How do bureaucrats implement public policy when faced with political intermediation? This article examines this issue in the distribution of land rights to informal settlements in the municipality of São Paulo, Brazil. Land regularization is a policy established over three decades, where politicians’ requests for land titles to their constituencies play a relevant role. Based on interviews and documents, this study finds that bureaucrats adopt a twofold approach to regulate distribution: they document informal settlements, enacting eligibility criteria; then, they manage and prioritize beneficiaries, accommodating qualifying political demands. In this process, they enforce eligibility rules consistently across cases, constraining political intermediation to a rational scheme. Therefore, bureaucrats reconcile nonprogrammatic politics and policy rules by separating eligibility assessment from beneficiary selection. This paper bridges urban distributive politics and street-level bureaucracy literature by revealing that policy implementers may use technical expertise to curb political influence and negotiate conflicting interests and constraints.

Public Employment Services (PES) increasingly use automated statistical profiling algorithms (ASPAs) to ration expensive active labour market policy (ALMP) interventions to those they predict at risk of becoming long-term unemployed (LTU). Strikingly, despite the critical role played by ASPAs in the operation of public policy, we know very little about how the technology works, particularly how accurate predictions from ASPAs are. As a vital first step in assessing the operational effectiveness and social impact of ASPAs, we review the method of reporting accuracy. We demonstrate that the current method of reporting a single measure for accuracy (usually a percentage) inflates the capabilities of the technology in a peculiar way. ASPAs tend towards high false positive rates, and so falsely identify those who prove to be frictionally unemployed as likely to be LTU. This has important implications for the effectiveness of spending on ALMPs.

The idea that Protestantism in post-Reformation England was inherently hostile to the visual arts has a long history and has become embedded across an interdisciplinary scholarship and within popular consciousness. While more recent historiography addresses numerous exceptions to this prevailing trend, this article provides a new assessment of how English Protestantism in a more positive mood not only came to terms with the image but actively embraced it. In identifying patterns of thinking within a wide body of contemporary comment, we offer a chart in the mode of early modern figurative diagrams to emphasize the diverse criteria that Protestants weighed when considering whether an image was suitable for its intended purpose, from the circumstances of its making and using through audience response to location, medium, subject matter, and patron. In doing so, we stress the importance of historicizing the sense of the terms civil and religious use, which do not map neatly onto a modern reading of secular and sacred spaces. We further illustrate how the criteria of the model operated in practice, through detailed analysis of two extant artworks commissioned by committed Protestants, highlighting keen engagement with pictorial art in theory and in practice. The shift in emphasis from rejection to reconciliation captures the spirit of English Protestantism's negotiation and rapprochement with the image over the period ca. 1560–ca. 1640.

Prime ministers in parliamentary systems confront a challenging agency problem in leading cabinets toward cross-government priorities: ministers tend to prioritize departmental interests and may lack incentives and/or information enabling co-ordinated effort. In Canada, a novel mechanism for both increasing incentives and information provision has been developed in recent decades: the mandate letter. These letters are issued by Canadian prime ministers to their ministers, reinforcing government priorities, each minister's responsibilities, and specific policy expectations. This article examines mandate letters as mechanisms inducing interministerial policy co-ordination, focusing on the 2015–2021 period, under Justin Trudeau, as the first Canadian prime minister to release these letters publicly. Using topic modelling and social network analysis, I find that Trudeau has increasingly sought to strengthen ministerial co-ordination and ministers’ focus on crosscutting policy priorities. This case study contributes to our understanding of intraexecutive co-ordination and the agency problem in cabinet government.

Our previous studies have suggested that spastin, which aggregates on spindle microtubules in oocytes, may promote the assembly of mouse oocyte spindles by cutting microtubules. This action may be related to CRMP5, as knocking down CRMP5 results in reduced spindle microtubule density and maturation defects in oocytes. In this study, we found that, after knocking down CRMP5 in oocytes, spastin distribution shifted from the spindle to the spindle poles and errors in microtubule–kinetochore attachment appeared in oocyte spindles. However, CRMP5 did not interact with the other two microtubule-severing proteins, katanin-like-1 (KATNAL1) and fidgetin-like-1 (FIGNL1), which aggregate at the spindle poles. We speculate that, in oocytes, due to the reduction of spastin distribution on chromosomes after knocking down CRMP5, microtubule–kinetochore errors cannot be corrected through severing, resulting in meiotic division abnormalities and maturation defects in oocytes. This finding provides new insights into the regulatory mechanisms of spastin in oocytes and important opportunities for the study of meiotic division mechanisms.

