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The authors examine the 1910, 1920, 1930, and 1940 US censuses to identify demographic characteristics of children who resided in public and private institutions for minors, with special attention to patterns of racial segregation and exclusion. The article focuses on public and private institutions founded exclusively to serve children and youth and also on correctional institutions for children and adults. The authors found racial segregation in private institutions, underrepresentation of children of color in both private and public institutions, and overrepresentation of boys of color in correctional institutions for minors and adults. They also identified a historical pattern, with few exceptions, of excluding girls of color from all types of public and private institutions.
This paper examines the impact of weather conditions on wheat production in the Florence and Siena regions in the early modern age, emphasizing the need to contextualize this influence within historical, geographical, and economic frameworks. Our quantitative findings suggest that, on average, hotter and wetter spring and summer weather conditions were beneficial for wheat yields in early modern Tuscany, though this relationship holds true only within a certain optimal range; otherwise, extreme conditions are detrimental. However, the boundaries between optimal and non-optimal conditions vary based on the historical, economic, and geographical context, ultimately determining the level of agricultural productivity. Specifically, we argue that two macro causes – primary production factors and the degree of market volatility – play a crucial role in shaping the effects of weather on agricultural outcomes. First, soil conditions, technology (broadly defined), and capital-labour ratios are the most significant determinants of agricultural productivity. Second, competitive and integrated markets, when supported by countercyclical institutions – in our case, the annona system – can mitigate the negative consequences of adverse weather by reducing the resulting volatility. Where such institutions are weak or absent, speculation (i.e., hoarding), driven by price expectations under high volatility, may arise and amplify disruptions.
Certain prescription drugs used during pregnancy are associated with offspring autism spectrum disorder (ASD). Nonetheless, ASD risk following prenatal exposure to most drugs remains unknown. Furthermore, methodological challenges and ethical concerns hinder the scope for causal inference.
Methods
We used a case-cohort study design of a nationally representative sample from Israel to examine the associations between maternal prescription drug use during pregnancy and offspring ASD. To scrutinize these associations, the analyses were (a) adjusted for indication proxy (level 2 Anatomical Therapeutic Chemical (ATC) codes), (b) repeated using shared pharmacological targets as exposures, and (c) inspected further through target-enrichment analysis.
Results
The sample included 1,400 individuals with and 94,713 without an ASD diagnosis. Among all drugs prescribed during pregnancy, five were statistically significantly associated with increased offspring ASD risk after adjustment for indication proxy (e.g., hazard ratio [95% confidence interval] cyproterone = 2.71 [1.17–6.25] and prednisolone = 2.10 [1.27–3.49]), and two with decreased risk (ferrous sulfate = 0.82 [0.68, 0.99] and lynestrenol = 0.43 [0.2, 0.93]). Further analysis revealed four pharmacological targets shared by these drugs, which were themselves associated with ASD (e.g., neuronal acetylcholine receptor α4β4 = 1.45 [1.05–1.99] and serotonin 2b receptor = 1.31 [1.04–1.61]). Enrichment analysis suggested the association between ASD and medications affecting cholinergic and serotonergic signaling.
Conclusions
Increased ASD risk followed prenatal exposure to five prescription drugs, and decreased risk followed exposure to two. Subsequent analyses suggested no confounding by indication in these associations, but further studies are warranted.
