AT, at the level of REE, was defined as a significantly lower measured v. predicted (using regression models with baseline data) REE. Two pre-cited REE equations were used, using both fat mass and fat-free mass (FFM) (predicted REE using equation 1) or FFM only (predicted REE using equation 2). Measured and predicted REE significantly decreased between T0 and T1 (P < 0·001) and remained lower at T2 compared with T0 (measured REE: P = 0·017; predicted REE: P < 0·001). Predicted REE using equation 2 was significantly higher than measured REE at T1 (P = 0·012), suggesting the presence of AT. FFM at T0 was negatively correlated with ATp1T1 (Rho = –0·428; P = 0·033) and ATp2T1 (Rho = –0·485; P = 0·014). The variation of FFM between T0 and T1 was negatively correlated with AT at T1 and T2. These preliminary results suggest the existence of AT in response to WL in adolescents with obesity, independently of the degree of WL. AT was associated with subsequent body weight and fat regain, suggesting AT may represent a damper to WL attempts while increasing the adolescents’ risks for subsequent weight and adiposity rebounds.
Salmonella enterica serovar Dublin is host-specific to cattle, causing severe symptoms and economically impacting milk herds. Despite an eradication programme in Denmark, levels of infection have not decreased and suspicion has fallen on the common starling Sturnus vulgaris as a potential vector between herds. The number of breeding starlings in Denmark declined by 60% between 1976 and 2015, a trend correlated with decreases in the number of cattle grazing outside. Ironically, more starlings are now coming into Danish cattle sheds to feed on maize silage outside the breeding season, so it is increasingly important to understand the role of starlings in dispersing Salmonella between cattle herds. We caught and tested 394 different starlings at seven separate dairy farms infected with Salmonella Dublin by swabbing breast feathers, legs, feet and undertail coverts as well as taking faecal samples at these and four other infected farms. We found no trace of the pathogen, indicating that starlings are highly unlikely to be significant in spreading Salmonella Dublin between Danish cattle herds. We recommend investigating alternative contacts that may occur between herds as the cause of disease spread.
This article examines the pedagogical challenges and opportunities of teaching the Israeli–Palestinian conflict amid rising global polarization and campus tensions. We report on a cross-institutional course taught concurrently at Middlebury College (United States) and Yeditepe University (Turkey) after October 7 that was designed to address affective polarization and dehumanization through dialogic education. Drawing on mixed methods including pre- and post-semester surveys, student reflections, and podcast projects, we assess the impact of dialogic practices such as structured dialogue, active listening, and engagement with Israeli and Palestinian peace activists. Our findings indicate that dialogic classrooms (1) deepen historical and analytical understanding of the conflict, (2) foster empathy and curiosity, (3) mitigate polarization even in politically divided contexts, and (4) humanize opposing perspectives without erasing convictions. These results underscore the value of dialogic pedagogy for teaching contentious topics across sociopolitical boundaries and suggest its adaptability to other polarizing issues in political science.
There is a lack of knowledge available on how cats adjust their macronutrient partitioning due to the consumption of single-macronutrient meals. The objective of this study was to evaluate consumption of a single meal of ingredients that contained foods of strictly carbohydrates (CHO), fat (FAT) or protein (PRO), on energy expenditure (EE) and macronutrient metabolism in cats. Ten domestic shorthair adult cats (1·9 years; 4·12 kg) were fed 22–24 g of chicken fat (FAT), 56–62 g of whey protein solution (PRO) or 54–56 g of cornstarch solution (CHO) for a single day in a randomised complete block design. Indirect calorimetry was conducted for 24 h post-feeding. Mean average EE over 24 h was highest in cats fed PRO (44 kcal/kg BW) and FAT (43 kcal/kg BW) compared with that in cats fed CHO (42 kcal/kg BW; P < 0·01). During 0 to 4 h, cats fed FAT had greater EE (49 kcal/kg BW), suggesting that cats respond to oxidising more dietary fat over protein in the early postprandial stage. Mean 24 h respiratory quotient (RQ) was greatest for cats fed CHO (0·76) followed by PRO (0·75) and FAT (0·74; P < 0·05). During 4 to 8 h, the RQ of cats fed PRO was the greatest (0·77), suggesting that cats initially increase gluconeogenesis from amino acids for subsequent glucose oxidation. In comparison to omnivores and herbivores, obligate carnivores have unique responses to single macronutrient intake, where they apparently generate energy from carbohydrate metabolism and rely more on gluconeogenic precursors.
