We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Corporations use financial contributions to gain access to influential policymakers. How do these actors respond when officeholders violate widely held norms, such as accepting the results of free and fair elections? We argue that businesses are sensitive to norm violations because they balance their economic interests with accountability demands from employees and other stakeholders. Using a difference-in-differences approach, we find that legislators who supported Donald Trump’s false claims about a ‘stolen election’ experienced a significant decline in contributions from Fortune 500 PACs in 2021 and 2022. Additionally, our analysis reveals that companies continue to contribute more to party leaders and members of key committees, consistent with our hypothesis. These findings suggest that corporations are willing to balance the interests of their two audiences by sending signals of disapproval towards those who violate established norms while continuing to lobby key lawmakers.
Clinical and preclinical data about perinatal inflammation show its implication in brain injuries leading to autism spectrum disorder (ASD). For instance, Group B Streptococcus (GBS) chorioamnionitis generates autistic manifestations in the progeny. However, the precise way(s) how chorioamnionitis exerts its noxious effect on the central nervous system remains to be define. The pathogen-induced inflammatory response effects on the permeability of the blood brain barrier (BBB) have been documented in the mature brain. No study deals with the effect of GBS-induced chorioamnionitis, on the fetal BBB, even though it is one of the most common infection affecting the fetal environment. Given that dysfunctions of several key cells and molecules from the BBB seem to be involved in the pathogenesis of ASD from genetic and/or environmental origins, we hypothesized that pathogen-induced chorioamnionitis affects structurally and functionally the BBB. We used a well-established preclinical model of GBS chorioamnionitis leading to ASD phenotype in male offspring. We document a significant decrease of albumin permeability of the BBB in the white and gray matters of fetuses exposed versus unexposed to GBS chorioamnionitis. In line with this result, a significant increase in the expression of claudin-5 – component of tight junctions of the BBB – is detected in endothelial cells from BBB exposed to chorioamnionitis. Altogether, our results show that beyond genetic determinants, environmental factors such as bacterial infections affect the integrity of the BBB and might be involved in the fetal programming of ASD.
Tacrolimus is the standard immunosuppressant used in paediatric orthotopic heart transplantation, but it can be associated with rare and life-threatening haemolysis.
Methods:
Retrospective chart review was used for this case report.
Results/Conclusion:
We present the case of a 6-year-old heart transplant recipient who developed life-threatening haemolysis in the setting of mycoplasma infection while on tacrolimus immunosuppression that was treated successfully with eculizumab.
The dominant focus on rheumatic aetiology of mitral regurgitation (MR) often overshadows other causes. This challenges optimal management when the aetiology is non-rheumatic, as exemplified below in an 8-year-old girl, hailing from Uganda, who was diagnosed and managed as rheumatic MR with unusually elevated and persistent systemic inflammatory state with chronic renal dysfunction disproportionate to her cardiac status. Further workup led towards the possibility of early onset systemic lupus erythematosus (SLE). The valvular involvement in SLE closely resembles rheumatic heart disease (RHD). A high level of clinical suspicion is essential for diagnosing childhood-onset SLE. Coexistence of RHD and SLE is extremely rare and has significant implications for management.
We study infinite groups interpretable in power bounded T-convex, V-minimal or p-adically closed fields. We show that if G is an interpretable definably semisimple group (i.e., has no definable infinite normal abelian subgroups) then, up to a finite index subgroup, it is definably isogenous to a group $G_1\times G_2$, where $G_1$ is a K-linear group and $G_2$ is a $\mathbf {k}$-linear group. The analysis is carried out by studying the interaction of G with four distinguished sorts: the valued field K, the residue field $\mathbf {k}$, the value group $\Gamma $, and the closed $0$-balls $K/\mathcal {O}$.
Clinical guidelines for personality disorder emphasise the importance of patients being supported to develop psychological skills to help them manage their symptoms and behaviours. But where these mechanisms fail, and hospital admission occurs, little is known about how episodes of acutely disturbed behaviour are managed.
Aims
To explore the clinical characteristics and management of episodes of acutely disturbed behaviour requiring medication in in-patients with a diagnosis of personality disorder.
Method
Analysis of clinical audit data collected in 2024 by the Prescribing Observatory for Mental Health, as part of a quality improvement programme addressing the pharmacological management of acutely disturbed behaviour. Data were collected from clinical records using a bespoke proforma.
