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High-energy, short-pulse laser-driven proton–boron (p–11B) fusion has attracted growing interest due to its aneutronic character and potential for clean energy generation. In this study, we report on two experimental campaigns carried out at the LFEX laser facility using petawatt-class laser systems (energy $\sim$1.2–1.4 kJ, pulse duration 2.7 ps, peak intensity $\sim$(2–3) × 1019 W/cm2). The experiments explored the influence of complex target geometries – including spherical, cylindrical and wedge-shaped configurations – on α-particle yield. Our results demonstrate that spherical targets can enhance α-particle production by up to two orders of magnitude compared to planar targets of identical composition and also lead to a noticeable shift of the α-particle energy spectrum toward higher values. Furthermore, we implemented a novel diagnostic technique for unambiguous α-particle detection using a CR-39 detector integrated into a Thomson parabola spectrometer. Particle-in-cell simulations performed with the Smilei code provide additional insight into the role of self-generated magnetic fields in modulating particle dynamics. These simulations highlight the critical interplay among target geometry, confinement effects and fusion efficiency. Overall, our findings underscore the potential of optimized target designs to significantly enhance fusion yield and α-particle output in p–11B fusion, with promising implications for the development of laser-driven α-particle sources and advanced clean energy concepts.
Governments are increasingly implementing policies to improve population diets, despite food industry resistance to regulation that may reduce their profits from sales of unhealthy foods. However, retail food environments remain an important target for policy action. This study analysed publicly available responses of industry actors to two public consultations on regulatory options for restricting unhealthy food price and placement promotions in retail outlets in Scotland.
Design:
We conducted a qualitative content analysis guided by the Policy Dystopia Model to identify the discursive (argument-based) and instrumental (tactic-based) strategies used by industry actors to counter the proposed food retail policies.
Setting:
Scotland, UK, 2017–2019.
Participants:
N/A.
Results:
Most food and retail industry responses opposed the policy proposals. Discursive strategies employed by these actors commonly highlighted the potential costs to the economy, their industries and the public in the context of a financial crisis and disputed the potential health benefits of the proposals. They claimed that existing efforts to improve population diets, such as nutritional reformulation, would be undermined. Instrumental strategies included using unsubstantiated and misleading claims, building a coordinated narrative focused on key opposing arguments and seeking further involvement in policy decision-making.
Conclusions:
These findings can be used by public health actors to anticipate and prepare for industry opposition when developing policies targeted at reducing the promotion of unhealthy food in retail settings. Government action should ensure robust management of conflicts of interest and establishment of guidance for the use of supporting evidence as part of the public health policy process.
This paper studies the dynamic extraction problem of an exhaustible common-pool resource. We build on classical closed-economy growth models with intertemporally maximizing, infinitely lived dynasties exhibiting a constant population growth rate. Utility is obtained from periodic consumption based on the fixed-rate capital and the extraction of the resource, and from the amenity values derived from the standing resource stock. The resource contributes to both consumptive and amenity utilities, while different generations are interconnected by intergenerational altruism. Dynamic allocation of the natural resource is determined by a benevolent social planner. This allows us to examine intra-generational inequity issues in combination with the intergenerational concerns. We demonstrate how the optimal allocation of the resource depends on the population growth, wealth level, inequality, ecological vulnerability of the resource and rivalry on the amenity value. Our results highlight the trade-offs between reducing the degree of inequality and preserving the ecological values of the resource.