Schizophrenia is a severe mental disorder with heterogeneous outcomes that depend heavily on symptom stability as a prerequisite for psychosocial rehabilitation and reintegration. Long-acting injectable antipsychotics (LAIs) are a relevant treatment tools that can help advance meaningful outcomes through improved antipsychotic adherence and relapse prevention, deliver pharmacokinetic advantages less achievable with oral formulations, improve patient autonomy, increase functioning, and reduce the risk of premature mortality even more than oral antipsychotics. However, LAIs remain largely underutilized. Non-modifiable and modifiable risk factors for relapse are summarized, potential advantages and disadvantages of LAIs are reviewed, and myths and misconceptions regarding LAIs are outlined and contrasted with evidence. This information is crucial when engaging in shared decision-making and motivational interviewing to educate patients and caregivers about the treatment option of LAIs, including in early illness stages. Since the first episode and early phases of schizophrenia are a defining time, choosing treatments with the greatest potential for improved outcomes is key. In adults with multi-episode schizophrenia, LAIs have shown superiority over oral antipsychotics for relapse/hospitalization and a variety of multiple other efficacy, effectiveness, functionality, and survival metrics. Additionally, LAIs have shown superiority over oral antipsychotics in patients with first-episode/ or early-phase illness, at least in meaningful subgroups of studies and patients that point toward superiority in settings, individuals, and treatment paradigms that more closely match clinical care. Based on this evidence, hesitancies to discuss and offer LAIs in clinical care need to be overcome, framing LAIs not as a last resort but a viable first-line/earlyphase treatment option that can meaningfully transform the long-term course of schizophrenia.
Parental criminality is a risk factor for crime, but little is known about why some individuals exposed to this risk refrain from crime. We explored associations of resting heart rate (RHR), systolic blood pressure (SBP), cognitive ability (CA), and psychological functioning (PF) with criminal convictions among men with a convicted parent, accounting for unmeasured familial factors in sibling analyses. Data were obtained from Swedish registers, including all men born in Sweden between 1958 and 1992 with a convicted parent (N = 495,109), followed for up to 48 years. The potential protective factors were measured at mandatory conscription. Outcomes were conviction of any, violent, and non-violent crime. Survival analyses were used to test for associations, adjusting for measured covariates and unmeasured familial factors. Higher levels of RHR, SBP, CA, and PF were associated with reduced risk of criminality after adjusting for covariates. RHR associations were largely explained by familial factors. CA and PF associations were not due to sibling-shared confounders, in line with a causal interpretation. SBP results, indicating a protective effect against non-violent crime, warrant further investigation.
Continuous monitoring of the mass balance of the Greenland ice sheet is crucial to assess its contribution to the rise of sea levels. The GRACE and GRACE-FO missions have provided monthly estimates of the Earth’s gravity field since 2002, which have been widely used to estimate monthly mass changes of ice sheets. However, there is an 11 month gap between the two missions. Here, we propose a data-driven approach that combines atmospheric variables from the ERA5 reanalysis with GRACE-derived mass anomalies from previous months to predict mass changes. Using an auto-regressive structure, the model is naturally predictive for shorter times without GRACE/-FO observations. The results show a high r2-score (> 0.73) between model predictions and GRACE/-FO observations. Validating the model’s ability to reproduce mass anomalies when observations are available builds confidence in estimates used to bridge the GRACE and GRACE/-FO gap. Although GRACE and GRACE-FO are treated equally by the model, we see a decrease in model performance for the period covered by GRACE-FO, indicating that they may not be as well-calibrated as previously assumed. Gap predictions align well with mass change estimates derived from other geodetic methods and remain within the uncertainty envelope of the GRACE-FO observations.
Let G be a locally compact, Hausdorff, second countable groupoid and A be a separable, $C_0(G^{(0)})$-nuclear, G-$C^*$-algebra. We prove the existence of quasi-invariant, completely positive and contractive lifts for equivariant, completely positive and contractive maps from A into a separable, quotient $C^*$-algebra. Along the way, we construct the Busby invariant for G-actions.
Newgrange, the Neolithic monument and centerpiece of the Brú na Bóinne UNESCO World Heritage complex, is a high-profile example of prehistoric societies’ observation of, and reverence for, solar events. Comparatively little is known about how these concepts were remembered by those using Newgrange over subsequent millennia. While excavations have uncovered large quantities of later material culture, debate continues about what these subsequent activities represent. We combine zooarchaeological, radiocarbon, and isotopic evidence to assess the nature and seasonality of human–animal–environment relationships at Newgrange. Results show a concentration of feasting activity, focused on pigs, dating to 2600–2450 BC and indicate that most pigs were slaughtered shortly after a period of rapid, pannage-fueled weight gain. This seasonal specificity indicates feasting likely occurred in the weeks around the winter solstice and suggests that, centuries after passage tomb construction ended, practices at Newgrange continued to focus on the general winter solstice timeframe. We also connect a unique isotopic signature for mast (tree nuts) with pannage husbandry, a pattern that should allow for reinterpretation of archaeological pig diets and human–woodland relationships across Europe.
