This brief commentary on Greenberg's article ‘When the illness speaks’ addresses the problem of agency in mental disorder. Complementing the perspective of the article, it advocates an approach that does not see the causal mechanism of disorder-related behaviour in terms of an exclusive disjunction between the effects of the individual patient's own agency or manifestations of the illness. When reduced agency becomes part of the person's self-conception, passivity no longer means behaviour that is alien to their ‘genuine self’. Relatedly, the requirement that the patient's self-conception be validated raises some questions regarding its therapeutic constraints.

There is no evidence, nor need, for a fast block to polyspermy in animal oocytes. The idea that oocytes have evolved a mechanism to allow the entry of one spermatozoon and repel all others has, however, gained consensus over the last century. The main culprit is the sea urchin, which has been used for over a century in in vitro studies of the fertilization process. Images of sea urchin oocytes with thousands of sperm attached to the surface are commonplace in textbooks and appeal to the nature of the reader implying an intriguing surface mechanism of sperm selection despite these oocytes being fixed for photography (Figure 1). The abundance of gametes in this marine invertebrate and the ease of experimentation have given us the possibility to elucidate many aspects of the mechanism of fertilization, but has also led to ongoing controversies in reproductive biology, one being polyspermy prevention. Kinetic experiments by Rothschild and colleagues in the 1950s led to the hypothesis of a fast partial block to polyspermy in sea urchin oocytes that reduced the probability of a second spermatozoon from entering the oocyte by 1/20th. In the 1970s, Jaffe and colleagues suggested, with circumstantial evidence, that this partial block was due to the sperm-induced depolarization of the oocyte plasma membrane. However, the fate of supernumerary spermatozoa is determined well before the plasma membrane of the oocyte depolarizes. Transmembrane voltage does not serve to regulate sperm entry. Scholastic texts have inadvertently promulgated this concept across the animal kingdom with no logical correlation or experimentation and, as of today, a molecular mechanism to regulate sperm entry in oocytes has not been identified.

Paraconularia planicostata (Dawson, 1868) is one of two species in this genus (Sinclair, 1940) of conulariid cnidarian currently known from Mississippian strata in the Maritimes Basin in Atlantic Canada (Babcock and Feldmann, 1986). A salient characteristic of the species is the presence of a low and narrow internal carina at or near the longitudinal midline of each of the four faces of the gently tapered periderm (Van Iten et al., 2020). Paraconularia planicostata occurs in marine carbonates in the Upper Mississippian lower Windsor and lower Codroy groups in Nova Scotia and western Newfoundland, respectively (e.g., Bell, 1929; Stacy, 1953; Dix and James, 1988; Boehner et al., 1989; Boehner and Prime, 1993; Lavoie and Sami, 1998; Jutras et al., 2006; Ryan and Giles, 2017; Van Iten et al., 2020). The species is exceptionally abundant, with richly fossiliferous biohermal limestones containing up to approximately 20 specimens per 1000 cm3 of host rock (Van Iten, unpublished observations)—a volumetric density matched by few other conulariid-bearing rock units.

Despite the large body of ALMP evaluations focussing on isolated training programmes for unemployed jobseekers, our understanding of potential reasons for (in)effectiveness remains limited. Specific training programmes aim to remediate particular supply- or demand-side barriers to employment experienced by targeted jobseekers. Consequently, this study unpacks training into four different types: (I) general classroom training (GCT) to enhance motivation and job search skills, (II) occupation-specific classroom training (OCT) addressing gaps in human capital, (III) non-contractual workplace training (NCWT) combining human capital acquisition with workplace experience, and (IV) contractual workplace training (CWT) additionally including a temporary wage subsidy to reduce hiring costs for employers. Using large-scale longitudinal register data, dynamic propensity score matching, and hazard models indicate positive effects of OCT participation, and particularly NCWT programmes allowing human and social capital accumulation in a workplace setting, on the transition into (stable) regular employment. In contrast, the non-effects for GCT participants highlight the need for more follow-up programmes, and the fact that, after controlling for the selective recruitment by employers of unemployed jobseekers with relatively strong profiles, CWT programme participants show moderate, short-lived positive effects which might inspire policymakers to reconsider programme assignment in light of cream-skimming by employers.