Excessive zinc (Zn) intake can lead to Zn toxicity, causing adverse effects in gastrointestinal system. To date, there remains no definitive consensus on the mechanisms by which Zn overload induces cell death and intestinal injury. This study was to assess the toxicity mechanism of Zn overload in intestine, with a particular concentrate on oxidative stress and energy metabolism. We first explore the effects of short- and long-term Zn imbalances on intestinal health in mice. We found that the Zn imbalances resulted in oxidative damage, and impaired ketoglutarate dehydrogenase (α-KGDH) activity, which collectively contributed to a detrimental impact on the integrity of the intestinal barrier in mice. We next determined the dynamics of oxidative stress and energy metabolism in Zn overload treatment IPEC-J2 cells. Excessive Zn activated reactive oxygen species (ROS) overproduction and the PKC-NOX oxidative stress pathway. Moreover, the increase of mitochondrial Zn2+ caused mitochondrial ROS accumulation and influenced the expressions of α-KGDH andisocitrate dehydrogenase (IDH), two pivotal rate-limiting enzymes in tricarboxylic acid (TCA) cycle. Zn overload also significantly inhibited the expressions of key nicotinamide adenine dinucleotide (NAD+) synthesis enzymes, namely NMNAT1 and NAMPT, leading to a notable decline of NAD+ and ATP. Furthermore, rescue experiments showed supplementation of NAD+ or boosting NAD+ synthesis, but not antioxidants addition, could rescue Zn toxicity. The collective findings suggest NAD+ reduction is the primary factor contributing to intestinal Zn toxicity, although ROS also plays a role. This indicates that the modulation of NAD+ synthesis may prove an effective strategy for the minimization or elimination of Zn toxicity.
Identifying use-related residues from stone artefacts has become increasingly important in determining starchy plant exploitation over time and in different locales. Standard methods for processing residues samples are widely available but there is no clear consensus on suitable methods for attributing unknown starch grains to known plant taxa. We revisit the case study of a flaked stone artefact (K/76/S29B) recovered from Phase 1 (c. 10,000 ka) at Kuk Swamp in Papua New Guinea (PNG). Starch grains from taro (Colocasia esculenta) were identified in the residue extraction, but there were other grains that could not be attributed a plant origin at that time. The new analysis applied robust statistical methods, categorial attributes and expert input. In addition to C. esculenta, kudzu bean (Pueraria montana var. lobata) was identified, representing the earliest use of kudzu bean in the PNG highlands. Importantly, we also determined that starch grains from C. esculenta and Dioscorea esculenta are morphologically indistinguishable. We turned to other attributes of potential contributing plant taxa in determining distinguishing features: habit/growing requirements; the sedimentary context of the archaeological find; and environmental settings. Cultural use of both plants, artefacts and artefact technologies can be critical elements in confident identification outcomes, as exemplified here.
Let ${\mathscr {G}} $ be a special parahoric group scheme of twisted type over the ring of formal power series over $\mathbb {C}$, excluding the absolutely special case of $A^{(2)}_{2\ell }$. Using the methods and results of Zhu, we prove a duality theorem for general ${\mathscr {G}} $: there is a duality between the level one twisted affine Demazure modules and the function rings of certain torus fixed point subschemes in affine Schubert varieties for ${\mathscr {G}} $. Along the way, we also establish the duality theorem for $E_6$. As a consequence, we determine the smooth locus of any affine Schubert variety in the affine Grassmannian of ${\mathscr {G}} $. In particular, this confirms a conjecture of Haines and Richarz.
Refreezing is a critical component of the mass balance of glaciers in Svalbard, yet the processes and changes under a warming climate are not fully understood. Here, we investigate changes in firn properties of the Austfonna ice cap, Svalbard, using a combination of observations and model simulations. We analyze firn stratigraphy and density from five newly retrieved and 11 previously retrieved firn cores, collected at elevations ranging from 506 m a.s.l. to 791 m a.s.l. between 1958 and 2022. All cores exhibit frequent ice layers that indicate persistent refreezing of meltwater; however, no ice slabs (layers exceeding 1 m) were observed. A 13-year-long firn temperature time series from a site near the summit (773 m a.s.l.) shows that annual water percolation reaches depths of 7 m to over 13 m. A notable transition in the firn thermal regime occurred in 2013, transitioning from cold to temperate conditions above the firn-ice interface despite the seasonal cooling occurring in the upper firn layers. Simulations using the CryoGrid community model from 2009 to 2022 corroborate this thermal shift and suggest the development of a firn aquifer multiple times since 2013, with increasing duration and thickness over time.
