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The local priest was the most ubiquitous embodiment of the Church for many people in medieval Christian Europe. By centring this key figure in post-Carolingian Europe, this book provides a fresh perspective on the transition between two focuses of historiographical attention, the Carolingian reform and the Gregorian reform. This pivot away from Church elites such as popes, bishops and abbots, and the institutional structures of dioceses and parishes, sheds light on new lines of continuity and moments of transformation, examining the resources and kinship ties of local priests and assessing their relationship with the bishop at both the collective and the individual level. It draws on a variety of methodologies and forms of evidence, ranging from the detailed study of specific manuscripts to wide-ranging overviews of liturgical and documentary evidence. This title is also available as Open Access on Cambridge Core.
Yogurt acid whey (YAW) contains significant amounts of calcium as well as small amounts of protein, thus the idea of its reintroduction, especially of its calcium content, to the food chain is attractive. Calcium in milk is mainly complexed with casein micelles, whereas YAW contains only small amounts of protein, with no caseins at all, differing substantially from milk in the form in which calcium occurs. Therefore, the objective of the present research paper was to evaluate whether calcium bioavailability differs between YAW and milk. Following the INFOGEST protocol for simulated digestion and by coupling it with the Caco-2 model for intestinal absorption, calcium in YAW had higher bioaccessibility than calcium in milk. However, there were no differences in calcium transport by the intestinal cells and the transcription level of calcium absorption-related genes (VDR, TRPV6, S100G and PMCA1). Lastly, there were no differences in calcium bioaccessibility and the transcription of the calcium absorption-related genes between YAW samples of bovine, ovine or caprine origin obtained from Greek dairy products enterprises. In conclusion, despite the major differences in the protein profile between YAW and milk, there were no differences in calcium transport by the cells, but YAW was associated with higher calcium bioaccessibility, which ultimately may result in higher amount of absorbed calcium.
Let $K^r_n$ be the complete $r$-uniform hypergraph on $n$ vertices, that is, the hypergraph whose vertex set is $[n] \, :\! = \{1,2,\ldots ,n\}$ and whose edge set is $\binom {[n]}{r}$. We form $G^r(n,p)$ by retaining each edge of $K^r_n$ independently with probability $p$. An $r$-uniform hypergraph $H\subseteq G$ is $F$-saturated if $H$ does not contain any copy of $F$, but any missing edge of $H$ in $G$ creates a copy of $F$. Furthermore, we say that $H$ is weakly$F$-saturated in $G$ if $H$ does not contain any copy of $F$, but the missing edges of $H$ in $G$ can be added back one-by-one, in some order, such that every edge creates a new copy of $F$. The smallest number of edges in an $F$-saturated hypergraph in $G$ is denoted by ${\textit {sat}}(G,F)$, and in a weakly $F$-saturated hypergraph in $G$ by $\mathop {\mbox{$w$-${sat}$}}\! (G,F)$. In 2017, Korándi and Sudakov initiated the study of saturation in random graphs, showing that for constant $p$, with high probability ${\textit {sat}}(G(n,p),K_s)=(1+o(1))n\log _{\frac {1}{1-p}}n$, and $\mathop {\mbox{$w$-${sat}$}}\! (G(n,p),K_s)=\mathop {\mbox{$w$-${sat}$}}\! (K_n,K_s)$. Generalising their results, in this paper, we solve the saturation problem for random hypergraphs $G^r(n,p)$ for cliques $K_s^r$, for every $2\le r \lt s$ and constant $p$.
The idea of a ‘late colonial state’ has been surprisingly durable. It is also the case that the meaning and significance of decolonisation – indeed our understanding of when it took place and how long it lasted – has been widened and deepened. We no longer tend to think of it as a purely political let alone constitutional event, but as a much broader shift in the relations between the ‘colonial world’ and its (former) masters and as having many more dimensions: economic, cultural, demographic among them. Needless to say, we are no closer to an agreed explanation than we were twenty-five or fifty years ago: the primacy of nationalist resistance, or of metropolitan politics or of geopolitical change still have their adherents even if it was the ricochet effect of all three on each other that offers the most plausible analysis. However, regardless of which account is favoured it seems clear that the nature of the ‘end game’ of the colonial state is the best place in which to search for answers. The late colonial state still has work to do.
Monolingual children tend to assume that a word labels only one object, and this mutual exclusivity supports referent selection and retention of novel words. Bilingual children accept two labels for an object (lexical overlap) for referent selection more than monolingual children, but in these previous studies, information about speakers’ language backgrounds was minimal. We investigated monolingual and bilingual 4-year-old children’s ability to apply mutual exclusivity and lexical overlap flexibly when objects were labelled either by one or two speakers with the same or different language backgrounds. We tested referent selection and retention of word–object mappings. Both language groups performed similarly for mutual exclusivity, were more likely to accept lexical overlap in the two-language than one-language condition, and performance was similar for referent selection and later retention. Monolingual and bilingual children can adapt their word-learning strategies to cope with the demands of different linguistic contexts.
