This paper presents the first continuous multi-proxy record of climate and vegetation change from the central Namib Desert extending over much of the last ca. 39,000 years. Derived from rock hyrax middens, evidence from stable carbon and nitrogen isotopes, pollen, and microcharcoal reveals significant differences between glacial-age and Holocene climates and vegetation types. Although still arid to semi-arid, conditions during Marine Oxygen Isotope Stages (MIS) 2–3 were significantly more humid than in the Late Holocene. Considerable associated vegetation change is apparent, with cooler temperatures and higher/more-regular rainfall promoting the westward expansion of relatively mesic shrubby karroid vegetation during MIS 2–3. With the last glacial–interglacial transition, increasing temperatures and less/less-regular rainfall resulted in marked vegetation changes and the establishment of current xeric grasslands. The inter-plant spacing of the karroid vegetation promoted by wetter conditions does not carry fire effectively, and the microcharcoal record indicates that more extensive fires may develop only with the development of grassier vegetation under drier conditions. As with other terrestrial records from the Namib Desert and environs, no Cape flora elements were found to support previously hypothesised expansion of the Fynbos Biome during the last glacial period.

This article revisits a series of articles published in the early 1980s on Punjab politics in the pre-partition decade that grew out of my thesis ‘The Growth of the Muslim League in the Punjab’ which was supervised by Francis Robinson. It initially locates the publications in the existing literature, before assessing the extent to which subsequent research has enriched academic understanding. The article concludes with some brief reflections on the conceptualisation of the Unionist Party's power-sharing as a form of consociationalism.

This document introduces and explains common implementation concepts and frameworks relevant to healthcare epidemiology and infection prevention and control and can serve as a stand-alone guide or be paired with the “SHEA/IDSA/APIC Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2022 Updates,” which contain technical implementation guidance for specific healthcare-associated infections. This Compendium article focuses on broad behavioral and socio-adaptive concepts and suggests ways that infection prevention and control teams, healthcare epidemiologists, infection preventionists, and specialty groups may utilize them to deliver high-quality care. Implementation concepts, frameworks, and models can help bridge the “knowing-doing” gap, a term used to describe why practices in healthcare may diverge from those recommended according to evidence. It aims to guide the reader to think about implementation and to find resources suited for a specific setting and circumstances by describing strategies for implementation, including determinants and measurement, as well as the conceptual models and frameworks: 4Es, Behavior Change Wheel, CUSP, European and Mixed Methods, Getting to Outcomes, Model for Improvement, RE-AIM, REP, and Theoretical Domains.

Since 2017, the government of the People’s Republic of China has heightened repression of Uyghur and other minorities in the Xinjiang Uyghur Autonomous Region (XUAR). Repressive tactics involve family separations, mass incarceration, forced labour and cultural indoctrination. This has been accompanied, in recent years, with an aggressive industrialization of the area which relies heavily on the forced labour of Uyghur and other minorities. The automotive industry, in particular, has expanded into the region. This piece describes China’s push of heavy industry into XUAR and recent findings by Sheffield Hallam University and NomoGaia of abuses against Uyghurs and their links to the global automotive sector. It then explains the methodology employed by NomoGaia in its co-authored report with scholars from Sheffield Hallam University for linking abuses in the XUAR to global brands, and proposes a way forward for the industry.

In the early 1650s in Mughal India ‘Mobad’ (Kaikhusrau Isfandyār) wrote a remarkable work, titled Dabistān, devoted to a description of the world's major religions. He adopted an avowedly objective approach that he strives to maintain throughout. An account of the religious tendencies under Akbar is offered in a long concluding chapter, dedicated to Islam. The account is given in two nearly totally different versions. In Version A, Akbar is credited with supernatural powers, with many anecdotes offered of their exercise. In Version B, all such anecdotes have been deleted and replaced by an extensive account of inter-religious debates held under Akbar, in which Christian (and Jewish) objections to Islamic traditions figure prominently. This version also seems to have been the major source of the belief current in later times that Akbar established a sect of his own under the designation of dīn-i ilāhī. In both versions the section on Akbar closes with the insightful observation that Akbar's policy of forming a nobility composed of diverse racial and religious elements was designed to protect the monarchy from any possibility of a unified aristocratic opposition.

In January 2022, the UK National Contact Point (UK NCP) issued a final statement in a specific instance claim brought against Bonsucro, a multi-stakeholder initiative (MSI) that aims to promote sustainable production of sugarcane. The claim alleged that Bonsucro had failed to comply with the OECD Guidelines because it had not carried out appropriate due diligence towards one of its members, accused of human rights abuses. While NCP complaints had been brought against MSIs and certifiers before, the UK NCP’s final statement is the first to recognize the leverage MSIs have over members due to their ability to deny membership and related reputational benefits to companies wishing to show sustainability logos, and to affirm their responsibility to use this leverage to avoid abuses. The statement sheds light on the accountability of actors involved in private voluntary sustainability standard systems, with possible impacts on other actors such as third-party certifiers.