The COVID-19 pandemic and government responses led to a halt in economic activity. While this reduced pollution in urban areas, its effect on deforestation in areas outside of cities is unclear. Deforestation may have decreased due to the restrictions on economic activity, but, it may have increased due to the drying up of alternative income sources. We analyzed bi-weekly data on tropical forests worldwide in relation to the dates when different countries implemented lockdown restrictions. Our analysis found that while lockdowns did reduce mobility in forest municipalities, the average effect on deforestation was not significant. However, we did observe variations in the impact of lockdowns on deforestation based on the share of lockdown-vulnerable GDP and the level of government effectiveness. These results stand across tropical countries and within Colombia. These findings highlight the importance of alternative income sources and strong state capacity for effective policies aimed at reducing deforestation.

Zokors (Myospalacinae) continue to be the center of systematics discussions. Phylogenetic schemes based on molecular data do not always agree with each other, nor can phylogenetic schemes based on paleontological material be complete due to the only-partial description of West Siberian zokors. This paper tries to fill this gap and presents a description of the West Siberian lineage from the late early Pleistocene to the present, together with an analysis of molar development in other zokor lineages. We describe two new species and one subspecies (Myospalax myospalax krukoveri n. ssp., Myospalax convexus n. sp., Prosiphneus razdoleanensis n. sp.) ancestral to the extant Myospalax myospalax Laxmann, 1769. We also reveal differences in the ontogeny of molars of modern species that were not previously detailed. These differences, together with paleontological data, indicate that in the West Siberian lineage, peramorphosis occurred in the structure of the chewing surface (with the exception of the lower m1), whereas in all other zokor lineages, there was pedomorphosis. On the basis of these results, we suggest a new view on the systematics of Myospalacinae.

UUID: http://zoobank.org/b06d6c99-1648-454b-9b95-4d869bfe8bdc

Human height and related traits are highly complex, and extensively research has shown that these traits are determined by both genetic and environmental factors. Such factors may partially affect these traits through epigenetic programing. Epigenetic programing is dynamic and plays an important role in controlling gene expression and cell differentiation during (early) development. DNA methylation (DNAm) is the most commonly studied epigenetic feature. In this study we conducted an epigenome-wide DNAm association analysis on height-related traits in a Sub-Saharan African population, in order to detect DNAm biomarkers across four height-related traits. DNAm profiles were acquired in whole blood samples of 704 Ghanaians, sourced from the Research on Obesity and Diabetes among African Migrants study, using the Illumina Infinium HumanMethylation450 BeadChip. Linear models were fitted to detect differentially methylated positions (DMPs) and regions (DMRs) associated with height, leg-to-height ratio (LHR), leg length, and sitting height. No epigenome-wide significant DMPs were recorded. However we did observe among our top DMPs five informative probes associated with the height-related traits: cg26905768 (leg length), cg13268132 (leg length), cg19776793 (height), cg23072383 (LHR), and cg24625894 (sitting height). All five DMPs are annotated to genes whose functions were linked to bone cell regulation and development. DMR analysis identified overlapping DMRs within the gene body of HLA-DPB1 gene, and the HOXA gene cluster. In this first epigenome-wide association studies of these traits, our findings suggest DNAm associations with height-related heights, and might influence development and maintenance of these traits. Further studies are needed to replicate our findings, and to elucidate the molecular mechanism underlying human height-related traits.

We study cofinal systems of finite subsets of $\omega _1$. We show that while such systems can be NIP, they cannot be defined in an NIP structure. We deduce a positive answer to a question of Chernikov and Simon from 2013: In an NIP theory, any uncountable externally definable set contains an infinite definable subset. A similar result holds for larger cardinals.

