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We classify finite groups that act faithfully by symplectic birational transformations on an irreducible holomorphic symplectic (IHS) manifold of $OG10$ type. In particular, if X is an IHS manifold of $OG10$ type and G a finite subgroup of symplectic birational transformations of X, then the action of G on $H^2(X,\mathbb {Z})$ is conjugate to a subgroup of one of 375 groups of isometries. We prove a criterion for when such a group is determined by a group of automorphisms acting on a cubic fourfold, and apply it to our classification. Our proof is computer aided, and our results are available in a Zenodo dataset.
The cerebellar cognitive affective syndrome (CCAS) scale has been developed to screen for possible cognitive and affective impairments in cerebellar patients, but previous studies stressed concerns regarding insufficient specificity of the scale. Also, direct comparisons of CCAS scale performance between cerebellar patients with and without CCAS are currently lacking. The aim of this study was to evaluate the validity of the CCAS scale in cerebellar patients.
Method:
In this study, cerebellar patients with CCAS (n = 49), without CCAS (n = 30), and healthy controls (n = 32) were included. The Dutch/Flemish version of the CCAS scale was evaluated in terms of validity and reliability using an extensive neuropsychological assessment as the gold standard for CCAS. Correlations were examined between the CCAS scale and possible confounding factors. Additionally, a correction for dysarthria was applied to timed neuropsychological tests to explore the influence of dysarthria on test outcomes.
Results:
Cerebellar patients with CCAS performed significantly worse on the CCAS scale compared to cerebellar controls. Sensitivity was acceptable, but specificity was insufficient due to high false-positive rates. Correlations were found between outcomes of the scale and both education and age. Although dysarthria did not affect the validity of the CCAS scale, it may influence timed neuropsychological test outcomes.
Conclusions:
Evaluation of the CCAS scale revealed insufficient specificity. Our findings call for age- and education-dependent reference values, which may improve the validity and usability of the scale. Dysarthria might be a confounding factor in timed test items and should be considered to prevent misclassification.
This article proposes a framework to understand questions of fairness in EU law. It builds on the scholarly literature on the meaning and scope of this concept, to then consider its relevance to legal orders and specifically the European Union’s. Having set out an umbrella definition of fairness as a legal principle, the article applies it to a specific example: namely, the system of border procedures introduced by the new asylum and migration pact. The objective of this paper is twofold. Firstly, it aims to provide a blueprint for discussing issues of fairness in the EU beyond a specific area of law and policy. Secondly, in concretely adapting that blueprint to the specificities of the ‘case study’ analysed in the paper, it sheds light on the degree of its (un)fairness.
We consider the effect of labor market volatility on employment and wages in the meat processing sector. The period of study includes the COVID-19 pandemic, which resulted in significant labor market shocks in the sector. We examine the relationship between historical volatility of employment and wages and current employment and wages, focusing on the animal slaughtering and processing sector (NAICS 3116). We utilize county-level data to estimate dynamic panel data models of employment and wages. We find that historical volatility in both employment and wages had a significant negative impact on employment in the sector. In the case of wage volatility, we find that wages are higher following periods of significant wage volatility, suggesting that workers demand higher wages under conditions of market volatility. During COVID, smaller meat processors had lower levels of employment, but a small number of large processors had significantly higher levels of employment. In contrast, wages were higher after COVID-19 for almost all counties included in the analysis. In an aggregate sense, COVID tended to largely reduce employment but increase wages in the meat processing sector.
The need for critical minerals for various technologies for commercial and defense use has led to a range of national policy interventions. However, many of these new laws to encourage mining, or protect local industries have not considered as scientific data on mineral reserves or the economic viability of setting specific targets. The EU’s Critical Raw Materials Act is a pivotal case in point that illustrates this challenge. We present a review of the range of laws and policies that have been set forth worldwide.
Technical Summary
Growing international conflict between countries that have large mineral production and processing capacity and those which are in demand of critical raw materials for new technologies has led to a proliferation of policies that promote resource nationalism or ‘friend-shoring’. We analyzed over 400 critical raw material policies to date that have been documented by the International Energy Agency's policy tracking tool and present the findings of the six most active jurisdictions. The EU's Critical Raw Materials Act which came into force in May 2024 stands out as the most significant legislative step taken thus far but needs better interface with environmental and social data on impacts and benefits. By analyzing the challenges faced by lithium mining projects across a range of technologies and geographic locations in Europe, we suggest the use of data generated from life cycle analyses, economic geological calculations, and ecosystem service valuation in improving the implementation of such policies and also mitigate social conflicts.
Social Media Summary
There are now more than 400 critical raw material policies worldwide, but they need to be predicated in economic and geological data to be effective.