This paper examines rates of physical restraint and seclusion under the Mental Health Act 2001 in acute adult psychiatry inpatient facilities (“approved centres”) in Ireland.
Methods:
Analysis of rates of physical restraint and seclusion in acute adult approved centres in Ireland in 2023, based on data made publicly available by the Mental Health Commission, Health Research Board, and Central Statistics Office.
Results:
Rates of physical restraint vary 16-fold between approved centres, ranging from 116 episodes of physical restraint per 100,000 population per year to 7 per 100,000 population, with a national rate of 39 per 100,000 population. Among the six approved centres with the highest rates of physical restraint, five are in Dublin (i.e. urban). Among approved centres that use seclusion, rates vary 19-fold, ranging from 38 episodes of seclusion per 100,000 population to 2 per 100,000 population, with a national rate of 15 per 100,000 population.
Conclusions:
There are within-country variations in rates of physical restraint and seclusion in Ireland, but these are of a lesser magnitude than between-country variations. Overall, Ireland’s rates of restrictive practices are lower than those in other jurisdictions, consistent with Ireland’s low rate of involuntary admission. Future research could usefully focus on the relationship between restrictive practices and urbanicity, among other themes.
This analysis evaluated potential differences in subjective well-being (SW) among patients with early-phase schizophrenia (SZ) randomized to treatment with either long-acting injectable (LAI) or oral aripiprazole or paliperidone within the “European Long-acting Antipsychotics in Schizophrenia Trial” (EULAST).
Methods
A total of 478 patients were followed for up to 19 months. SW was measured using the Subjective Well-being under Neuroleptic Treatment scale (SWN). Linear mixed-effects models assessed treatment differences. Comprehensive analyses included age, sex, symptomatology (Positive and Negative Syndrome Scale [PANSS]), and side effects (Systematic Monitoring of Adverse Events Related to Treatments [SMARTS] and St. Hans rating scale [SHRS] for extrapyramidal syndromes) on SWN changes.
Results
Overall, SW improved over the course of the study. No significant differences emerged between LAI and oral administration (p = 0.1533) or between aripiprazole and paliperidone (p = 0.2008). Similarly, age and sex were not relevant in this regard. In contrast, negative, positive, and affective symptoms (all p < 0.0001) as well as the overall side effect burden (SMARTS sum-score, p < 0.0001) showed significant inverse associations with SW. Certain SHRS subscales correlated with SW in partial models, but associations disappeared in the fully adjusted model.
Conclusions
Patients with SZ initiating LAI or oral treatment with aripiprazole or paliperidone reported comparable SW improvements. Findings emphasize that treatment choice should be guided less by formulation or substance and more by individual patient needs, prioritizing symptom control while minimizing adverse effects. A patient-centered approach remains essential to optimize both clinical outcomes and subjective well-being in early-phase SZ.
Hookworms are common parasites of Eurasian badgers (Meles meles), typically identified as Uncinaria criniformis. The taxonomic distinction from Uncinaria stenocephala, a species found in dogs and foxes, has long been debated. In this study, we molecularly characterized U. criniformis from a Eurasian badger in Romania using genome skimming. We assembled the complete mitochondrial genome and internal transcribed spacer (ITS) rDNA region from 2 adult hookworms morphologically consistent with U. criniformis. Phylogenetic analysis of 12 mitochondrial protein-coding genes demonstrated strongly supported clade of U. criniformis with Ancylostoma spp. ITS rDNA and cox1 sequence comparisons revealed only 92.4–92.8% and 88.0–88.5% identity, respectively, between U. criniformis and U. stenocephala, confirming their molecular distinctiveness. In contrast, our sequences showed >99% identity to sequences from Arthrostoma leucurus, a hookworm recently described from the Asian badger (Meles leucurus), suggesting conspecificity. These findings support the validity of U. criniformis as a distinct species parasitizing M. meles, and we propose A. leucurus as a junior synonym of U. criniformis. Our results highlight the polyphyly of the genus Uncinaria and point to the need for broader mitogenomic sampling of hookworms. The molecular markers generated here provide a reference for future parasitological surveys and wildlife disease studies.
