The Mineiro Belt is an example of the Tonalite-Trondhjemite-Granodiorite (TTG)-Sanukitoid transition, exemplified by the Lagoa Dourada (LDS, 2350 Ma) and the Alto Maranhão (AMS, 2130 Ma) suites. Their opaque mineralogy, along with the amphibole chemistry, was investigated to better understand the granitic magmatism at that time. The LDS contains magnetite, ilmenite, chalcopyrite and pyrite as opaque primary phases, while the AMS includes ilmenite, pyrrhotite, chalcopyrite, pyrite, magnetite, pentlandite and sphalerite. With magnetite predominating in the LDS and ilmenite in the AMS, they should be classified as magnetite and ilmenite series granitoids, respectively. In the TTGs, the amphiboles are ferrotschermakite, whereas in the sanukitoids, they are primarily Mg-hornblende to actinolite. Despite the opaque mineralogy, the positive correlation between Fe# and AlIV in the amphiboles, along with the lower Fe# values in the ilmenite-bearing sanukitoids, suggests higher fO2 conditions compared to the magnetite-bearing TTGs. Although both opaque assemblages indicate fO2 values above the FMQ buffer, exceeding 10−18 bars for the ilmenite-bearing sanukitoids and 10−17 bars for the magnetite-bearing TTGs, their crystallization occurs close to the equilibrium reaction titanite + magnetite + quartz – Fe-Mg-Ca silicates + ilmenite. The assemblages show that the magnetite-bearing TTGs crystallized at lower temperatures (700–800°C) than ilmenite-bearing sanukitoids (800°C), showing a temperature dependency of fO2 once the latter register higher fO2, despite being ilmenite-series granitoids. This intriguing scenario may be due to a combination of heterogeneously metasomatized magma sources, temperature condition, fH2O and sediment entrance in the subduction, explained by the changes in crustal growth processes towards modern plate tectonics.