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Edited by
Grażyna Baranowska, Friedrich-Alexander-Universität Erlangen-Nürnberg,Milica Kolaković-Bojović, Institute of Criminological and Sociological Research, Belgrade
Turbulence–chemistry interaction in a Mach-7 hypersonic boundary layer with significant production of radical species is characterised using direct numerical simulation. Overriding a non-catalytic surface maintained as isothermal at 3000 K, the boundary layer is subject to finite-rate chemical effects, comprising both dissociation/recombination processes as well as the production of nitric oxide as mediated by the Zel’dovich mechanism. With kinetic-energy dissipation giving rise to temperatures exceeding 5300 K, molecular oxygen is almost entirely depleted within the aerodynamic heating layer, producing significant densities of atomic oxygen and nitric oxide. Owing to the coupling between turbulence-induced thermodynamic fluctuations and the chemical-kinetic processes, the Reynolds-averaged production rates ultimately depart significantly from their mean-field approximations. To better characterise this turbulence–chemistry interaction, which arises primarily from the exchange reactions in the Zel’dovich mechanism, a decomposition for the mean distortion of finite-rate chemical processes with respect to thermodynamic fluctuations is presented. Both thermal and partial-density fluctuations, as well as the impact of their statistical co-moments, are shown to contribute significantly to the net chemical production rate of each species. Dissociation/recombination processes are confirmed to be primarily affected by temperature fluctuations alone, which yield an augmentation of the molecular dissociation rates and reduction of the recombination layer’s off-wall extent. While the effect of pressure perturbations proves largely negligible for the mean chemical production rates, fluctuations in the species mass fractions are shown to be the primary source of turbulence–chemistry interaction for the second Zel’dovich reaction, significantly modulating the production of all major species apart from molecular nitrogen.
Lurasidone is a second-generation antipsychotic with antidepressant properties, but its effect on depressive symptoms across diagnostic domains is not known.
Aims
This systematic review aims to synthesise the evidence for the transdiagnostic efficacy of lurasidone in reducing depressive symptoms.
Method
Electronic databases were searched up to October 2024 to identify randomised controlled trials comparing the effects of lurasidone and placebo on depressive symptoms, as measured by any standardised scale, in populations with different psychiatric diagnoses. Acceptability, tolerability and safety were also measured. The Cochrane risk of bias tool was used to assess study quality, and the GRADE tool to evaluate certainty of evidence. A random-effects meta-analysis was performed to estimate standardised mean differences (SMDs, for continuous outcomes) or relative risks (for dichotomous outcomes) with 95% CI.
Results
Fourteen trials met inclusion criteria. Pooled analysis of 5239 participants found lurasidone to be more efficacious than placebo in improving depression scores (SMD −0.26, 95% CI −0.37, −0.15) across multiple diagnoses (including schizophrenia, bipolar disorder and major depressive disorder). Secondary analyses showed better acceptability (relative risk 0.55, 95% CI 0.43, 0.71) and safety (relative risk 0.73, 95% CI 0.58, 0.91) and comparable tolerability (relative risk 0.74, 95% CI 0.54, 1.02) between lurasidone and placebo. The main limitations were the high risk of bias of several included studies and the high heterogeneity observed in our findings.
Conclusion
Lurasidone is a potentially efficacious and safe strategy for reducing depressive symptomatology across a range of psychiatric diagnoses. Further long-term, robust trials employing precision psychiatry methods are needed to support its broader use to target depressive symptoms transdiagnostically.
This paper reports on a web-based experiment to investigate the perception of prominence in words with different focus structures in Italian. In the experiment, native listeners of the Bari variety of Italian, and German learners of Italian, rated the perceived prominence of object nouns in broad and narrow focus and post-focally using a visual analogue scale. Although both groups of listeners rated words in narrow focus as higher in prominence than words in broad focus, there were differences between the two groups in rating post-focal words. While German learners rated post-focal words as less prominent than those in broad focus, native Italian listeners perceived words in both of these conditions as equally prominent. The Italian ratings are particularly striking, as post-focal words had flat pitch and were weaker in terms of periodic energy mass than words in broad focus, leading to the conclusion that the native listeners were rating the words by taking their knowledge of the prosodic system of Italian into account. Our results confirm phonological accounts of Italian as having post-focal accents, even when the pitch is flat.
