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Time-dependent fluid dynamics plays a crucial role in both natural phenomena and industrial applications. Understanding the flow instabilities and transitions within these dynamical systems is essential for predicting and controlling their unsteady behaviour. A classic example of time-dependent flow is the Stokes layer. To study the transition mechanism in this flow, we employ the finite-time Lyapunov exponent (FTLE) to demonstrate that a linear energy amplification mechanism may explain the intracyclic instability in the transitional Stokes layer, supported by favourable comparisons with experimental measurements of axial turbulence intensity. This complements existing theories applied to the Stokes layer in the literature, including the Floquet analysis and the instantaneous/momentary analyses, which have struggled to capture this experimental observation accurately. The FTLE analysis is closely related to the transient growth analysis, formulated as an optimisation problem of the disturbance energy growth over time. We found that the energy amplification weakens as the finite Stokes layer becomes more confined, and the oscillating frequency has a non-monotonic effect on the maximum transient growth. Based on these results, we recommend future experimental studies to validate this linear mechanism.
An experimental study was conducted in the CICLoPE long-pipe facility to investigate the correlation between wall-pressure and turbulent velocity fluctuations in the logarithmic region, at high friction Reynolds numbers ($4794 \lesssim Re_\tau \lesssim 47\,015$). Hereby, we explore the scalability of employing wall-pressure to effectively estimate off-the-wall velocity states (e.g. to be of use in real-time control of wall-turbulence). Coherence spectra for wall-pressure and streamwise (or wall-normal) velocity fluctuations collapse when plotted against $\lambda _x/y$ and thus reveals a Reynolds-number-independent scaling with distance-from-the-wall. When the squared wall-pressure fluctuations are considered instead of the linear wall-pressure term, the coherence spectra for the wall-pressure-squared and velocity are higher in amplitude at wavelengths corresponding to large-scale streamwise velocity fluctuations (e.g. at $\lambda _x/y = 60$, the coherence value increases from roughly 0.1 up to 0.3). This higher coherence typifies a modulation effect, because low-frequency content is introduced when squaring the wall-pressure time series. Finally, quadratic stochastic estimation is employed to estimate turbulent velocity fluctuations from the wall-pressure time series only. For each $Re_\tau$ investigated, the estimated time series and a true temporal measurement of velocity inside the turbulent pipe flow yield a normalised correlation coefficient of $\rho \approx 0.6$ for all cases. This suggests that wall-pressure sensing can be employed for meaningful estimation of off-the-wall velocity fluctuations and thus for real-time control of energetic turbulent velocity fluctuations at high-$Re_\tau$ applications.
Visual word recognition is constrained by writing systems. The orthographic depth hypothesis (ODH) was proposed to account for phonological activation in various degrees depending on how transparent the grapheme–phoneme conversion rule is in a writing system. This current study extends the investigation of ODH in bilingualism to understand the cross-language cognitive processes in bi-script readers. In two cross-language masked priming experiments, we show asymmetrical cognate facilitation effects, which are typically reported as a result of shared phonology and/or orthography between languages, in addition to meaning equivalence. That is, with the same set of items, when the primes were Chinese and the targets English (Experiment 1), there was no cognate facilitation effect; however, when we switched the languages in prime–target pairs (Experiment 2), the cognate facilitation effects emerged. These results indicate that shared phonology across languages is not sufficient to induce cognate facilitation effects and that language-dependent processing mechanisms play a crucial role.
