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During the perinatal period, women may be more susceptible to depressive symptoms because of fluctuating oestrogen levels. Genetic variations, epigenetic modifications and varying gene expression levels of oestrogen receptor genes may contribute to inter-individual differences in the encoded receptors’ sensitivity to oestrogen, ultimately modulating the susceptibility to depressive symptoms.
Aims
The aim of this systematic review was to provide an overview of the literature on the association between oestrogen receptor genes and perinatal depression symptoms by including genetic, epigenetic and gene expression studies.
Method
A systematic search of three public databases, PubMed, PsycINFO and Web of Science, was conducted in accordance with the PRISMA guidelines (PROSPERO registration number: CRD42023447446). Two independent reviewers extracted data and assessed study quality.
Results
A total of 29 studies were finally included, of which 16 investigated genetic variants, five investigated epigenetic modifications and eight investigated gene expression levels of oestrogen receptor genes. A limited number of genetic variations were found to be associated with perinatal depression symptoms, most of them in ESR1. Moreover, DNA methylation marks involved in oestrogen signalling, and gene expression levels of ESR1 and ESR2, were found to be associated with perinatal depression symptoms.
Conclusions
Genetic variations, epigenetic modifications and gene expression levels of oestrogen receptor genes are associated with susceptibility to perinatal depression symptoms. The underlying mechanism might be the inter-individual modulation of the encoded receptors’ sensitivity to oestrogen. Future research employing more comprehensive and integrative approaches is needed to better understand the aetiology of perinatal depression symptoms.
The recent proposal by NHS England to establish specialist mental health crisis centres has prompted considerable discussion. This editorial examines the initiative, which aims to reduce accident and emergency pressure and provide tailored care. However, it raises significant questions about the potential to exacerbate systemic fragmentation. Concerns highlight inadequate funding, the risk of resegregation of mental health from physical care and increased stigma if not properly integrated. This article argues that true holistic care requires seamless integration, advocating strongly for co-located mental health and medical emergency departments, which have shown improved outcomes. Ultimately, the success of these centres depends on addressing wider NHS issues, robust evaluation and a comprehensive vision prioritising the entire mental health pathway, from prevention to long-term recovery, to genuinely transform patient lives.
Social determinants of health (SDH) impact older adults’ ability to age in place, including their access to primary and community care services. Yet, older service users are infrequently consulted on the design and delivery of health services; when they are consulted, there is scant recruitment of those who are Indigenous, racialized and/or rural. This study aimed to identify SDH for socially and culturally diverse community-dwelling older adults and to understand their views on how primary and community care restructuring might address these SDH. We recruited a diverse group of 83 older adults (mean = 75 years) in Western Canada and compared quantitative and qualitive data. The majority resided rurally, identified as women, lived with complex chronic disease (CCD), had low income and/or lived alone; nearly a quarter were Indigenous or Sikh. Indigenous status correlated with income; gender correlated with income and living situation. Thematic analysis determined that income, living situation, living rurally, Indigenous ancestry, ethno-racial minority status, gender and transportation were the main SDH for our sample. Income was the most predominant SDH and intersected with more SDH than others. Indigenous ancestry and ethno-racial minority status – as SDH – manifested differently, underscoring the importance of disaggregating data and/or considering the uniqueness of ‘BIPOC’ groups. Our study suggests that SDH models should better reflect ageing and living rurally, that policy/decision makers should prioritize low-income and ethno-racial minority populations and that service providers should work with service users to ensure that primary and community care (restructuring) addresses their priorities and mitigates SDH.
Bias and discrimination influence the experience of many in health care, including antimicrobial stewardship providers. In this mixed-methods study, we explore the perceptions of bias and discrimination among antimicrobial stewards.
Methods:
We conducted a nationwide survey of stewardship providers including physicians, pharmacists, advanced practice providers, and trainees. Participants were recruited via convenience sampling using X and professional listservs during May and June 2023. We solicited steward and program demographics and responses to statements exploring bias and discrimination through a 67-item electronic survey (Qualtrics). We further explored these experiences through semi-structured interviews.