Some people act despite knowing their actions are wrong. Others know and do the right thing. This paper focuses on people who rightly believe that gaining specific knowledge would be enough to motivate moral action but remain strategically ignorant due to self-interest. This paper argues that such individuals have a moral obligation to acquire the salient knowledge given the following applies: first, such individuals are aware of the morally efficacious knowledge; and second, the efficacious knowledge is accessible to them. Then, we examine similarities and differences between morally mandatory knowledge and culpable ignorance. Finally, morally mandatory knowledge shows that ignorance can result from deficient moral character.
Several malaria control measures aim to reduce infection levels in mosquitoes, and evaluation of these measures usually relies on experimental infections of mosquitoes or evaluation in field populations. Both require robust statistical tools to account for multiple variables and non-normal distributions of parasites in the vector host. We argue that a well-chosen generalized linear or mixed model is the most appropriate statistical tool for analysing and interpreting these biological data. We suggest specific methods to overcome datasets where some groups have zero/close to zero prevalence, or many zero counts of parasite numbers (as would be seen with an effective transmission blocking intervention). These methods are more broadly applicable across many parasitic infections with similar patterns of parasite numbers across hosts.
As hybrid work arrangements have become more prevalent in the wake of the COVID-19 pandemic, the alignment between jobs and workers has also evolved, arguably in ways that research has yet to fully capture. We build on the theoretical foundation of person-environment fit – and person-job fit specifically – to investigate how employees’ work arrangements and their perceived fit with their work arrangements influence important personal (e.g., work-life balance, stress) and work-related (e.g., organizational commitment, engagement) outcomes. Quantitative evidence from a survey of 427 hybrid workers supports the idea that the extent to which an individual’s desires, needs, and values align with their work arrangement plays an important role in their personal and work-related well-being. We advocate for expanding the conceptualization of person-job and person-environment fit models to incorporate work arrangements and provide recommendations for research and practice.
Global discussions around the risks, benefits and governance of solar radiation modification (SRM) in the climate change response portfolio are accelerating, but the topic remains nascent in Latin America and the Caribbean (LAC). In 2023, a US start-up (Make Sunsets) performed a small-scale, non-research deployment of SRM in Baja California, Mexico, without prior permission or community engagement. Their actions prompted Mexico to announce its intention to ban SRM experimentation, underscoring the need for governance to prevent irresponsible practices that could discredit legitimate research. We perform an empirical and ethical analysis of the landscape of academic discussions and media coverage on SRM in the LAC region, focusing on the Make Sunset case. Our analysis leads us to three conclusions: first, a lack of regulations in LAC that fosters mistrust, fuels perceptions of neo-colonialism and restricts potentially valuable and responsible research; second, we argue that the theatrical Make Sunsets case is not ethically justified in light of the diversity of risks associated with it; third, we offer foundational, participatory recommendations to promote effective, transparent and sustainable governance of SRM, including LAC in global conversations.
Compensation schemes are certainly not a new phenomenon in England and Wales, and they are increasingly being used, and called for, to compensate victims in the field of occupational and public health. Despite their long existence, compensation schemes have always been thought to develop on ad hoc basis, without any real discernible logic behind them. This paper suggests that, contrary to this idea, compensation schemes emerging in the field of occupational and public health are generally following an identifiable, if covert, pattern that is deeply rooted in their relationship with the tort system. This relationship, the paper contends, is crucial not only to explain the creation and operation of compensation schemes but also to shed some light on the place and limits of the tort system in this legal system. More than that, this paper demonstrates that the relationship between these two sources of compensation could be the key to offer the beginning of a categorisation of compensation schemes that could help identify which schemes are in need of reform.
Despite prior research on political capabilities and their relationships with meaningful outcomes at work, it remains unclear why certain employees are incapable of successfully navigating workplace politics. To clarify this, our research develops and validates a measure of political self-efficacy at work (PSEW) across seven independent and varying samples. Evidence from faculty members and subject-matter experts in Study 1 provides initial support for the content validity of the new PSEW scale. Then, in Studies 2 and 3, we employ two separate samples to confirm the scale’s convergent and discriminant validity and factor structure. We repeat this process, in Study 4, on several new nomological neighbors (e.g., the Dark Triad traits, general political behavior, impression management, and political will). In Studies 5 and 6, using multi-wave and multi-source data, we assess the criterion-related and predictive validity of the PSEW scale, and in Study 7, we test our full theoretical model. Altogether, these findings verify the nomological network and validity of the new PSEW measure and provide theoretical and practical developments surrounding organizational politics.
