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Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Space exploration to date relies heavily on rockets. Although most rockets have been driven by chemical propellants, there are many other types of rocket, such as ion engines and nuclear rockets. In this chapter we look at the general principles of a rocket, regardless of the mechanism used to generate thrust. We derive the important rocket equation and examine its consequences for space travel.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 2.4 gives an overview of user charges. User charges are out of pocket (OOP) payments made at the point of use for health services. Nearly all countries have some user charges, most commonly for medicines. They are intended to raise revenue and also to reduce the use of unnecessary health care services and products. Key learning includes that
User charges can generate revenues but have many unintended negative consequences – creating barriers to access, contributing to inequities and increasing the risk of financial hardship for households.
Health systems can reduce unnecessary or wasteful use of care without user charges by
– Strengthening prescribing and referral systems to make sure care is appropriate
– Offering more information to steer patients and providers towards more cost-effective care.
Supply-side mechanisms that guide providers’ behaviour are more equitable and effective than demand-side mechanisms like user charges and have fewer negative impacts on patients – especially those with chronic or severe conditions or the economically disadvantaged.
User charges are a suboptimal policy but – if they are to be used – health systems can mitigate the harm they cause and protect health care users through mechanisms such as exemptions, reduced copayments, income-related copayment caps, and to a lesser extent, price control and regulation.
In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), the cholinergic system has been implicated in cognitive and gait decline. The nucleus basalis of Meynert (NBM), within the substantia innominata (SI), is the main cholinergic nucleus projecting to the cortex. In this study, the relationship between atrophy of the SI on cognitive phenotypes and quantitative gait performance was evaluated in relation to gray matter (GM) volume.
Methods:
Ninety-nine participants – 20 control, 42 PD with normal cognition (PD-NC), 19 PD with mild cognitive impairment (PD-MCI) and 18 PD dementia or DLB patients (PDD/DLB) – were examined. Measures included Montreal Cognitive Assessment (MoCA) score, motor symptom severity, quantitative gait analysis measures and dual-task cost (DTC) to gait speed. Manual measurement of SI volume was performed on T1 MRI scans; automated methods were used for GM volumes. The relationships between gait changes, volumetric imaging and clinical measures were assessed.
Results:
Smaller SI volumes were seen in PD-MCI and PDD/DLB subjects adjusting for age. SI and GM atrophy were both associated with greater step length variability, and GM was associated with increased DTC to gait speed. These were not significant after adjusting for the false discovery rate. Lower MoCA score was associated with impairments in gait speed, DTC to gait speed and gait variability.
Conclusion:
The SI was associated with cognitive impairment in participants with Lewy body diseases. However, more widespread cortical atrophy may be better related to selected cognitive aspects of gait (DTC to gait speed with animal fluency).
A finite wall-mounted cylinder (FWMC) refers to a cylinder mounted to a flat wall, characterised by flow over its free end and at the wall junction. In the present study, finite wall-mounted harbour seal vibrissal cylinders with different spanwise aspect ratios ($\textit{AR} = L/D$, where $L$ is the length of the cylinder and $D$ is its diameter) are examined at a Reynolds number of $\textit{Re} = 12\,000$ based on the cylinder diameter, with an incoming turbulent boundary layer thickness of $\delta /D = 0.16$. The far-field acoustic spectra of the harbour seal vibrissal FWMCs are broadband for all aspect ratios and effectively suppress the tonal peaks observed in the spectra of circular FWMCs. However, the effectiveness of the suppression mechanism diminishes with decreasing aspect ratio. For the shortest harbour seal vibrissal FWMC ($\textit{AR}= 3.2$), the overall sound pressure level exceeds that of its circular counterpart, and the tonal peak is replaced by broadband noise of comparable magnitude. Spanwise-intermittent recirculation zones and cellular vortex shedding are identified in the near wake of the harbour seal vibrissal FWMCs. For all harbour seal vibrissal FWMCs, as well as for circular FWMCs with $\textit{AR}$ = 6.5, hairpin vortex shedding is observed rather than classical von Kármán vortex shedding. This corresponds to the absence of tonal peaks in the far-field acoustic spectra. Wavy separation lines play a crucial role in the formation of hairpin vortices and in inducing phase differences in vortex shedding in the spanwise direction. Concentrated quadrupole streamwise vortical structures periodically appear along the span in the wake of the longest harbour seal vibrissal FWMC, which diminish with $\textit{AR}$ decreasing to $\textit{AR}$ = 6.5. This concentrated quadrupole arrangement of positive–negative streamwise vortices suppresses the vortex shedding observed along the span of circular FWMCs by disrupting the acoustic-coherent structures into smaller, spanwise-wavy organised elements. It also stabilises the flow and balances transverse ($y$) forces.
