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Irisin is a glycosylated polypeptide hormone derived from muscles that plays a crucial role in learning and memory by promoting the growth of hippocampal neurons, thereby influencing cognitive function.
Objective
Despite increasing evidence, a comprehensive understanding of the exact role of irisin remains elusive, necessitating further research to unravel the complex mechanisms through which irisin influences cognitive function and to explore therapeutic approaches targeting irisin.
Method
A literature review was performed by searching PubMed for articles published between 2012 and 2024, using the keywords ‘fibronectin type III domain-containing 5 (FNDC5)’, ‘irisin’, ‘cognitive impairment’, ‘Alzheimer’s disease’, ‘Age-related cognitive dysfunction’ and ‘Diabetes-associated cognitive dysfunction’, combined with Boolean operators (AND/OR).
Results
This review highlighted the potential impact of irisin on cognitive function in the context of ageing, diabetes and Alzheimer’s disease. The anti-cognitive impairment effects of irisin are associated with the regulation of energy metabolism, insulin resistance, inflammation, oxidative stress, amyloid-beta deposition, synaptogenesis and plasticity. The signalling pathways through which irisin improves cognitive impairment are complex and highly regulated processes, involving multiple signalling pathways such as the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, mitogen-activated protein kinase (MAPK) signalling pathway, nuclear factor-κB (NF-κB) signalling pathway, ERK-STAT3 signalling pathway, cAMP/PKA/CREB signalling pathway and Nrf2/HO-1 signalling pathway.
Conclusion
This review delves into the positive effects of irisin on cognitive impairment, examines the signalling pathways related to fibronectin type III domain-containing 5 (FNDC5)/irisin and provides future perspectives for research on the anti-cognitive impairment effects of irisin.
Comprehend, Cope and Connect (CCC) is a trauma-informed, transdiagnostic and evidence-based psychological intervention for mental health crises that can be applied cross-culturally. CCC has been implemented in acute and crisis mental health settings across the South of England and in services elsewhere in the UK. More recently, it has been taken up and adapted for specialist community settings, including perinatal services, addiction services and primary care settings. A continuously growing evidence base indicates that CCC could be the next step towards solving the national problem of mental health crises. It is now time for CCC to be piloted and researched nationally.
Spectroscopic observations are essential for confirming associations, measuring kinematics, and determining stellar populations in dwarf galaxies. Here, we present Keck Cosmic Web Imager spectra for 12 MATLAS survey dwarfs. For 9, we confirm recession velocities consistent with their literature-assumed host galaxies. We propose revisions of the host galaxy associations for MATLAS-631, 1494, and 1938. For MATLAS-1494, our measured redshift reclassifies it from an ultra-diffuse galaxy candidate to a dwarf galaxy that is of smaller physical size and places it in the field. It also appears old and passive, providing a challenge to models that invoke quenching by tidal effects. Additionally, we measure stellar population estimates for 7 of the 12 galaxies, finding a ‘mixed bag’ of old quenched galaxies and those that are currently forming stars. Compared to the literature we find generally younger ages and higher metallicities. This result may help reconcile the observed offset of MATLAS survey dwarf galaxies from the universal stellar mass–metallicity relationship reported by Heesters et al. (2023).
Single-crystal synchrotron X-ray diffraction data were collected up to 10 GPa at room temperature on a natural omphacite with composition close to Jd43Di57, at the Xpress beamline at Elettra Synchrotron, using a diamond anvil cell. A second-order Birch-Murnaghan equation of state (EoS) fit to the unit-cell volumes determined at 20 pressure points yielded V0 = 422.85(15) Å3, and K0 = 121.3(1.2) GPa. These elastic parameters are consistent with the general trend of the diopside–jadeite join. The structural evolution with pressure was determined from both ab initio simulations and structure refinements to the X-ray intensity data. The consistency between experimental findings and local geometrical distortions identified through ab initio calculations is discussed. A distortion variation at the M1 polyhedron occurs at ∼3 GPa, which correlates with the TILT angle of the T2 tetrahedron which stabilises at a similar pressure, coinciding with a decrease in the rate of M1 deformation under pressure.
These results revealing the structural evolution with pressure correlate with changes observed previously in some Raman shifts in the same pressure range in the same material.
