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Changes in executive function (EF) occur during adolescence with several factors (e.g., parenting styles, socioeconomic status) influencing the development of EF abilities. These changes are important as EF has been strongly linked with a range of outcomes including academic achievement, job performance, and social–emotional well-being. However, few studies have examined variability in EF trajectories during this critical developmental period, or trajectories in samples known to have specific impairments with EF, such as adolescents diagnosed with attention-deficit/hyperactivity disorder (ADHD). The present study examined differential trajectories of three domains of parent-rated EF in 302 adolescents (167 males; Mage = 13.17 years) with and without ADHD (53.6% with ADHD) from grade 8 to 10. The study also explored whether adolescent ADHD, parent ADHD, and parents’ own EF predicted EF trajectories in addition to the longitudinal relation between trajectories and academic outcomes. Findings suggest that adolescence is marked by significant variability in EF development due to factors such as ADHD status, parent ADHD, and parent EF ability. Additionally, adolescents who displayed poor EF abilities throughout middle and high school had significantly lower grade point averages and poorer parent-, teacher-, and self-reported academic outcomes. Implications for interventions targeting EF deficits among adolescents with and without ADHD are discussed.
Frank Sherwood Taylor was director of the Science Museum London for just over five years from October 1950. He was the only historian of science ever to have been director of this institution, which has always ridden a tightrope between advocacy of science and advocacy of its history, balancing differently at different points in its history. He was also president of the BSHS from 1951 to 1953. So what happened when a historian got his hands on the nation's pre-eminent public museum of science? To what extent did his historian's training and instincts affect his policies whilst director, and with what effect in the longer term? Taking this exceptional case, I suggest, enables us to consider how museum accounts of the past of science relate to historiographies of science otherwise available in the culture. In this discussion, drawing on new archival research, I consider the role of history within a key policy paper he wrote in 1951. I analyse and contextualize its main themes before considering, by way of conclusion, his legacy.
Isocitrate dehydrogenase (IDH) mutation status is a key diagnostic and prognostic feature of gliomas. It is thought to occur early in glioma tumorigenesis and remain stable over time. However, there are reports documenting a loss of IDH mutation status in a subset of patients with glioma recurrence. Here, we identified patients with a documented loss of IDH mutation status longitudinally and performed multi-platform analysis in order to determine if IDH mutations are stable throughout glioma evolution.
Methods:
We retrospectively identified patients from our institution from 2009 to 2018 with immunohistochemistry (IHC)-recorded IDH mutation status changes longitudinally. Archived formalin-fixed paraffin-embedded and frozen tissue samples from these patients were collected from our institution’s tumour bank. Samples were analysed using methylation profiling, copy number variation, Sanger sequencing, droplet digital PCR (ddPCR) and IHC.
Results:
We reviewed 1491 archived glioma samples including 78 patients with multiple IDH mutant tumour samples collected longitudinally. In all instances of documented loss of IDH mutation status, multi-platform profiling identified a mixture of low tumour cell content and non-neoplastic tissue including perilesional, reactive or inflammatory cells.
Conclusions:
All patients with a documented loss of IDH mutation status longitudinally were resolved through multi-platform analysis. These findings support the hypothesis that IDH mutations occur early in gliomagenesis and in the absence of copy number changes at the IDH loci and are stable throughout tumour treatment and evolution. Our study highlights the importance of accurate surgical sampling and the role of DNA methylome profiling in diagnostically uncertain cases for integrated pathological and molecular diagnosis.
Mark Murphy has recently defended a novel account of divine agency on which God would have very minimal requiring reasons and a wide range of merely justified reasons. This account grounds his response to the problem of evil. If God would not have requiring reasons to promote the well-being of creatures, Murphy argues, then the evil we observe would not count as evidence against theism. I argue that Murphy's conclusion, if successful in undermining the problem of evil, also undermines probabilistic arguments for theism. However, there is good reason to resist his conclusion. Even if God does not have requiring reasons, but merely has justifying reasons, to promote creaturely well-being, God may nevertheless have most motivating reason to do so, and this would be enough to predict divine action, at least given Murphy's further assumption that God is perfectly free. It does not follow from the rational permissibility of God's Φ-ing that it is possible for God to Φ.
