Recently, mathematical and computational approaches have been incorporated into ICSI interventions as guiding tools. However, those tools carry no prognostic potential. Improving this capability may enhance ICSI attempts and assist clinicians working in infertility clinics. This study, thus aimed to investigate whether parental parameters could have predictive potential for the quality of resulting embryos with the ICSI approach using mathematical modelling techniques. Patient data including follicle number, MI and MII oocyte numbers, sperm number, sperm morphology and motility for 765 distinct couples attending British Cyprus IVF hospital was collected. Furthermore, morphological quality data as well as aneuploidy status for the 4123 resultant embryos were obtained. Regression analyses were conducted to observe the possible correlations between parental parameters and embryo quality and ploidy. Correlation analyses showed that follicle and oocyte numbers, as well as sperm parameters can be indicative of morphological quality of resulting embryos via ICSI (p values < 0.05). On the other hand, aneuploidy prediction remains too complicated to be predicted solely by these parameters (p values > 0.05). This study indicates a predictive potential of infertility measurements for male and female partners on ICSI success and is expected to act as a basis for the development of prognostic softwares to be used in IVF clinics.

This article focused on the erotic encounters between male characters in the Ottoman frontier epic of the Battalname that led to conversion to Islam. It argues that these moments of eroticism between two male warriors parallel other literary and cultural expressions wherein male-male eroticism was the norm. Romantic and erotic encounters in these frontier epics have focused on the much more limited cases of female-male interactions, obscuring the fact that these were more often the exception. While male-male eroticism has been largely studied for elite literary works, narratives considered to be expressions of folktale have been treated as if they belong to separate cultural worlds. I show that some of the language of eroticism and conversion had strong parallels between the two forms of cultural expression and thus highlight the normalized all-male space of eroticism both in the Ottoman frontier and in nascent Ottoman urban culture.

Why are some firms more successful than others in obtaining privileged treatment from their government? Trade policy, as an unusually targeted tool, offers a rich context to understand such questions of special-interest politics and corporate power. Studying decisions on anti-dumping petitions in the United States, we introduce a novel source of privileged treatment. We argue that firms with more linkages throughout the domestic economy enjoy a privileged political position. Benefits to these firms extend indirectly to a wider set of constituents, which allows firms to assemble broader coalitions and to portray protectionist policy as more than purely particularistic politics. We provide evidence for this argument by developing original measures of linkages between firms, derived from over 600,000 customer–supplier relationships among industries, matching them with data on anti-dumping petitions filed by US firms, written briefs filed by members of Congress on behalf of these firms, and the geographic distribution of industries. Our account identifies a new explanation of differences in the political influence of firms, underscores the relevance of domestic production networks in politics, and offers a novel perspective on cleavages and coalitions in trade politics. Our results also suggest that the expansion of global supply chains, long considered a hallmark of political power, has weakened the clout of some of the largest firms by limiting their domestic footprint.

Max Nicholls had an almost unique experience as a medical practitioner, researcher and teacher of medical genetics. An earlier paper described his contribution to the etiology of neurofibromatosis. This was followed by Nicholls’ own experience as lecturer in the Faculty of Medicine, University of New South Wales, Australia. This note draws attention to his research in immunology. For example, he was instrumental in the study of the buffy coat leuko-agglutination (BCLA) test, a sensitive assay for cell-mediated immunity that he introduced to detect conditions (including cancer) in preclinical stages.

This paper investigates the dynamic effects of environmental and fiscal policy shocks in a New Keynesian dynamic stochastic general equilibrium model featuring price and wage rigidity and a polluting intermediate goods sector. I compare carbon taxes and cap-and-trade systems under abatement cost and government spending shocks, considering three revenue-recycling schemes: lump-sum transfers, labor tax cuts, and consumption tax cuts. Abatement cost shocks reduce output and consumption, with stronger effects under cap-and-trade due to rising permit prices. These effects are mitigated when revenues are used to reduce distortionary taxes, especially consumption taxes. Government spending shocks stimulate output and labor, particularly under lump-sum financing, but their expansionary effects are dampened under cap-and-trade. Nominal rigidities amplify these dynamics. The findings support the double dividend hypothesis and highlight the importance of fiscal design and policy coordination. Carbon taxes, combined with targeted tax reductions, offer superior macroeconomic stabilization in the face of environmental and fiscal shocks.

This article explores the interplay between the individual and the collective in The Blind Owl and illustrates how a distinctive historical perspective emerges from its complex allegorical form. A close reading of the novel reveals how the text superimposes biographical and cultural pasts through the juxtaposition of sexual fetishism and nostalgia, presenting both as symptoms of a fraught relationship with one’s infantile and cultural histories. The article reads The Blind Owl as a satirical critique of a figure whose conflicting desires to commemorate and forget the past drive a series of fetishistic behaviors, culminating in failure. Ultimately, the novel offers a cynical reflection on the nationalist nostalgia cultivated by traditionalist intelligentsia within the peripheral modernity of early twentieth-century Iran.