Results:
Of 211 responses, 204 participants were included. Approximately half had been practicing for 5 years or less, 65% identified as female, and 24% identified as nonwhite or multiracial. Half of female stewards (50%) reported experiencing bias or discrimination in their role as an antimicrobial steward compared to 26% of male stewards. When controlling for race and ethnicity, seniority, and credentials, females were 2.8 times more likely (95% CI, 1.5–5.4; P < 0.01) to have experienced bias or discrimination when performing stewardship duties. Themes from our 16 interviews illuminated sources of perceived bias against stewards, the impact they had, and strategies to mitigate the influence of these biases.
Conclusions:
Bias and discrimination are felt disproportionately by women and junior antimicrobial stewards and can lead to poor job satisfaction and a lack of perceived effectiveness. Acknowledging these experiences and equipping stewards with strategies to mitigate their effects should be a priority of institutions and professional societies.
This article critically examines the frequent claim that Pherecydes of Syros deliberately composed his treatise to be read figuratively. More specifically, it is argued that mythopoeic images from the sixth century BCE ought to be distinguished from Classical and Hellenistic allegories lest later categories and distinctions be anachronistically projected onto an archaic thinker. Since this study shows how mythopoeic images are used to fill conceptual gaps in abstract discourse, and how philosophical vocabulary arises in the process of metaphorization, its findings might have implications beyond the context of Pherecydes’ contribution to the development of the allegorical tradition.
Houses of worship are often shelters after the storm. Yet, as climate change fuels natural disasters and communities increasingly rely on congregations during disaster recovery, are houses of worship ready to be houses of refuge? Examining clergy influence, does a higher concern about climate change by clergy result in improved congregational disaster readiness? Data for the study come from a 2019 nationwide survey of clergy. The survey includes measures of congregational disaster preparedness along with one of the first applications of the SASSY climate concern measure to clergy. Results show that clergy have mixed opinions about climate change and that congregations led by high climate-concern clergy are no more prepared for disasters than those led by unconcerned clergy. While seemingly a null result, understanding the relationship between leaders, climate change, and disaster preparedness benefits the study of leader influence on organizations, religion and climate change, and the politics of disaster resilience.
The study of animal welfare is essential for undergraduates seeking to pursue careers with animals, yet pedagogical research on this topic is limited. While animal welfare is an accepted (albeit relatively new) scientific discipline, student views on animal welfare as a science require further exploration. This article reports the findings from a mixed-methods action research project undertaken at Harper Adams University (HAU) in the UK. Undergraduate student questionnaire responses (n = 123) revealed key attitudinal constructs related to animal welfare, and relationships to demographic factors. Students overwhelmingly defined animal welfare in terms of health; however, rural (compared to urban) students more often perceived ‘naturalness’ as important in the maintenance of good welfare. Notions of what constitutes good animal welfare appeared to be mediated by prospective career paths. For instance, veterinary nursing students were more likely to define animal welfare based upon resource-based measures and appropriate treatment of animals, which may link to their future role in educating clients on these topics. Finally, student attitudes toward animal welfare science revealed deeper epistemological views on the meaning of ‘science’. That is, natural sciences were seen as trustworthy; students invoked the Scientific Method and disciplines such as neurobiology to bring credence to animal welfare science. Conversely, aspects of animal welfare addressed by the social sciences were dismissed as unscientific. Based on these results, recommendations for action are proposed, which include further research into the attitudes of educators, strategies for engaging with dissatisfied student groups, and elevating the social sciences within animal welfare curricula.