Gold-silver telluride deposits in central Montana contain > 400 t Au and are spatially and genetically related to major faults in the Great Falls Tectonic Zone (GFTZ) and the Lewis and Clark Line. They are also related to alkaline igneous intrusive rocks, including monzonites, syenites, diorites, tinguaites, dacites, lamprophyres, and trachytes. Deposit styles include bonanza veins, carbonate replacement at igneous-carbonate contacts, breccia pipe-hosted, and structurally controlled igneous-hosted. Ore-related breccias are a common feature. The ore mineralogy is complex, and locally contains native gold/electrum, Au-Ag tellurides (calaverite, sylvanite, krennerite, petzite, empressite, stützite, and hessite), Bi-tellurides (tetradymite, tellurobismuthite), Bi sulphosalts, and rare precious-metal sulphotellurides. Alteration related to ore-stage fluids is localised primarily adjacent to veins and characterised by silicification, fluoritisation, adularia-sericite, and roscoelite±clays. Fluid inclusion studies suggest that gold telluride ores were deposited from low-temperature (130o–270 oC), moderately saline (1–12 equiv. wt % NaCl), locally boiling, CO2-poor, near neutral, relatively oxidising fluids. Oxygen and hydrogen isotope studies support the concept that the deposits formed from a continuum between magmatic and meteoric fluids, whereas sulphur isotope compositions of sulphides suggest a magmatic sulphur source or sulphur that was leached from sulphides in volcaniclastic and clastic sedimentary rocks. Lead isotope compositions are permissive of a crustal source with a contribution from Palaeozoic or Proterozoic sedimentary rocks hosting the alkalic igneous rocks. Porphyry molybdenum and Carlin-like Au-Te deposits are also genetically related to the GFTZ and Lewis and Clark Line and represent end-members that form a continuum with epithermal gold-silver telluride deposits.
The use of cannabis in adolescence and early adulthood, critical phases for brain development, is linked to psychotic-like experiences (PLEs). The underlying mechanisms, however, remain unclear. This research examined the relationship between recreational cannabis use and PLEs, emphasizing the connectivity of the salience network (SN), which plays a role in salience processing and psychosis. To determine whether this relationship reflects shared genetic or environmental contributions, twin modeling was used.
Methods
We included 232 healthy adolescent Turkish twins who underwent diffusion MRI and psychometric assessment. SN connectivity was quantified using graph theory metrics. Linear mixed models were used to examine the associations among cannabis use, SN factors, and PLEs. Mediation analyses assessed whether SN parameters explained the cannabis–PLEs association. Twin models disentangle genetic and environmental contributions to these traits and their covariation.
Results
Cannabis use was significantly associated with higher overall PLE frequency. A specific SN factor predicted both total and positive PLEs. However, SN connectivity did not mediate the cannabis–PLEs relationship. Twin modeling showed that cannabis use and PLEs were mainly influenced by unique environmental factors. No significant phenotypic covariations were found among cannabis use, PLEs, and SN parameters.
Conclusions
Recreational cannabis use during adolescence and young adulthood is associated with heightened PLEs, although this association is not mediated by SN connectivity. The environment plays an important role during adolescence in shaping these traits independently. The findings underscore the need for longitudinal and genetically informed studies to clarify the mental health effects of adolescent cannabis use.
With the increased prevalence of major depressive episodes with mixed features specifier (MDE-MFS), the pharmacological treatment for MDE-MFS has attracted great clinical attention. This study aimed to investigate the efficacy and safety of medication use for MDE-MFS.
Methods
Commonly used databases were searched for the meta-analysis. Primary efficacy outcomes included response rate and the change in the Young Mania Rating Scale scores; the primary safety outcome was the rate of treatment-emergent hypomania/mania. Effects were expressed as relative risk (RR) or standardized mean difference (SMD).
Results
In patients with MDE-MFS, antipsychotics significantly improved depressive (RR = 1.46 [95% CI: 1.31, 1.61]) and manic (SMD = −0.35 [95% CI: −0.53, −0.17]) symptoms without increasing the risk of manic switch (RR = 0.91 [95% CI: 0.53, 1.55]). However, subgroup analysis of bipolar disorder (BD) patients with MDE-MFS indicated that antipsychotics had limited effects on manic symptoms. Mood stabilizers, especially valproate, demonstrated significant effects in BD patients with MDE-MFS by relieving depressive and manic symptoms. For MDE-MFS in patients with major depressive disorder, trazodone has shown potential effectiveness in retrospective studies, while the effectiveness of antidepressants on BD patients with MDE-MFS lacked evidence.
