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Early adversity is a major risk factor for the emergence of psychopathology across development. Identifying mechanisms that support resilience, or favorable mental health outcomes despite exposure to adversity, is critical for informing clinical intervention and guiding policy to promote youth mental health. Here we propose that caregivers play a central role in fostering resilience among children exposed to adversity via caregiving influences on children’s corticolimbic circuitry and emotional functioning. We first delineate the numerous ways that caregivers support youth emotional learning and regulation and describe how early attachment lays the foundation for optimal caregiver support of youth emotional functioning in a developmental stage-specific manner. Second, we outline neural mechanisms by which caregivers foster resilience—namely, by modulating offspring corticolimbic circuitry to support emotion regulation and buffer stress reactivity. Next, we highlight the importance of developmental timing and sensitive periods in understanding caregiving-related mechanisms of resilience. Finally, we discuss clinical implications of this line of research and how findings can be translated to guide policy that promotes the well-being of youth and families.
Status-seeking is ubiquitous in world politics, and the literature is currently dominated by state-centrism and rationalism, which is almost exclusively focus on state elites. This results in a thin and limited understanding of what ‘status-seeking’ is, where it works, and how it is effected. This article challenges the existing approaches by introducing a performativity framework and offers an overhaul of how ‘status’ can be studied. It suggests replacing ‘status-seeking’ with ‘status performances’ that are conceptualised as part of ‘statecraft’ process. Drawing on post-structuralist and queer approaches as well as aesthetics in International Relations (IR), it is argued that status performances participate in the production of the state itself as a subject in world politics, so all states are ‘status-seekers’. This subject-production process occurs in multiple political sites, including the academic IR discourse in a country and visual presentations in the media. It is concluded that there is no ‘status’ beyond the subject, and status can never be achieved because it always needs repetitive performances. The argument is illustrated by an analysis of the production of ‘Turkey’ as a humanitarian state and demonstrates how this is effected in state-elite pronouncements, IR scholarship in Turkey, and visual representations.
This article offers a re-evaluation of Louis Riel's political, philosophical and religious writings by reconstructing these writings along utopian lines. In so doing, it supplements the existing literature on Riel's writings that tends to see Riel as either a prophetic figure or a practical man of action, but rarely, if ever, both. In its reconstruction of Riel's utopian vision, this article focuses on three aspects of his writings. First, it addresses his critical conception of Métis self-government before Confederation. Second, it examines his proposals for the overthrow of what he perceived as Anglo-Canadian tyranny in the North-West. Third, it considers his visions of an ideal—that is, utopian—society in the North-West. The article concludes by examining the implications of this reading of Riel's utopian vision for his legacy in Canadian political science.
The power exchange between fluid and structure plays a significant role in the force production and flight efficiency of flapping wings in insects and artificial flyers. This work numerically investigates the performance of flapping wings by using a high-fidelity fluid–structure interaction solver. Simulations are conducted by varying the hinge flexibility (measured by the Cauchy number, $Ch$, i.e. the ratio between aerodynamic and torsional elastic forces) and the wing shape (quantified by the radius of the first moment of area, $\bar {r}_1$). Results show that the lift production is optimal at $0.05 < Ch \leq 0.2$ and larger $\bar {r}_1$ where the minimum angle of attack is around $45^\circ$ at midstroke. The power economy is maximised for wings with lower $\bar {r}_1$ near $Ch=0.2$. Power analysis indicates that the optimal performance measured by the power economy is obtained for those cases where two important power synchronisations occur: anti-synchronisation of the pitching elastic power and the pitching aerodynamic and inertial powers and nearly in-phase synchronisation of the flapping aerodynamic power and the total input power of the system. While analysis of the kinematics for the different wing shapes and hinge stiffnesses reveals that the optimal performance occurs when the timing of pitch and stroke reversals are matched, thus supporting the effective transfer of input power from flapping to passive pitching and into the fluid. These results suggest that careful optimisation between wing shapes and hinge properties can allow insects and robots to exploit the passive dynamics to improve flight performance.
Innovative large language model (LLM)-powered chatbots, which are extremely popular nowadays, represent potential sources of information on resuscitation for the general public. For instance, the chatbot-generated advice could be used for purposes of community resuscitation education or for just-in-time informational support of untrained lay rescuers in a real-life emergency.
Study Objective:
This study focused on assessing performance of two prominent LLM-based chatbots, particularly in terms of quality of the chatbot-generated advice on how to give help to a non-breathing victim.
