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The Phonomaton, a public web-facing facility, computes phonological derivations based on a user’s underlying representations and rules. The tool allows a formal implementation of phonological analyses using familiar methods and lets students interactively explore the mechanics of feature systems and serial derivations. We demonstrate a number of the program’s features and end with a discussion of its implementation in the classroom.
With the rise of digital and online technologies, subtitling practices once reserved for traditional media to regiment language are now available to ordinary netizens. This article explores the nature of these practices and the publics they project in digital media, focusing on a viral remix video that uses on-screen text to ridicule a Hong Kong government official for his Cantonese-accented Mandarin. Through parodic revoicing, the subtitles in the video mock the official’s linguistic blunders and create a series of incongruities to provoke humor intended for Cantonese-speaking Hongkongers. These subtitles, despite reproducing standard language ideology, bring into being a vernacular counterpublic organized around Cantonese and undermine the legitimacy of the public figures in the video. This article not only prompts us to reconsider the commonly assumed link between standard languages and national publics but also reveals subtitling practices in participatory media as potential sites where ideological reproduction and political resistance intersect. (Subtitling, counterpublic, Mandarin Chinese, Hong Kong, China)
Before the planters arrived, the Mississippi River Delta was a swampy jungle. In his 1941 memoir Lanterns on the Levee, William Alexander Percy, a prominent member of the regional plantation elite, described what the Delta might have looked like in those early days, with an emphasis on the area’s fluid nature. “A still country it must have been then, ankle-deep in water, mostly in shadow, with mere flickers of sunshine, and they motey and yellow and thick like syrup.”1 But in the early nineteenth century, news had started to spread about the fertility of the Delta soil. The younger sons of plantation families in the eastern states, looking for new land to plant staple crops, began to move west, turning the Deep South of the United States into the vertex of the cotton frontier. In Mississippi they settled near the river, which provided transportation, information, and recreation, in the form of leisure trips to New Orleans. “The real highway was the river,” Percy wrote in his personal history of the Mississippi Delta. The steamer Pargo regularly arrived on Sunday mornings in the Delta town of Greenville. Most people would be in church then, but when the Pargo’s whistle blew, the men immediately stood up from the pews and made for the riverfront, to hear the latest news and gossips.2 Knowledge was an important cargo aboard riverboats like the Pargo.3
Early-onset sepsis (EOS) is a significant cause of neonatal morbidity and mortality. Due to fear of missing cases, many newborns are unnecessarily exposed to antibiotics. We implemented the neonatal EOS calculator to reduce over-utilization of antibiotics and decrease costs.
Design:
Quality improvement study.
Setting:
Neonatal Intensive Care Unit (NICU).
Patients:
Infants born at ≥34 weeks’ gestation were divided between two periods: the pre-EOS calculator time frame and the post-EOS calculator time frame.
Intervention:
We changed our EOS evaluation for inborn infants by implementing the EOS-calculator and decreasing “rule-out sepsis” time frame from 48 to 36 hours for infants started on antibiotics.
Results:
1,306 infants, with similar demographics, were included: 814 in pre-EOS calculator time frame and 492 in post-EOS calculator time frame. Following our interventions, the percentage of NICU admissions ≥34 weeks’ gestation started on antibiotics decreased from 62% to 51% (P < .01). In the chorioamnionitis subgroup, antibiotic starts decreased by 50% (P < .01). There was a reduction in days of therapy per 1,000 NICU (168 vs 110, P < .01) and total (93 vs 57, P < .01) patient days. Fewer patients had blood cultures drawn (84% vs 67%, P < .01) with a decrease in infants treated for culture-negative sepsis (7% vs 3%, P < .01). NICU and hospital length of stay reduced by 1 day (P < .01), equivalent to a savings of $916,000 to $1.84 million per 1,000 NICU patients in costs and savings of $5.82 million to $12.5 million per 1,000 NICU patients in charges.
Conclusions:
Antibiotic usage significantly decreased, with substantial savings after implementation of the EOS calculator, without significant negative effects.