Heartwater is a tick-borne disease (TBD) of wild and livestock ruminants that threatens food security and the economy throughout much of Africa. Furthermore, the geographic range of heartwater is expanding and is predicted to continue doing so. Despite this, our understanding of heartwater dynamics lags far behind that of many other TBDs. We are therefore limited in our ability to design effective disease control strategies. In this study, we derive and analyse a mathematical model of heartwater dynamics. We analyse our model to predict the most influential parameters for disease risk, both in terms of new outbreaks and in heartwater-endemic regions. We show that the host-finding efficiency of ticks is the most influential parameter affecting outbreak risk. Also, outbreak risk is highly sensitive to the impact of the heartwater pathogen on tick fitness – a previously unexplored concept for any TBD system. In areas where heartwater is established, we show that disease can be controlled via enzootic stability (prolonged host immunity attained via frequent pathogen exposure). However, the maintenance of enzootic stability was dependent on several ecological and physiological parameters. Regarding practical output, we suggest prioritizing tick control measures during periods when ticks are most active in terms of dispersing towards hosts, so as to mitigate heightened outbreak risk. In addition, given the specificity of conditions required for enzootic stability, we caution against relying solely on enzootic stability for long-term heartwater protection. More broadly, our study highlights important tick life history parameters that have been neglected by previous TBD models.
This is a radiobiological modelling study aimed at comparing stereotactic ablative body radiotherapy (SABR) with conventional palliative radiotherapy (CPRT) and curative-dose volumetric-modulated arc therapy (CD-VMAT) in the palliation of patients with previously untreated head and neck cancer.
Methods:
Three radiotherapy plans were generated for 8 patients with head and neck cancer: SABR, prescribed to 45 Gy in 5 fractions; CPRT, prescribed to 30 Gy in 5 fractions and CD-VMAT, prescribed to 70 Gy in 35 fractions. The tumour control probability (TCP) and normal tissue complication probability for salivary and swallowing function (NTCPsaliva and NTCPswallow, respectively) were determined. From those values, the therapeutic ratio, as measured by the uncomplicated tumour control probability (UTCP), was determined.
Results:
Dosimetric objectives were achieved in all treatment plans. SABR had a higher mean TCP compared to CPRT and CD-VMAT (100% vs 81% vs 93%, p = 0·003). There were no statistically significant differences in the mean NTCPs for salivary or swallowing function (mean NTCPsaliva 27% vs 41% vs 36%, p = 0·093 and mean NTCPswallow 9% vs 12% vs 23%, p = 0·093). This resulted in the mean UTCP being statistically significantly higher for SABR plans compared to CPRT and CD-VMAT (66% vs 42% vs 49%, p = 0·004).
Conclusion:
It is feasible to create SABR plans that satisfy the dosimetric objectives in this study. Based on radiobiological modelling, SABR has superior TCP and similar NTCP, leading to a better therapeutic ratio than CPRT and CD-VMAT.
The impact of CHD on safe driving for adolescents is currently unknown. A prospective, qualitative descriptive study was conducted among adolescents with CHD to describe perceived barriers, facilitators, and impacts of CHD on safe, independent driving among adolescents.
Study design:
Twenty-eight adolescents aged 15–19 years with CHD participated in virtual, semi-structured interviews in 2023. Adolescent interview data were analysed with conventional content analysis refined by Theoretical Domains Framework in NVivo software.
Results:
Mean participant age was 16.4 ± 0.23 years (57% male). Single ventricle physiology (25%) and septal defects (32%) were prevalent diagnoses among the study population. Most participants (92%) did not have driving restrictions.
Two themes emerged from the data:
Driving as a normal rite of passage for adolescents with CHD; and confident—but curious—about the impacts of CHD on driving. Adolescents felt confident that driving is not impacted by CHD. They were curious about the likelihood of cardiovascular emergencies and related symptoms while driving. Perceived barriers and facilitators to safe, independent driving were like what has been described in published literature among adolescents without CHD.
Conclusion:
These findings celebrate the normalcy of driving during adolescence and reveal curiosities about the impacts of stress, anxiety, fatigue, and risks of heart attack and stroke on driving. Adolescents may look to CHD healthcare providers to help them learn about driving. These findings may inform the development of tools to facilitate meaningful conversations with adolescents regarding driving safety as part of the transition to adult CHD care.
Sponge-Sticks (SS) and ESwabs are frequently utilized for detection of multidrug-resistant organisms (MDROs) in the environment. Head-to-head comparisons of SS and ESwabs across recovery endpoints are limited.
Design:
We compared MDRO culture and non-culture-based recovery from (1) ESwabs, (2) cellulose-containing SS (CS), and (3) polyurethane-containing SS (PCS).