This longitudinal study aimed to investigate the role of maternal cognitive functioning and psychopathology in parent-child relationship quality during residential treatment for mothers with Substance Use Disorder (SUD), in order to identify factors that may enhance or limit intervention effects.

We assessed cognitive functioning (Esame Neuropsicologico Breve-2 [ENB-2]) and psychopathology (Symptom Checklist-90 Revised [SCL-90-R]) in 60 mothers diagnosed with SUD (Mage = 30.13 yrs; SD = 6.79) at treatment admission. Parent-child relationship quality was measured during free-play interactions using the Emotional Availability Scales every three months from admission (Child Mage = 17.17m; SD = 23.60) to the 15th month of the residential treatment.

A main effect of maternal psychopathology and an interaction effect of time and cognitive functioning were found. More maternal psychopathology predicted lower mother-child relationship quality. Mothers with higher cognitive functioning presented a better treatment trajectory, with an increase in mother-child relationship quality, whereas mothers with lower cognitive functioning showed a decrease in relationship quality after initial improvement.

These findings suggest that maternal psychopathology and cognitive functioning may influence the treatment of parent-child relationships in the context of SUD, although causality is not yet established. Implications for assessment and intervention are discussed.

Left ventricular tumour is a rare condition in children. The causes include vegetations, thrombus, and fibroma. 2-year-old asymptomatic female presented with an innocent heart murmur at 6 months of age. Subsequent follow-ups at 18 months of age showed left ventricular mass. Surgical pathology revealed “nodular fasciitis.” This type of tumour has never been described in the heart before.

Men with diabetes frequently experience spermatogenic dysfunction, which is the most significant sign that diabetes has harmed their ability to reproduce. The effect of various doses of the hydro-alcoholic extract of Nerium oleander leaves on the pituitary–gonadal axis, sperm motility and number, antioxidant system, changes in testicular tissue structure, and spermatogenesis in healthy and diabetic rats has been examined in the current study. Eighty male rats that had been streptozotocin-induced diabetic and healthy were divided into eight groups: (1) control, (2) Nerium (50 mg/kg), (3) Nerium (100 mg/kg), (4) Nerium (200 mg/kg), (5) DM (6) DM+Nerium (50 mg/kg), (7) DM+Nerium (100 mg/kg) and (8) DM+Nerium (200 mg/kg) and were administered orally for 48 days consecutive. Following the studies, analysis of the testicular tissues’ antioxidant capacity as well as sperm parameters, Johnsen’s scoring and morphometric evaluation, histology, biochemical and stereology studies were performed.

The outcomes showed that Nerium 50 and 100 mg/kg considerably enhanced the testicular morphology, sperm parameters, and reproductive organs to varying degrees in diabetic rats. After Nerium 50 mg/kg administration, glutathione peroxidase (GPX) and catalase (CAT) levels in the testicular tissue were increased whereas malondialdehyde (MDA) levels were markedly decreased. Nerium may help protect against diabetic-induced spermatogenic dysfunction in male rats by enhancing the activities of antioxidant enzymes in lower dosages.

We develop methods for testing factor models when the weights in portfolios of factors and test assets can vary with lagged information. We derive and evaluate consistent standard errors and finite sample bias adjustments for unconditional maximum squared Sharpe ratios and their differences. Bias adjustment using a second-order approximation performs well. We derive optimal zero-beta rates for models with dynamically trading portfolios. Factor models’ Sharpe ratios are larger but standard test asset portfolios’ maximum Sharpe ratios are larger still when there is dynamic trading. As a result, most of the popular factor models are rejected.

Brazil et al. [‘Maximal subgroups of infinite symmetric groups’, Proc. Lond. Math. Soc. (3) 68(1) (1994), 77–111] provided a new family of maximal subgroups of the symmetric group $G(X)$ defined on an infinite set X. It is easy to see that, in this case, $G(X)$ contains subsemigroups that are not groups, but nothing is known about nongroup maximal subsemigroups of $G(X)$. We provide infinitely many examples of such semigroups.