This article examines three key cases decided by the CERD Committee to show how the semantic conundrum of the International Convention on the Elimination of All Forms of Racial Discrimination (ICERD) becomes an obstacle in extending protection against racial discrimination to various racialized groups. It is argued that the wording of Article 1 of ICERD creates a tripartite classification of semantics, in which meaning generated through different protected grounds obscures the conception of racial discrimination. This places constraints on the Committee’s ability to decide in favour of racialized non-citizens. The article proceeds to examine the jurisprudence of direct, indirect, and positive discrimination in the context of Article 1. It contends that while the semantic conundrum of ICERD confines racial discrimination to limited grounds, using the forms of discrimination can yield positive results. This is shown by re-examining the three cases, this time using the lens of forms of discrimination. It is argued that this approach can enable the Committee to transcend the semantic conundrum of ICERD and arrive at more nuanced conclusions.
Cardiac complications significantly contribute to mortality in Duchenne muscular dystrophy patients. Early detection of cardiac involvement is crucial for optimising therapeutic interventions. This study aimed to evaluate the role of N-terminal pro-brain natriuretic peptide in detecting cardiac involvement, as assessed by real-time three-dimensional (four-dimensional) and three-dimensional speckle-tracking echocardiography in patients with Duchenne muscular dystrophy.
Material and methods:
This cross-sectional study enrolled individuals under 21 years. Participants underwent clinical evaluation, real-time three-dimensional echocardiography, three-dimensional speckle-tracking echocardiography, and simultaneous measurement of serum N-terminal pro-brain natriuretic peptide levels. Correlation analysis between echocardiographic parameters and N-terminal pro-brain natriuretic peptide was performed.
Results:
The study comprised 38 Duchenne muscular dystrophy patients with a mean age of 9.40 ± 4.13 years. Moderate significant correlations were observed between N-terminal pro-brain natriuretic peptide and echocardiographic parameters, including basal anterolateral and inferolateral longitudinal strain, apical septal longitudinal strain, and basal anterolateral and inferolateral radial strain (p < 0.05). Subgroup analysis based on N-terminal pro-brain natriuretic peptide (<125 pg/ml vs. ≥125 pg/ml) revealed impaired basal anterolateral longitudinal strain in patients with high N-terminal pro-brain natriuretic peptide.
Conclusion:
This is the first study that includes N-terminal pro-brain natriuretic peptide in conjunction with real-time three-dimensional echocardiography and three-dimensional speckle-tracking echocardiography for assessing cardiac involvement in Duchenne muscular dystrophy patients. The observed correlations between N-terminal pro-brain natriuretic peptide levels and regional contraction parameters hold promise for its relevance as a biomarker for cardiac dysfunction. Prospective studies with a larger population with a broader range of disease severity are necessary in patients with Duchenne muscular dystrophy.
This article examines the trajectory of two Native American songs transcribed by French Jesuits in the seventeenth century, their subsequent inclusion in printed books in the eighteenth and nineteenth centuries, and their use by historians and entertainers in the twentieth century. The study focuses on how these songs, initially part of Native American oral and aural tradition, were transformed into primary-source evidence for historical research and racialized entertainment. This is an intellectual and cultural history that uses history-of-the-book and bibliographical methodologies to understand the discipline of history’s formation in the academy. The article argues that converting these songs into written musical notation inherently altered their meaning and context. It highlights how transcribing music by ear involves subjective interpretation and the loss of crucial performative elements. Furthermore, reproducing these songs in printed form further distanced them from their original cultural context, making them susceptible to misinterpretation and appropriation. The fact that these changes occurred as history was founded as a discipline is crucial to understanding the argument. The study employs a multidisciplinary approach, drawing on historical documents, musical scores, and popular-culture materials. It examines the role of women scholars, such as Emma Helen Blair and Edna Kenton, in making these sources accessible to a broader audience through their work on primary-source anthologies. However, it also points out the unintended consequences of this accessibility, as the songs were increasingly decontextualized and used to perpetuate romanticized and inaccurate portrayals of Native American culture. The work of Blair and Kenton is central to the formation of history as a discipline in the academy, especially as they worked with and for men like Reuben Gold Thwaites and Frederick Jackson Turner. The research concludes that the transformation of these songs into historical sources and entertainment props reflects the complex relationship between scholarship, popular culture, and the representation of Native American culture in the twentieth century. It raises critical questions about authenticity, ownership, and access to Indigenous cultural expressions. Finally, this study emphasizes the importance of considering notated music as a historical primary source, acknowledging its limitations and potential for misinterpretation.