Should people be protected by law from discrimination on the grounds of political affiliation and belief? I argue that individuals’ democratic right to exercise political agency – which implies freedom of association and freedom to express one’s political belief – requires that individuals should not be vulnerable to being treated disadvantageously because of their political affiliation and belief. To accomplish this, the protectorate of discrimination law should be expanded where relevant to include that characteristic. Moreover, in contexts where political and specifically affective polarisation is severe, the risk of such treatment increases, further justifying the legal innovation. While this thesis has received almost no prior discussion in the literature on the normative justification of discrimination law, and is revisionary in the UK and the USA, this absence is striking both in a comparative legal context and especially given the centrality of these freedoms to democratic politics.
Heirs’ property is a form a land tenure that can negatively impact landowners, particularly those who want to use their land for agricultural purposes. Over the past decade there has been an increase in legal reforms and assistance programs aimed at addressing issues associated with heirs’ property. Yet, this phenomenon has received little attention in the applied economics literature. With the aim of motivating future economic research, we make the following two contributions. First, we synthesize the existing multi-disciplinary literature on heirs’ property into an economically tractable framework. Second, we use parcel-level tax record data from 2015 and 2021 to track changes to the amount of heirs’ property over time and examine its rate of formation net of land leaving heirs’ property. We examine the changes to heirs’ property on non-agricultural and agricultural parcels (and the number of acres of land within parcels) separately. We find that the total number of parcels and acres, on non-agricultural lands, declined by about one percent and six percent, respectively. Whereas, acreage on heirs’ property agricultural lands decreased by about two percent. These small changes mask large transitions in and out of heirs’ property. Our estimates suggest that the formation of heirs’ property persists today and offsets most of the reductions obtained from land leaving heirs’ property. Additional analysis reveals significant heterogeneity across regions and localities.
Analysis of feeder and early weaned pig markets, important segments in pork production, is nearly nonexistent. We derive and estimate a structural econometric model relating demand and supply for market hogs, feeder pigs, and early weaned pigs. Estimates from the econometric model predict how disruptions are transmitted through hog and pig markets. Results indicate that hog and pig markets are most sensitive to hog processing plant utilization relative to capacity and that this sensitivity has increased compared to prior estimates. A set of counterfactual scenarios quantify the effects of shocks to hog processing capacity, wholesale pork demand, and supply response.
Epistemic democrats indirectly evaluate democratic decisions by directly evaluating the inputs into the election. However, the fundamental problem of measurement in the philosophy of science shows that procedures are often as difficult to evaluate as outcomes. This paper brings this highly refined framework into political philosophy to show that epistemic democrats face an analogous ‘fundamental problem of evaluation’. This cross-fertilization of political philosophy with the philosophy of science shows that the quality of democratic mechanisms and their inputs regarding their ability to track the truths of justice is as difficult to evaluate as the quality of the resulting decisions themselves.