In the dynamical systems approach to turbulence, unstable periodic orbits (UPOs) provide valuable insights into system dynamics. Such UPOs are usually found by shooting-based Newton searches, where constructing sufficiently accurate initial guesses is difficult. A common technique for constructing initial guesses involves detecting recurrence events by comparing past and future flow states using their $L_2$-distance. An alternative method uses dynamic mode decomposition (DMD) to generate initial guesses based on dominant frequencies identified from a short time series, which are signatures of a nearby UPO. However, DMD struggles with continuous symmetries. To address this drawback, we combine symmetry-reduced DMD (SRDMD) introduced by Marensi et al. (2023, J. Fluid Mech., vol. 954, A10), with sparsity promotion. This combination provides optimal low-dimensional representations of the given time series as a time-periodic function, allowing any time instant along this function to serve as an initial guess for a Newton solver. We also discuss how multi-shooting methods operate on the reconstructed trajectories, and we extend the method to generate initial guesses for travelling waves. We demonstrate SRDMD as a method complementary to recurrent flow analysis by applying it to data obtained by direct numerical simulations of three-dimensional plane Poiseuille flow at the friction Reynolds number $\textit{Re}_\tau \approx51$ ($\textit{Re}=802$), explicitly taking a continuous shift symmetry in the streamwise direction into account. The resulting unstable relative periodic orbits cover relevant regions of the state space, highlighting their potential for describing the flow.
There is growing evidence that smoking increases the risk of developing psychiatric disorders, but the underlying mechanisms are largely unknown. We examine brain structure as a potential pathway between smoking and psychiatric disease liability.
Methods
We test associations between smoking (initiation, cigarettes per day, cessation, lifetime use) and depression, bipolar disorder, and schizophrenia, with and without correcting for volume of the amygdala, hippocampus, lateral and medial orbitofrontal cortex, superior frontal context, and cortical thickness and surface area. We use three methods that use summary statistics of genome-wide association studies to investigate genome-wide and local genetic overlap (genomic structural equation modeling, local analysis of (co)variant association), as well as causal associations (Mendelian randomization).
Results
While we find causal effects of smoking on brain volume in different brain areas, and with psychiatric disorders, brain volume did not seem to mediate the effect of smoking on psychiatric disorders.
Conclusions
While these findings are limited by characteristics of the included summary statistics (e.g. sample size), we conclude that brain volume of these areas is unlikely to explain a substantial part of any effect of smoking on psychiatric disorders. Nevertheless, genetic methods are valuable tools for exploring other potential mechanisms, such as brain functional connectivity, foregoing the need to collect all phenotypes in one dataset.
The Iberian Pyrite Belt contains one of the largest accumulations of massive sulphide deposits on Earth. Many of these deposits are hosted by latest Devonian black shales rich in terrestrial and marine palynomorphs. Among the marine fossils, the most abundantly reported species is Maranhites mosesii. By means of a multi-analytical methodology, including (1) biometry of specimens, (2) TOFSIMS imaging and spectral analysis of selected specimens and (3) host-rock geochemistry, we detected that cysts of M. mosesii are smaller and lighter in massive sulphide-generating environments than in coeval non-massive sulphide-generating environment. Cysts of M. mosesii sank after encystment and maturated in the seafloor of different subbasins affected by disparate anoxic conditions. The specimens that maturated in anoxic settings enriched in pollutants, like Arsenic (As) and Lead (Pb), were smaller and lighter than those from non-polluted anoxic environments. Their organic walls were also enriched in As. Neither the anoxia nor the pollutants prevented the proliferation of M. mosesii, as this was the most abundant phytoplanktonic species in all environments. To explain this, we suggest that this species developed a successful adaptive mechanism that might involve anaerobic metabolic interchange with the surrounding oxygen-depleted media and high levels of tolerance to stressors. Whatever the reason, it entails a causal relationship between cyst size and seafloor environmental conditions. In consequence, the biometry of M. mosesii can be envisaged as a promising vector for sulphide deposit exploration in the Iberian Pyrite Belt.
In recent decades, activists and leaders of government and nongovernment organizations have increasingly and explicitly called for greater attention to human dignity in their efforts to promote pro-social relations. In this study, we investigate whether appeals to this core human value actually influence how individuals act with regard to those who might be otherwise ignored or neglected. Using the digital advertising platform on Facebook, we randomly assign ads to over 90,000 adult American users to estimate the effects of dignity appeals on their likelihood of engaging with content concerning people facing homelessness or incarceration. Consistent with preregistered hypotheses and specifications, we find that adding dignity appeals increases the likelihood of positive reactions to such ads, but only when the vulnerable are considered less “blameworthy” for their situation.