This article explores the relationship between tax law and settler colonialism by looking at the ways in which taxes can be part of the “civilizing” process of Indigenous peoples. In 1921, the Territory of Alaska enacted a “license tax on the business of fur-farming, trapping and trading in pelts and skins of fur-bearing animals.” Since most trappers were Natives, the “fur tax” de facto targeted them. This article unpacks the sociocultural and political dimensions of the fur tax against the backdrop of Alaska’s settler colonial history. Despite what the Alaska attorney general claimed was its “strict” revenue-raising function, the tax was part of a much broader settler colonial agenda. That agenda sought to turn semi-nomadic, “uncivilized” Native hunters into spatially grounded, “civilized” farmers, gardeners, reindeer herders, or wage workers. Ultimately, I suggest, within many if not most settler colonial spaces political and sociocultural ideologies alter the initial revenue-raising function of taxes.
A spectral method using associated Legendre functions with algebraic mapping is developed for a linear stability analysis of wake vortices. These functions serve as Galerkin basis functions, capturing correct analyticity and boundary conditions for vortices in an unbounded domain. The incompressible Euler or Navier–Stokes equations linearised on a swirling flow are transformed into a standard matrix eigenvalue problem of toroidal and poloidal streamfunctions, solving perturbation velocity eigenmodes with their complex growth rate as eigenvalues. This reduces the problem size for computation and distributes collocation points adjustably clustered around the vortex core. Based on this method, strong swirling $q$ vortices with linear perturbation wavenumbers of order unity are examined. Without viscosity, neutrally stable eigenmodes associated with the continuous eigenvalue spectrum having critical-layer singularities are successfully resolved. The inviscid critical-layer eigenmodes numerically tend to appear in pairs, implying their singular degeneracy. With viscosity, the spectra pertaining to physical regularisation of critical layers stretch out toward an area, referring to potential eigenmodes with wavepackets found by Mao & Sherwin (J. Fluid Mech., vol. 681, 2011, pp. 1–23). However, the potential eigenmodes exhibit no spatial similarity to the inviscid critical-layer eigenmodes, doubting that they truly represent the viscous remnants of the inviscid critical-layer eigenmodes. Instead, two distinct continuous curves in the numerical spectra are identified for the first time, named the viscous critical-layer spectrum, where the similarity is noticeable. Moreover, the viscous critical-layer eigenmodes are resolved in conformity with the $Re^{-1/3}$ scaling law. The onset of the two curves is believed to be caused by viscosity breaking the singular degeneracy.
In the last two decades, a robust consensus has emerged among philosophers of science, whereby political, ethical, or social values must play some role in scientific inquiry, and that the ‘value-free ideal’ is thus a misguided conception of science. However, the question of how to distinguish, in a principled way, which values may legitimately influence science remains. This question, which has been dubbed the ‘new demarcation problem,’ has until recently received comparatively less attention from philosophers of science. In this paper, I appeal to Rawls’s theory of justice (1971) on the basis of which I defend a Rawlsian solution to the new demarcation problem. As I argue, the Rawlsian solution places plausible constraints on which values ought to influence scientific inquiry, and, moreover, can be fruitfully applied to concrete cases to determine how the conflicting interests of stakeholders should be balanced. After considering and responding to the objection that Rawls’s theory of justice applies only to the “basic structure” of society, I compare the Rawlsian solution to some other approaches to the new demarcation problem, especially those that emphasize democratic criteria.
This paper proposes a novel method of algorithmic subsampling (data sketching) for multiway cluster-dependent data. We establish a new uniform weak law of large numbers and a new central limit theorem for multiway algorithmic subsample means. We show that algorithmic subsampling allows for robustness against potential degeneracy, and even non-Gaussian degeneracy, of the asymptotic distribution under multiway clustering at the cost of efficiency and power loss due to algorithmic subsampling. Simulation studies support this novel result, and demonstrate that inference with algorithmic subsampling entails more accuracy than that without algorithmic subsampling. We derive the consistency and the asymptotic normality for multiway algorithmic subsampling generalized method of moments estimator and for multiway algorithmic subsampling M-estimator. We illustrate with an application to scanner data for the analysis of differentiated products markets.
