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Under what conditions are people more likely to support judicial invalidation of legislative acts? We theorize that constitutional recency confers greater democratic legitimacy on constitutional provisions, reducing concerns that judges may use dated language to impose their own will on a living majority. Exploiting differences among US state constitutions, we show in a pre-registered vignette experiment and conjoint analysis that Americans are more supportive of judicial review and original intent interpretation when presented with a younger constitutional provision or constitution. These results imply that Americans might alter their approach to the US Constitution if it were changed as easily and as often as a typical state constitution.
Cestodiases, like echinococcoses and cysticercoses, represent a global health problem. Currently available anthelmintics, as benzimidazoles and praziquantel, have limited effectiveness against these cestodiases, creating a demand for the identification of new and more effective drugs. Here, the potential of statins (simvastatin and fluvastatin), for repositioning as novel anthelmintic is explored. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a main enzyme in the mevalonate pathway, which is vital for the synthesis of non-steroidal isoprenoids and the maintenance of normal cell functioning. A survey for HMG-CoA reductase encoding genes showed that they are present in a single copy in the genomes of parasitic helminths and their mammal hosts. Sequence alignments and phylogenetic analyses showed 20–95% overall identities among ortholog HMG-CoA reductases, with special conservation of their catalytic domains. The HMG-CoA reductase 3D-structure was predicted for orthologs from 3 cestodes of medical importance (Echinococcus multilocularis, Echinococcus granulosus sensu lato, and Taenia solium), and from a model cestode species (Mesocestoides corti). Molecular docking between cestode HMG-CoA reductase orthologs with simvastatin demonstrated that the Arg, Ser, Lys, and Glu residues in conserved positions of the active site interact with this drug, similarly to the interactions predicted for the human reference ortholog enzyme. Furthermore, in vitro assays demonstrated that simvastatin produced a significant reduction of M. corti viability, being able to reduce 100% of parasite viability at 150 μm. Fluvastatin was also assessed showing a lower, although significant anthelmintic effect. The predicted overall structures and interactions together with in vitro assays suggest that cestodes HMG-CoA reductases are inhibited by simvastatin, being a potential therapeutic target for the repurposing of simvastatin as anthelmintic drug. Furthermore, these results pave the way for the in vivo evaluation of the potential effects of simvastatin on cestode larvae.
This study investigated the role of temperament in oral language development in over 200 Mandarin and Cantonese speakers in the Growing Up in New Zealand pre-birth longitudinal cohort study. Mothers assessed infant temperament at nine months using a five-factor Infant Behaviour Questionnaire-Revised Very Short Form. They also reported on children’s vocabulary and word combinations at age two using adapted MacArthur-Bates Communicative Development Inventory short forms. Regression analyses were employed to examine unique links between infant temperament and language, respectively, controlling for demographic factors. Fear was associated with larger English vocabularies for English-Mandarin speakers and larger Cantonese vocabularies for Cantonese speakers. Orienting capacity was associated with more advanced word combinations for Mandarin speakers, whereas negative emotionality was associated with less advanced word combinations for Cantonese speakers. Positive affect/surgency was associated with more advanced word combinations for English-Cantonese speakers. This study revealed predictive patterns of infant temperament across Chinese-speaking children’s multiple languages.
Gas furnaces are the prevalent heating systems in Europe, but efforts to decarbonize the energy sector advocate for their replacement with heat pumps. However, this transition poses challenges for power grids due to increased electricity consumption. Estimating this consumption relies on the seasonal performance factor (SPF) of heat pumps, a metric that is complex to model and hard to measure accurately. We propose using an unpaired dataset of smart meter data at the building level to model the heat consumption and the SPF. We compare the distributions of the annual gas and heat pump electricity consumption by applying either the Jensen–Shannon Divergence or the Kolmogorov–Smirnov test. Through evaluation of a real-world dataset, we prove the ability of the methodology to predict the electricity consumption of future heat pumps replacing existing gas furnaces with a focus on single- and two-family buildings. Our results indicate anticipated SPFs ranging between 2.8 and 3.4, based on the Kolmogorov–Smirnov test. However, it is essential to note that the analysis reveals challenges associated with interpreting results when there are single-sided shifts in the input data, such as those induced by external factors like the European gas crisis in 2022. In summary, this extended version of a conference paper shows the viability of utilizing smart meter data to model heat consumption and seasonal performance factor for future retrofitted heat pumps.