Culinary education interventions may effectively improve cooking skills and dietary outcomes; however, interventions lack theoretical underpinning and rigorous evaluation. ‘Let’s Get Cooking’ (LGC) is a culinary education intervention operating a ‘school and community-based’ programme targeting children and ‘food waste reduction’ programme targeting adults. LGC is delivered through cookery clubs, operating a ‘train the trainer’ model, whereby club leaders are centrally trained and resourced. This study aims to understand initial assessments of LGC’s effectiveness, the content of resources provided for programme delivery and club leaders’ perceptions of the programme.
Design:
Three previous evaluations of the ‘school and community-based’ programme were synthesised and critically appraised. LGC resources were coded to identify behaviour change techniques (BCT), map the age-appropriateness of included cooking skills and to identify food waste reduction strategies. Qualitative one-on-one interviews with club leaders (n 7) were conducted online and thematically analysed.
Setting:
UK
Participants:
N/A
Results:
Previous evaluations suggest LGC’s ‘school and community-based’ programme may effectively disseminate cooking skills. However, reports lacked assessment of ‘fidelity’ or ‘dose delivered’. LGC resources primarily target behaviour change through describing how and when to perform cooking behaviour and contain age-appropriate cooking skills for participating children. ‘Food waste reduction’ resources primarily include appropriate food storage and preparation strategies to reduce waste. Club leaders perceive the intervention and training positively, however, adapt resources and sessions due to delivery challenges.
Conclusions:
LGC may be an effective intervention; however, content improvement may support programme delivery. Rigorous process evaluation is needed to improve understanding of LGC’s effectiveness.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
The special theory of relativity rests on just two axioms: the identity of the laws of physics in all inertial reference frames, and the invariance of the speed of light. After briefly reviewing the basics of special relativity, including the Lorentz transformations and time dilation, we look at the effects of relativity during an accelerated journey. Time dilation has implications even for a spacecraft moving at low velocities. We examine the relativistic rocket equation and then rockets that are propelled by photons or a combination of matter and photons. General relativistic effects are not considered. In a later chapter we look at the impact of relativistic motion on optical phenomena.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 2 develops the conceptual foundations for studying hype. Synthesising insights from Science and Technology Studies, Organisation and Management Theory, Cultural Entrepreneurship, and Economic Sociology, it positions hype as distinct yet overlapping with adjacent concepts such as bubbles, fashions, and organising visions. The chapter advances seven tenets for analysing hype, emphasising its collective rather than individual origins, its cyclical promise–requirement dynamics, and its shifting role across the innovation lifecycle. Hype is treated as both performative — enacting futures — and reflexive — subject to recalibration as evidence emerges. Special attention is given to accountability mechanisms, which are increasingly shaping expectations of whether ventures can ‘live up to the hype’. This framework reorients scholarly debate from moralising accounts of deception to the situated practices and infrastructures that sustain hype. By formalising these tenets, the chapter provides a conceptual platform for the empirical chapters that follow.
Successful surgery for Cushing’s disease (CD) leads to an abrupt change in cortisol levels, and patients often experience symptoms that can adversely affect their quality of life (QOL). The goal of this study was to provide a detailed characterization of the changes in QOL before and after successful surgery.
Methods:
The QOL-CD, a CD-specific questionnaire, was administered at routine clinical visits during active disease prior to surgery and during the early postoperative phase following successful surgery. Descriptive statistics and nonparametric tests characterized clinical, endocrinological, and ophthalmological attributes at both phases. Euclidean hierarchical clustering of the 34 patients who completed both pre- and postoperative questionnaires identified latent subgroups of QOL change.
