To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Forthcoming changes to clozapine monitoring present an opportunity to expand, not dilute, specialist care for chronic schizophrenia. Reduced administrative burden should support timely clozapine use, structured assessment, access to psychological therapies and embedded physical health care. Experience from Cambridgeshire shows that secondary-plus clinics within community mental health teams can deliver sustained, equitable long-term care.
Interest in psilocybin as a treatment for depression has risen over the past decade, fuelled by promising clinical trials and a rapidly evolving regulatory landscape. Media coverage plays a critical role in shaping public perceptions, yet little is known about how psilocybin is portrayed in global anglophone online news for the treatment of depression.
Methods:
This study examines the comprehensiveness and sentiment of English-language online news articles (n = 125) discussing psilocybin as a treatment for depression from January 2000 to May 2024. Articles were sourced from the top 30 global anglophone news outlets, assessed using a 13-item instrument for comprehensiveness, and analysed for sentiment across five thematic categories. A separate sub-analysis was completed for Irish media.
Results:
Findings indicate a significant increase in coverage over time, with 43.2% of articles published between 2022 and 2024, predominantly from the USA (68%). While 90.4% of articles cited researchers, fewer addressed risks (47.2%), long-term evidence (46.4%), or patient perspectives (25%). Sentiment analysis revealed a very positive sentiment across articles which was 2.27 on a scale from −5 (most negative) to + 5 (most positive) (SD 1.33), with no significant changes over the time period. Reporting on psilocybin’s onset and duration of effects increased significantly, reflecting growing clinical evidence. However, coverage remains concentrated in prominent outlets, with limited attention to patient experiences and long-term safety.
Conclusions:
These findings highlight the media’s role in shaping discourse on emerging treatments and suggest a need for more balanced reporting to align public understanding with scientific evidence. This study provides a foundation for future research on media portrayals of psilocybin and implications for public perception and policy.
Spectral analysis of the transport process of turbulence kinetic energy (TKE) in a channel roughened with spanwise-aligned circular-arc ribs is conducted based on direct numerical simulations (DNS). Test cases of varying pitch-to-height ratios ($P/H=3.0$, 5.0 and 7.5) and bulk Reynolds numbers (${\textit{Re}}_b=5600$ and 14 600) are compared. It is observed that the characteristic spanwise wavelength of the energy-containing eddies in the internal shear layer (ISL) increases as the value of $P/H$ increases, but decreases as the Reynolds number increases. In the ISL, the energy transport processes are dominated by turbulent production as the lead source term, but by turbulent diffusion and dissipation as the lead sink terms. It is found that regions with high production and dissipation rates of TKE in the ISL are associated with moderate and small wavelengths, respectively. The TKE production for sustaining moderate- and large-scale motions enhances gradually with an increasing value of $P/H$, while that for sustaining small-scale motions augments as the Reynolds number increases. It is interesting to observe that the interscale-transport term plays a critical role in draining TKE at moderate wavelengths as a sink and carries the drained TKE to small-scale eddies as a source. It is discovered that a higher pitch-to-height ratio leads to shortening of the characteristic spanwise wavelength of the dissipation process but prolongation of those of the production, interscale-transport and turbulent-diffusion processes in the ISL. By contrast, a higher Reynolds number results in reductions in the characteristic spanwise wavelengths of all spectral transport terms.
This study examines the intricate relationship between financial development, institutional quality and environmental efficiency. While financial development has the potential to support environmental sustainability, concerns remain regarding its unintended negative effects through unchecked economic expansion. The objective of this research is to investigate how financial development affects environmental efficiency and to assess the moderating role of institutional quality, particularly when financial development proxies reflect financial market accessibility and efficiency. Using a directional distance function within a stochastic frontier framework and incorporating multiple financial development indicators alongside measures of institutional quality, we find that financial development significantly reduces environmental inefficiency, with institutional quality strengthening this effect. These results highlight the importance of policy approaches that simultaneously enhance financial development and institutional quality. Furthermore, our findings support targeted initiatives such as promoting green finance, building institutional capacity and investing in research and data infrastructure to inform evidence-based policymaking for sustainable development.
Questions about race and representation often hinge on the public’s beliefs about which policies affect different communities, yet there is limited evidence on how these associations are actually perceived. Using a nationally representative survey experiment, we examine how the issue priorities of political candidates shape perceptions of who they represent. Most policy areas are perceived to benefit White Americans; only a few, especially criminal justice and poverty, are strongly associated with African Americans. We also show that perceptions of candidate ideology and race correlate with perceptions of Black representation, but mediation analysis reveals that criminal justice is associated with Black representation above and beyond ideological inferences. Finally, analyzing nearly 200,000 congressional newsletters and find that while race is rarely explicitly mentioned, Black Americans are most frequently referenced in the context of criminal justice and poverty. Together, these results underscore how race-policy associations operate through both public perception and elite messaging, shaping broader understandings of political representation.
