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Fontan-associated liver disease is a condition characterised by structural, functional, and clinical alterations secondary to the haemodynamic changes of this circulation.
Objective:
To describe the experience of a series of paediatric patients with Fontan-associated liver dysfunction.
Methods:
A retrospective study including 12 patients with Fontan-associated liver disease. Patients were selected from the single-ventricle program at a high-complexity centre in Colombia between 2001 and 2024.
Results:
During the study period, 108 patients were in the Fontan stage. Among them, 12 met the criteria for Fontan-associated liver disease (11.1%). The median age at extracardiac Fontan completion was 3.9 years, while the median age at Fontan-associated liver disease diagnosis was 14.5 years. Concomitant protein-losing enteropathy and/or plastic bronchitis were present in 33% of cases. Echocardiographic follow-up showed systolic dysfunction in 41% and diastolic dysfunction in 16% of patients. All patients exhibited some degree of valvular insufficiency, mild in 83.3% and moderate in 16%. Haemodynamic variables at the time of diagnosis did not show significant abnormalities.
Conclusions:
Liver disease is a persistent concern in paediatric patients with Fontan physiology, posing diagnostic and therapeutic challenges. Healthcare professionals managing these patients should be aware of its early identification and appropriate treatment.
We investigate the dynamics of circular self-propelled particles in channel flow, modelled as squirmers using a two-dimensional lattice Boltzmann method. The simulations explore a wide range of parameters, including channel Reynolds numbers ($\textit{Re}_c$), squirmer Reynolds numbers ($\textit{Re}_s$) and squirmer-type factors ($\beta$). For a single squirmer, four motion regimes are identified: oscillatory motion confined to one side of the channel, oscillatory crossing of the channel centreline, stabilisation at a lateral equilibrium position with the squirmer tilted and stable upstream swimming near the channel centreline. For two squirmers, interactions produce not only these four corresponding regimes but also three additional ones: continuous collisions with repeated position exchanges, progressive separation and drifting apart and, most notably, the formation of a stable wedge-like conformation (regime D). A key finding is the emergence of regime D, which predominantly occurs for weak pullers ($\beta = 1$) and at moderate to high $\textit{Re}_c$ values. Hydrodynamic interactions align the squirmers with streamline bifurcations near the channel centreline, enabling stability despite transient oscillations. Additionally, the channel blockage ratio critically affects the range of $\textit{Re}_s$ values over which this regime occurs, highlighting the influence of geometric confinement. This study extends the understanding of squirmer dynamics, revealing how hydrodynamic interactions drive collective behaviours. The findings also offer insights into the design of self-propelled particles for biomedical applications and contribute to the theoretical framework for active matter systems. Future work will investigate three-dimensional effects and the stability conditions for spherical squirmers forming stable wedge-like conformations, further generalising these results.
Normative data of neuropsychological tests in the Vietnamese population is considerably lacking. We aim to evaluate the effects of age, education, and sex on the performance of common neuropsychological tests, and to generate normative data for these tests in cognitively normal Vietnamese adults.
Method:
Participants were recruited from two hospitals in Ho Chi Minh City, with inclusion criteria as follows: age ≥ 40 years, normal cognition and function, and Mini-Mental State Examination (MMSE) scores ≥ 26. Neuropsychological tests were administered in a paper-and-pencil format, including the CERAD Word List, Trail Making Tests, Digit Span, Animal Naming, and Clock Drawing Test. Effects of age, education, and sex on test performance were evaluated using multiple linear regression analyses. Normed scores were reported as regression-based and discrete norms tables.
Results:
Participants included 385 cognitively normal Vietnamese, with age 61.4 ± 10.9 years (range 40 – 89), female 56%, who were relatively highly educated (42% attended college and beyond, 36% attended high school or equivalent institutions, 22% had less than high school education), and had MMSE scores 27.8 ± 1.0. Trail Making Test Part B was completed within 300 s by only 204/385 (53%) participants. Regression analyses demonstrated significant associations between age and education with performance on all or most tests, and between sex and all CERAD Word List measures and Clock Drawing Test.
