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Studies of petitioning activity in the early years of the Long Parliament (1640–2) have often focused on the large-scale petitions which engaged with issues of high politics and religion in the charged atmosphere prior to the outbreak of Civil War. However, many subjects were drawn to petition the Commons and the Lords for relief in much more particular economic disputes. Utilizing overlooked manuscript petitions in the parliamentary archives and papers of the MP Bulstrode Whitelocke, this article re-examines petitioning activity between 1640 and 1642. It finds that, despite the absence of parliament during the Personal Rule, subjects eagerly embraced the calling of a new parliament, their perceptions of it shaped by its contemporary history. As MPs and peers increasingly utilized and preserved records, petitioners too evoked and confronted the parliamentary past. While some like the Merchant Adventurers’ Company glossed its presentation tactically, others including London-based glassmakers and merchants were driven by ideological beliefs in the historic role of parliament as a protector against arbitrary fiscal policies. This article contributes to post-revisionism by showing that subjects viewed parliament not as an event, but as an institution, fostering connections between past and present sessions as they petitioned for redress.
This paper explores the role of identity in constitutional law, moving beyond the dominant concept of constitutional identity. While many European constitutional texts reference various forms of identity – such as national, religious, or cultural – constitutional identity has been disproportionately emphasised in academic discourse. Through an empirical analysis of constitutional provisions and court rulings across 47 European states, this study demonstrates that identity plays a broader and more nuanced role in constitutional law than previously recognised. The paper categorises four types of relationships between identity and constitutional norms: identity as a right to protection, a basis for additional rights, a principle guiding constitutional interpretation, and an identity of the constitution itself. It highlights how constitutional courts interpret and balance competing identities, influencing the application of fundamental rights and constitutional principles. By highlighting examples that represent different models of identity systems, the paper reveals the necessity of giving scientific attention to the relationships between identities. Indeed, identities can undermine liberal constitutional values by privileging certain collective identities over individual identities and individual rights. Ultimately, the study argues that focusing solely on constitutional identity as an analytical concept to designate everything even remotely related to identity in constitutional law obscures the broader dynamics of identity within constitutional systems. It calls for a strict conceptual redefinition of constitutional identity in order to better understand how identity, in all its potential forms, continuously reshapes constitutional law and influences the evolution of democratic and human rights protections in European states.
The erection of the Berlin Wall in November 1961 gave the separation between the West and the Eastern Bloc, and particularly between the two Germanies, an enduring symbol. It also concretized the division of the Berlin Phonogram Archive, which had been separated by the Second World War, in a seemingly unsurmountable way. But while the wall made cross-border academic collaborations considerably more difficult, it did not prevent them entirely. This article relies on previously unexplored primary sources to relate and contextualize the extraordinary story of how two ethnomusicologists were able to bring together a large part of the cylinder collections of the Berlin Phonogram Archive, even as the geopolitical situation surrounding them grew ever more tense. From 1966 to 1967, Kurt Reinhard, then head of the Berlin Phonogram Archive and the Ethnomusicology Department of the Ethnological Museum in West Berlin, and Erich Stockmann, an academic employee of the Academy of Sciences in East Berlin and caretaker of the archival recordings returned by the Soviets, succeeded in exchanging and copying over 5,000 cylinder recordings and their documentation despite a litany of political and financial difficulties. Their collaboration illuminates a little-known aspect of the history of this foundational archive, while raising important questions about ethnomusicology’s political history and the roles the Cold War and Second World War played in the discipline’s formation.
This article examines the siege of Gaza as a paradigmatic case of Achille Mbembe’s necropolitics, revealing how Gaza operates as a “laboratory of violence” where advanced military occupation, border control, and surveillance techniques are tested and exported. By tracing the intensifying militarization and orchestrated deprivation imposed on its population, this study demonstrates how colonial biopolitics embodied in strict movement restrictions, engineered food scarcity, and segregated medical care undermine human rights and perpetuate chronic vulnerability. These necropolitical practices obstruct key United Nations Sustainable Development Goals (SDGs), including SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-Being), and SDG 16 (Peace, Justice, and Strong Institutions), exposing moral and political contradictions within international frameworks committed to “leaving no one behind.” Yet the SDG rubric itself arose within a development discourse entangled with colonial power, making any assessment of Gaza’s “progress” by these indicators ethically and epistemically fraught. Gaza’s predicament exemplifies the destructive potential of protracted conflict and structural violence in derailing global development targets. This article reframes Gaza’s siege as both a localized humanitarian crisis and a global precedent with serious implications for international policy and human rights law. By situating Gaza as a focal point for understanding necropolitical governance, this study seeks to portray the urgency of policy interventions that move beyond rhetoric and have demonstrably challenged and mitigated such regimes in comparable contexts.