Recruitment of participants for research is often difficult in primary care, especially children and adolescents. Poor recruitment often leads to extension or discontinuation of randomized controlled trials involving patients. This study describes the impact of media recruitment compared to recruitment via general practitioners (GPs) on characteristics of 152 children aged 7–17 years with functional abdominal pain (FAP) and irritable bowel syndrome. Demographics, clinical and psychosocial characteristics were compared. No clinically relevant differences were found, except for longer pain symptom duration and more diagnoses of FAP in children recruited via media compared to children recruited by their GP. Our results suggest that recruitment via media is effective to recruit children in primary care without inducing relevant baseline characteristic differences and this might decrease research recruitment load for GPs. Subgroup analyses on recruitment method are recommended because recruitment strategy might induce differences in unknown baseline characteristics between groups.
Periodic travelling waves at the free surface of an incompressible inviscid fluid in two dimensions under gravity are numerically computed for an arbitrary vorticity distribution. The fluid domain over one period is conformally mapped from a fixed rectangular one, where the governing equations along with the conformal mapping are solved using a finite-difference scheme. This approach accommodates internal stagnation points, critical layers and overhanging profiles, thereby overcoming limitations of previous studies. The numerical method is validated through comparisons with known solutions for zero and constant vorticity. Novel solutions are presented for affine vorticity functions and a two-layer constant-vorticity scenario.
Bayesian estimates from experimental data can be influenced by highly diffuse or “uninformative” priors. This paper gives examples of how diffuse priors can affect estimates, and discusses how practitioners can use their expertise to critique and select a prior.1
The Cold War is often depicted in binary terms: communists against anti-communists, the left against the right, or the free world versus the communist world. However, during the latter part of the Cold War, particularly following the 1979 war between China and Vietnam, earlier Cold War binaries no longer applied, and new alliances were established. These alliances often brought people with the same enemies together, despite having little in common ideologically. This article examines the historical circumstances and Cold War geographies of ethnic Khmu anti-Lao PDR and anti-Vietnamese insurgents, including their alliances with right-wing governments in Thailand and the communist People’s Republic of China (PRC). As neutralists, these Khmu occupied a political space rarely discussed in relation to the Cold War. Although the PRC provided training, weapons, and supplies to the neutralist Khmu between 1979 and 1983, later their political leader, General Kong Le, had a falling out with the Chinese, and the PRC stopped supporting his largely ethnic minority soldiers. However, up until 1989, the Thai government continued to allow the Khmu to maintain bases in Thailand for launching military operations inside Laos, until the Thai government adopted the “Battlefield to Marketplace” policy. Some Khmu continued resisting inside northwestern Laos during the early 1990s, but with declining numbers of soldiers and decreased outside support, armed resistance ended in 2003. It is critical that the geographies and alliances of the later Cold War be differentiated from those of the earlier years of the Cold War. This transnational insurgency deserves attention.
Children are known to derive more implicatures when the required alternative is made salient through contrast or when it is made contextually relevant through a story or a Question Under Discussion. We investigated the exclusivity implicature of three disjunctions (sau “or”, sau… sau, and fie…fie “either…or”) in child Romanian, an understudied language in the previous literature. Three experiments reveal that the mere presence of the stronger alternative, that is, simply hearing unrelated conjunctive statements in the course of the experiment, is not enough to boost implicatures. Rather, implicatures increase as a result of both access to alternatives and contextual relevance (expressed through conjunctive questions such as Did the hen push the train and the boat?). Interestingly, the boost in implicatures was observed only for sau-based disjunctions, not for fie…fie, which we conjecture may be due to children treating the latter as ambiguous between disjunction and conjunction.