Invasive Group B Streptococcus (GBS) infection caused by the highly virulent Sequence Type 283 (ST283) strain has been linked to consumption of raw freshwater fish. In late summer 2024, enhanced surveillance in Hong Kong detected a surge of invasive ST283 cases.
A retrospective case–control study was conducted involving all invasive GBS patients reported during August to September 2024. Data were collected through standardised interviewer-administered questionnaires. Cases were defined as patients infected with the ST283 strain, while controls had non-ST283 strains. A multivariate logistic regression analysis was conducted to determine the risk factors.
Among 170 invasive GBS patients, 131 (77%) were identified as cases and 39 (23%) as controls. Physical handling of raw freshwater fish was found to be the strongest risk factor for ST283 infection (adjusted odds ratio: 8.4, 95% confidence interval: 1.4–50.1).
This study represents the first epidemiological evidence specifically linking physical contact with raw freshwater fish to an increased risk of invasive GBS ST283 infection. Effective interdepartmental coordination, intensive public health education, active surveillance, and prompt environmental interventions effectively mitigated this large outbreak. The findings underscore the need for sustainable preventive strategies targeting high-risk fish handling practices, particularly during warm periods favouring environmental proliferation of ST283.
Prior research indicates that language stimuli, when co-presented with sensory inputs, can enhance perceptual discrimination. However, whether this facilitation is unique to spoken language as opposed to non-verbal auditory stimuli, such as musical patterns, remains unclear. To address this question, we used difficult-to-discriminate tactile stimulus patterns and paired them repeatedly either with specific verbal, language-like labels or with matched musical sequences. Crucially, we implemented a within-subject learning design with well-matched stimuli counterbalanced across subjects. This approach involved pairing specific tactile patterns with either linguistic labels or matched sequences of musical tones and exposing all subjects to both conditions. Participants’ discrimination ability of the tactile patterns presented in isolation was evaluated both before and after associative learning. Results demonstrated that after 5 days of learning, only the tactile pattern sets associated with language stimuli – not those paired with musical sequences – showed significant improvement in discrimination. These results indicate that spoken language may indeed have an advantage over other forms of auditory input in facilitating perceptual discrimination. We discuss the underlying mechanisms of this observed perceptual advantage.
Major depressive disorder (MDD) is a complex and heterogeneous disorder, and this heterogeneity poses a significant challenge for advancing precision medicine in patients with MDD. MRI-based subtyping analysis has been widely employed to address the heterogeneity of MDD patients. In this study, we investigated the subtypes of first-episode and drug-naive (FEDN) MDD patients based on the individualized structural covariance network (IDSCN).
Methods
In this study, we used T1-weighted anatomical images of 164 FEDN MDD patients and 164 healthy controls from the REST-meta-MDD consortium. The IDSCN of participants was obtained using the network template perturbation method. Subtypes of FEDN MDD were identified using k-means clustering analysis, and differences in neuroimaging findings and clinical symptoms between the identified subtypes were compared using two-sample t-tests.
Results
This study identified two subtypes of FEDN MDD: subtype 1 (n = 117) and subtype 2 (n = 47) by characterizing 10 edges that were significantly altered in at least 5% of patients (i.e., 8 patients) in the IDSCN. Compared with subtype 2, subtype 1 had significantly higher anxiety symptom scores, stronger structural covariance edges in 9 edges within the thalamus, and a significantly reduced gray matter volume (GMV) in the frontal and parietal regions, and in the thalamus.
Conclusions
Our results suggest that patients with FEDN MDD can be classified into two different subtypes based on their IDSCN, providing an important reference for personalized treatment and precision medicine for patients with FEDN MDD.