To explore the associations between early adverse stress, attachment insecurity in adulthood (anxious and avoidant), pathological personality styles (self-criticism and dependency), difficulties in emotion regulation, and depression severity.
Methods:
Cross-sectional study of 178 outpatients diagnosed with major depression in Santiago, Chile. Participants filled the Childhood Trauma Questionnaire Short Form, the Experience in Close Relationships Scale, the Depressive Experience Questionnaire, the Difficulties in Emotion Regulation Scale, and the Patient Health Questionnaire-9 item. Full-information maximum likelihood path analyses with bias-corrected bootstrapped confidence intervals were conducted.
Results:
Anxious attachment in adulthood and self-criticism mediated the association between early adverse stress and depression severity through their effects on difficulties in emotion regulation. Early adverse stress was not associated with avoidant attachment in adulthood and dependency; these variables were indirectly associated with depression severity. Difficulties in emotion regulation were exclusively directly related to depression severity, mediating the effects of the preceding variables.
Conclusions:
Our findings propose an integrative model for psychological mechanisms mediating between early adverse stress and depression. Difficulties in emotion regulation should be considered when treating adults with depression exposed to early adverse stress. The contribution of specific types of early adverse stressors and difficulties in emotion regulation should be further explored.
The structure and the frequency spectra of wall pressure fluctuations beneath a planar turbulent boundary layer interacting with a conical shock wave at Mach number $M_\infty =2.05$ and Reynolds number $\textit {Re}_\theta \approx 630$ (based on the upstream boundary layer momentum thickness) are examined to elucidate the effects of pressure gradient and flow separation on the characteristics of the wall pressure fluctuations, by exploiting a direct numerical simulation database. Upstream of the interaction, in the zero pressure gradient region, wall pressure statistics compare well with canonical compressible boundary layers in terms of fluctuation intensities and frequency spectra. Across the main interaction zone (APG1), the root-mean-square of wall pressure fluctuations becomes very large (corresponding to approximately 173.3 dB), with maximum increase approximately 12.7 dB from the incoming level. In the second adverse pressure gradient zone (APG2), the root-mean-square of wall pressure fluctuations attains a second peak (corresponding to $164.7$ dB), with an increase of 8.4 dB from the upstream level. Both the APG1 and APG2 regions feature a substantial fraction of flow reversal events, which are, however, scattered and interspersed with regions of attached flow. The wall pressure power spectral density exhibits a broadband and energetic low-frequency component associated with the global unsteadiness of the separation bubble/conical shock system. Analysis of the two-point correlations and wavenumber/frequency spectra of wall pressure fluctuations further suggests that the typical eddies become more elongated along the spanwise direction, as the flow in the separated region tends to escape the centreline, and the convection velocity is significantly reduced.
We study the existence of large solutions for nonlocal Dirichlet problems posed on a bounded, smooth domain, associated with fully nonlinear elliptic equations of order $2\,s$, with $s\in (1/2,\,1)$, and a coercive gradient term with subcritical power $0< p<2\,s$. Due to the nonlocal nature of the diffusion, new blow-up phenomena arise within the range $0< p<2\,s$, involving a continuum family of solutions and/or solutions blowing-up to $-\infty$ on the boundary. This is in striking difference with the local case studied by Lasry–Lions for the subquadratic case $1< p<2$.