We explore debt and debt management among older Americans (ages 51–61 years) using the 2018 National Financial Capability Study. Though these individuals should have been at the peak of their retirement savings, we show that many were heavily indebted, often due to unpaid medical bills and student loans. Additionally, fewer than half (43%) could correctly answer three basic financial literacy questions; importantly, less financially literate people were more likely to hold excessive debt, be contacted by debt collectors, and carry medical debt or student loans. Our findings show that, even before the pandemic, a sizable proportion of older Americans was financially distressed, underscoring the need for researchers and policymakers to devote attention to specific types of debt that burden the older population. Particularly vulnerable groups include African-Americans, women, and the least-educated.
Unlike many other industrial societies, the partisan fights on the vaccination against COVID-19 in Taiwan centred on its brand choice rather than acceptance. Did the incumbent DPP supporters adhere to their party line of Medigen to vaccinate against COVID-19 during the pandemic? We argue that individual COVID-19 vaccine brand choices as gradually updated judgements during the pandemic were not solely determined by the party line, but jointly shaped by the strength of party affiliation and the level of government trust to facilitate decision-making in the highly uncertain information environment at the early stage of the pandemic. More specifically, when choosing COVID-19 vaccine brand, the incumbent DPP supporters, particularly weak ones, were more likely to adhere to their party line of Medigen as they trusted government more; however, this was only for the highly uncertain first shot, due to the absence of reliable information for making informed judgements about COVID vaccine brand choice at the early stage of the pandemic, not for the informationally rich booster shot. We report empirical findings consistent with our argument from statistical analyses of original data from a survey of 1642 Taiwanese adult respondents conducted in the fall of 2022.
In this short narrative review, we would like to discuss the immunomodulatory effects of South African geranium (Pelargonium sidoides) root extract EPs7630 in treating acute rhinosinusitis. The plant has been used for centuries to treat respiratory tract inflammation, such as sinusitis, pharyngitis and bronchitis. South African geranium is rich in polyphenols, flavonoids, tannins, diterpenes and proanthocyanidins, but the main constituent is a type of coumarin called ‘umckalin’ (6–hydroxy–5,5–dimethoxy–coumarin). The substance is standardised as an aqueous-ethanolic extract from the root of this plant under the code name EPs7630.
Methods
The article presents the results of in vitro and in vivo studies of administering this herbal drug in acute viral, post-viral and bacterial rhinosinusitis. The focus is on the immunomodulatory effects of EPs7630 during the therapy of this acute inflammation of the nasal mucosa.
Results
According to the results of some studies, EPs7630 stimulates monocyte-dependent activity and inhibits neutrophil-dependent chemokine activity. However, given the small number of studies, the level of evidence is low, implying the need for new research.
Conclusion
Particular attention should be paid to the effect of EPs7630 on bradykinin, the mediator that triggers most inflammatory processes in acute rhinosinusitis.
The advent of new technologies, particularly artificial intelligence (AI), has expanded the array of options and enhanced performance in addressing biothreats. This article provides a comprehensive overview of the specific applications of AI in addressing biothreats, aiming to inform and enhance future practices. Research indicates that AI has significantly contributed to infectious disease surveillance and emergency responses, as well as bioterrorism mitigation; despite its limitations, it merits ongoing attention for further study and exploration. The effective deployment of next-generation AI in mitigating biothreats will largely hinge on our ability to engage in continuous experiential learning, acquire high-quality data, refine algorithms, and iteratively update practices. Meanwhile, it is essential to assess the operational risks associated with AI in the context of biothreats and develop robust solutions to mitigate potential risks.
Existing evidence on the association between combined lifestyle and depressive symptoms is limited to the general population and is lacking in individuals with subthreshold depression, a high-risk group for depressive disorders. Furthermore, it remains unclear whether an overall healthy lifestyle can mitigate the association between childhood trauma (CT) and depressive symptoms, even in the general population. We aimed to explore the associations of combined lifestyle, and its interaction with CT, with depressive symptoms and their subtypes (i.e. cognitive-affective and somatic symptoms) among adults with subthreshold depression.