Generation of steady streaming vortices is usually accomplished by mechanically vibrating bodies, as occurs in several microfluidic applications for mixing, as well as for transport and handling of microparticles. Here, we propose the generation of streaming from the harmonic electromagnetic forcing of a free-moving circular magnet held afloat on a shallow electrolytic layer, and show that the sense of rotation of steady vortices is the opposite to that of the classical streaming flow. Reverse streaming is attributed to the coupling between the fluid and the free-moving body. Analytical solutions offer a physical rationale for the observed flow dynamics, while numerical simulation reproduces the experimental observations satisfactorily.
To investigate the association of dietary patterns (DP) with prediabetes and type 2 diabetes (T2D) among Tibetan adults, first to identify DP associated with abdominal obesity and examine their relationships with prediabetes and T2D. Additionally, the study aims to investigate the mediating effects of body fat distribution and altitude on the associations between these DP and the prevalence of prediabetes and T2D.
Design:
An open cohort among Tibetans.
Setting:
Community-based.
Participants:
The survey recruited 1003 participants registered for health check-ups from November to December 2018 and 1611 participants from December 2021 to May 2022. During the baseline and follow-up data collection, 1818 individuals participated in at least one of the two surveys, with 515 of them participating in both.
Results:
Two DP were identified by reduced rank regression. DP1 had high consumption of beef and mutton, non-caloric drink and offal and low intake in tubers and roots, salty snacks, onion and spring onion, fresh fruits, desserts and nuts and seeds; DP2 had high intake of whole grains, Tibetan cheese, light-coloured vegetables and pork and low intake of sugar-sweetened beverages, whole-fat dairy products and poultry. Individuals in the highest tertile of DP1 showed higher risks of prediabetes (OR 95 % CI) 1·35 (1·05, 1·73) and T2D 1·36 (1·05, 1·76). The highest tertile of DP2 exhibited an elevated risk of T2D 1·63 (1·11, 2·40) in full adjustment.
Conclusion:
Abdominal adiposity-related DP are positively associated with T2D. Promoting healthy eating should be considered to prevent T2D among Tibetan adults.
Miocene lacustrine clay deposits formed in the Şile region of Türkiye rest unconformably on Cretaceous andesite, basaltic andesite, basalts and rare dacites. Factors controlling the genesis of this sequence include: (1) sediment provenance, (2) tectonic uplift and climatic regimes during syn- and post-depositional times, (3) burial diagenesis and (4) changes from surface weathering alterations (i.e. oxidation and hydrolysis reactions) in the critical zone. Clay minerals are dominated by kaolinite and illite, with their relative abundances varying in relation to the proximity of coal seams, stratigraphic sequence and in an overlying sand-rich fluvial deposit. Variations in the mineral abundances reveals cyclothem-like sequences with patterns of fining upwards (i.e. increasing clay mineral abundance) capped by thin coal seams. The Clay Mineral Alteration Index values for the Şile clay sequence indicate a slight trend of decreasing chemical weathering intensity up-section, which is consistent with regional geological data for terrain uplifting and a drying climate during the Miocene. Critical zone processes have modified the mineral and chemical assemblages, as evidenced by the appearance of iron oxides putatively formed from recent oxidation of the ferrous minerals siderite and pyrite, which are not found in the upper sections. Taken together, the evidence indicates that the clay minerals are derived from a combination of prior weathering of basement rocks, diagenesis after deposition and modern critical-zone weathering. The degree of each process is dependent on depositional history, stratigraphic position and depth below the land surface, all under the changing influences of tectonic uplift and regional climate. The Şile deposits provide an economical clay resource that could be important to the ceramics industry of Türkiye.
All orthodox believers accept that ‘God’s ways are not our ways’ and that ‘the peace of God passes all understanding’. The sceptical theist tries to apply these principles to the mystery of evil in the world, by arguing that we cannot tell what the divine purpose might be in the sufferings that we cannot explain. There is a danger that an undisciplined putting of evil into the fog of mystery might free our understanding too much from rational constraint. I argue that by combining sceptical theism with the way that Peter van Inwagen deploys the fact of our fallen nature to explain Divine withdrawal, we can give a rational account of the limitations there are on how we can judge God’s justice.