This study investigates the phonetic structures of Lushootseed obstruents from archival recordings dating to the 1950s, and seeks to address the following questions: (i) Which acoustic dimensions characterize the stop, affricate, and fricative contrast in Lushootseed? (ii) which acoustic dimensions characterize ejective types in Lushootseed? and (iii) which methods can be used to characterize acoustic properties of Lushootseed obstruents from old archival recordings? Several acoustic measures were used on two elder speakers. These measurements include: Voice Onset Timing (VOT); closure duration; burst intensity for stops; dynamic measures of intensity for affricates; voice onset quality measures for stops and affricates, which include f0 perturbation, jitter perturbation, and amplitude characteristics of the following vowel; and spectral measurements for affricates and fricatives, which includes the frequency of the main peak at the low- and mid-frequency ranges (FreqM) and DCT coefficients. The findings reveal that several of these acoustic measures characterize the stop, affricate, and fricative contrast in Lushootseed.
Psychotherapy chatbots have attained remarkable fluency, skill and ubiquity – having become the single most frequent reason people use artificial intelligence. Their uncanny ability to engage and validate is a two-edged sword – useful for the majority of users who are experiencing problems of everyday life or have milder mental disorders, but dangerous for the minority who have more severe problems (e.g. psychosis, bipolar disorder, self-mutilation, suicide, antisocial impulses, eating disorders, conspiracy theories, religious and political extremism). Chatbots are created to make money, without meaningful quality control, safety guardrails and external regulation. They will likely be misused to create addiction, reduce human contact, invade privacy, allow exploitation and create opportunities for marketing and political propaganda. Chatbots also make mistakes (’hallucinations’), deceptively cover them up and sometimes go rogue (acting outside the parameters set by their human programmers). Psychotherapy practitioners and associations are curiously complacent about the rapid emergence of artificial intelligence competition. Their passivity reflects ignorance about the power of chatbots, denial of their likely impact and arrogance regarding their capacities (e.g. ‘no machine will ever replace me’). This is both incorrect and foolhardy – human therapists expect to win in competition for most healthier patients and must train or retrain to do things artificial intelligence does poorly – working with the more seriously ill and in settings and situations that are more idiosyncratic, chaotic or quickly changing. If we can’t work with artificial intelligence, we are likely to be replaced by it. I will describe: (a) benefits of chatbot therapy, (b) its terrifying dangers, (c) its likely impact on human therapy and training and 4) ways we can adapt to the artificial intelligence threat.
Schizophrenia (SCZ) and genetic high-risk (GHR) individuals exhibit deficits in brain functional networks and cognitive function, potentially impacted by SCZ risk genes. This study aims to delineate these impairments in SCZ and GHR individuals, and further explore how risk genes affect brain networks and executive function.
Methods
A total sample size of 292 participants (100 SCZ, 68 GHR, and 124 healthy controls [HCs]) in the study. The Wisconsin Card Sorting Test (WCST) and resting-state functional magnetic resonance imaging (rs-fMRI) are utilized to evaluate executive function and brain network topology. SCZ-related polygenic risk scores (SCZ-PRS) were used to evaluate genetic risk levels. WCST and PRS were not applied to all participants.
Results
Significant reductions in nodal efficiency and degree centrality (Dnodal) were observed within the right median cingulate and paracingulate gyri (MCPG_R) in both SCZ and GHR groups, compared to HCs. There were significant correlations between SCZ-PRS, Dnodal in MCPG_R, and WCST scores. Moreover, Dnodal in MCPG_R completely mediated the relationship between SCZ-PRS and executive function. The enrichment analysis of these risk genes indicates their involvement in biological processes of signal transduction and synaptic transmission.
Conclusions
This study highlights the pivotal role of impaired cingulate function in mediating the effects of genetic risks on executive deficits, offering new insights into the genetic-neuro-cognitive nexus in schizophrenia and potential targets for clinical interventions.
Intellectual disability is defined as an IQ of 70 or below. Women with intellectual disability frequently experience menstrual distress leading to the use of hormonal medications such as depot medroxyprogesterone acetate (DMPA). Despite risks such as reduced bone mineral density (BMD) and weight gain, DMPA is widely used in this cohort, prompting investigation into its suitability and risks.
Aims
A narrative review and local service evaluation were conducted to determine whether clinical management reflected recommendations in the literature.