Methods
This dynamic cohort was initiated in Shenzhen, China in 2019, including adults aged 18–65 years with the Patient Health Questionnaire-9 (PHQ-9) score of ≥ 5 but not diagnosed with depressive disorders at baseline. CT (present or absent) was assessed with the Childhood Trauma Questionnaire-Short Form. Combined lifestyle, including no current drinking, no current smoking, regular physical exercise, optimal sleep duration and no obesity, was categorized into 0–2, 3 and 4–5 healthy lifestyles. Depressive symptoms were assessed using the PHQ-9 during follow-up. This cohort was followed every 6 months, and as of March 2023, had been followed for 3.5 years.
Findings
This study included 2298 participants (mean [SD] age, 40.3 [11.1] years; 37.7% male). After fully adjusting for confounders, compared with 0–2 healthy lifestyles, 3 (β coefficient, −0.619 [95% CI, −0.943, −0.294]) and 4–5 (β coefficient, −0.986 [95% CI, −1.302, −0.671]) healthy lifestyles were associated with milder depressive symptoms during follow-up. There exists a significant synergistic interaction between a healthy lifestyle and the absence of CT. The CT-stratified analysis showed that compared with 0–2 healthy lifestyles, 3 healthy lifestyles were associated with milder depressive symptoms in participants with CT, but not in those without CT, and 4–5 healthy lifestyles were associated with milder depressive symptoms in both participants with and without CT, with a stronger association in those with CT. The lifestyle-stratified analysis showed that CT was associated with more severe depressive symptoms in participants with 0–2 healthy lifestyles, but not in those with 3 or 4–5 healthy lifestyles. Cognitive-affective and somatic symptoms showed similar results.
Conclusions
In this 3.5-year longitudinal study of adults with subthreshold depression, an overall healthy lifestyle was associated with subsequent milder depressive symptoms and their subtypes, with a stronger association in adults with CT than those without CT. Moreover, an overall healthy lifestyle mitigated the association of CT with depressive symptoms and their subtypes.
The article examines the drivers of migrant atypical employment in the manufacturing sector of Emilia-Romagna, an Italian region that is well known for its high-quality manufacturing productions and industrial relations. By drawing on administrative data based on mandatory communications, we document that, even in such an institutional context, migrants have a disproportionately higher likelihood of being hired through either fixed-term or agency contracts than native workers. We interpret this evidence through a set of different theories, including human capital theory, dual labour market processes, the use of precarious contracts as screening devices, and institutional segmentation theories. The empirical analysis reveals that while migrant employment through fixed-term contracts is consistent with dual processes and screening practices, the hiring of migrants with agency contracts is driven by processes of institutional segmentation, through which employers shift the costs of flexibility to the most vulnerable and less organized segments within the labour force, such as migrants. Managerial and policy implications are discussed.
Bubble–particle collisions in turbulence are key to the froth flotation process that is widely employed industrially to separate hydrophobic from hydrophilic materials. In our previous study (Chan et al., 2023 J. Fluid Mech.959, A6), we elucidated the collision mechanisms and critically reviewed the collision models in the no-gravity limit. In reality, gravity may play a role since, ultimately, separation is achieved through buoyancy-induced rising of the bubbles. This effect has been included in several collision models, which have remained without a proper validation thus far due to a scarcity of available data. We therefore conduct direct numerical simulations of bubbles and particles in homogeneous isotropic turbulence with various Stokes, Froude and Reynolds numbers, and particle density ratios using the point-particle approximation. Generally, turbulence enhances the collision rate compared with the pure relative settling case by increasing the collision velocity. Surprisingly, however, for certain parameters the collision rate is lower with turbulence compared with without, independent of the history force. This is due to turbulence-induced bubble–particle spatial segregation, which is most prevalent at weak relative gravity and decreases as gravitational effects become more dominant, and reduced bubble slip velocity in turbulence. The existing bubble–particle collision models only qualitatively capture the trends in our numerical data. To improve on this, we extend the model by Dodin & Elperin (2002 Phys. Fluids14, 2921–2924) to the bubble–particle case and found excellent quantitative agreement for small Stokes numbers when the history force is negligible and segregation is accounted for.
The fields of archaeology and museology are working to encourage and enforce research methodologies and policies that center reciprocity and respect among archaeologists, institutions, and Native Nations. This shift in approach is grounded in part by the inclusion of the Duty of Care clause in the revised NAGPRA regulations and partly by a revised awareness of ethical standards. Policy-level changes around research access are the most impactful but can also be the most challenging to initiate. In this article, we address shifts in both institutional research policies and researchers’ approaches and practices that actively incorporate Native perspectives. The framework presented was developed as a complement to the Indigenous Collections Care Guide and is grounded in case studies from three institutions that have changed their research policies. The resulting prompts, tips, examples, and challenges are provided for both researchers and institutions to evaluate research and access practices and how they intersect with Native perspectives. Seeking input and consent from Native Nations adds challenging layers to research, but the depth, quality, and impact of the research and the strengthening of relationships and trust with the communities significantly outweigh the extra time and effort.