Methods:
In May 2023, the new Bing (Microsoft Corporation, USA) and Bard (Google LLC, USA) chatbots were inquired (n = 20 each): “What to do if someone is not breathing?” Content of the chatbots’ responses was evaluated for compliance with the 2021 Resuscitation Council United Kingdom guidelines using a pre-developed checklist.
Results:
Both chatbots provided context-dependent textual responses to the query. However, coverage of the guideline-consistent instructions on help to a non-breathing victim within the responses was poor: mean percentage of the responses completely satisfying the checklist criteria was 9.5% for Bing and 11.4% for Bard (P >.05). Essential elements of the bystander action, including early start and uninterrupted performance of chest compressions with adequate depth, rate, and chest recoil, as well as request for and use of an automated external defibrillator (AED), were missing as a rule. Moreover, 55.0% of Bard’s responses contained plausible sounding, but nonsensical guidance, called artificial hallucinations, that create risk for inadequate care and harm to a victim.
Conclusion:
The LLM-powered chatbots’ advice on help to a non-breathing victim omits essential details of resuscitation technique and occasionally contains deceptive, potentially harmful directives. Further research and regulatory measures are required to mitigate risks related to the chatbot-generated misinformation of public on resuscitation.
My comment highlights the key contributions and promising directions for future research of Lindsay Schakenbach Regale’s essay in this volume. While in agreement with Schakenbach Regele’s call for more specificity for different times and places, I argue that we also ought to be able to answer the question of what makes a variety of capitalism, well, capitalist. To do that, we need to delimit the theoretical and historical bounds of capitalism itself.
Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length (RTL) of leucocytes. This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A generalised linear regression model and a restricted cubic spline model were used to assess the correlation of DAI and its components with RTL. Generalised linear regression analysis revealed that DAI (β = 0·005, P = 0·002) and the intake of its constituents vitamin C (β = 0·043, P = 0·027), vitamin E (β = 0·088, P < 0·001), Se (β = 0·075, P = 0·003), and Zn (β = 0·075, P = 0·023) were significantly and positively correlated with RTL. Sex-stratified analysis showed that DAI (β = 0·006, P = 0·005) and its constituents vitamin E (β = 0·083, P = 0·012), Se (β = 0·093, P = 0·006), and Zn (β = 0·092, P = 0·034) were significantly and positively correlated with RTL among females. Meanwhile, among males, only vitamin E intake (β = 0·089, P = 0·013) was significantly and positively associated with RTL. Restricted cubic spline analysis revealed linear positive associations between DAI and its constituents’ (vitamin E, Se and Zn) intake and RTL in the total population. Sex-stratified analysis revealed a linear positive correlation between DAI and its constituents’ (vitamin E, Se and Zn) intake and RTL in females. Our study found a significant positive correlation between DAI and RTL, with sex differences.
For $k\geq 2$ and a nonzero integer n, a generalised Diophantine m-tuple with property $D_k(n)$ is a set of m positive integers $S = \{a_1,a_2,\ldots , a_m\}$ such that $a_ia_j + n$ is a kth power for $1\leq i< j\leq m$. Define $M_k(n):= \text {sup}\{|S| : S$ having property $D_k(n)\}$. Dixit et al. [‘Generalised Diophantine m-tuples’, Proc. Amer. Math. Soc.150(4) (2022), 1455–1465] proved that $M_k(n)=O(\log n)$, for a fixed k, as n varies. In this paper, we obtain effective upper bounds on $M_k(n)$. In particular, we show that for $k\geq 2$, $M_k(n) \leq 3\,\phi (k) \log n$ if n is sufficiently large compared to k.