Oocyte cytoplasmic evaluation is based on homogeneity and granular appearance. Our study investigated if a granular cytoplasm, highly heterogeneous, would affect oocyte competence in bovine. In two experiments, bovine cumulus–oocyte complexes (COCs) with homogeneous cytoplasm (control, CC) and granulated cytoplasm (granular, GC) were selected from a regular pool of COCs. Experiment 1 was performed with slaughterhouse ovaries, and Experiment 2 was carried out in Girolando COCs obtained from ovum pick-up. Granular oocytes had higher caspase 3 levels (66.17 ± 11.61 vs 172.08 ± 16.95, P < 0.01) and similar GAP junction activity (5.64 ± 0.45 vs 6.29 ± 0.29). ZAR1 relative mRNA amount was lower in granular oocytes (178.27 ± 151.63 vs 0.89 ± 0.89, P = 0.01) and no effect was detected for MATER, PPP2R1A, ENY2, IGF2R, and BMP15 genes. Despite molecular differences, no detrimental effect was detected on oocyte competence in GC oocytes. Cleavage (Experiment 1: 59.52 ± 7.21% vs 59.79 ± 6.10% and Experiment 2: 68.88 ± 4.82 vs 74.41 ± 5.89%) and blastocyst (Experiment 1: 29.28 ± 4.14% vs 23.15 ± 2.96% and Experiment 2: 21.11 ± 3.28% vs 21.02 ± 6.08%) rates were similar between CC and GC (Experiments 1 and 2, respectively). Post-transfer embryo development revealed that pregnancy (CC: 24.27 ± 9.70% vs GC: 26.31 ± 7.23%) and calving (23.68% vs 33.33%) rates and fetal growth were not affected by the presence of cytoplasmic granules. Our results demonstrated that oocytes with granular cytoplasm present equivalent efficiency for IVF and calf production compared with homogenous cytoplasm oocytes. This could be observed through similar cleavage, blastocyst rates, and fetal growth development. In addition to differences in oocyte gene expression related to oocyte quality, it seems not to affect oocyte developmental competence.

MOR's D3 section seeks to stimulate dialogue, debate, and discussion among scholars. When I took over as editor of D3, MOR's editorial team brainstormed how to further develop the D3 feature. We agreed that in addition to seeking original articles, we also wanted to encourage debate on articles that have already appeared in MOR. In this issue, we publish a commentary on Shaalan, Eid, and Tourky's (2022) article ‘De-Linking from Western Epistemologies: Using Guanxi-Type Relationships to Attract and Retain Hotel Guests in the Middle East’. The commentary, entitled ‘Questioning the Appropriateness of Examining Guanxi in a Wasta Environment: Why Context Should Be Front and Center in Informal Network Research’, has been written by Horak, Abosag, Hutchings, Alsarhan, Ali, Al-Twal, Weir, ALHussan, and AL-Husan (2023). As their title suggests, the commentators take issue with transferring the concept of guanxi into an environment in which another idea about informal interpersonal networks, wasta, already exists. I sense that the desire to write a critical comment was fueled by the fact that Shaalan et al. (2022) never referred to the concept of ‘wasta’ in their original article. We invited the authors of the original article to write a rejoinder (Shaalan, Eid, & Tourky, 2023) in which they emphasize even further that they only argue that guanxi-type relationships exist in the Middle East and not that guanxi itself exists.

Enacting stringent climate policy has proven politically challenging, not least because of concentrated losses in fossil fuel-producing communities. “Just transition” strategies have been proposed to mitigate this distributional challenge. Yet, little is known about how such strategies affect voting behavior. Using a mixed-methods approach, we exploit a local climate policy in Spain—a “Just Transition Agreement” (JTA) to phase out coalmining, support affected workers, and invest in affected municipalities—which was negotiated by the incumbent Socialist Party (PSOE) government with affected unions and businesses shortly before a national election. A difference-in-differences study shows that PSOE’s vote share in coalmining municipalities increased at the 2019 election relative to similar municipalities, implying that the JTA was electorally successful. Further statistical tests and elite interviews suggest that this electoral boost was driven by unions’ support of the JTA. Our findings have implications for how parties can craft popular climate policy.

After defeating the 20th-century challengers to the international order, the United States must today calibrate its response to the rise of the PRC, whose foreign policy poses problems both for policy-makers and IR scholars. Wilhelmine and Nazi Germany, Imperial Japan and USSR have left a heavy mark on the scholarship on revisionist threats and their management. Like the mythological Titans, these states launched their challenge all the way to ‘Olympus’: they longed to build a new international order by war or a large-scale and long-standing competition. However, the myth of Prometheus teaches us that this ‘revolutionary’ path is not the only road for secondary states to gain primacy. Revisionism can also take a more careful shape, both by means and objectives. The article preliminarily discusses the understudied type of careful revisionism and distinguishes the subtypes of ‘incrementals’, ‘moderates’ and ‘gamblers’. These more nuanced forms compel status quo power(s) to face a dilemma between two strategic options: engagement or confrontation. Then it posits that a wisely gauged assessment of the careful revisionist challenge by the dominant power must inevitably lay at the basis of any grand strategy for preserving the status quo and preventing systemic change. Finally, it tests this hypothesis by investigating the confrontation between a dominant power – the United Kingdom – and six careful revisionists – namely the United States (1814–1860), the Kingdom of Sardinia/Italy (1852–1882), France (1875–1904), Russian Empire (1864–1907), Imperial Japan (1919–1936) and Fascist Italy (1922–1935).