The present study investigated the associations among pre-loss grief, relational closeness, attachment insecurities, continuing bonds (CBs) with the deceased person, and the post-loss adjustment of the caregivers of patients with terminal cancer.
Methods
Data were collected in the hospice department of a cancer center in northern Taiwan; 66 bereaved caregivers completed both pre-loss and post-loss scales. The measures used for the pre-loss phase included the Hogan Grief Reaction Checklist (HGRC; pre-loss version), the Experiences in Close Relationship – Relationship Structures Questionnaire (ECR-RS), and the Inclusion of Other in the Self Scale. The measures used 6–12 months after the death of the patients were the HGRC (post-loss version) and the Continuing Bond Scale (CBS).
Results
Pre-loss grief and externalized CBs had a significant impact on the amount of post-loss grief, indicating that pre-loss grief and ongoing transformation of relationships after patients’ death may be predictors of caregivers’ post-loss grieving.
Significance of results
This longitudinal study provides preliminary evidence that pre-loss grief and the relationship with the patient are key to caregivers’ post-loss adjustment, suggesting that psychosocial intervention focuses on caregivers’ pre-loss grief and relationship quality with the patient during palliative care.
On October 3–4, 2023 and September 30–October 1, 2024, the Memorial Sloan Kettering Cancer Center Department of Psychiatry and Behavioral Sciences and Supportive Care Service hosted the 4th and 5th Annual U.S. Celebration of World Hospice and Palliative Care Day (WHPCD) conferences, respectively. This article describes both events and lessons learned in anticipation of the 6th annual conference to be held October 6–7, 2025.
Methods
The 4th and 5th annual events, conference planning team reflection, and attendee evaluation responses are summarized.
Results
Since 2020, the conference has attracted attendees from around the world. Two primary aims continue to guide the event: community building and wisdom sharing at the intersection of art and science. Both the 2023 and 2024 events consisted of 13 unique interactive sessions addressing diverse hospice and palliative care topics delivered by interprofessional experts in palliative care (43 faculty in 2023 and 54 in 2024). Multidisciplinary registrants more than doubled from 764 in 43 countries (2023) to 1678 in 87 countries (2024). Complimentary registration for colleagues in low- and middle-income countries (LMIC), students and trainees, and individuals experiencing financial hardship remains a cornerstone of inclusion and equitable access to the event.
Significance of results
The U.S. WHPCD Conference provides a virtual platform to disseminate high-quality science, honor both clinician and patient and caregiver experiences, and celebrate hospice and palliative care delivery during substantial local and global change across practice and policy domains. We remain committed to ensuring an internationally relevant, culturally diverse, and multidisciplinary and interprofessional agenda that will draw increased participation worldwide during future annual events.
Cross-gender behaviour gradually entered the spheres of aetiology and diagnosis during the eighteenth century with reference to scattered instances of male cross-dressing. But well into the nineteenth century, “gender identity” (a mid-twentieth-century term) remained a poorly theorised instance of medicalisation. Late eighteenth-century concepts of “dynamic hermaphroditism” accounted for gender-nonconforming behaviours and aspirations, but could not account for the observed heterogeneity in disparities between sexed body and mind. Increasingly substantive contributions to aetiology were seen during the late 1870s and 1880s, particularly in response to Carl Westphal’s convoluted, 1869 concept of “contrary sexual feeling” (conträre Sexualempfindung). Richard von Krafft-Ebing’s notion of metamorphosis sexualis paranoica provided one of the most authoritative approaches to the question of gender identification in “sexual inversion”. The notion, which took the first seven German editions of his Psychopathis sexualis to achieve a definitive formulation, needs to be seen in light of Krafft-Ebing’s earlier conceptions of sexual delusion, which straddled the realms of the experienced sexual body and sense of self. Moreover, Krafft-Ebing was not the first to outline a theory of non-cisgender identity, as demonstrated by the mid-1880s work of Théodule-Armand Ribot and Rudolph Arndt, as well as various significantly earlier approaches to what had been considered the “monomania of sexual transformation”.