This study aimed to investigate the causal effect of dietary habits on COVID-19 susceptibility, hospitalisation and severity. We used data from a large-scale diet dataset and the COVID-19 Host Genetics Initiative to estimate causal relationships using Mendelian randomisation. The inverse variance weighted (IVW) method was used as the main analysis. For COVID-19 susceptibility, IVW estimates indicated that milk (OR: 0·82; 95 % CI (0·68, 0·98); P = 0·032), unsalted peanut (OR: 0·53; 95 % CI (0·35, 0·82); P = 0·004), beef (OR: 0·59; 95 % CI (0·41, 0·84); P = 0·004), pork (OR: 0·63; 95 % CI (0·42, 0·93); P = 0·022) and processed meat (OR: 0·76; 95 % CI (0·63, 0·92); P = 0·005) were causally associated with reduced COVID-19 susceptibility, while coffee (OR: 1·23; 95 % CI (1·04, 1·45); P = 0·017) and tea (OR: 1·17; 95 % CI (1·05, 1·31); P = 0·006) were causally associated with increased risk. For COVID-19 hospitalisation, beef (OR: 0·51; 95 % CI (0·26, 0·98); P = 0·042) showed negative correlations, while tea (OR: 1·54; 95 % CI (1·16, 2·04); P = 0·003), dried fruit (OR: 2·08; 95 % CI (1·37, 3·15); P = 0·001) and red wine (OR: 2·35; 95 % CI (1·29, 4·27); P = 0·005) showed positive correlations. For COVID-19 severity, coffee (OR: 2·16; 95 % CI (1·25, 3·76); P = 0·006), dried fruit (OR: 1·98; 95 % CI (1·16, 3·37); P = 0·012) and red wine (OR: 2·84; 95 % CI (1·21, 6·68); P = 0·017) showed an increased risk. These findings were confirmed to be robust through sensitivity analyses. Our findings established a causal relationship between dietary habits and COVID-19 susceptibility, hospitalisation and severity.
This study aimed to assess the impact of caloric intake and weight-for-age-Z-score after the Norwood procedure on the outcome of bidirectional cavopulmonary shunt.
Methods:
A total of 153 neonates who underwent the Norwood procedure between 2012 and 2020 were surveyed. Postoperative daily caloric intake and weight-for-age-Z-score up to five months were calculated, and their impact on outcome after bidirectional cavopulmonary shunt was analysed.
Results:
Median age and weight at the Norwood procedure were 9 days and 3.2 kg, respectively. Modified Blalock-Taussig shunt was used in 95 patients and right ventricle to pulmonary artery conduit in 58. Postoperatively, total caloric intake gradually increased, whereas weight-for-age-Z-score constantly decreased. Early and inter-stage mortality before stage II correlated with low caloric intake. Older age (p = 0.023) at Norwood, lower weight (p < 0.001) at Norwood, and longer intubation (p = 0.004) were correlated with low weight-for-age-Z-score (< –3.0) at 2 months of age. Patients with weight-for-age-Z-score < –3.0 at 2 months of age had lower survival after stage II compared to those with weight-for-age-Z-score of –3.0 or more (85.3 versus 92.9% at 3 years after stage II, p = 0.017). There was no difference between inter-stage weight gain and survival after bidirectional cavopulmonary shunt between the shunt types.
Conclusion:
Weight-for-age-Z-score decreased continuously throughout the first 5 months after the Norwood procedure. Age and weight at Norwood and intubation time were associated with weight gain. Inter-stage low weight gain (Z-score < –3) was a risk for survival after stage II.
We examine the role of peer (e.g., Lipper manager indices) versus pure (e.g., S&P 500) benchmarks in fund manager compensation. We model their impact on manager incentives and then test those predictions using novel data. We find that 71% of managers are compensated based on peer benchmarks. Consistent with the model, peer-benchmarked fund managers exhibit higher effort generating higher gross performance and collect higher fee income. Analyzing advisors’ choice between benchmark types, we show that peer-benchmarking advisors cater to more sophisticated and performance-sensitive investors, and are more likely to sell through direct channels, consistent with investor heterogeneity and market segmentation.
We extend the notion of polynomial integration over an arbitrary circle C in the Euclidean geometry over general fields $\mathbb {F}$ of characteristic zero as a normalised $\mathbb {F}$-linear functional on $\mathbb {F}[\alpha _1, \alpha _2]$ that maps polynomials that evaluate to zero on C to zero and is $\mathrm {SO}(2,\mathbb {F})$-invariant. This allows us to not only build a purely algebraic integration theory in an elementary way, but also give the super Catalan numbers
Deux manifestations d’anaphoriques fonctionnant « sans antécédent » (l’exophore et l’anaphore indirecte) sont analysées afin de mettre en évidence le fonctionnement véritable de l’anaphore. Nous verrons ainsi la manière dont ceux-ci réalisent une référence dépendante, non par le biais d’un élément particulier de leur co-texte (un « antécédent » conventionnel), mais plutôt en fonction d’une représentation discursive déjà installée en mémoire de travail. Celle-ci aura été évoquée dans l’interaction par les participants dans un événement communicatif, et sera supposée saillante au moment du renvoi.
Seront examinées dans ce sens les contributions des valeurs de genre portées par des pronoms anaphoriques, les propriétés intrinsèques de ceux-ci, la pertinence des « noms de base » pour les pronoms employés ainsi, puis le rôle de la prédication « hôte » dans son ensemble. Ainsi « libérés » de la contrainte d’une mise en relation préalable avec un « antécédent » textuel, leur contribution à la gestion et à l’évolution du discours sera plus aisément perceptible.