Research informed by sociological neoinstitutionalism often frames organizational reactions to legal norms as either loose coupling, where formal legal commitments are only weakly aligned with actual practices, or tight coupling, where strong internal or external compliance pressures drive close alignment. This article introduces a third pattern – contentious coupling – where some organizational members attempt to realign practices with legal commitments, but these very efforts provoke pushback from others, resulting in substantive yet constrained success. This paradox is key to understanding the widespread yet limited effects of legal rights. I illustrate contentious coupling by examining how international human rights law has shaped solitary confinement reform in Taiwan. While hierarchical enforcement led by rights advocates and policymakers has successfully reduced prolonged solitary confinement, it has also alienated frontline correctional officers by triggering a sense of relative deprivation and perception of hypocrisy, encapsulated in their complaints of a “human rights upsurge.” In response, these officers engage in two forms of passive resistance – formalistic care and resistance spillover – both of which undermine the authority of human rights and hinder their capacity to transform correctional culture.
This study examined the motivational factors influencing African immigrants in New Zealand to become entrepreneurs and the factors that ensured their business success. Data were collected from 117 participants through survey questions employing the Qualtrics platform and its link was sent to participants in the Auckland region. Auckland was decided on for data collection, being the most populated city and the business nerve centre of New Zealand. The research was conducted using a descriptive and quantitative approach. From the analysis, the study found that passion for business entrepreneurship, flexibility, financial independence, generic independence, autonomy, and being one’s own boss are the most highly motivational factors for influencing African immigrants in New Zealand to opt for business ownership. The study also found that the six highest-rated reasons for African immigrants’ entrepreneurial business success in New Zealand were readiness to make sacrifices to succeed, always giving the best in everything that had to be done, the importance of action, a belief that everything is possible if the entrepreneur believes he/she can do it, the challenge of taking on new projects, and learning lessons from past failure. These findings are the most important factors helping African immigrant business owners in New Auckland Zealand to attain entrepreneurial and business success. This research maintains that the results shed light on why African migrants adopt business entrepreneurship and gear themselves up for success in New Zealand.
This work analyses the genetic potential of Stevia rebaudiana beyond its sweetening properties, aiming to reassess its conservation and utilization in breeding programmes. This focus is justified by the growing global demand for natural sweeteners and the challenges posed by extreme weather events and diseases affecting crop yield and quality. The relationship between the species’ genetic diversity and its response to biotic and abiotic stresses is explored, as well as the limitations of current conservation and breeding strategies. Findings reveal underutilized genetic resources, limited integration of genomic tools in breeding efforts and a lack of robust in situ conservation initiatives. Genotypic variability has been observed in response to diseases such as Septoria leaf spot, while abiotic factors, including salinity and drought, can significantly influence steviol glycoside content. It is concluded that an integrated approach, combining dynamic conservation, photoperiod‐informed breeding strategies, improvements in seed viability, omics‐based tools and coherent public policies, is essential to ensure crop resilience and genetic sovereignty, especially in regions of origin such as Paraguay. The sustainable use of Stevia’s genetic diversity could foster more sustainable, healthier and fairer production systems.
Using a behavioural intervention to target nutrition during pregnancy may be key in meeting recommendations for healthy eating. The aim was to assess the use of a short-term dietary intake measurement tool (3-day food intake record) to infer long-term habitual dietary intake during pregnancy (using a short-form FFQ). A convenience sample (n 90) between 12- and 18-weeks’ gestation was recruited from a larger randomised controlled trial for cross-sectional analysis. Participants completed a forty-four-item FFQ and 3-day food intake record. Using the participant food intake record, the investigator blindly completed a second frequency questionnaire. The frequency questionnaires were scored using dietary quality scores (DQS) and compared. Aggregate data were evaluated using a Wilcoxon signed rank test, and individual-level data were evaluated using a Bland–Altman plot. No significant difference was observed in the scores (Z = –1·88, P = 0·06), with small effect size (r= 0·19). The Bland–Altman plot showed that comparing the DQS derived from the two different dietary assessments underestimated scores by a mean difference of 0·4 points (95 % limits of agreement: −3·50 to 4·26). The data points were evenly spread suggesting no systematic variation for over- or underestimation of scores. Minimal difference was observed between the functionality of the two assessment instruments. However, the food intake record can be completed by pregnant individuals to estimate short-term nutrient intake and then scored by the investigator to estimate long-term dietary quality. Combining these two instruments may best capture the most accurate representation of dietary habits over time.
