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Medical device innovation is key to advancing healthcare and fostering economic development. As the global medical technology market expands, the capacity of regions and countries to attract and support innovation has become increasingly significant. This article examines the growing perception that China is becoming a more attractive environment for medical device development than Europe, focusing on key regulatory differences that may influence this shift. It compares the hierarchical structure of legislation, regulatory oversight bodies, and classification procedures, particularly for emerging technologies like artificial intelligence (AI). For instance, while Europe’s decentralised system of notified bodies offers developers flexibility, China’s centralised regulatory agencies and more adaptable classification system – alongside the absence of stringent AI-specific regulations like the EU’s AI Act – may present a different set of trade-offs and facilitate faster market entry for innovative technologies. Despite these differences, the paper argues that regulation alone does not fully explain China’s rising attractiveness. Other contributing factors, such as its vast market size, significant government support, and broader R&D policies, must also be considered. The analysis concludes that while regulatory structures are influential, they represent just one component of a multifaceted ecosystem that shapes the global geography of medical device innovation.
Sacrificing own resources to punish norm violators is often regarded an altruistic act, promoting cooperation and fairness within social groups. However, recent studies highlight difficulties in interpreting third-party punishment as a prosocial and cooperative signal. Moving beyond abstract, decontextualized settings typically employed in economic game paradigms, we aimed to better understand the appraisal of observed punishment and punishers in real-world situations. To this end, we created and validated 24 written vignettes of everyday-life scenarios depicting interactions between a perpetrator, a victim, and a punisher. Across two preregistered experiments, we systematically manipulated key aspects of third-party punishment: transgression type and punishment type (property-oriented, corporal, or psychological; Experiment 1; N = 48) and punishment severity (weak or strong; Experiment 2; N = 50). Participants rated punishment adequacy and the punisher’s warmth, competence, and suitability as an interaction partner, whether as a friend or team leader. Results indicated preferences for psychological punishments, punishments that aligned with transgression type, and less severe punishments. Our findings support the notion that punishment is an ambiguous issue and reveal important contextual factors that contribute to its evaluation as a useful social strategy.
This scoping review provides an overview of the impact of fruit and vegetable (FAV) consumption on cognitive function in adolescents and young adults between January 2014 and February 2024. A comprehensive search across six databases, CINAHL, PubMed-MEDLINE, ProQuest, Web of Science, Scopus, and Embase, identified 5,181 articles, of which six met the inclusion criteria after deduplication and screening. This scoping review focused on individuals aged 11–35 years in schools, colleges, universities, and communities. Following a descriptive and narrative synthesis of the data, tables and figures were used to present the findings. Across the six included studies, most consistently demonstrated a positive association between higher fruit and vegetable (FAV) intake and improved cognitive performance among adolescents and young adults. This association was evident in both cross-sectional and longitudinal studies, with stronger effects observed for whole fruits and vegetables high in fibre and polyphenols. Cognitive domains positively impacted included psychomotor speed, memory, attention, and mood. However, findings varied by type of food and cognitive domain; while whole FAVs were generally beneficial, results for fruit juice were mixed—some studies showed acute benefits. Differences in study designs, dietary assessment tools, and cognitive measures contributed to variability. Despite these inconsistencies, the overall trend supports a beneficial role of FAV consumption in promoting cognitive health during adolescence and early adulthood. This review demonstrates that increased fruit and vegetable consumption is consistently linked to improved cognitive function in adolescents and young adults. However, further research is needed to establish its long-term effects on cognitive ageing and disease prevention
Before daybreak on March 1966, in a lush small town called Dunkwa-on-Offin, women traders of the Ghana National Trading Corporation, the United African Company, and the Ghana Fishing Corporation adorned their bodies with white clay and calico. Calico represented “victory.” Dunkwa-on-Offin sits halfway between Kumasi – the capital city of the formerly powerful Asante Kingdom to its north – and Cape Coast – the former colonial capital of the British Gold Coast. The women were celebrating the events from the previous month. On February 24, Ghana’s leader Kwame Nkrumah was en route to Hanoi, Vietnam, to visit Vietnamese President Ho Chi Minh via China when the National Liberation Council (NLC) instigated a military coup d’état. Nkrumah’s government collapsed. His statues and edifices followed suit. The Chinese embassy was ransacked; some of its personnel were attacked. Violence continued on the streets of Ghana, “anyone who resisted them (NLC) was brutally shot…. Even young children were hit with rifle butts.” The NLC burned any literature on socialism, communism, or Nkrumah. The women were not alone in celebrating the downfall of Nkrumah’s government. Pass-book traders, wide-eyed and impressionable high school students, and Christian and Muslim congregationalists flanked them. Unlike Nkrumah’s return to Colonial Ghana from the United Kingdom (UK) in January 1957, a few months before independence (March 6), where he was greeted by his supporters dressed in calico and dancing and singing to drums, the women traders in Dunkwa-on-Offin sang in support of the NLC.