Conclusions
While antipsychotics are first options for MDE-MFS, their effect on manic symptoms in BD patients with MDE-MFS is still unclear. Mood stabilizers may also be considered, and the use of antidepressants remains a topic of controversy. Since our findings are mostly based on post-hoc analyses, the evidence remains preliminary, highlighting the need for further research to produce more conclusive evidence.
Pendant drops appear in many engineering applications, such as inkjet printing and optical tensiometry, and they have also been the subject of studies of droplet–particle interaction. While the hydrostatics of pendant drops has been studied extensively, the influence of external flow disturbances has received limited attention. This research aims to incorporate aerodynamic factors into the understanding of pendant drop behaviour. Employing a simplified model, an irrotational flow aligned with the drop’s axis is derived from a distribution of singularity elements within the drop. The drop’s equilibrium shape is then determined using a numerical model that couples the flow field with the Young–Laplace equation. The model’s predictions are compared to droplet images captured via high-speed shadowgraph in a vertical wind tunnel, showing good agreement with the experimentally observed shapes. Additionally, under certain flow conditions, the drop exhibits instability in the form of periodic pendulum-like motion. This instability was linked to two distinct critical drop heights, and the corresponding stability criterion was mathematically derived from the numerical model. Our theoretical and experimental findings provide the first quantitative description of the equilibrium shape and stability criterion of pendant drops under the influence of external flow.
Given a finite abelian group $G$ and $t\in \mathbb{N}$, there are two natural types of subsets of the Cartesian power $G^t$; namely, Cartesian powers $S^t$ where $S$ is a subset of $G$ and (cosets of) subgroups $H$ of $G^t$. A basic question is whether two such sets intersect. In this paper, we show that this decision problem is NP-complete. Furthermore, for fixed $G$ and $S$, we give a complete classification: we determine conditions for when the problem is NP-complete and show that in all other cases the problem is solvable in polynomial time. These theorems play a key role in the classification of algebraic decision problems in finitely generated rings developed in later work of the author.
Experiments have shown that ultrasound-stimulated microbubbles can translate through gel phantoms and tissues, leaving behind tunnel-like degraded regions. A computational model is used to examine the tunnelling mechanisms in a model material with well-defined properties. The high strain rates motivate the neglect of weak elasticity in favour of viscosity, which is taken to degrade above a strain threshold. The reference parameters are motivated by a 1 $\unicode{x03BC}$m diameter bubble in a polysaccharide gel tissue phantom. This is a reduced model and data are scarce, so close quantitative agreement is not expected, but tunnels matching observations do form at realistic rates, which provides validation sufficient to analyse potential mechanisms. Simulations of up to 100 acoustic cycles are used to track tunnelling over 10 bubble diameters, including a steady tunnelling phase during which tunnels extend each forcing cycle in two steps: strain degrades the tunnel front during the bubble expansion, and then the bubble is drawn further along the tunnel during its subsequent inertial collapse. Bubble collapse jetting is damaging, though it is only observed during a transient for some initial conditions. There is a threshold behaviour when the viscosity of the undamaged material changes the character of the inertial bubble oscillation. Apart from that, the tunnel growth rate is relatively insensitive to the high viscosity of the material. Higher excitation amplitudes and lower frequencies accelerate tunnelling. That acoustic radiation force, elasticity and bubble jetting are not required is a principal conclusion.
An asymptotic model for the flow of a highly viscous film coating the interior of a slippery, flexible tube is developed and studied. The model is valid for the axisymmetric flow of moderately thick films, and accounts for tube flexibility, wall damping, longitudinal tension, slip length and strength of base flow due either to gravity or airflow. In the absence of base flow, linear stability analysis shows the existence of one unstable mode; the presence of base flow allows for multiple unstable modes arising due to the Plateau–Rayleigh instability and elastic instability, with stronger base flow reducing the maximum growth rate. Numerical solutions in the absence of base flow show that slip decreases the amplitude of wall deformations and can significantly decrease the time to plug formation in weakly flexible or strongly damped tubes. For falling films, the impact of model parameters on the critical thickness required for plug formation was analysed by studying turning points in families of travelling-wave solutions; this thickness decreases with slip, flexibility and tension, while damping had a non-monotonic impact on critical thickness. In contrast to model solutions in rigid tubes, for flexible tubes the critical thickness cannot be made arbitrarily large through simply increasing the strength of the base flow. For air-driven films, both slip and flexibility increase the rate of film transport along the tube.