This article examines the progression of the counter-clockwise nasal vowel chain shift in Parisian French, investigating in particular the influence of biological sex and of sexuality on the propagation of this change from below. The research presented forms part of a study on the participation of sexual minorities in ongoing sound change; this study aims to address the continued exclusion of sexual minorities from sociolinguistic studies, which not only invisibilizes queer people, but underlines their behaviour, linguistic or otherwise, as gender-deviant. Using a sociophonetic methodology, an analysis of nasal vowel quality provides evidence for sex- and sexuality-differential linguistic behaviour in the advancement of the nasal vowel chain shift. The results confirm the progressive but non-conformative linguistic behaviour of women, both straight and queer, as outlined by Labov (1990) and numerous other sociolinguistic studies, but also indicate that queer men are centre-stage in driving the change forward. This research is a first step in formalizing data-driven principles about the linguistic behaviour of sexual minorities and their role in language change, akin to the principles advanced to account for the behaviour of women.
Takotsubo cardiomyopathy has an incidence of 1% of acute coronary syndrome in the adult population, and the risk of recurrence is approximately 1.5% per year. However, only a few cases have been reported in children. Having a neurologic disorder and being exposed to the same trigger repeatedly have been associated with an increased risk.
How is the white researcher perceived by the border apparatus? What does this interaction say about the border itself? Ethnographic research has framed such questions as a debate on ‘insiders’ and ‘outsiders’ in fieldwork. This is problematic, as it assumes that a researcher can really be ‘external’ to the social worlds they investigate, as if the field site existed in isolation from transnational processes of racialised extraction. This paper challenges such an assumption by arguing that the white researcher cannot be an ‘outsider’ to the North African border: they approach it as the beneficiaries of a system of colonial and capital extractivism that feeds itself through migration control. I build on Ahmed's work on white phenomenology to analyse how various border workers perceived, made sense of and reacted to my presence as a white European woman at three different sites on the Spanish–Moroccan border. I argue that the white researcher is an expected presence at the border, as the accumulated history of (post)colonial encounters leads them where others have been before. Although whiteness opens doors, only a certain kind of performed whiteness remains welcome in the borderscape. The white researcher who appears not to be aligning with or supporting the premises of migration control is perceived by border workers as a potentially disruptive presence, and contained in different ways.
We study curve-shortening flow for twisted curves in $\mathbb {R}^3$ (that is, curves with nowhere vanishing curvature $\kappa $ and torsion $\tau $) and define a notion of torsion-curvature entropy. Using this functional, we show that either the curve develops an inflection point or the eventual singularity is highly irregular (and likely impossible). In particular, it must be a Type-II singularity which admits sequences along which ${\tau }/{\kappa ^2} \to \infty $. This contrasts strongly with Altschuler’s planarity theorem, which shows that ${\tau }/{\kappa } \to 0$ along any essential blow-up sequence.
Aortopulmonary window is a condition characterized by a communication between the pulmonary artery and the ascending aorta. The coexistence of aortopulmonary window and an anomalous right coronary artery originating from the pulmonary artery is rarely observed together, as mentioned in previous studies. In this report, we aim to describe our diagnostic and treatment experiences with a 6-year-old patient diagnosed with aortopulmonary window associated with an abnormal origin of the right coronary artery from the pulmonary artery.
The deformable wing structure can change its aerodynamic shape according to the change of flight mission and flight environment, so as to obtain better lift-drag, stability and control characteristics, which is considered as one of the future research directions of aviation technology. Considering the current technology maturity and reliability, a gradient corrugated fin is designed to realise the bending deformation of the wing. The structure of the skin is optimised to keep the skin smooth during deformation. In addition, a progressive push and pull rod is proposed to drive the wing deformation, and the fluid-structure interaction simulation is carried out for the wing deformation. At the same time, the changes of wing aerodynamic characteristics under different angles of leading and trailing edges and different push rod action schemes are analysed. Finally, a dry wind tunnel simulation test of the designed progressive flexible variable bending wing is carried out. The results of fluid-structure interaction simulation and dry wind tunnel test show that the progressive flexible variable bending wing proposed in this paper has a simple and reliable structure and remarkable deformation effect. It has advantages in increasing lift and reducing drag, ensuring high lift-drag ratio and providing wing trim moment. The deformable wing dry wind tunnel test platform designed by this method is structurally reliable, easy to operate, and can accurately reflect the influence of wing deformation on its aerodynamic force, which provides a verification means for the development of the design method and the design of practical aircraft in the future.