A clinical case is presented to discuss a framework for use of advanced diagnostics for central nervous system infections. Advantages, limitations, and diagnostic stewardship strategies are discussed for each modality: multiplex molecular meningitis/encephalitis panel, plasma microbial cell-free DNA sequencing, and cerebrospinal fluid metagenomic next generation sequencing.
A ten-year retrospective review of 176 pneumococcal bloodstream infections found broad-spectrum antimicrobial use despite high penicillin susceptibility. Complications occurred in 15%, and ICU admission in 10%. Only 22% had pneumococcal vaccination recommended at discharge. Findings reveal missed opportunities for Antimicrobial Stewardship and preventative care in invasive pneumococcal disease management.
There are various types of nominal appositives. One is predicative, as in She invited Lulu Moppet, an old friend, to the party; one is specificational, as in She invited an old friend, Lulu Moppet, to the party; and a further type is equative, as in She invited Reginald Kenneth Dwight, Elton John, to the party. This paper argues that each type of nominal appositive comes from a reduced copular clause of a certain kind. Such a copular clause is base-generated as the complement of a categoryless functional head, like a low conjunct or a modifier. The combination of the reduced copular clause and the functional head is merged with, and categorized by, the matrix clause. Thus, a nominal appositive is not base-generated in the same proposition-denoting expression where its anchor occurs. Explicit steps of derivation for building a nominal appositive construction are proposed. The proposed syntactic derivations rule out unacceptable positions of nominal appositives. The research explores the general syntax of non-argument-taking relations.
In 1927, the city of Santa Barbara, California, began construction of a rubble mound breakwater to create a protected yacht harbor. The initial breakwater was an L-shaped structure that left a gap between the short “arm” of the breakwater and the shore, and engineers believed this configuration would allow sand to continue its normal movement along the coast.1 The engineers who designed the structure acknowledged that, “The design of a harbor on a sandy coast is one of the most difficult problems of engineering.” They anticipated some shoaling of the harbor and erosion of the beach to the east, particularly during storms.2 Their report framed the breakwater as an experiment in which trial-and-error would lead to an ideal harbor for the city, but they downplayed both risks and costs involved, including projecting that “the annual cost for maintenance will be negligible.”3 This optimism would prove badly misguided, as sand almost immediately began to fill the new harbor.
The establishment of rapid response teams (RRTs) has gained increasing prominence due to the growing threats of emerging infectious diseases, natural disasters, and other public health emergencies. As a center for Hajj and a regional hub for commerce and travel, the Kingdom of Saudi Arabia (KSA) faces distinct challenges. This study explores the Ministry of Health’s main reasons and challenges in establishing RRTs.
Methods
We employed a cross-sectional qualitative design, utilizing in-depth interviews with key stakeholders and document analysis to explore the historical process of establishing RRTs in KSA and the challenges encountered.
Results
Specialists’ insights revealed that the concept of RRTs was formally introduced and applied following the initiation of the Field Epidemiology Training Program (FETP) in KSA in 1989. However, its primary implementation began after the Middle East respiratory syndrome (MERS) outbreak in 2014. Identified challenges included a lack of trained personnel and resource availability due to unclear governance. There is a need for real-time data collection and technological solutions, improved inter-agency collaboration and information sharing, and governance.
Conclusions
The establishment of RRTs in KSA is estimated to have started with the initiation of the FETP. The challenges encountered provide valuable lessons for future emergency responses.