We propose CTREND, a new trend factor for cryptocurrency returns, which aggregates price and volume information across different time horizons. Using data on more than 3,000 coins, we employ machine learning methods to exploit information from various technical indicators. The resulting signal reliably predicts cryptocurrency returns. The effect cannot be subsumed by known factors and remains robust across different subperiods, market states, and alternative research designs. Moreover, it survives the impact of transaction costs and persists in big and liquid coins. Finally, an asset pricing model that incorporates CTREND outperforms competing factor models, providing a superior explanation of cryptocurrency returns.
Historical censuses have often served as valuable sources for understanding the past. Yet, their use as sources about women’s work has been highly debated. This article engages with the continuing debate regarding the reliability and validity of censuses by exploring significant potentials and issues of censuses’ information about women’s work. While recognizing a critical perspective on censuses’ information about women’s work, this article identifies the need for more careful and contextualized readings of censuses. To this end, it presents five novel analytical approaches that aim to enhance readings and interpretations of censuses. The approaches reveal the purposes, focuses, self-reflections, ambiguities, and evolving categorizations of censuses, respectively. Through analysis of Swedish census materials from 1910 to 1940, this article moreover demonstrates that historical census personnel engaged with women’s work in sophisticated ways and that censuses’ representations were complex. The article argues against dismissing censuses outright as a fruitful source about women’s work. Instead, it recommends leveraging their inherent qualities in new and creative ways. Though non-neutral by incorporating and disseminating ideas about gender, censuses can serve as rich historical sources about women’s work and societal roles when approached contextually in various ways. The article advocates for contextualized and historicized approaches to using census data, moving beyond simplistic labels to explore the complexities of these important historical sources.
Political professionals and scholars maintain that raising money early in the election season is critical to a successful campaign, having downstream consequences on a candidate’s future fundraising potential, the stiffness of competition she will face, and her likelihood of electoral victory. In spite of early money’s perceived importance, there is no common operationalization for money as “early.” Moreover, existing measures often fail to reflect definitional aspects of early money. In this paper, we first lay out a theoretical framework regarding the utility of early campaign fundraising for candidates. We argue that early fundraising can be expressed as two conceptually distinct quantities of interest centered on either a candidate’s own fundraising performance (candidate-centered) or her fundraising performance relative to her electoral competitors (election-centered). We next lay out steps for operationalizing candidate- and election-centered measures of early fundraising. Lastly, we demonstrate that both our proposed measures for early campaign fundraising are predictive of a candidate’s future fundraising and electoral success. By putting forward a set of best practices for early money measurement and, additionally, producing off-the-shelf measures for early fundraising in U.S. House elections, we fill an important gap in scholarly research on the measurement of money in politics.
The offshoring-fuelled growth of the Central and Eastern European business services sector gave rise to shared service centres (SSCs) – quasi-autonomous entities providing routine-intensive tasks for the central organisation. The advent of technologies such as intelligent process automation, robotic process automation, and artificial intelligence jeopardises SSCs’ employment model, necessitating workers’ skills adaptation. The study challenges the deskilling hypothesis and reveals that automation in the Polish SSCs is conducive to upskilling and worker autonomy. Drawing on 31 in-depth interviews, we highlight the negotiated nature of automation processes shaped by interactions between headquarters, SSCs, and their workers. Workers actively participated in automation processes, eliminating the most mundane tasks. This resulted in upskilling, higher job satisfaction, and empowerment. Yet, this phenomenon heavily depends upon the fact that automation is triggered by labour shortages, which limit the expansion of SSCs. This situation encourages companies to leverage the specific expertise entrenched in their existing workforce. The study underscores the importance of fostering employee-driven automation and upskilling initiatives for overall job satisfaction and quality.