We study the $\mathscr {D}\mathrm {isc}$-structure space $S^{\mathscr {D}\mathrm {isc}}_\partial (M)$ of a compact smooth manifold M. Informally speaking, this space measures the difference between M, together with its diffeomorphisms, and the diagram of ordered framed configuration spaces of M with point-forgetting and point-splitting maps between them, together with its derived automorphisms. As the main results, we show that in high dimensions, the $\mathscr {D}\mathrm {isc}$-structure space a) only depends on the tangential $2$-type of M, b) is an infinite loop space, and c) is nontrivial as long as M is spin. The proofs involve intermediate results that may be of independent interest, including an enhancement of embedding calculus to the level of bordism categories, results on the behaviour of derived mapping spaces between operads under rationalisation, and an answer to a question of Dwyer and Hess in that we show that the map $\mathrm {BTop}(d)\rightarrow \mathrm {BAut}(E_d)$ is an equivalence if and only if d is at most $2$.
Prandtl's secondary flows of the second kind generated by laterally varying roughness are studied using the linearised Reynolds-averaged Navier–Stokes approach proposed by Zampino et al. (J. Fluid Mech., vol. 944, 2022, p. A4). The momentum equations are coupled to the Spalart–Allmaras model while the roughness is captured by adapting established strategies for homogeneous roughness to heterogeneous surfaces. Linearisation of the governing equations yields a framework that enables a rapid exploration of the parameter space associated with heterogeneous surfaces, in the limiting case of small spanwise variations of the roughness properties. Channel flow is considered, with longitudinal high- and low-roughness strips arranged symmetrically. By varying the strip width, it is found that linear mechanisms play a dominant role in determining the size and intensity of secondary flows. In this setting, secondary flows may be interpreted as the time-averaged output response of the turbulent mean flow subjected to a steady forcing produced by the wall heterogeneity. In fact, the linear model predicts that secondary flows are most intense when the strip width is about 0.7 times the half-channel height, in excellent agreement with available data. Furthermore, a unified framework to analyse combinations of heterogeneous roughness properties and laterally varying topographies, common in applications, is discussed. Noting that the framework assumes small spanwise variations of the surface properties, two separate secondary-flow-inducing source mechanisms are identified, i.e. the lateral variation of the virtual origin from which the turbulent structure develops and the lateral variation of the streamwise velocity slip, capturing the acceleration/deceleration perceived by the bulk flow over troughs and crests of non-planar topographies.
The aim of this study was to analyse the validity and reliability of the Turkish version of the renal inpatient nutrition screening tool (Renal iNUT) for haemodialysis patients. The Renal iNUT and the malnutrition universal screening tool (MUST) were used in adult haemodialysis patients at two different centres to identify malnutrition. The subjective global assessment (SGA), regarded as the gold standard for nutritional status assessment, was utilised for comparison. Structural validity was assessed using biochemical values and anthropometric measurements, while reliability was assessed using repeated the Renal iNUT assessment. Of the 260 patients admitted, 42·3 % were malnourished (SGA score was B or C). According to the Renal iNUT, 59·6 % of the patients were at increased risk for malnutrition (score ≥ 1) and 3·8 % required referral to a dietitian (score ≥ 2). According to the MUST, 13·1 % of the patients were at increased risk for malnutrition and 8·5 % required referral to a dietitian. The Renal iNUT was found to be more sensitive in detecting increased risk of malnutrition in haemodialysis patients compared with the MUST (59·6 % v. 13·1 %). According to the SGA, the sensitivity of the Renal iNUT is higher compared to the MUST (89 % and 45 %, respectively). Kappa-assessed reliability of the Renal iNUT was 0·48 (95 % CI, 0·58, 0·9) and a moderate concordance was observed. The Renal iNUT is a valid and reliable nutritional screening tool for evaluating haemodialysis patients to determine their nutritional status. The use of the Renal iNUT by dietitians will contribute to the identification of malnutrition and its treatment.
Previous research has found that individuals harboring hostile sexist attitudes are more likely to support the use of political violence. In this study, we examine this relationship further. We theorize that the impact of hostile sexism on support for political violence is mediated through two mutually reinforcing factors: social dominance orientation and political illiberalism. We test this argument using an original survey we administered to over 1,400 subjects in the United States. We employ two operationalizations of individuals’ support for political violence: support in the abstract and support for specific acts of political violence. We find that individuals who exhibit hostile sexism are substantially more likely to support political violence, both abstract and specific. Moreover, we find that both social dominance orientation and political illiberalism together mediate 64.9% of the effect of hostile sexism on support for political violence in the abstract and 80.5% of the effect on support for specific acts of political violence. We conclude with a discussion of the implications of these findings.