Parkinson’s disease (PD) is a neurodegenerative disorder whose diagnostic motor symptoms appear only after significant progression of neurodegeneration. Identification of preclinical markers is essential. Idiopathic rapid eye movement sleep behavior disorder (iRBD) has a high risk of conversion to PD. Olfactory impairment (hyposmia) is present in both PD and iRBD; hyposmia in iRBD may be an additional clue indicating the development of PD. The processes underlying hyposmia in iRBD are unknown. Using resting-state functional connectivity (rsFC), a “sensory olfactory subnetwork” (SOS) has been identified that is thought to represent the processing of basic sensory olfactory information. We investigated whether changes in the SOS are seen in both PD and iRBD and whether changes are associated with hyposmia in both conditions.
Methods:
The University of Pennsylvania Smell Identification Test (UPSIT) and a seed-based approach to analyze SOS region rsFC in early PD, iRBD and healthy controls (HC) were employed. Our SOS regions included (right hemisphere) anterior piriform cortex, dorsal insula (INSd), ventral insula (INSv), posterior insula (INSp) and ventral posterior thalamus (THLvp).
Results:
Compared to HC, idiopathic iRBD and PD participants performed significantly worse on UPSIT and exhibited lower FC between INSd and INSv and higher FC between INSd and THLvp and INSv and THLvp. UPSIT scores were negatively correlated with FC between INSv and THLvp and INSp and THLvp.
Conclusion:
Idiopathic iRBD may be associated with similar functional and perceptual olfactory alterations and potential compensatory changes as early PD, which may show promise as additional preclinical biomarkers of PD.
This study aimed to explore the correlates of zero, one, and multiple performance validity test (PVT) failures on cognitive test performance in patients with various degrees of severity of traumatic brain injury.
Method:
306 participants completed the Trail Making Test as part of a neuropsychological evaluation within 1–36 months post-injury. They were assigned to zero, one, or ≥ two fail groups on the basis of at least two independent PVTs. Group differences in Trail Making Test performance were analyzed with analysis of variance, with post hoc contrasts with the Bonferroni correction for multiple comparisons. Groups were also compared on various background characteristics.
Results:
Participants who passed all PVTs had statistically significantly better performance on both parts of the Trail Making Test as compared to those who failed either one or multiple PVTs, with the latter two groups not differing statistically significantly from each other. PVT failure was relatively more common in participants who were female, had an uncomplicated mild TBI, were involved in financial compensation-seeking, and were seen at a longer time point since injury.
Conclusion:
Failure of even only one PVT is associated with lower neuropsychological test performance in patients with traumatic brain injury, especially when empirically validated criteria are used that are stratified by injury severity. Such failure does not always reflect malingering but must be interpreted and addressed in the context of patient background characteristics.
The emergence of large-scale spatial modulations of turbulent channel flow, as the Reynolds number is decreased, is addressed numerically using the framework of linear stability analysis. Such modulations are known as the precursors of laminar–turbulent patterns found near the onset of relaminarisation. A synthetic two-dimensional base flow is constructed by adding finite-amplitude streaks to the turbulent mean flow. The streak mode is chosen as the leading resolvent mode from linear response theory. In addition, turbulent fluctuations can be taken into account or not by using a simple Cess eddy viscosity model. The linear stability of the base flow is considered by searching for unstable eigenmodes with wavelengths larger than the base flow streaks. As the streak amplitude is increased in the presence of the turbulent closure, the base flow loses its stability to a large-scale modulation below a critical Reynolds-number value. The structure of the corresponding eigenmode, its critical Reynolds number, its critical angle and its wavelengths are all fully consistent with the onset of turbulent modulations from the literature. The existence of a threshold value of the Reynolds number is directly related to the presence of an eddy viscosity, and is justified using an energy budget. The values of the critical streak amplitudes are discussed in relation with those relevant to turbulent flows.
We study the bilateral preference graphs $\mathit{LK}(n, k)$ of La and Kabkab, obtained as follows. Put independent and uniform [0, 1] weights on the edges of the complete graph $K_n$. Then, each edge (i, j) is included in $\mathit{LK}(n,k)$ if it is bilaterally preferred, in the sense that it is among the k edges of lowest weight incident to vertex i, and among the k edges of lowest weight incident to vertex j. We show that $k = \log(n)$ is the connectivity threshold, solving a conjecture of La and Kabkab, and obtaining finer results about the window. We also investigate the asymptotic behavior of the average degree of vertices in $\mathit{LK}(n, k)$ as $n\rightarrow\infty$.