To adapt current iron intake reference values for Brazilian children aged 7–11 and 12–23 months, using the opportunity to apply the principles and rationale of the harmonisation approach.
Design:
Nutrient reference values (NRV), including the average requirement (AR) and population reference intake (PRI), were estimated for children aged 7–11 and 12–23 months. We applied and adapted methods from the Institute of Medicine (IOM) and the European Food Safety Authority (EFSA) to estimate the NRV. Body iron losses, iron needs for growth and dietary iron bioavailability were estimated using both local and external data.
Setting:
Rio de Janeiro, Brazil.
Participants:
Data on dietary intake from a probabilistic sample of children aged 7–23 months in the city of Rio de Janeiro, Brazil, were used to estimate iron consumption and bioavailability.
Results:
The mean physiological iron requirements were 0·78 mg/d (7–11 months, male), 0·53 mg/d (7–11 months, female), 0·79 mg/d (12–23 months, male) and 0·54 mg/d (12–23 months, female). Mean dietary iron bioavailability was 7·5 % across all age and sex groups. AR and PRI were 10 mg/d and 19 mg/d for children aged 7–11 months, and 7 mg/d and 13 mg/d for those aged 12–23 months. NRV did not differ by sex.
Conclusion:
The AR for children aged 7–11 and 12–23 months were 11 mg/d and 8 mg/d, respectively. The corresponding PRI were 20 mg/d and 14 mg/d. The estimated Brazilian NRV were higher than those of the IOM and EFSA. Iron bioavailability was the most influential factor explaining the differences from other NRV.
Antipsychotics are first-line treatments for schizophrenia, yet many patients show inadequate response. Clozapine, the gold standard for treatment-resistant schizophrenia, remains underutilised due to safety and monitoring concerns.
Aims
To evaluate the adverse effects of clozapine in schizophrenia through a meta-analysis of randomised controlled trials (RCTs).
Method
We systematically searched MEDLINE, CENTRAL, Embase, PsycINFO, ClinicalTrials.gov and WHO ICTRP up to 10 October 2024 for RCTs comparing clozapine (as either monotherapy or combination therapy) with other antipsychotics. We assessed 37 distinct adverse outcomes. Risk ratios were calculated for dichotomous outcomes and standardised mean differences for continuous outcomes, with confidence intervals.
Results
A total of 116 RCTs (n = 8431) were included. In 69 monotherapy RCTs (n = 6281), clozapine showed no difference in either mortality (risk ratio 1.01, 95% CI: 0.50, 2.01, prevalence 0.1%) or discontinuation due to adverse effects (risk ratio 1.18, 95% CI: 0.91, 1.53, prevalence 7.2%). Agranulocytosis risk was nearly tripled (risk ratio 2.81, 95% CI: 0.97, 8.12, prevalence 0.7%), although with wide confidence intervals. Clozapine increased the risk of seizures (risk ratio 3.61, 95% CI: 1.80, 7.95, prevalence 3.1%) and orthostatic hypotension/bradycardia/syncope (risk ratio 1.66, 95% CI: 1.00, 2.77, prevalence 11%). No difference was found for myocarditis/cardiomyopathy (risk ratio 0.33, 95% CI: 0.01, 8.13). Clozapine increased the risk of leukopenia, hypersalivation, sedation, tachycardia, hypertension, constipation, nausea/vomiting, fever, flu-like syndrome and headache. In 47 combination RCTs (n = 2150), clozapine combinations were not associated with increased risk of severe adverse effects; no cases of agranulocytosis (21 RCTs, n = 894) or seizures (8 RCTs, n = 313) were reported in trials that explicitly assessed these outcomes.
Conclusions
Life-threatening adverse events remain rare with clozapine. With appropriate monitoring, its safety profile supports broader and potentially earlier use. Future studies should refine monitoring protocols and explore additional indications.
Understanding gender identity in transgender and gender-diverse (TGD) individuals is crucial for effective care. The Gender Preoccupation and Stability Questionnaire (GPSQ) measures the preoccupation and stability of gender identity, but no Italian validation is available.
Aims
This study aimed to translate, culturally adapt and validate the Italian version of the GPSQ in a clinical sample of TGD adults.