This article studies the identification of complete economic models with testable assumptions. We start with a local average treatment effect ($LATE$) model where the “No Defiers,” the independent IV assumption, and the exclusion restrictions can be jointly refuted by some data distributions. We propose two relaxed assumptions that are not refutable, with one assumption focusing on relaxing the “No Defiers” assumption while the other relaxes the independent IV assumption. The identified set of $LATE$ under either of the two relaxed assumptions coincides with the classical $LATE$ Wald ratio expression whenever the original assumption is not refuted by the observed data distribution. We propose an estimator for the identified $LATE$ and derive the estimator’s limit distribution. We then develop a general method to relax a refutable assumption A. This relaxation method requires finding a function that measures the deviation of an econometric structure from the original assumption A, and a relaxed assumption $\tilde {A}$ is constructed using this measure of deviation. We characterize a condition to ensure the identified sets under $\tilde {A}$ and A coincide whenever A is not refuted by the observed data distribution and discuss the criteria to choose among different relaxed assumptions.
Field hospitals are deployable hospitals that treat patients directly on site before they are transported to permanent medical facilities. The supply of sterile surgical instruments is important, but not every field hospital is equipped with a sterile processing department. This concept therefore attempts to test a method of reprocessing surgical instruments under field conditions that can at least provide a provisional form of disinfection in case of logistic breakdowns.
Methods
Development, testing, and evaluation of a provisional chemical reprocessing procedure for reusable surgical instruments using hydrogen peroxide. The evaluation was carried out visually, microbiologically, and with regard to material damage.
Results
The concept is easy to implement but requires thorough training. The reprocessed surgical instruments were free of residual protein, showed no bacteriological growth, and were not damaged by the chemical reprocessing even after 10 cycles.
Conclusions
Provisional reprocessing of reusable surgical instruments seems possible using high-level chemical disinfection with hydrogen peroxide (3% for 150 minutes or 7.5% for 30 minutes) in case of necessity due to logistic breakdowns and patients that need immediate treatment. In addition, a multibarrier approach that includes hygiene measures and antibiotic stewardship is required to effectively reduce the risk of surgical site infections.
Workers with a vulnerable position on the labour market face difficulties finding and maintaining decent work. An increasing body of research on the demand-side of the labour market investigates the involvement of employers in active labour market policies, often referred to as employer engagement. However, the concept of employer engagement varies, causing ambiguity in its definition and use in research. This scoping review investigated sixty-three documents (e.g., peer reviewed scientific papers and grey literature) on employer engagement and outlines the current conceptualisations of employer engagement. By combining the conceptualisations taking a stakeholder-oriented approach, a four stakeholder group perspective on employer engagement was developed. With the organisation as an entity, HRM, line managers, and institutional stakeholders. This review deepens the understanding of employer engagement and contributes to the literature by taking an interdisciplinary approach and offers suggestions for future research.
People’s decisions may change when made in a foreign language (FL). Research testing this foreign language effect (FLE) has mostly used scenarios where uncertainty is expunged or reduced to a form of risk, whereas real-life decisions are usually characterized by uncertainty around outcome likelihood. In the current work, we aimed to investigate whether the FLE on decision-making extends to uncertain scenarios. Moreover, as it is still unclear what linguistic and psychological factors contribute to the FLE, we tested the effects of participants’ FL background, cognitive style and risk-taking attitude on decision processes under certain and uncertain conditions. Overall, we report null effects of language context (native versus foreign language) and problem condition (certain versus uncertain prospects) on participants’ choices. In addition, we found that both FL background and decision makers’ traits modulated participants’ choices in a FL, without emerging into the ‘classic’ FLE on decision-making. However, the direction of such effects was complex, and not always compatible with previous FLE theories. In light of these results, our study highlights the need to reconceptualize the FLE and its implications on decision-making.