Cue-reactivity responses in addictive behaviours are triggered by cues associated with the addictive activity itself. Although such cues may depict the rewarding aspects of the behaviour, responses may also generalise to more distal cues that do not directly convey this content.
Aims
To examine cue reactivity to distal cues (i.e. devices displaying starting or log-in screens of internet applications) in a diagnostically validated sample of individuals with specific problematic usage of the internet (PUIs) and determine whether laboratory-measured cue reactivity predicts real-life behavioural engagement and temptation experiences, in addition to differences across PUI stages and cue types.
Method
In this preregistered study, data were collected from October 2021 to 31 August 2024 from individuals with non-problematic (n = 268), risky (n = 135) and pathological (n = 133) engagement in specific internet activities (gaming, buying and/or shopping, pornography use and social networking). Participants were aged 18–65 years (mean age 26.12 years, s.d. 6.79), and 44.6% were female. A cue-reactivity paradigm with distal cues showing target and non-target internet activities was used. A within–between participants design was used, with repeated measures analyses of variance. Correlations between laboratory cue-reactivity measures and measures from a 14-day end-of-day assessment in the natural environment are reported.
Results
Heightened cue reactivity (arousal, urge and/or craving) was observed in individuals with risky and pathological use compared with those with non-problematic use across all levels of the paradigm. Individuals with pathological use showed elevated levels of urge and craving, along with generalised responses to stimuli showing starting and/or log-in screens not related to their specific (addictive) behaviour. These effects were consistent across different types of PUI and were associated with engagement in the behaviour and temptation experiences in naturalistic settings.
Conclusions
These findings indicate that cue reactivity and craving are central aspects of PUIs. Although different devices may elicit different types of action, our results highlight the challenges of regulating behaviour in environments saturated with unavoidable triggers, such as internet content and devices.
This article explores the variation surrounding the semi-modals be going to and gonna. While gonna is frequently mentioned alongside be going to, it remains under-described in traditional grammars and academic literature. However, recent studies within Construction Grammar suggest that gonna may represent an independent construction, prompting a reconsideration of other variants within the be going to / gonna paradigm such as gon and imma, which appear to derive directly from gonna and no longer from be going to. In light of recent work, what have traditionally been regarded as mere ‘phonetic realizations’ or ‘orthographic variants’ may in fact play a more significant role in the formation and definition of constructions, raising questions about the structure of constructional networks. This article analyzes the immediate syntactic environment of the variants to account for both the variation of forms and the status of such forms. The study is conducted using two corpora that are particularly prone to showing linguistic innovations and language change: a spontaneous spoken corpus and a web corpus. Findings indicate that shorter variants often involve elision of be and that gonna is more grammaticalized than going to, based on the types of verbs they precede.