Method
The GPSQ was translated with a forward–backward method and completed by 151 TGD adults at a gender clinic. Participants also filled out the Symptom Checklist-58 and Body Uneasiness Test. We assessed structural validity (EFA), internal consistency, test–retest reliability, and examined known-groups and predictive validity.
Results
The EFA supported a four-factor structure – Gender Identity Instability, Cognitive-Affective Salience, Preoccupation, and Distress/Intervention-Oriented Reflection – with good fit (root mean square error of approximation 0.06; Comparative Fit Index 0.95; Tucker–Lewis Index 0.93; standard root mean square residual 0.04). The GPSQ showed solid internal consistency (α = 0.78; ω = 0.73) and excellent test–retest reliability (r = 0.98; intraclass correlation coefficient 0.98). Higher scores correlated with psychological distress (r = 0.55, p < 0.001) and body image concerns (r = 0.48, p < 0.001). Preoccupation was most linked to obsessive–compulsive symptoms, and Cognitive-Affective Salience to body image concerns. Participants not on hormones scored higher (p = 0.010, Cohen’s d = 0.36).
Conclusions
The Italian GPSQ is a reliable and valid tool to assess gender-related preoccupation and identity instability in TGD individuals. Its multidimensional structure makes it useful in both clinical practice and research in the Italian context.
This paper examines the life trajectories, social contexts and living conditions of women of uncertain status in post-slavery, colonial-era Tabora, with a focus on those involved in the production and consumption of beer. It thereby searches insights into the aftermath of slavery in this region, particularly for women. It reflects on the persistent social unease surrounding slavery and its aftermath, and on the way it shapes and limits sources, arguing that a focus on post-slavery is nevertheless productive. Set in context, brewers’ life stories provide a vivid illustration of a competitive urban environment, the chances for self-emancipation that it offered, and the concomitant challenges and dangers. They thereby also enable fresh insight into the social history of alcohol and of urban women in colonial Africa. We find evidence of more successful brewing careers than existing studies would predict, but also of very stark vulnerability and persistent quests for safety in family networks. This spread of outcomes highlights the contingent nature of emancipation and the endlessly varied ways in which social constraints and personal motivations combined in individual lives.
The aim of this study was to identify potential risk factors for acute and late genitourinary toxicities and to determine, using a logistic regression model, which of these factors are also significant and robust predictors of these toxicities.
Methods:
We conducted a retrospective study by analysing the patient records and their treatment plans from 2013 to 2021. In total, a cohort of 46 patients with clinically staged cT1c-T4N0-1M0 prostate adenocarcinoma was treated with three-dimensional conformal radiotherapy (3D-CRT) with doses ranging from 66 to 80 Gy. Post-radiotherapy genitourinary toxicities were classified and graded according to the Common Terminology Criteria for Adverse Events (CTCAE v4.0).
Results:
Median follow-up was 57·5 months (range: 39 – 88 months). In univariable analysis, patient age (p = 0·040), the prostate volume (p = 0·0423), the clinical prostate volume irradiated at the prescribed dose (p = 0·029) and the volume of the bladder receiving doses varying from 60 to 70 Gy were correlated with acute GU toxicities. Arterial hypertension (p = 0·022), some pre-existing urinary symptoms, a history of catheterisation (p = 0·044) and acute genitourinary toxicity (p = 0.009) were linked to late genitourinary toxicities. The logistic regression model found that the prostate volume (p = 0·0423) and the clinical prostate volume irradiated at the prescribed dose (p = 0·029) were predictive of acute GU toxicity. Hypertension (p = 0·039) and acute toxicities were predictive of late GU toxicity.
Conclusion:
The results of our study showed that it is essential to identify patients at risk of toxicities from the start of radiotherapy and to offer more proactive monitoring and management.
J.L. Schellenberg’s argument from divine hiddenness partly rests on the claim that non-resistant non-belief exists. In this paper, I take up the question of whether such non-belief is pervasive and argue that it is, in fact, relatively common. To support this claim, I present a novel argument grounded in a distinction between acquisition responsibility and maintenance responsibility. I argue that, for a non-believer to count as resistant in Schellenberg’s sense, they must be acquisition-responsible for their non-belief in God. I further contend that many non-believers lack such responsibility and therefore qualify as non-resistant. This argument has the added benefit of showing that many prominent objections to the existence of non-resistant non-belief are irrelevant or incomplete. Finally, I highlight the broader significance of this conclusion, both for Schellenberg’s argument and in light of recent shifts in the literature towards more evidential approaches.