Recent crises have cast doubt on the legitimacy of technocratic power, yet its role in global economic governance remains poorly understood. Revisiting the collapse of Bretton Woods, we propose a dynamic theory of global monetary governance to explain how expanding central bank discretion can destabilise systems. While most studies attribute the postwar system’s failure to power-political struggles, institutional weaknesses, or shifting economic ideas, they overlook the policies designed to manage and stabilise it. Drawing on historical institutionalism, we show how coordination tensions between rule-bound and discretionary policymakers – and the mutually reinforcing adaptation risks they faced – produced responses that appeared stabilising in the short term but ultimately eroded long-run stability. New archival evidence from the International Monetary Fund, Bank for International Settlements, and Organisation for Economic Co-operation and Development reveals how tools like the London Gold Pool and currency swap lines extended central bank power, concealed macroeconomic imbalances, and crowded out political momentum for structural reform. As technocratic authority grew misaligned with political support and functional economic adjustment, it became a liability. In building this theory, we highlight the sociological, agent-level sources of instability rooted in technocratic policy discretion and interpersonal ties among central bankers – challenging the dominant view that technocratic actors are inherently superior in managing global economic policy.
This article explores the evolution and shifting interpretations of the dissolution of the Kingdom of Hungary and the creation of its successor states as reflected in the historiographies of Central European nations. It analyses the complex interaction between politics and the socio-cultural milieu, on the one hand, and historiography, on the other. A palpable tension exists between the national narratives and the efforts to construct a commonly accepted story. Inspired by the entangled history approach, the paper identifies common features within these historiographies, which exist despite ostensibly distinct points of departure. Additionally, major interpretative trends in the area up to the present day are characterised, and the impact of the socio-cultural turn and the recent centenary of the First World War critically assessed. The article argues for the practicality of moderate national narratives, which should take into consideration recent developments in the discipline and can help bridge the divide between nation-states on sensitive issues.
The magnitude and duration of the COVID-19 pandemic has highlighted the need for countries to continuously reflect and improve on their ongoing response. The World Health Organization (WHO) introduced the guidance for conducting COVID-19 intra-action reviews (IARs) in July 2020. As of November 25, 2022, 136 IARs have been conducted by 78 countries in all 6 WHO regions. IARs are country-led and outcomes country-owned, with the flexible methodology enabling countries to focus on COVID-19-related priority issues in their national and subnational contexts. WHO’s approach to promoting the use of IARs recognizes the importance of 3 learning modalities: countries learning through self-reflection, countries learning from each other, and WHO and partners learning from countries to improve WHO guidance and tools. Moving forward, the value of reflective learning in public health emergencies can be further enhanced by institutionalizing an ongoing learning mindset and translating reflective learning-based recommendations into policy change and action.
Nineteenth-century sanitary and burial reform were motivated by public health concerns and transformed the Victorian landscape with two forms of new infrastructure: sewers and out-of-town cemeteries. However, the history of burial reform ‘always sat awkwardly’ (in the words of Julie Rugg) with that of sanitary reform. In this article, we re-examine the campaigning career of George Alfred Walker (1807–84), a surgeon-apothecary who made public health the core of his argument for burial reform, to demonstrate that burial and sanitary reform were deeply intertwined via sanitary science, politics and science communication. We argue that Walker represented city graveyards as a nuisance similar to poor sewerage, utilising Thomas Southwood Smith’s heterodox fever theory to make his argument amenable to Edwin Chadwick’s goals and solutions: infrastructure ahead of poor relief. Walker’s solutions gave the medical profession positive reasons to support sanitary reform, as they proffered much-needed employment via burial reform. At the same time, his extremely active and varied campaigning throughout the 1840s took inspiration and strategy from the broader sanitation movement. By providing a comprehensive account of his campaigning for the first time, we show that sanitary reform politics was central to changing British burial management as a contested scientific theory was utilised to fit political ends.
Cognitive intra-individual variability (IIV) is a neuropsychological marker reflecting divergent performance across cognitive domains. In this brief communication, we examined whether clinical severity, apolipoprotein E (APOE) ε4 carriers, and higher polygenic risk were associated with higher cognitive IIV, and whether higher polygenic risk and cognitive IIV synergistically influence clinical severity.
Method:
This large study involved up to 24,248 participants (mean age = 72) from the National Alzheimer’s Coordinating Center (NACC) and multiple regression controlling for age, sex, and education was used to analyze the data.