Conclusions:
The present work provides the first known normative data for a relatively comprehensive neuropsychological battery in Vietnamese adults. Performance on all tests was significantly influenced by age and education.
According to the International Code of Zoological Nomenclature (ICZN, 1999), the Principle of Homonymy (Article 52) states that when two or more taxa are distinguished from each other, they must not be denoted by the same name because this would cause confusion. Consequently, in a case of homonymy, only the senior name may be used as valid (Art. 52.2). The ICZN (1999) also indicates that if the rejected junior homonym has no known available and potentially valid synonym, it must be replaced by a new substitute name (Art. 60.3), that is, a replacement name.
We explore a reduced-order model (ROM) of plane Couette flow with a view to performing near-wall turbulence control. The ROM is derived through Galerkin projections of the incompressible Navier–Stokes system onto a basis of controllability modes. Such ROMs were found to reproduce key aspects of turbulence dynamics in Couette flow with only a few hundred degrees of freedom, and here we use them to devise a control strategy. We consider a ROM with an extra forcing term whose structure is given by a combination of eigenfunctions of a linear viscous diffusion equation, optimised in order to minimise the total fluctuation energy. The optimisation is performed at Reynolds numbers $Re=1000, 2000, 3000$, and produces a novel control mechanism wherein the optimal forcing leads the flow to laminarisation in all cases. The forcing acts by reducing the shear in a large portion of the channel, hindering the main energy input mechanism. The forced flow possesses a new laminar solution which is linearly stable at $Re=1000$ and unstable at higher $Re$, but whose transient growth of streaky structures is substantially lower than that of laminar Couette flow, leading the flow to full laminarisation when the forcing is removed. Forcings optimised in the ROM are subsequently applied in direct numerical simulations (DNS). The same control mechanisms are observed in the DNS, where laminarisation is also achieved. We show that the ROMs provide an effective framework to design turbulence control strategies, despite the high degree of truncation, which opens up interesting possibilities for turbulence control.
Based on data from pore-resolved direct numerical simulation of turbulent flow over mono-disperse random sphere packs, we evaluate the budgets of the double-averaged turbulent kinetic energy (TKE) and the wake kinetic energy (WKE). While TKE results from temporal velocity fluctuations, WKE describes the kinetic energy in spatial variations of the time-averaged flow field. We analyse eight cases which represent sampling points within a parameter space spanned by friction Reynolds numbers $Re_\tau \in [150, 500]$ and permeability Reynolds numbers $Re_K \in [0.4, 2.8]$. A systematic exploration of the parameter space is possible by varying the ratio between flow depth and sphere diameter $h/D \in \{ 3, 5, 10 \}$. With roughness Reynolds numbers of $k_s^+ \in [20,200]$, the simulated cases lie within the transitionally or fully rough regime. Revisiting the budget equations, we identify a WKE production mechanism via viscous interaction of the flow field with solid surfaces. The scaling behaviour of different processes over $Re_K$ and $Re_\tau$ suggests that this previously unexplored mechanism has a non-negligible contribution to the WKE production. With increasing $Re_K$, progressively more WKE is transferred into TKE by wake production. A near-interface peak in the TKE production, however, primarily results from shear production and scales with interface-related scales. Conversely, further above the sediment bed, the TKE budget terms of cases with comparable $Re_\tau$ show similarity under outer-scaling. Most transport processes relocate energy in the near-interface region, whereas pressure diffusion propagates TKE and WKE into deeper regions of the sphere pack.
Three fossil tube fragments from middle Eocene to late Oligocene strata in western Washington State, USA, are here interpreted as those of ancient Ceriantharia (Hexacorallia, Cnidaria). The tube fragments are 3–6 mm in diameter, up to 60 mm long, and the surfaces show an overlapping, fibrous knitted pattern. This surface pattern resembles that of the extant ceriantharid Cerianthus membranaceus. One specimen has numerous benthic foraminiferans associated with, and apparently even embedded in, the tube wall, analogous to some extant Ceriantharia. These fossils likely represent the first fossil Ceriantharia and indicate that their present-day mode of tube construction using ptychocysts was established at latest by the middle Eocene.