While evaluation approaches for community-academic research groups are established, few tools exist for academic institutional advisory groups across multi-core centers and research, education, and clinical care missions. Institutional advisory group evaluation should consider group processes and their impact on community-centered outcomes. This study describes the community-engaged development of a mixed-method evaluation approach to address this gap and presents pilot outcomes across an NIH-funded center.
Methods:
We utilized a Community of Practice model to co-develop a survey with 14 community and academic representatives of four advisory groups. The final survey included five categories of group process and four categories of outcomes. Storytelling sessions with community partners explored areas where the survey identified discrepancies in perspectives between community and academic team members, as well as areas with lower scores.
Results:
Nine community and 14 academic (staff and faculty) partners completed the survey. Respondents positively assessed group process outcomes (shared values, leadership, community-centeredness, and decision-making), and slightly less positive assessments of institutional outcomes. Storytelling sessions confirmed the overall satisfaction of community partners but highlighted actionable concerns within power-sharing, decision-making, funding equity, and trust-building.
Conclusions:
The results of this equity-centered evaluation suggest the utility and importance of participatory, mixed-methods approaches to evaluating community-academic institutional advisory groups.
By a celebrated result of Kučera and Slaman [5], the Martin-Löf random left-c.e. reals form the highest left-c.e. Solovay degree. Barmpalias and Lewis-Pye [1] strengthened this result by showing that, for all left-c.e. reals $\alpha $ and $\beta $ such that $\beta $ is Martin-Löf random and all left-c.e. approximations $a_0,a_1,\dots $ and $b_0,b_1,\dots $ of $\alpha $ and $\beta $, respectively, the limit
exists and does not depend on the choice of the left-c.e. approximations to $\alpha $ and $\beta $.
Here we give an equivalent formulation of the result of Barmpalias and Lewis-Pye in terms of nondecreasing translation functions and generalize their result to the set of all (i.e., not necessarily left-c.e.) reals.
Climate policy discussions often veer into questioning whether actions are worthwhile, if technological fixes are the solution, or if others should take responsibility instead. Interest groups can use these discussions – also known as ‘discourses of climate delay’ – to downplay the need for ambitious climate action. But in other contexts, such discussions can reflect the legitimate concerns of citizens. Here we examine possible ways to make such a distinction and judge when someone intends to delay climate policy.
Technical summary
We conduct a review of the climate policy discourse literature with a focus on how studies evaluate intent. We find that they usually refer to one of three actor-based categories: interest, behaviour, or track record. That is, actors are considered more likely to have intent when they have material or ideological connections to fossil interest groups, behave in ways that undermine climate policy (e.g. through voting or funding oppositional science), or have a track record of rhetorical opposition to climate policy (e.g. having previously articulated climate denial). We further suggest that argument density (e.g. the number of claims they make against climate policy), ambiguity (e.g. whether they leave room for an interpretation of delay), and professional context (e.g. whether they are professional communicators) matters. We summarise these categories to provide a companion to ‘discourses of climate delay’ that focuses on intent. We further consider how the evaluation of intent can support traditional fact and logic-based misinformation identification strategies.
Social media summary
Examine interests, behaviour and track record to evaluate intent in climate delay discourses.
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Abnormalities in sleep metrics among ADHD children gradually garnered attention. However, whether significant differences existed in sleep metrics between ADHD children and their typically developing (TD) counterparts remained controversial, with inconsistent conclusions across studies. Furthermore, the potential moderating effects of age and gender on these differential patterns remained insufficiently characterized.
Methods
The current study systematically analyzed multimodal sleep monitoring data (polysomnography, actigraphy, electroencephalography, and questionnaires) from 34 articles spanning three decades (44 independent studies: 2,239 ADHD children vs. 57,181 TD children), focusing on core sleep metrics (total sleep time, sleep efficiency, sleep latency, wake after sleep onset, awakening index, and stage shifts) and their complex moderating mechanisms.
Results
The results demonstrated that ADHD children exhibited impaired sleep continuity (reduced total sleep time, increased stage shifts), severe sleep interruption (prolonged wake after sleep onset, elevated awakening index), and abnormal sleep process effectiveness (decreased sleep efficiency, extended sleep latency). Demographic analyses revealed that maturation exacerbated ADHD-related sleep deficits, and male ADHD children had more severe sleep problems than female ADHD children. Furthermore, the moderating effect of gender composition on the awakening index showed interaction effects with other sleep metrics. In addition, slow-wave sleep acted as both a moderator and mediator in group differences of the awakening index.