Digital multimodal composing (DMC) has been valued as an engaging pedagogy in language teaching and learning in recent decades. Although research on DMC is flourishing and evidences its benefits for students' development as second language (L2) users and writers, there are some missing links between research findings and classroom practices. In this article, we examine three kinds of relationships between research and practice with regard to DMC: areas in which research findings have not been well applied, areas in which research findings have been reasonably well applied, and areas in which research findings have been usefully applied. As recent research–practice frameworks in education research emphasize a collaborative relationship between researchers and practitioners, we argue that L2 writing researchers' and teacher educators' reflections and experiences are crucial to facilitate the dialogue between DMC research and practice in writing contexts. We suggest that DMC should be incorporated into L2 teacher education programs so that instructors are equipped with the necessary knowledge and competence to design, implement, and assess students' DMC productions.
When considering the implications of the shareholder-stakeholder debate in defining the purpose of a company, epistemological clarity is vital in this emerging theory of the firm. Such clarity can prevent recurrence based solely on rephrasing key terms. To understand how various stakeholders develop and interpret a shared purpose, I argue for the necessity of a pragmatist approach that is normative and process-oriented. Mental models play a crucial role in interpretive processes that define decision-making, where individual perspectives converge. The figures of Milton Friedman and Ed Freeman serve as “beacons,” as artefacts, in the transmission of knowledge through which we, as individuals, shape a shared understanding. In current societies, profound polarization obstructs solutions to grand challenges. Pragmatism starts by questioning the underlying values of everyone involved. It assumes that sound deliberative processes are the only way to reach real solutions—not only for the mind but, above all, for the heart.
An identity that is reminiscent of the Littlewood identity plays a fundamental role in recent proofs of the facts that alternating sign triangles are equinumerous with totally symmetric self-complementary plane partitions and that alternating sign trapezoids are equinumerous with holey cyclically symmetric lozenge tilings of a hexagon. We establish a bounded version of a generalization of this identity. Further, we provide combinatorial interpretations of both sides of the identity. The ultimate goal would be to construct a combinatorial proof of this identity (possibly via an appropriate variant of the Robinson-Schensted-Knuth correspondence) and its unbounded version, as this would improve the understanding of the mysterious relation between alternating sign trapezoids and plane partition objects.
Anxiety affects around one in five women during pregnancy and after birth. However, there is no systematic information on the proportion of women with perinatal anxiety disorders who want or receive treatment.
Aims
To examine (a) the prevalence of anxiety disorders during pregnancy and after birth in a population-based sample, and (b) the proportion of women with anxiety disorders who want treatment and receive treatment.
Method
This study conducted 403 diagnostic interviews in early pregnancy (n = 102), mid-pregnancy (n = 99), late pregnancy (n = 102) or postpartum (n = 100). Participants also completed self-report measures of previous/current mental health problems and desire for treatment at every time point.
Results
The prevalence of anxiety disorders over all time points combined was 19.9% (95% CI 16.1–24.1), with greatest prevalence in early pregnancy (25.5%, 95% CI 17.4–35.1). The most prevalent disorders were obsessive–compulsive disorder (8.2%, 95% CI 5.7–11.3) and generalised anxiety disorder (5.7%, 95% CI 3.7–8.4). The majority of women with anxiety disorders did not want professional help or treatment (79.8%). Most women with anxiety disorders who did want treatment (20.2%) were receiving treatment. The majority of participants with anxiety disorders had a history of mental health problems (64.6%).
Conclusions
Prevalence rates overall are consistent with previous research, lending validity to the findings. However, findings challenge the assumption that everyone with a psychological disorder wants treatment. These findings highlight the importance of relationship-based care, where individual needs and contextual barriers to treatment can be explored.
By harnessing optical memories based on electromagnetically induced transparency in warm vapors of gaseous alkali metals and cold atomic clouds, this article presents new methods for motion sensing. The proposed scheme for velocimetry can substantially increase the sensitivity of some recent works based on the light-dragging effect in a moving medium, and on the other hand, our proposal, when realized using cold atoms, opens new research questions with regard to limits of light storage in cold atomic clouds. Ultimately, a detailed experimental setup is presented for the realization of the velocimetry scheme using stopped light, which includes considerations for the choice of the medium, laser configuration and control. By investigating the limits of optical memories in motion sensing applications, this research opens up new avenues for employing optical memories beyond applications in quantum information science.