Methods:
Known quantities of each MDRO were pipetted on a stainless-steel surface and swabbed by each method. Samples were processed, cultured, and underwent colony counting. DNA was extracted from sample eluates, quantified, and underwent metagenomic next-generation sequencing (mNGS). MDROs underwent whole genome sequencing (WGS). MDRO recovery from paired patient perirectal and PCS-collected environmental samples from clinical studies was determined.
Setting:
Laboratory experiment, tertiary medical center, and long-term acute care facility.
Results:
Culture-based recovery varied across MDRO taxa, it was highest for vancomycin-resistant Enterococcus and lowest for carbapenem-resistant Pseudomonas aeruginosa (CRPA). Culture-based recovery was significantly higher for SS compared to ESwabs except for CRPA, where all methods performed poorly. Nucleic acid recovery varied across methods and MDRO taxa. Integrated WGS and mNGS analysis resulted in successful detection of antimicrobial resistance genes, construction of high-quality metagenome-assembled genomes, and detection of MDRO genomes in environmental metagenomes across methods. In paired patient and environmental samples, multidrug-resistant Pseudomonas aeruginosa (MDRP) environmental recovery was notably poor (0/123), despite detection of MDRP in patient samples (20/123).
Conclusions:
Our findings support the use of SS for the recovery of MDROs. Pitfalls of each method should be noted. Method selection should be driven by MDRO target and desired endpoint.
To examine the relationship between children’s adaptive functioning and neighborhood resources – such as school quality, access to healthy food, green spaces, and housing quality – using a large, diverse clinical outpatient sample.
Method:
Pediatric outpatients (N = 6,942; age M = 10.44 years; 67.0% male; 50.3% White; 33.9% Medicaid), aged 1-18, who underwent neuropsychological or psychological evaluation were included if their caregiver completed the Adaptive Behavior Assessment System, 3rd Edition (ABAS-3) and had a nationally normed Child Opportunity Index (COI) score, a composite measure of 29 geo-coded neighborhood characteristics.
Results:
Children from higher-opportunity neighborhoods demonstrated significantly stronger adaptive functioning across conceptual, social, and practical domains. Those in the top 40% of neighborhood advantage exhibited stronger adaptive skills than those in the bottom 60%. Neighborhood resources and family financial resources were associated with greater adaptive skills beyond child age, sex, and racial/ethnic background.
Conclusion:
Neighborhood resources are linked to children’s adaptive functioning, possibly due to increased opportunities to practice these skills in safer, more supportive environments. These findings emphasize the importance of considering environmental factors in assessing adaptive skills and highlight the need for public health investments and legislation related to community resources.
The concept of provisional possession in Kant presents a significant interpretative challenge. Scholars agree that prior empirical possession must be rationalized but have struggled to identify a form of omnilaterality within the state of nature. I propose understanding provisionality through the Pure Concept of Understanding of Possession (PUP) – a unilateral yet normative framework that rationalizes empirical possession based on temporal priority. Possession understood through PUP serves as a precursor to intelligible possession within the state of nature. To support this account, I first demonstrate that intelligible possession starts from empirical possession, thereby requiring an explanation of the transition from the latter to the former. I then argue that provisional possession unfolds in two distinct steps: first, prior empirical possession acquires an empirical title through the postulate of practical reason, which confers normative significance on temporal priority; second, PUP abstracts from empirical conditions, facilitating the progression towards a rational title.
The endosymbiotic association between the diatom Hemiaulus and the cyanobacterium Richelia was first observed in the Sea of Marmara in July 2021. The spatial distribution of the host diatom Hemiaulus spp. and the endosymbiont cyanobacterium Richelia intracellularis was investigated along with available physicochemical parameters. Three species of the Hemiaulus genus (H. hauckii, H. membranaceus, and H. sinensis) were morphologically identified in the study area. Hemiaulus hauckii and H. sinensis reached up to 128 × 103 cells L−1 and 38 × 103 cells L−1, respectively, while H. membranaceus was rarely observed. Each Hemiaulus cell contained one Richelia trichome, which had heterocysts at both ends. The surface water temperatures and salinity varied between 23.2°C and 28.5°C, 21.4 and 23.5, respectively. Dissolved oxygen levels ranged from 6.2 to 7.6 mg L−1, while chlorophyll-a concentrations were between 0.3 and 6.8 µg L−1. Nutrient concentrations varied between 0.05 and 0.18 μM for NO3 + NO2–N, 0.04–0.24 μM for NH4–N, 0.02–0.39 μM for PO4–P, and 0.18–1.42 μM for SiO2–Si. This study reveals that the Hemiaulus–Richelia symbiosis may promote the proliferation of diatom populations and may play an important role in nutrient dynamics in nitrogen-limiting environments and in the overall functioning of the marine ecosystem.