Conclusions
These findings provided novel neurodevelopmental explanations for sleep dysregulation in ADHD and proposed clinically translatable strategies involving gender-specific interventions and neuromodulation targeting slow-wave sleep.
The potential withdrawal of the United States from European security commitments has raised questions about the future of nuclear deterrence on the continent. This article explores the feasibility of France assuming the role currently played by the United States in the ‘dual-key’ nuclear sharing arrangements with European NATO members. The analysis is divided into five main sections. The article begins by outlining the strategic context in which this analysis takes place, focusing on the potential withdrawal of the United States from European security commitments and the growing emphasis on the European Union’s strategic autonomy. Against this backdrop, the article first examines France’s technical capabilities to lead a dual-key system in Europe, addressing aspects such as the number of nuclear warheads, delivery vectors, and operational compatibility with European allies. Next, it analyses the political and doctrinal implications of a French-led dual-key system, identifying which aspects of French nuclear doctrine might require revision or could create friction. The article also explores potential forums for nuclear dialogue and coordination, as well as the challenges of harmonising France’s national doctrine with a hypothetical extended framework for dual-key countries. In the third section, the article evaluates the political and security utility of a French-based dual-key system. Finally, it assesses the strategic, operational, and doctrinal implications of shifting from a US nuclear provider to a French one, highlighting both potential benefits and challenges. The findings suggest that, while a French-led dual-key system is technically feasible, significant political obstacles must be overcome for successful implementation.
Historians of the Cold War and the nuclear age have largely overlooked the existence of tabletop role-playing games (TTRPGs), while films, comics, novels, and television programmes that tackled the challenging imaginary, yet all-too-possible, wastes of a post-nuclear landscape have been abundantly analysed. As cultural products and tools through which to imagine other worlds, TTRPGs offer powerful insights into how, where, and why certain groups thought about the spectre of the nuclear age and how they dealt with this threat by gaming within make-believe postapocalyptic worlds. This article draws together several threads in its analysis of the American-designed and -produced Twilight: 2000 TTRPG’s historical significance. Through analysing Twilight: 2000 as a case study of how a TTRPG functions as a specific nuclear-cultural object in its own right, the article also locates this game as a part of a wider-reaching dystopian fantasy rooted in the massive everyday reality of atomic annihilation. Likewise, the game, its mechanics, setting, and artwork are analysed here as part of a distinctive Cold War culture that permitted participants to derive pleasure and affirmation from fictional “adventures” in the postapocalyptic environment.
There is a rich history of using the arts in psychiatric care, e.g. in various forms of arts therapies. A more recent development is the collaboration of the arts in psychiatric research. The arts and psychiatric research have several fundamental differences which can lead to fruitful inspiration and innovative approaches in research. The benefits include a wider engagement of individuals and non-academic groups in research, creativity in designing research approaches, a reach to societal groups that academic research usually cannot access, and the provision of real life meaning to research evidence. Two examples of such collaborations illustrate the potentials.
Voters are increasingly turning away from governing parties in parliamentary elections, with junior parties in coalition governments often bearing the brunt of the electorate’s dissatisfaction. Can the design of legislative institutions help parties mitigate the electoral costs of governing? We suggest that in systems with strong legislative committees, junior coalition parties are better positioned to protect their party’s policy brand from being eroded, which in turn helps insulate them from the electoral costs of governing. Analyzing data on legislative committees and party-level electoral outcomes in 36 European and OECD countries from 1990 to 2019, we find that stronger parliamentary committee systems are associated with harsher electoral costs for the prime minister’s party but reduced electoral costs for junior coalition parties. Our findings suggest that the structure of legislative institutions in parliamentary systems can have significant electoral implications, including relatively positive outcomes for smaller governing parties.
This article analyses how forms of private cooperation between East and West were reshaped during the late Cold War and beyond. It does so by studying an elitist East–West club, called the International Vienna Council, which brings together leaders of multinational companies and leaders of the planned economy. While the permeability of the iron curtain has been well documented, little is known about the evolution of East–West circulation patterns during that time or the role played by economic elites. The International Vienna Council, initially a forum for ‘parallel diplomacy’, gradually became a platform for concrete business cooperation. The club’s activities continued after 1989, but it struggled with the transition from an East–West club to an interest group within the European Union. These dynamics shed light on the gradual autonomy of a private East–West cooperation group and its contribution to defining a pan-European economic space since the 1970s.