Results
Sixty-two mental health Trusts submitted data on 951 episodes of acutely disturbed behaviour involving patients with a personality disorder, with this being the sole psychiatric diagnosis in 471 (50%). Of the total, 782 (82%) episodes occurred in female patients. Compared with males, episodes in females were three times more likely to involve self-harming behaviour or be considered to pose such a risk (22% and 70% respectively: p < 0.001). Parenteral medication (rapid tranquillisation) was administered twice as often in episodes involving females than in males (64 and 34% respectively: p < 0.001).
Conclusions
Our findings suggest that there are a large number of episodes of acutely disturbed behaviour on psychiatric wards in women with a diagnosis of personality disorder. These episodes are characterised by self-harm and regularly prompt the administration of rapid tranquillisation. This has potential implications for service design, staff training, and research.
This study aimed to explore the effect of various feedback types on word learning in preschool children, with consideration of the word’s morpho-phonological structure. Sixty-three five-year-old children participated in three sessions of learning artificial words derived from pseudo-roots in Hebrew, with half constructed using established morpho-phonological patterns. Participants received either no feedback, verification feedback, corrective feedback, or verification plus corrective feedback. The training encompassed word identification and production. Accuracy and reaction time (RT) were measured. The results indicated that corrective feedback produced the highest accuracy and fastest RTs. Providing verification feedback led to improved performance compared to no feedback. While words with existing morpho-phonological patterns were learned more efficiently, the positive impact of corrective feedback remained consistent across both word types. These findings offer practical implications for optimizing word learning conditions, highlighting the importance of corrective feedback in word learning, and more broadly, aligning the feedback type to the learning task.
In this paper, we study the Cauchy problem for pseudo-parabolic equations with a logarithmic nonlinearity. After establishing the existence and uniqueness of weak solutions within a suitable functional framework, we investigate several qualitative properties, including the asymptotic behaviour and blow-up of solutions as $t\to +\infty$. Moreover, when the initial data are close to a Gaussian function, we prove that these weak solutions exhibit either super-exponential growth or super-exponential decay.
The article looks at the question of how property is constitutive of identity. Dominance over material resources and formation of markers of identity are often conjoint processes aided by constitutional processes. We frame the discursive construction of property and public space in India through the judicial discourse on the hijab ban in colleges in the state of Karnataka. Courts often look at space as an autonomously existing physical object rather than a socially constructed arena to which access is granted or denied depending on one’s socio-cultural location. We suggest that this is a natural consequence of over-emphasizing the ‘thingness’ of property as opposed to understanding the discursive and historically contingent nature of property rights. This has a direct relation with how certain identities are allowed the freedom to make public spaces their own while others, though occupying these ostensibly neutral spaces, are not allowed to ‘perform’ their identities.
Infants born at high altitudes, such as in the Puno region, typically exhibit higher birthweights than those born at low altitudes; however, the influence of ethnicity on childhood anthropometric patterns in high-altitude settings remains poorly understood. This study aimed to characterise the nutritional status, body composition and indices, and somatotype of Quechua and Aymara children aged 6–10 years. A cross-sectional, descriptive, and comparative design was employed, with a simple random sampling of children from six provinces representative of the Puno region, including 1,289 children of both sexes. Twenty-nine anthropometric measurements were taken, and fat, muscle, and bone components were assessed using bioelectrical impedance analysis. Standardised equations were applied to determine body indices. Among the findings, most children presented normal nutritional status according to BMI-for-age and height-for-age Z-scores. However, high rates of overweight and obesity were observed in Aymara (39%) and Quechua (28.4%) children, with differences in fat content between ethnic groups at the 5th, 10th, 50th, and 75th percentiles. Both groups were characterised by brachytypy and brachybrachial proportions; Quechua children were mesoskelic and Aymara brachyskelic, with macrocormic proportions, rectangular trunks, and broad backs. The predominant somatotype was mesomorphic, with a stronger endomorphic tendency among Aymara. It is concluded that both groups exhibit normal nutritional status; however, Aymara children show a greater tendency towards fat accumulation and notable morphological differences. Differences were also observed in limb proportions, particularly a relatively shorter lower limb.
We present a number of measures and techniques to characterise and effectively construct quasi-isodynamic stellarators within the near-axis framework, without the need to resort to the computation of global equilibria. These include measures of the reliability of the model (including aspect-ratio limits and the appearance of ripple wells), quantification of omnigeneity through $\epsilon _{\mathrm{eff}}$, measure and construction of MHD-stabilised fields, and the sensitivity of the field to the pressure gradient. The paper presents, discusses and gives examples of all of these, for which expansions to second order are crucial. This opens the door to the exploration of how key underlying choices of the field design govern the interaction of desired properties (‘trade-offs’) and provides a practical toolkit to perform efficient optimisation directly within the space of near-axis quasi-isodynamic configurations.