The objective was to identify the predictive markers and develop a diagnostic model with predictive markers for Parkinson’s disease (PD) and investigate the roles of immune cells in the disease pathology. Microarray datasets of PD and control samples were obtained from the Gene Expression Omnibus (GEO) database. We then performed a comprehensive analysis of differentially expressed genes (DEGs), functional enrichment, and protein-protein interactions to pinpoint a set of promising candidate genes. To establish a diagnosis model for PD, we utilized machine learning algorithms and evaluated the corresponding diagnostic performance using the receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC). Additionally, the differential abundance of immune cell subsets between PD and control samples was evaluated using the single-sample Gene Set Enrichment Analysis (ssGSEA) method. A total of 264 DEGs were identified in GSE72267. The PPI network ultimately identified 30 hub genes for model construction. Seven genes, namely CD79B, CD40, CCR9, ADRA2A, SIGLEC1, FLT3LG, and THBD, were identified as diagnostic markers for PD, with an AUC of 0.870. This seven-gene signature model was subsequently validated in an independent cohort (GSE22491), demonstrating an AUC of 0.825. Ultimately, the infiltration of 28 immune cells showed that activated B cells, natural killer T cells, and regulatory T cells may contribute to the occurrence and progression of PD. We also found complex associations between these genes and immune cells. CD79B, CD40, CCR9, ADRA2A, SIGLEC1, FLT3LG, and THBD were identified as diagnostic markers for PD, and the infiltration of immune cells may contribute to the pathogenesis of the disease.

Existing research often interprets the limited impact of candidate gender on vote choice as evidence of minimal gender bias in politics. However, this overlooks the dual role of candidate gender, as both a heuristic for substantive representation and a trigger for sexism in voter decision-making. These competing mechanisms can diminish the effects of each other, obscuring the true influence of gender bias in electoral behavior. Using conjoint experiments in South Korea, a context where gender issues are highly politicized and sexism remains widespread, we examine how candidate gender affects voter evaluations in low- and high-information environments. Our findings reveal that in low-information settings, candidate gender serves as a cue for substantive representation, leading to co-sex voting among women, while simultaneously activating hostile sexism among male voters, reducing support for female candidates. In high-information settings, explicit candidate policy positions diminish the reliance on gender cues but do not eliminate gender bias. Instead, sexism manifests through opposition to gender-equity policies rather than direct discrimination against female candidates. These results suggest that information environments shape the expression of gender bias, rather than eliminating it, offering a more nuanced understanding of the conditions under which candidate gender influences electoral preferences.

We theorize on how and when CEO humility positively shapes stakeholders’ evaluations of a firm. We posit that CEO humility has a positive effect on organizational virtuousness and, hence, on firm reputation in the eyes of the government in China when the firm is intensively connected to government intermediaries. Data for this study were collected from a large-scale on-site survey and archives of 195 firms in 32 Chinese industrial towns. Our 1,099 respondents included 975 top managers and 124 local government officers. Empirical analysis results support our theory. We also complemented our quantitative findings with qualitative evidence. We offer a new perspective for understanding humble CEOs’ influence and condition in shaping their firms’ reputational judgments.

An observational pilot in walk-in clinics assessed workflow impacts of personal protective equipment (PPE) use for COVID-19 cases. PPE added time, waste, and cost despite a low incidence period of illness. Limited supporting data for contact transmission and operational barriers suggest ambulatory PPE guidance for COVID-19 warrants modification.

Exchange rate manipulation—the active devaluation of a currency through intervention in the foreign exchange market—is a frequent trigger of international disputes. Yet it is not an obvious policy choice: as a blunt tool to boost export competitiveness, it is disliked by citizens and importers because of the loss of purchasing power it entails, and because it benefits those with investment abroad at the expense of those with savings at home. It is thus notable that a group of East Asian countries, from Japan and Korea to Thailand, undertake frequent and often large interventions to devalue their currencies. What explains their policy choice? We provide evidence that exchange rate depreciations are undertaken at the behest of export industries. Because lobbying activities in East Asian countries are not directly observable, we focus on Japan and Korea and construct a proxy measure of lobbying by exporters, drawing on news reports. We use machine learning to scale daily reports of industry demands in the two leading financial newspapers, the Japanese Nihon Keizai Shimbun and, in a robustness check, the Korean Hankyung, over twenty-five years. We find evidence that mounting public pressure by organized economic interest groups precedes intervention and induces currency depreciation.