Inappropriate dental antibiotic prescriptions to prevent infective endocarditis in the United States results in ∼$31 million in excess costs to the healthcare system and patients. This includes out-of-pocket costs ($20.5 million), drug costs ($2.69 million) and adverse event costs (eg, Clostridioides difficile and hypersensitivity) of $5.82 million (amoxicillin), $1.99 million (clindamycin), and $380,849 (cephalexin).

This paper takes, as its starting point, Preston and Haines’ observation in Fatal Years that social class was the most important influence on infant and child mortality in England and Wales in the early twentieth century. A subsequent study suggested that this could in part be due to the spatial distribution of the different classes across different types of place, and that some of the mortality differences by social class might actually reflect the contextual effects of healthy and unhealthy places. Although this line of argument has received a considerable amount of attention in health geography literature, it has rarely been examined for a specific historic period, and then only within particular urban areas. In this paper, we apply multi-level models to a complete count individual-level dataset of the 1911 census of England and Wales, comparing influences on infant and child mortality at the level of the individual couple and for two spatial levels. We find that although most variation in infant and child mortality operates at the individual level, there is also important variation at the two spatial levels and part of the mortality differences between social classes is better explained by the areas in which people lived rather than by their social class. A consideration of independent variables at all three levels suggests that different spatial scales capture different sorts of influences on early age mortality.

Recent work on the status of astrophysical modeling in the wake of quantum gravity indicates that a “fauxrizon” (a portmanteau of faux horizon), such as is relevant to understanding astrophysical black holes according to the fuzzball proposal within string theory, might ultimately solve the familiar black hole evaporation paradox. I clarify, with general upshots for the foundations of quantum gravity research, some of what this suggestion would amount to: identification of intertheoretic constraints on global spacetime structure in (observer-relative) semiclassical models of fuzzballs.

Let X be a d-dimensional diffusion and M the running supremum of its first component. In this paper, we show that for any $t>0,$ the density (with respect to the $(d+1)$-dimensional Lebesgue measure) of the pair $\big(M_t,X_t\big)$ is a weak solution of a Fokker–Planck partial differential equation on the closed set $\big\{(m,x)\in \mathbb{R}^{d+1},\,{m\geq x^1}\big\},$ using an integral expansion of this density.

Dr Helen B. Taussig (1898–1986) worked a paediatric cardiologist at the Johns Hopkins University in Baltimore, Maryland from 1930 to 1963. Dr Taussig would become world-renowned for her contributions to the systemic-to-pulmonary artery shunt to treat congenital heart patients with cyanosis. This shunt would eventually be named after the surgeon/cardiologist as the Blalock–Taussig shunt. Dr Taussig’s name was also attached to the description of one form of double outlet right ventricle called the Taussig-Bing malformation. Dr Taussig ultimately received the Presidential Medal of Freedom in 1964 as a testimony to her life-long contributions to the field of congenital heart surgery.

In 1963, Dr Taussig retired from clinical practice but continued her teaching and academic pursuits at Johns Hopkins for another 14 years. Upon her “second retirement” in 1977, she moved to Kennett Square, PA. This paper will review the retirement years of Dr Helen Taussig and the curious intersection between art and medicine.

The branched-chain amino acid (BCAA) is a group of essential amino acids that are involved in maintaining the energy balance of a human being as well as the homoeostasis of GABAergic, glutamatergic, serotonergic and dopaminergic systems. Disruption of these systems has been associated with the pathophysiology of autism while low levels of these amino acids have been discovered in patients with autism. A pilot open-label, prospective, follow-up study of the use of BCAA in children with autistic behaviour was carried out. Fifty-five children between the ages of 6 and 18 participated in the study from May 2015 to May 2018. We used a carbohydrate-free BCAA-powdered mixture containing 45·5 g of leucine, 30 g of isoleucine and 24·5 g of valine in a daily dose of 0·4 g/kg of body weight which was administered every morning. Following the initiation of BCAA administration, children were submitted to a monthly psychological examination. Beyond the 4-week mark, BCAA were given to thirty-two people (58·18 %). Six of them (10·9 %) discontinued after 4–10 weeks owing to lack of improvement. The remaining twenty-six children (47·27 %) who took BCAA for longer than 10 weeks displayed improved social behaviour and interactions, as well as improvements in their speech, cooperation, stereotypy and, principally, their hyperactivity. There were no adverse reactions reported during the course of the treatment. Although these data are preliminary, there is some evidence that BCAA could be used as adjunctive treatment to conventional therapeutic methods for the management of autism.

This study aims to assess changes in long-term care (LTC) residents’ quality of life (QoL) before and during the COVID-19 pandemic. A pre-test post-test study of 49 QoL measures, across four dimensions from the interRAI self-reported QoL survey, was conducted. Secondary data from 2019 (n = 116) and 2020 (n = 128) were analysed to assess the change in QoL. A significant decline in 12 measures was observed, indicating a change in QoL of LTC residents during the pandemic. Social life was the dimension mostly affected with residents reporting less opportunities to spend time with like-minded residents, explore new skills and interests, participate in meaningful religious activities, and have enjoyable things to do in the evenings. Several measures of personal control, staff responsiveness and care, and safety also demonstrated a significant change. The results can inform future strategies for pandemic and outbreak preparedness. Balancing the safety of residents with attention to their QoL should be a priority moving forward.