This paper will explore the relationship between Theophilos and the generation of the 1930s on the basis of two parameters. On the one hand, an attempt will be made to reconfigure the image of Theophilos as a ‘spontaneous’ bearer of an immaculate and uninterrupted national tradition; on the other, the paper will address the reasons that determined this interest in the ‘illiterate’ (even ‘lunatic’) painter from Lesbos. It will be argued that what impressed the young intellectuals of the 1930s generation was not only Theophilos’ ‘primitive’ visual idiom but his idiomatic modernist idiom, precisely because it found an echo in their own contradictions as bearers of European modernity.
With the increasing manufacturing of electric vehicles, car battery recycling is crucial for environmental sustainability. The disassembly of car batteries includes critical health hazards for the operator, due to potential chemical reactions or physical injuries. These reasons make robots particularly interesting for automatic disassembly. This paper proposes a systematic approach to automation and human–robot cooperation in car battery disassembly tasks with a case study on screw removal. A novel parameter is proposed to evaluate whether a human operator or a robot is more appropriate for each specific task, considering both performance and associated risks. The proposed metrics are validated with an experimental example, in which the performance of a robot and a human on a screw-removal task is compared numerically using statistical methods. The advantages and disadvantages of both options are examined through the application and show how the new performance criterion effectively provides insights into the distribution of tasks between humans and robots.
Developing reduced-order models for the transport of solid particles in turbulence typically requires a statistical description of the particle–turbulence interactions. In this work, we utilize a statistical framework to derive continuum equations for the moments of the slip velocity of inertial, settling Lagrangian particles in a turbulent boundary layer. Using coupled Eulerian–Lagrangian direct numerical simulations, we then identify the dominant mechanisms controlling the slip velocity variance, and find that for a range of Stokes number ${S{\kern-0.5pt}t}^+$, Settling number ${S{\kern-0.5pt}v}^+$ and Reynolds number $\textit{Re}_\tau$ (based on frictional scales),the slip variance is primarily controlled by local differences between the ‘seen’ variance and the particle velocity variance, while terms appearing due to the inhomogeneity of the turbulence are subleading until ${S{\kern-0.5pt}v}^+$ becomes large. We also consider several comparative metrics to assess the relative magnitudes of the fluctuating slip velocity and the mean slip velocity, and we find that the vertical mean slip increases rapidly with ${S{\kern-0.5pt}v}^+$, rendering the variance relatively small – an effect found to be most substantial for ${S{\kern-0.5pt}v}^+\gt 1$. Finally, we compare the results with a model of the acceleration variance (Berk & Coletti 2021 J. Fluid Mech.917, A47) based the concept of a response function described in Csanady (1963 J. Atmos. Sci.20, 201–208), highlighting the role of the crossing trajectories mechanism. We find that while there is good agreement for low ${S{\kern-0.5pt}v}^+$, systematic errors remain, possibly due to implicit non-local effects arising from rapid particle settling and inhomogeneous turbulence. We conclude with a discussion of the implications of this work for modelling the transport of coarse dust grains in the atmospheric surface layer.
An adverse in utero experience negatively impacts perinatal growth in livestock. Maternal heat stress (HS) during gestation reduces placental growth and function. This progressive placental insufficiency ultimately leads to fetal growth restriction (FGR). Studies in chronically catheterized fetal sheep have shown that FGR fetuses exhibit hypoxemia, hypoglycemia, and lower anabolic hormone concentrations. Under hypoxic stress and nutrient deficiency, fetuses prioritize basal metabolic requirements over tissue accretion to support survival. Skeletal muscle is particularly vulnerable to HS-induced placental insufficiency due to its high energy demands and large contribution to total body mass. In FGR fetuses, skeletal muscle growth is reduced, evidenced by smaller myofiber size and mass, reduced satellite cell proliferation, and slower rate of protein synthesis. Disruptions in skeletal muscle growth are associated with mitochondrial dysfunction, including reduced pyruvate flux into the mitochondrial matrix and lower complex I activity in the mitochondrial electron transport chain. This review summarizes current research on the mechanisms by which HS-induced placental insufficiency affects skeletal muscle growth in the fetus, with an emphasis on myogenesis, hypertrophy, protein synthesis, and energy metabolism. The evidence presented is primarily drawn from experiments using chronically catheterized fetal sheep exposed to maternal HS during mid-gestation. Additionally, we explore emerging nutritional strategies aimed at enhancing skeletal muscle growth in animals with FGR. These strategies hold promise not only for improving reproductive efficiency in livestock affected by prenatal stress but also for their translational relevance to human pregnancies complicated by placental insufficiency.