Results:
In the cohort as a whole, hypertension (OR = 0.31, p = .003), emotional health (p = .026) and physical health (p < .001) improved following treatment. Changes in emotional health were correlated with changes in mental status (r = 0.66, p < .001) and social well-being (r = 0.53, p = .001). The cluster analysis revealed five distinct patterns of pre- to postoperative changes in QOL domains, grouped into three categories based on severity. Group 1 (n = 5) patients showed worsening in most domains of QOL, Group 2 (n = 20) showed marginal changes in QOL and Group 3 (n = 9) demonstrated improvements across all QOL domains.
Conclusions:
Our results highlight the need to educate and support patients before and after surgery for CD. Long-term follow-up studies are needed to better understand the trajectory of QOL recovery and to identify predictors of treatment response.
Little has been written about the rights of children in delict (a functional equivalent of tort), the legal field concerned with compensating those who have suffered injury or loss due to wrongful actions of others. Yet in many legal systems children can, and do, raise legal proceedings seeking damages for injuries caused by another’s negligence. Negligent wrongdoers (normally adults) often attempt to reduce any damages awarded by arguing that the injured child was contributorily negligent. This paper analyses and compares how Scotland and South Africa approach such claims. Both have mixed, uncodified legal systems and have embedded children’s rights in domestic law. In South Africa the provisions of the UN Convention on the Rights of the Child are incorporated in the Constitution of the Republic of South Africa 1996 and in various statutes, notably the Children’s Act 38 of 2005. The recent UN Convention on the Rights of the Child (Incorporation) (Scotland) Act 2024 directly incorporates the child’s Convention rights in Scottish law. We examine how each jurisdiction assesses childhood capacity for contributory fault, exploring what a rights-based approach might involve. Finally, we consider the (potentially) transformative role of courts. Drawing on the South African experience, we propose a way Scottish courts could integrate children’s rights in contributory negligence decisions concerning children.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 1.3 considers voluntary health insurance (VHI). VHI is paid for privately by or on behalf of individuals and normally covers care in addition to the publicly financed benefits package. Premiums are not typically based on the policyholder’s income but may well vary depending on their risk of ill health. Key learning includes that
Despite prepayment and risk pooling, VHI has limitations and does not align well with progress towards universal health coverage because:
– Risk pools in VHI schemes are typically much smaller than pools established through statutory schemes which means there are fewer people to share risk
– Inequities are created because of the cost of premiums, which may not be affordable or accessible to everyone including those most in need.
VHI has wider equity implications because it offers those who can afford to pay faster access or greater choice of services (supplementary insurance) or coverage of excluded services or user charges for statutory care (complementary insurance)
Governments seeking to use VHI to expand coverage typically have to make significant interventions, including through tax subsidies to make premiums more affordable, but this creates market distortions and is inefficient.
Policy-makers can secure better value for money by improving access to publicly financed health care than by promoting VHI.
The general principle of a rocket is to expel propellant in one direction, thereby forcing the rocket to move in the opposite via conservation of momentum. Most rockets built so far are propelled by burning a fuel to produce a gas jet. In this chapter we see how a convergent–divergent nozzle is used to accelerate the gas to a large velocity by maximizing the conversion of its thermal energy (random motion) into kinetic energy (linear motion). We will examine the characteristics of liquid and solid fuels, and look at a few examples of real rockets that use them.
The Italian priest, politician and sociologist Luigi Sturzo developed a distinctive form of Catholic internationalism during his exile in the United States (1940–6). Sturzo, a major political figure in European social Catholicism, founded in 1919 the Partito Popolare Italiano. During the war, he argued that Catholicism provided the moral and theoretical toolkit for constructing a vision of a democratic post-war world in which persons and communities could live in peace and prosperity. Focusing on two books that Sturzo published in English, this study argues that his vision of democracy beyond the nation-state was based on pluralism, federalism and popular participation. As a religiously grounded alternative to liberal and socialist visions, Sturzo’s internationalism highlights how moral and political arguments were intertwined in imagining democracy on a global scale.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London