Results:
We found that disease severity (B = 0.055, SE = 0.001, P < 0.001), APOE ε4 carriers (B = 0.02, SE = 0.003, P < 0.001), and higher polygenic risk (B = 0.02, SE = 0.004, P < 0.001) were associated with higher cognitive IIV. Polygenic risk and cognitive IIV also interacted to influence clinical severity, beyond APOE ε4 (B = 0.11, SE = 0.05, P = 0.02), such that individuals with high polygenic risk and cognitive IIV had the greatest clinical severity.
Conclusions:
Heightened polygenic risk and increased cross-domain cognitive variation are implicated in dementia and may impact clinical decline in tandem.
Social isolation and loneliness have been linked to adverse health outcomes such as depression in old age. However, limited data exist on the association of loneliness and social isolation with probable depression (PD) in low- and middle-income countries (LMICs), while psychosocial mediators are largely unknown. This study investigates the individual and joint associations of social isolation and loneliness with PD among older adults in Ghana. It quantifies the extent to which psychosocial factors mediate the associations. Cross-sectional data from the Aging, Health, Well-being, and Health-seeking Behaviour Study were analyzed. PD was defined as moderate to severe depressive symptoms with the Center for Epidemiologic Studies Depression (CES-D-9) scale. Loneliness and social isolation were assessed with the University of California, Los Angeles 3-item loneliness scale and the Berkman-Syme Social Network Index, respectively. Multivariable logistic models and PROCESS macro bootstrapping mediation analyses were performed. Among the 1,201 adults aged ≥50 years (Mage = 66.1 ± 11.9 years, 63.3% women), 29.5% PD cases were found. The prevalence of social isolation and loneliness was 27.3% and 17.7%, respectively. Loneliness (OR = 3.15, 95% CI = 3.26–5.28) and social isolation (OR = 1.24, 95% CI = 1.10–1.41) were independently associated with higher odds of PD. The loneliness and PD association was modified by spatial location (Pinteraction = 0.021); thus, the association was more pronounced in rural areas (OR = 7.06) than in urban areas (OR = 3.43). Psychosocial factors (e.g. sleep problems) mediated the loneliness/social isolation and PD association. Loneliness and social isolation were independently associated with a higher likelihood of PD, and psychosocial factors mediated the associations. Interventions to reduce PD in later life should also consider addressing loneliness and social isolation, as well as sleep problems.
Soil acidity and the decline in organic matter content of the soil are among the major yield-limiting factors in the northwest highlands of Ethiopia. Therefore, a 4 × 4 factorial field experiment was conducted in a randomized complete block design in two dry seasons, under irrigation at the Koga Irrigation Scheme, in northwestern Ethiopia to examine the effect of carbonized rice husk application timing (CRHT) and soil amendments (SAs) on water use efficiency, lodging, and yield of tef. Treatments were four SAs: without SA (control), compost (10 t ha−1), lime (2.5 ton ha−1), and 10 t ha−1 compost + 2.5 t ha−1 lime (CL); four CRHT: control (no application), whole rate during sowing (CRHT2), equal splitting during sowing and tillering (CRHT3), and whole rate during tillering (CRHT4), with a total of 16 treatment combinations, replicated four times. The pooled mean ANOVA results showed that the SA significantly influenced lodging index (p < 0.01), leaf area index (p < 0.001), and aboveground biomass yield (p < 0.01), but not water use efficiency, plant height, panicle length, and number of plants per square meter (p > 0.05). The CRHT only significantly (p < 0.05) influenced chlorophyll content. The effect of lime on grain, aboveground biomass, and straw yield parameters was statistically similar to the application of compost. Compost and CL showed significantly increased sensitivity of tef to lodging, which ranged from 46.2% to 65.9%, compared with lime and control treatments. In conclusion, the application of CL significantly improved tef grain, aboveground biomass, and straw yields by 12.1%, 14.5%, and 15.2%, compared with lime, 12.3%, 9.3%, and 8.4%, respectively, from the control treatment.