A spline is an assignment of polynomials to the vertices of a graph whose edges are labeled by ideals, where the difference of two polynomials labeling adjacent vertices must belong to the corresponding ideal. The set of splines forms a ring. We consider spline rings where the underlying graph is the Cayley graph of a symmetric group generated by a collection of transpositions. These rings generalize the GKM construction for equivariant cohomology rings of flag, regular semisimple Hessenberg and permutohedral varieties. These cohomology rings carry two actions of the symmetric group $S_n$ whose graded characters are both of general interest in algebraic combinatorics. In this paper, we generalize the graded $S_n$-representations from the cohomologies of the above varieties to splines on Cayley graphs of $S_n$ and then (1) give explicit module and ring generators for whenever the $S_n$-generating set is minimal, (2) give a combinatorial characterization of when graded pieces of one $S_n$-representation is trivial, and (3) compute the first degree piece of both graded characters for all generating sets.
While a role of language in the development of Theory of Mind (ToM) is well established, the interplay with a child’s ability to understand structured scenarios remains unclear. A new scale (Pictorial Theory of Mind Scale), assessing true and false belief comprehension at different levels of linguistic complexity, was used to explore language effects on ToM while accounting for scenario comprehension. Thirty-nine children (aged 4–6 years; 53.8% female) participated in this study. Results showed that 46.8% of 4- to 6-year-olds can understand false beliefs from picture-based scenarios with limited language output. Both language and scenario comprehension contributed to ToM in first-order false beliefs, whereas only scenario comprehension predicted true beliefs. In contrast, only language predicted second-order false beliefs, highlighting their different roles in ToM development.
The article is concerned with contemporary changes in the spatialization of the Russian-Finnish borderland as an example of re-bordering politics. The main material is a long-term ethnographic study in the territory of former Finnish Karelia, ceded by Finland to the Soviet Union following World War II. By extending the historical context of bilateral relations between the USSR (later Russia) and Finland, the article questions the implications of changing international relations regimes for situational forms of borderwork. The article contributes to the debate on contemporary border practices and the contradictory effects of foreign diplomacy by combining institutional and situational approaches to border territoriality and by focusing on border memory and heritage as resources of local identity and instruments of soft power. Examining the successive shifts of de- and re-bordering regimes in the Russian-Finnish borderlands from the late Soviet period to the present, the article demonstrates the unforeseen impact of foreign relations on local life and memory.
In this article, I consider the 2012–13 productions of The Magic Flute in Lagos, Nigeria, by the Musical Society of Nigeria (MUSON), as a means of rethinking broad conceptions of opera performance in postcolonial Africa. I explore the extent to which visual representation in this production creates cultural contact, exchange and hybridity, affording a pathway for experiencing opera from both Western and African perspectives without homogenisation or a clash of differences. Arguing against notions of race that pit Africa against the West, this study privileges Achille Mbembe’s writings on Afropolitanism as a framework for examining the multiple modes of meaning and identity created through this production. By scrutinising the textuality of visual elements and conceiving them as sites of localised ideological or identity struggles, I argue specifically that opera in Nigeria requires a critical framework that moves beyond notions of ‘whiteness’ and indigenisation. I will show that this staging invokes indigenous knowledge from Nigerian traditional religious and socio-cultural conceptions. In other words, mixed codes of visual elements operate as cultural signifiers that perpetuate an Afropolitan identity through which audiences interact with this art form.
In typical atomic force microscopy (AFM) measurements, the AFM probe, mounted on a compliant cantilever, is brought into close proximity to the test substrate. At this range, interfacial attractive van der Waals (vdW) forces can deflect the cantilever by pulling the probe, often causing the probe to suddenly jump into contact with the substrate. For deformable substrates such as gels or bio-tissues, the attraction-induced substrate deformation can further reduce the gap beneath the probe, which can increase the vdW force and hence trigger jump-to-contact prematurely. Since soft gels and tissues are frequently tested in liquid environments, where surface tension and the approaching dynamics of the probe can significantly influence deformation behaviour, this study examines the statics and dynamics of jump-to-contact on elastic substrates incorporating the effect of solid surface tension. We first discuss the theoretical setting for the static problem, deriving perturbation solutions for limiting cases of small and large solid surface tension. Notably, even under conditions of large solid surface tension, elasticity remains critical, as far-field elastic forces are required to smooth surface deformations in a convergent manner. Recognising that practical experiments are inherently dynamic, we also analyse the role of hydrodynamic pressure, which can delay the premature jump-to-contact. Our analysis focuses on identifying the conditions under which dynamic effects are negligible, enabling the simple analytical solutions in the static problem to reliably interpret AFM experimental results.