This epilogue considers the approach and conception of this collection, highlighting key analytical strands in the essays while also suggesting possible avenues of further research. It spotlights the global nature of their analysis, which offers one structural framework – individual scientific personas and the often transnational networks which they inhabit – as a possible avenue to imagine a so-called global Space Age. The epilogue also investigates possible frames for further analyses, particularly regarding gender and translation. Men dominate the pantheon of space personas, which, I argue, is a function of the way popular discourses about space travel are still dominated not only by patriarchal and often misogynistic tropes, but also by how we define ‘technology’ itself as essentially a male domain of activity. More broadly, we need further investigation of multiple and gendered erasures involved in the creation of male space personas. Similarly, the kinds of tools, work and strategies the space personas deployed to translate their visions across different social, discursive, cultural and temporal domains require attention. In particular, one can imagine that the afterlife of these personas will be susceptible to change and alteration as their messages, reputations, and principal attachments are continually reshaped by historical change, popular culture, and academic currents.
Almost 12% of the human population have insufficient access to food and hence are at risk from nutrient deficiencies and related conditions, such as anaemia and stunting. Ruminant meat and milk are rich in protein and micronutrients, making them a highly nutritious food source for human consumption. Conversely, ruminant production contributes to methane (CH4) emissions, a greenhouse gas (GHG) with a global warming potential (GWP) 27-30 times greater than that of carbon dioxide (CO2). Nonetheless, ruminant production plays a crucial role in the circular bioeconomy in terms of upcycling agricultural products that cannot be consumed by humans, into valuable and nutritional food, whilst delivering important ecosystem services. Taking on board the complexities of ruminant production and the need to improve both human and planetary health, there is increasing emphasis on developing innovative solutions to achieve sustainable ruminant production within the ‘One Health’ framework. Specifically, research and innovation will undoubtedly continue to focus on 1) Genetics and Breeding; 2) Animal nutrition and 3) Animal Health, to achieve food security and human health, whilst limiting environmental impact. Implementation of resultant innovations within the agri-food sector will require several enablers, including large-scale investment, multi-actor partnerships, scaling, regulatory approval and importantly social acceptability. This review outlines the grand challenges of achieving sustainable ruminant production and likely research and innovation landscape over the next 15 years and beyond, specifically outlining the pathways and enablers required to achieve sustainable ruminant production within the One Health framework.
Accessibility at the Sterkfontein Caves UNESCO World Heritage Site limits public and scientific engagement. The authors digitally visualised part of the cave using laser scans and photogrammetry, geospatially integrating the digital cave and fossil datasets. This enables broader access for learners, educators and scientists and enhances scientific outreach potential.
Radiocarbon (14C) activity in aquatic environments is usually different from that of the atmosphere, the result being that organisms that grow in these different environments will have different 14C ages, even though they are contemporary. This age offset in marine samples is known as the “marine reservoir effect.” The marine calibration curve takes this effect into account as a global approximation, but local variations due to ocean dynamics and other factors must be individually studied and corrected for. With a littoral of more than 11,000 km and a great interest in dating malacological marine samples, Mexico has scarce local reservoir effect studies. Most of the available data come from studies done in the 1960s and 1990s. In this study, we present new reservoir effect corrections for four sites in the Pacific Ocean with positive ΔR values as expected, and one from the Caribbean Sea with a negative average value of ΔR. The results were obtained by dating known-age shells from the malacological collection of the Natural History Museum Felipe Poey, in Havana, Cuba. This new data will be useful to do more precise reservoir effect corrections to malacological samples of the region, with special interest in contexts where it is difficult to date other kinds of organic samples, due to difficulties in their preservation.
Biomarkers alone cannot resolve psychiatry’s diagnostic challenges, particularly the boundary between normal variation and pathology. Diagnosis should prioritise the subjective, phenomenological experiences of patients rather than solely relying on biological evidence, emphasising a framework centred on suffering, debilitation and societal impact.