Network science was used to create and examine semantic networks of cue and response words from a word association task in learners of Kaqchikel (an endangered language indigenous to Guatemala) and monolingual English speakers. English speakers provided a wide range of responses indicative of creative language use, whereas the Kaqchikel learners provided straightforward and utilitarian responses. The observed differences in network structure in the English/Kaqchikel learners resembled the structural differences previously observed in more/less creative individuals, suggesting an alternative account of the “foreign language effect” based on the size and structure of the semantic network in the native/foreign language.
The complex field, equipped with the multivalued functions of raising to each complex power, is quasiminimal, proving a conjecture of Zilber and providing evidence towards his stronger conjecture that the complex exponential field is quasiminimal.
Since 1979, plastic companies have significantly expanded their markets. Evidence suggests that excessive plastic use in Ethiopia has exacerbated environmental pollution, contributing to a “quadruple crisis” involving climate change, biodiversity loss, pollution and public health and economic impacts. To address this, the Ethiopian government needs to establish effective plastic waste management strategies. Key future direction and recommendation include (1) Developing and enforcing national strategies, including a ban on many single-use plastics, for sustainable plastic waste management; (2) adopting international best practices and policies to move toward a zero-waste approach; (3) investing in a circular economy and plastic waste management systems; (4) strengthening policies through comprehensive legislation and extended producer responsibility frameworks; (5) establishing a council to integrate scientific research into policymaking; (6) promoting green technologies and innovations, such as plastic waste-to-energy and smart waste management; (7) engaging in global efforts to monitor hazardous chemicals in plastics and support transparency in a toxic-free circular economy to ensure the public’s right to information.
Can exposure to a foreign language in the first year of school enhance divergent thinking skills? Ninety-nine monolingual children from predominantly White neighbourhoods (MAge = 57.7 months, SD 1.2; 47 girls) attending bilingual schools, schools with weekly foreign language lessons, or schools without a foreign language provision (= controls) completed divergent thinking and executive function tasks at the beginning of the school year and 24 weeks later. The groups did not differ on creativity measures at the beginning of the school year. Only bilingual school children and weekly language learners improved divergent thinking at the second testing point, with the former significantly outperforming controls on creative fluency and flexibility. Improvements could not be explained by executive function development. Therefore, a considerable amount of exposure to a foreign language in early formal education appears to boost creative thinking.
Recent approaches to heritage languages have sought to identify explanations for variability in heritage grammars. The present study explores variable patterns of Spanish differential object marking (DOM) in 40 heritage Spanish speakers (HSs) from the United States and 28 Spanish-dominant bilingual speakers (SDSs) from Mexico. Participants completed a picture description task including human, animal and inanimate direct objects. Both groups exhibited patterns of DOM following the Animacy Scale. However, HSs showed lower DOM rates and greater individual variability with human referents compared to SDSs, even when individual differences in language dominance were considered. Conversely, SDSs produced lower rates of DOM with inanimate objects than HSs. DOM use was constrained by verb-specific animacy biases across animacy conditions and speaker groups. These findings reveal that Spanish HSs maintain baseline-like variable patterns of DOM. Moreover, HSs may advance language change in predictable directions based on patterns of variation present in the baseline variety.
Arctic human settlements experience formidable challenges from accelerating climate change and environmental transformations. While these towns have demonstrated adaptive resilience, the looming threat of local climate extremes raises concerns about the results of adaptation and mitigation efforts. With the further development of Arctic settlements, it is necessary to consider changes in local climatic conditions, shifting the adaptation focus from regional to local scales. The local climate perspective in this literature synthesis study is built upon constraints from physical climatology, focused on the climate and environment within and around the town of Longyearbyen, Svalbard. The study provides insights into Longyearbyen’s local climate dynamics, including physical mechanisms, climate localisation, factors and trends, as well as their implications. Three model pathways for development are discussed, centred on (1) industrial development, (2) public services, and (3) tourism and conservation. This categorisation is introduced to distinguish development scenario sensitivity to the local climate effects. The synthesis indicates that any development concentrated spatially will amplify local warming and climate change, as positive climate feedback predominate. The study emphasises the need for a comprehensive understanding of the environmental factors sustaining local climatic anomalies.