This article explores a unique case of Jewish–Muslim cohabitation in colonial Algeria: the harat in the town of Sétif. Families from different religious communities shared communal facilities, private spaces and everyday activities in these housing complexes. At the same time, these neighbours arrived in the city under different historical conditions, possessed different legal statuses and occupied different positions in colonial society. Through a study of the setting, architecture and oral traditions of the harat, this article shows that being neighbours in colonial Algeria fostered a locally grounded sense of cohesion in an age when abstract forms of belonging gained ground.
To analyse the evolution of the vertigo index and its relationship with perceived disability in unilateral and bilateral Ménière’s disease, assessing differences based on disease progression and clinical subtypes.
Methods
A longitudinal descriptive study was conducted on unilateral and bilateral Ménière’s disease patients, with data collected between 1977 and 2023 from two referral centres. Clinical and functional data were retrospectively reviewed to ensure compliance with updated diagnostic criteria. The vertigo index, integrating episode duration and frequency, quantified vertigo burden. Functional impact was assessed using the six-item American Academy of Otolaryngology Head and Neck Surgery disability scale, categorising patients into mild or moderate/severe disability groups.
Results
Bilateral Ménière’s disease patients had a higher proportion of moderate/severe episodes (31.4 per cent) than unilateral Ménière’s disease patients (11 per cent). In unilateral Ménière’s disease patients, disability perception increased after 20 years of disease evolution. The vertigo index declined over time, except in later stages, where episodes were more disabling.
Conclusion
These findings underscore the need for long-term follow up, particularly in bilateral Ménière’s disease, where greater disability was observed. Disease management should adapt over time, addressing both vertigo burden and psycho-affective consequences.
Stroke due to basilar artery occlusion (BAO) carries poor outcomes despite advancements in endovascular therapy (EVT). Predictors of recovery remain underexplored. This study evaluates clinical and imaging predictors of outcomes following EVT, including a Critical Area Diffusion Score (CADS), assessing infarct location and extent in critical brainstem regions on post-EVT MRI.
Methods:
This retrospective study analyzed 48 BAO patients treated with EVT at a provincial stroke center (2015–2021). Patients were categorized by outcomes (favorable: modified Rankin Scale [mRS] 0–3; unfavorable: mRS 4–6). Clinical, demographic and imaging data – age, baseline National Institutes of Health Stroke Scale (NIHSS), reperfusion success (thrombolysis in cerebral infarction [TICI] 2b–3) and post-EVT CADS from diffusion-weighted MRI – were assessed using univariate and multivariate logistic regression.
Results:
Patients with favorable outcomes were younger (median 64.0 vs. 73.0 years, p = 0.031), had lower NIHSS scores at presentation (median 8 vs. 16, p = 0.018) and achieved higher successful reperfusion rates (81.0% vs. 48.1%, p = 0.020). CADS ≤ 3 was linked to better outcomes (median mRS 3 vs. 5, p = 0.026) and higher odds of recovery in univariate analysis (OR = 10.89, p = 0.038). However, in multivariate analysis, CADS was not an independent predictor, with successful reperfusion (OR = 18.8, p = 0.044) as the strongest factor.
Conclusion:
Age, NIHSS scores and successful reperfusion predict recovery in BAO patients undergoing EVT. Although CADS ≤ 3 is linked to favorable outcomes, it is not independently predictive. CADS holds promise as a prognostic tool, but its utility should be considered alongside clinical markers to enhance outcome prediction in BAO.