This study was designed to understand how drought stress impact on the physiological and molecular status of genetically diverse Lolium perenne L. (perennial ryegrass) populations. The sensitivities of the 36 perennial ryegrass populations were checked against PEG-6000-simulated drought stress by analysing physiological status. Afterward, drought-related gene expressions were evaluated under normal and stressed conditions. The drought stress significantly up-regulated the drought-related genes in P6, P10, P15 and P30, while no difference was observed in drought-sensitive ones. The results collectively showed that four populations (P6, P10, P15, P30) are tolerant to drought stress and activate drought-related genes. Genetic similarities of the populations were also monitored using microsatellite (SSR) markers. The ten SSR primers detected 38 alleles. Surprisingly, the drought-tolerant populations were classified into different groups by principal component (PCA) and cluster analysis, showing that they are genetically different. Moreover, four unique alleles were identified by two SSR primers (P-07, and P-08) in P6, P10 and P15. In addition, the drought-tolerant populations (P6, P10, P15, P30) can be used to develop new perennial ryegrass cultivars for areas having drought problems.
Grammatical tone (GT) can be the sole exponent or a co-exponent of grammatical meaning (Hyman 2012; Rolle 2018), but there has been little discussion of how they distribute within a single language. In this article, I explore the relationship between tonal and segmental materials in Gyeli (Bantu A801, Cameroon), adopting a property-driven approach to phonological typology (Plank 2001; Hyman 2009). Gyeli has eight GTs in simple predicates, which serve as sole exponents of tense, aspect, mood and polarity distinctions and object-marking. When GT is a co-exponent accompanied by segmental material, for example, in auxiliary constructions, the information that the tonal component contributes to the meaning is insufficient to distinguish between grammatical categories: its functional load is weak. The decrease in functional load is correlated with an increase in length of a segmental co-exponent. This can be explained by the tonal cophonologies of segmental morphemes and their different GT dominance types.
Rapid and radical digitalization and the “fourth industrial revolution” are generally associated with progress, but also pose significant risks to privacy rights and democracy. This article proposes a public law reading of the South African Constitution to respond to the dangers posed by disruptive technological change, in light of the constitution's rights-orientated and rule-of-law-centred approach to interpreting the right to privacy. It examines the legal resources available in the South African legal system and, specifically, its constitution. The article emphasizes the way South African privacy jurisprudence infuses the right to privacy with the value of dignity, and how this allows an interpretation that sees privacy as a public, as well as private, right. The article concludes that this rights jurisprudence, alongside the constitutional principles of proportionality, subsidiarity and supremacy, has established a working foundation to articulate the right to privacy in a way that is suitable in the digital age.
Following ideas of Lurie, we give a general construction of equivariant elliptic cohomology without restriction to characteristic zero. Specializing to the universal elliptic curve we obtain, in particular, equivariant spectra of topological modular forms. We compute the fixed points of these spectra for the circle group and more generally for tori.
This study advances a coopetition perspective to argue that an intangibility gap, defined as the difference in intangible asset intensity between industry-frontier foreign firms and local firms, generates both competitive threats and cooperative opportunities for local firms. Thus, an intangibility gap may affect local firms’ internal research and development (R&D) efforts beyond a linear, catching-up way of thinking. Using a sample of manufacturing firms in China, we find that intangibility gap has an inverted U-shaped relationship with the internal R&D intensity of local firms such that a moderate intangibility gap is more likely to stimulate local firms’ R&D than a small or large intangibility gap. Moreover, the results show that export intensity and state ownership of local firms serve as two boundary conditions under which the inverted U-shaped relationship becomes less and more pronounced, respectively.
Although practitioners and scientists agree that user adoption of new technologies is a key success factor in digital transformations, little is known about how specific management factors are related to user behavior. In particular, the temporal nature of digital transformation projects is largely neglected. Therefore, we propose a systematic, theory-based framework for the management of digital adoption (MDA) and derive specific process-oriented hypotheses for content-, process-, and context-related management factors, their relationships to user adoption, and underlying psychological processes (e.g., performance expectancy or social influence). We applied the MDA framework in the context of a large digital transformation project in a logistics company in a two-wave research design. We tested the process-oriented hypotheses based on latent change score analysis among 1,095 users. The results support the assumption that changes in management factors, largely mediated by changes in the psychological processes, lead to changes in user behavior.