Inflammation has been implicated in psychosis, but its role in individuals at clinical (CHR) and genetic (GHR) high-risk remains unclear. We therefore conducted a network meta-analysis (NMA) to compare circulating cytokine levels across CHR, GHR, and healthy control (HC) groups.
Methods
We systematically searched multiple databases up to February 2025, extracting cytokine levels (plasma/serum) from CHR, GHR, and HC groups. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were estimated using random-effects models. Given that no direct head-to-head comparisons between CHR and GHR were available, indirect comparisons were performed through the common comparator (HC). The transitivity assumption was assessed by comparing key study and participant characteristics across comparisons.
Results
Thirty studies were included (CHR: 1601, GHR: 675, HC: 1980). NMA estimates indicated higher IL-6 levels in CHR compared with GHR, while IL-6 and IL-1β levels were lower in GHR compared with HC. In pairwise subgroup analyses, CHR converters showed higher IL-13 levels than non-converters. The evidence network was sparse and star-shaped, with all CHR–GHR estimates relying exclusively on indirect comparisons.
Conclusions
This study represents the first NMA to synthesize cytokine alterations in individuals at high risk for psychosis using indirect evidence. Elevated IL-6 in CHR individuals suggests immune activation, whereas reduced IL-6 in GHR may reflect a distinct immune profile. Increased IL-13 levels in converters highlight potential involvement of Th2-related pathways during transition to psychosis. However, the sparse nature of the evidence network necessitates cautious interpretation of the findings, and larger, standardized multi-center studies are required for confirmation.
Early-onset frontotemporal dementia (EO-FTD) presents before age 65 and is frequently misdiagnosed as psychiatric or behavioural disorders, delaying care.
Objective
This scoping review synthesizes research on EO-FTD’s earliest cognitive symptoms from patients, companions (family and friends), healthcare professionals, and cognitive tests to promote early detection.
Methods
A systematic search of six databases (Medline, Embase, CINAHL, PsycInfo, Scopus, and Proquest Dissertations and Theses) identified 2197 studies of which 16 met inclusion criteria, encompassing 663 EO-FTD participants.
Findings
A total of 35 unique cognitive symptoms were identified. Memory, attention, and executive dysfunction were most frequently reported. Symptom terminology varied widely, often mirroring cognitive test phrasing, limiting clinical applicability. Many studies relied on cognitive test scores rather than detailed symptom descriptions, with patient and companion reports underrepresented.
Discussion
The findings underscore the need for standardized nomenclature, improved assessment tools, and greater inclusion of patient and companion perspectives to enhance EO-FTD early diagnosis and intervention strategies.
Many theorists tie social norms to attitudes, such as expectations towards others, perhaps along with conforming practices. Challenging this view, we instead ground social norms in a social norming process, an often non-verbal social communication process that ‘makes’ the norm through mutual expressions of support. We present the process-based account of social norms and social normativity, and distinguish social norms from social pressures, social practices and Lewisian conventions. The process-based view brings social norms closer to legal norms, by tying them to ‘expressive acts’, just as laws and contracts arise through acts of voting or signing, not through mere attitudes.
Political and legal theorists have long been interested in how the principle of national self-determination emerged over the course of the twentieth century, particularly in relation to anti-colonial movements. In general, national self-determination has been associated with the anti-colonial turn to statehood, sovereignty, and representative government. This article recovers an anti-statist, anti-electoral theorization of self-determination from the work of Indian political thinker Radhakamal Mukerjee. I show how Mukerjee’s engagement with evolutionary theories of politics in the early twentieth century led him to depart from Indian nationalist appropriations of the discourse of self-determination in the aftermath of WWI. Mukerjee historicized state sovereignty, representative government, and individual rights as products of Western Europe’s trajectory of political development and constructed “Asia” as a region marked by anti-statist collectivism. The article thereby highlights the overlooked role of evolutionary arguments in forming a novel, anti-statist conceptualization of anti-colonial self-determination.