Method
PsycINFO and Medline were searched for articles post-1995 on contraception in menstruating women with intellectual disability. Contraceptive use in 100 randomly selected women was evaluated. Data were collected on physical health issues, general practitioner records were reviewed for contraceptive administration and risk discussions, and surveys assessed risk understanding and satisfaction.
Results
The review identified 27 papers with higher DMPA use in the intellectual disability population compared to the general population, and specific BMD risks. The case series found 23 women with intellectual disability using DMPA, and revealed knowledge gaps in risk and monitoring, inappropriate use given individual risk, and poor proactive risk management.
Conclusions
Findings indicate disproportionate DMPA use in women with intellectual disability, with inadequate clinical justification and risk awareness. Many women and carers were unaware of BMD risks, and DMPA alternatives were rarely considered. Individualised contraceptive management and closer review of DMPA use in this cohort is needed. Monitoring could include dual X-ray absorptiometry (DEXA) scans, vitamin D and calcium supplementation, and weight management. Further research is needed into higher DMPA use and risks within this population.
Over the last two decades, Marxism has experienced a significant revival, including in the discipline of law. The 2003 Iraq War and, perhaps more obviously, the 2008 financial crisis posed questions about the relationship between law, capitalism and imperialism that mainstream legal scholarship had difficulty answering. One marked exception to this revival has been in the field of European Union (EU) law. EU law scholarship, perhaps understandably given that few Member States participated in the invasion, had little to say about the Iraq War. For its part, the 2008 financial crisis and its manifestation in Europe as the ‘Euro-Crisis’ prompted a ‘critical turn’ in EU legal studies.1 However, these two movements – the Marxist tradition and critical EU law scholarship – have largely failed to meet. Marxist analyses of EU law, let alone the development of a full-blown Marxist theory of EU law, remain almost non-existent.
This article explores the systems of policing that emerged in the early Cape Colony (1652–1830). Contrary to previous historical scholarship that understood the institution to be largely nonexistent or of marginal importance to the colony’s political economic development, this article argues that the Cape colony’s systems of policing, which doubled as ad hoc military organizations, were not so much weak as privatized. It shows how this persistent tendency was motivated by the Dutch East India Company’s desire to maximize profits—though it manifested differently in different parts of the colony. Moreover, this article demonstrates that the mercantile economy that the company installed at the Cape ensured that private policing would become a vehicle of indigenous dispossession. In doing so, it seeks to contribute to the field of African carceral studies and understandings of processes of racialization in the early Cape.
This article is the introduction to the Special Issue on The Constitution of Political Economy. It provides an overview of six articles which in distinctive yet overlapping ways explore three key issues. First, how the economy and the polity are embedded in society. Second, how interdependence shapes institutional arrangements. Third, how different levels of aggregation determine levels of policy-making, notably the importance of intermediate institutions.
Common milkweed is a creeping perennial weed that is problematic in row crops and pastures. Its ability to readily reproduce via adventitious root buds enables it to persist, and full control often requires several growing seasons of management. Although it is a troublesome agricultural weed, common milkweed is ecologically important due to its use as a food source for many arthropod species. Declines in common milkweed populations in North America have been correlated with and blamed for declines in monarch butterfly populations. This review summarizes available information on the biology, ecology, and management of common milkweed, as well as its potential uses and provisioning of ecosystem services.
A new species of Blastulospongia Pickett and Jell, 1983 from the middle Cambrian Devoncourt Limestone, Georgina Basin, Australia exhibits distinct perforation patterns characteristic of sphinctozoans. Recognition as a sphinctozoan-grade sponge confirms the poriferan affinity of this enigmatic genus, which appeared prior to the development of other hypercalcified sponge forms of chaetetids and stromatoporoids. Blastulospongia bouliaensis new species occurs together with four species of primitive spicular radiolarians: Echidnina irregularis Won in Won and Iams, 2002, Parechidnina aspinosa Won in Won and Below, 1999, Palaeospiculum reedae Won in Won and Below, 1999, and Palaeospiculum devoncourtensis Won in Won and Below, 1999. Micro-computed tomographic (MCT) analysis of Parechidnina aspinosa reveals its skeletal construction through the fusion of unirayed spicules, indicating a close phylogenetic link with archeoentactinids. Blastulospongia bouliaensis n. sp. and Palaeospiculum devoncourtensis represent promising Miaolingian accessory species for biostratigraphy during the Drumian-Guzhangian interval.