The Kura-Araxes culture spread over a large area of South-west Asia, participating in the transformational dynamics of Early Bronze Age societies in the region. Yet, the absence of a robust chronological framework for this cultural horizon hinders its integration into wider regional and interregional models. Drawing on a substantial new radiocarbon dataset, collating novel Bayesian chronological models for eight sites and existing data from the wider region, this article identifies settlement patterns that coincide with broader reconfigurations of the Kura-Araxes cultural landscape, which in turn track socioeconomic, and possibly political, shifts observed in eastern Anatolia and the greater Near East.
Shakespeare’s Cymbeline explores the tension between the desire for freedom and the obligations individuals owe to their social and political communities. Through the course of the play, characters seek freedom from the authority of their fathers, kings, emperors, and gods with devastating consequences. Tragedy is only averted once these characters understand that the freedom and authority they variously desire is only fulfilled in a mutual love or good will that is bolstered by forgiveness. The play’s setting at the birth of Christ is carried through in the Christian argument and outcome of the plot.
Within a collaboration between the Brazilian Federal Police and the Radiocarbon Laboratory of the Fluminense Federal University (LAC-UFF), this work studies seized art objects made from ivory. We aim to develop protocols to verify whether they are illegal according to the Convention on International Trade of Endangered Species from Wild Flora and Fauna (CITES) law by measuring the carbon-14 concentration in the modified ivory samples from different sampling spots and comparing it to the bomb peak curve. Over the course of this research, we evaluate the uncertainties related to the determination of the elephants’ death. These uncertainties are due to several factors such as the provenance of the elephants, growth pattern of the tusks and incorporation of atmospheric radiocarbon to the tissues, sampling methods of ivory objects of different sizes and shapes, and radiocarbon data analysis. This work is a pioneer study in Brazil and is likely to become a reference in the country in the field of radiocarbon analyses in forensic contexts.
This work investigates the Richtmyer–Meshkov instability (RMI) at gas/viscoelastic interfaces with an initial single-mode perturbation both experimentally and theoretically. By systematically varying the compositions and concentrations of hydrogels, a series of viscoelastic materials with tuneable mechanical properties is created, spanning from highly viscous to predominantly elastic. Following shock impact, the interface exhibits two distinct types of perturbations: small-amplitude, short-wavelength perturbations inherited from initial single-mode condition, and large-amplitude, long-wavelength perturbations arising from viscous effects. For hydrogels with high loss factors, viscosity dominates the interface dynamics, leading to pronounced V-shaped deformation of the entire interface accompanied by a rapid decay of the initial single-mode perturbation. In contrast, for hydrogels with low loss factors, elasticity plays a prominent role, leading to sustained oscillations of the single-mode perturbation. By employing the Maxwell model to simultaneously incorporate both viscous and elastic effects, a comprehensive linear theory for RMI at gas/viscoelastic interfaces is developed, which shows good agreement with experimental results in the early stages. Although deviations arise at later times due to factors such as the shear-thickening feature of hydrogels and three-dimensional effects, the model well reproduces the oscillation behaviour of single-mode perturbations. In particular, it effectively captures the trend that increasing elasticity reduces both oscillation period and amplitude, providing key insights into the role of material properties in interface dynamics.
In this paper, we study the existence and stability of solitary wave solutions for the generalized Benjamin equation in both the $L^2$-critical and $L^2$-supercritical cases by applying the variational methods and the non-homogeneous Gagliardo–Nirenberg inequality. Our main results generalize and complement the existing results in the literature.