The efficiency of polymerase chain reaction (PCR) decreases under suboptimal conditions, such as low template concentration combined with high concentrations of similar sequences. Under these circumstances, mis-priming can occur, leading to the generation of erroneous copies. Specifically, in 16S amplicon sequencing of human intestinal biopsy samples, host off-target sequences are frequently generated and subsequently sequenced, particularly when the commonly used V3-V4 primers are employed. This issue not only introduces errors in data interpretation but also results in the unnecessary consumption of sequencing depth. In response to this challenge, we analysed over 1,300 publicly available V3-V4 amplicon sequences related to the human colon, profiling the colon microbiota while elucidating the biases introduced by host off-targets. Briefly, our findings reveal that unaddressed host DNA contamination can lead to false bacterial identifications and obscure significant differences in microbiota composition. Furthermore, we identified human sequences on chromosomes 5, 11, and 17 as the main contributors to the majority of off-target sequences. Finally, we suggest practical approaches to mitigate this issue without altering the original protocol design, retaining the widely used V3–V4 primers. In particular, using a C3 spacer-modified nucleotide targeting the off-target sequence is here proposed as a promising strategy acting upstream of the off-target generation.
To compare temporal trends, variation, and correlations between antibiotic use metrics across U.S. neonatal intensive care units (NICUs) and assess associations with mortality.
Methods:
We conducted a retrospective cohort study of 438,156 infants admitted to 272 NICUs from 2017 to 2021 using the Premier Health Database. Antibiotic use rate (AUR), days of therapy (DOT), and antibiotic spectrum index (ASI) per 1,000 patient or therapy days were calculated both cumulatively by year and at the center level. Mixed-effects models adjusted for center-level characteristics were used for all analyses.
Results:
All three metrics declined over time: AUR by 16.8%, DOT by 19.0%, and ASI by 2.5%. AUR and DOT were highly correlated (r = 0.989, P < 0.001), while ASI showed weaker correlations with AUR (r = 0.247, P < 0.001) and DOT (r = 0.338, P < 0.001). None were significantly associated with center-level mortality. ASI had the least variability, indicating more uniform antibiotic selection and lower center-level discriminatory value.
Conclusions:
DOT and AUR were comparable measures of antibiotic consumption, both showing significant declines. ASI exhibited the least variability, reflecting more consistency in antibiotic selection. The similarity in dispersion and decline between AUR and DOT suggests that neonatal antibiotic exposure is primarily influenced by initiation and discontinuation decisions rather than regimen complexity. Given its ease of calculation, AUR may be the most practical metric for evaluating the impact of antibiotic stewardship interventions at the center level.
Max Nicholls had an almost unique experience as a medical practitioner, researcher and teacher of medical genetics. An earlier paper described his contribution to the etiology of neurofibromatosis. This was followed by Nicholls’ own experience as lecturer in the Faculty of Medicine, University of New South Wales, Australia. This note draws attention to his research in immunology. For example, he was instrumental in the study of the buffy coat leuko-agglutination (BCLA) test, a sensitive assay for cell-mediated immunity that he introduced to detect conditions (including cancer) in preclinical stages.
To estimate the coexistence of autism spectrum disorder (ASD) traits in an adult sample diagnosed with attention-deficit/hyperactivity disorder (ADHD); to compare individuals with ASD traits to those without, in terms of functionality, quality life and clinical outcomes; to explore the effects of ADHD medication on three main outcomes (clinical, quality of life, and functionality) in those with only ADHD and in those with coexistence of ASD and ADHD
Methods:
Prospective longitudinal study of an adult sample diagnosed with ADHD. Data were collected on age, gender, medications and on scales: Autism Spectrum Quotient (AQ-10); Adult ADHD Clinical Outcome Scale; Adult ADHD Quality of Life Questionnaire; Weiss Functional Impairment Rating Scale.
Results:
A sample of 165 participants was recruited. The AQ-10 showed that almost half, n = 74 (44.8%) of the participants had traits of ASD. Longitudinal analyses demonstrated that people with ADHD and ASD traits have worse clinical outcomes, quality of life, social skills, and family functioning, compared to those with ADHD only.
Conclusions:
The study shows a high rate of co-existence of ASD in adults with ADHD. Comorbid ASD traits were associated with poorer overall clinical and functional outcomes, quality of life, social skills, and family functioning. Study limitations with particular reference to dropout rate are considered. Implications for improving services are discussed.