This paper builds on a thought experiment by Professor Harry van Buren, asking what might emerge if the Business and Human Rights field took a temporary ‘break’ from the UN Guiding Principles (UNGPs). It critically analyzes how the UNGPs’ pragmatic and consensus-oriented design, while instrumental in institutionalizing the field, has also shifted its normative orientation. The paper argues that the increasing dominance of procedural pragmatism has led to compliance-driven approaches that risk displacing more justice-oriented, participatory visions of accountability. In response, the paper aims to contribute to potential reimagining of the field outside of the confines of the UNGPs by offering an alternative pathway grounded in Critical Dialogic Accounting and Accountability, Worker-driven Social Responsibility, and prefigurative politics. The paper concludes with a reflection that the future of BHR depends not just on expanding the implementation of existing norms but on rethinking what accountability can look like when built from below.
We investigate the long-time asymptotic behavior of solutions to the Cauchy problem for the KdV equation, focusing on the evolution of the radiant wave associated with a Wigner–von Neumann (WvN) resonance induced by the initial data (potential). A WvN resonance refers to an energy level where the potential exhibits zero transmission (complete reflection). The corresponding Jost solution at such energy becomes singular, and in the NLS context, this is referred to as a spectral singularity. A WvN resonance represents a long-range phenomenon, often introducing significant challenges, such as an infinite negative spectrum, when employing the inverse scattering transform (IST). To avoid some of these issues, we consider a restricted class of initial data that generates a WvN resonance but for which the IST framework can be suitably adapted. For this class of potentials, we demonstrate that each WvN resonance produces a distinct asymptotic regime – termed the resonance regime – characterized by a slower decay rate for large time compared to the radiant waves associated with short-range initial data.
Plastic pollution in our aquatic systems is a pressing issue, and the spread of these particles is determined by several factors. In this study, the advection and dispersion of negatively buoyant finite-size particles of four different shapes (spheres, circular cylinders, square cylinders and flat cuboids) and two sizes (6 and 9 mm) are investigated in turbulent open-channel flow. The volume, mass and characteristic length are fixed for each size. Four different turbulent conditions are considered, varying the free stream velocity $U_{\infty }=$ 0.25 and 0.38 m s–1 and turbulence intensity ($(u'/U)_\infty =4$ % and 9 %). The particles are released individually from below the water surface. A catch-grid is placed along the bottom floor to mark the particle landing location. The average particle advection distance remains unchanged between the turbulence levels, suggesting that the mean settling velocity is independent of turbulence in this regime. Based on the root mean square of the landing locations, the particle dispersion varies with particle shape, size, settling velocity and turbulent flow conditions. For the square cylinders investigated in this work, the effect of particle shape on dispersion is difficult to predict at low flow velocities and turbulence intensities. As the turbulent fluctuations increase, the dispersion becomes more predictable for all shapes. An empirical expression is proposed to relate turbulent velocity fluctuations, integral length scales, particle settling velocity and particle size to streamwise dispersion. It is found that finite-size inertial particles do not disperse per simple turbulent diffusion, meaning that particle geometry has to be incorporated into dispersion models.
Religious and ethnic communities have long helped people cope with risks. Does state-provided welfare substitute for ethnicity-based social insurance? If so, does it improve intergroup relations? Ethnicity-based insurance operates through reciprocity and solidarity, requiring social investment in in-group ties. This limits the formation of out-group ties, exacerbating ethnic divisions. Welfare reduces dependence on the ethnic group, allowing individuals to form productive out-group ties and increasing intergroup integration. I test this argument in caste networks in India. I leverage panel data on household loans to show that an income support program reduced within-caste borrowing by 38.5%. Using survey data from 3,020 households, I show that welfare enhanced intercaste ties, mainly in areas with lower caste-based land inequality. I draw on 56 qualitative interviews to document how caste-based social insurance exacerbates social segregation, and why intercaste ties increase with lower group inequality. These findings illuminate the persistence and demise of ethnic divisions.