A large empirical literature examines how judges’ traits affect how cases get resolved. This literature has led many to conclude that judges matter for case outcomes. But how much do they matter? Existing empirical findings understate the true extent of judicial influence over case outcomes since standard estimation techniques hide some disagreement among judges. We devise a machine learning method to reveal additional sources of disagreement. Applying this method to the Ninth Circuit, we estimate that at least 38% of cases could be decided differently based solely on the panel they were assigned to.
This article aims to further our understanding of the mechanics of physical weed control, specifically the mechanism of using a cutting blade to cut weeds. Research on weed stem cutting is sparse, so this paper draws on examples of plant stem cutting. It reviews the factors that affect the plant stem cutting process. Among the, Cutting speed, blade sharpness, and moisture content, factors that can easily be controlled, are discussed. The indicators for evaluating the cutting process and the methods for measuring the influencing factors are introduced as well. Finally, different blade designs, examples of the application of mechanisms that affect the cutting process of plant stems are provided. This review argues that, under conditions of high cutting speed, high blade sharpness, and high moisture content, plastic deformation would be reduced and the stems would exhibit brittle material characteristics. This would help to reduce the cutting force and energy, but excessive brittleness can cause stem fragmentation and degrade cutting quality. This paper also lists some possible future research directions. First, friction behavior during the cutting process of fresh plant stems. Another, cutting blade design based on the comprehensive application of cutting speed, blade wedge angle, and sliding cutting angle on the cutting process. At present, the mechanism of plant stem cutting process is still not clear. Further research is needed.
To what extent can intellectual humility be formalized? One natural idea links humility to open-mindedness, captured by a regularity principle: no coherent hypothesis should get probability zero. While debates over regularity often concern infinities, my objection is different. Regularity is feasible only for ideally rational, logically omniscient agents. Yet on a common view, humility involves appreciating our limitations—including our failure to be such agents. So whatever its merits for ideal cognition, regularity is a poor model for human humility. Indeed, taking it as such would itself be un-humble, by failing to appreciate our own epistemic limitations.
Arcade video games evolved in a constrained design space, following patterns of diversification, stabilisation, and collapse that mirror macroevolutionary processes. Despite their historical significance and detailed digital records, arcade games remain underexplored in cultural evolution research. Drawing on a dataset of 7,205 machines spanning four decades, we reconstruct the evolutionary trajectories of arcade niches using a multi-scale framework that integrates trait-level innovation, genre-level selection, and systemic constraints. We identify two contrasting dynamics: (1) resilient genres—such as Fighter and Driving—maintained long-term viability through innovation and collaboration networks, while (2) early Maze and Shooter subgenres collapsed due to imitation and weak collaboration. Morphospace analysis reveals how technological traits—specifically CPU speed and ROM size—co-evolved with gameplay complexity, shaping the viable design space. We argue that genres operated as evolving cultural-ecological units—structured niches that shaped trait evolution through reinforcement, constraint, and feedback. This multi-scale perspective positions arcade games as a rich model system for studying cultural macroevolution.
The decision to work is an important yet understudied facet of women’s economic empowerment. This study explores the relationship between married women’s agency over the decision to work, workforce participation, and control over financial resources, using cross-sectional survey data collected in 2022 in India’s three most populous states: Bihar, Uttar Pradesh, and Maharashtra. Employing logistic regression, inverse probability weighting, and partial identification approaches, we demonstrate that married women in all three states are significantly more likely to engage in paid work when they alone have the final say over the decision to work, compared to when their spouse is the primary decision-maker. We also find that sole decision-making about paid work is positively related to married women’s control over money in Bihar and Maharashtra, and with savings and remittances in Maharashtra. In Maharashtra, women who jointly decide about employment with their spouse are also more likely to work than women whose husbands are the sole decision-makers. Joint decision-making is positively associated with women’s control over money in all three states. Our study highlights work-related agency as an important pathway to married women’s economic opportunities and inclusion in India, and is among the first to empirically examine the relationship between women’s work-related decision-making and economic outcomes. These results align with existing evidence on the positive relationship between women’s household bargaining power and health and human capital outcomes, and offer support for designing programmes to promote women’s participation in the workforce.