Procolophonidae, a clade of stem reptiles, are hypothesized to be some of the first highly specialized herbivores to evolve following the end-Permian mass extinction event. That hypothesis is largely based on qualitative observations of tooth shape, which are highly subjective and not generalizable. Quantitative studies of reptilian tooth shape have employed relatively sophisticated methods to capture tooth complexity, but these approaches often require expensive equipment and software and are time intensive. In this study, we built a predictive model based on extant lizards to quantitatively predict the diets of procolophonids using simple measures of tooth morphology. We use linear discriminant analysis (LDA) to predict dietary ecology from tooth dimensions and phylogenetic MANOVA to test for significant differences in tooth dimensions for different diet categories. We report two key findings: (1) procolophonids are largely predicted as herbivorous but occupy a different area of the LDA space from extant lizards, and (2) simple metrics return similar results as complex methods, but with less confidence. We hypothesize that Triassic flora posed different mechanical and processing challenges from modern plants, which contributed to the unique tooth morphologies of procolophonids and likely other Triassic taxa.
This article examines the structure and role of the Ulster Special Constabulary (USC) in rural Ulster in 1922. It is argued the actions of the USC during this period have not received sufficient academic or public attention. The origins and organisational structure of the Specials are considered and it is claimed that the force’s decentralised make-up made it almost impossible to control. In terms of personnel, access to newly released archives gives unique insight into the force. Traditional assumptions about the connection between the pre-war Ulster Volunteer Force and the USC are questioned. Furthermore, it is found that few ‘B’ Specials had prior service with the British army. Overall, it is concluded that the Specials were an almost exclusively Protestant force made up of inexperienced and at times ill-disciplined recruits, most of whom were ill-suited to any policing role. Furthermore, it is argued that the Specials played a significant role in shaping post-partition identities in Northern Ireland.
Social isolation and loneliness are concerns in gerontology. The impact of the human–animal interaction (HAI) on loneliness for older adults living alone is understudied. This scoping review explored the extent to which HAI is included in studies investigating social connectedness, specifically social isolation and loneliness, and if HAI bolsters healthy aging through increased perceived support. Following the PRISMA-ScR protocol, data from 58 articles were thematically categorized, identifying (a) existing inclusion of HAI; (b) definitions and descriptions of HAI; and (c) the relationships between HAI and loneliness outcomes, in social connectedness research. Studies including HAI (animal companions and animal-assisted interventions) have increased over time; many noting protection against loneliness and few noting health detriments. Older adults overwhelmingly consider interactions with companion animals as meaningful relationships, whether living at home or in care. Substantial knowledge gaps exist concerning the influence of HAI on perceived social connectedness for older adults living alone.
We study the existence of several families of reversible-symmetric periodic solutions in a three-dimensional system of differential equations that admits a reversible symmetry and includes differentiable perturbations depending on a small parameter $\varepsilon $, where the periodic solutions arise as continuations of circular solutions from the unperturbed system. We essentially impose symmetric constraints on the initial conditions and make use of the Poincaré continuation method. Both fixed-period and variable-period reversible-symmetric solutions are obtained. We provide sufficient conditions for their existence, expressed in terms of the perturbation functions. In addition, we compute the characteristic multipliers of these families of reversible-symmetric periodic solutions. We also compare different types of reversible symmetries with results from the averaging method. Several examples illustrating our results are presented.
A stratigraphic section made of Quaternary alluvial–lacustrine sediments belonging to the Baza Formation (South Spain) has been logged and studied for paleomagnetism, rock magnetic cyclostratigraphy, and electron spin resonance (ESR) quartz dating. Our results indicate that the section, which is found in the vicinity of a number of paleontological and archaeological localities, falls within the mid-Early Pleistocene (Calabrian), within the Matuyama Chron, and runs to the Jaramillo Subchron, encompassing the Cobb Mountain Subchron. The magnetostratigraphic results combined with rock magnetic cyclostratigraphy and ESR provide solid timelines, which allow gross accumulation rates to be estimated, and revealing an upsection decrease of sedimentation in accordance with the lithological and paleodepositional changes. Our study furnishes new chronologies to better understand the timing of the latest stages of endorheic sedimentation that precedes the capture of the Baza Basin by the Gualdalquivir River in the Middle Pleistocene.
In this article, we investigate the quantitative law of large numbers for noncommutative random variables. Firstly, we establish a Baum–Katz theorem for noncommutative successively independent random variables, which resolves an open problem posed by Stoica [48]. Our approach differs from the classical treatment but relies on the theory of asymmetric maximal inequality for noncommutative martingales. Additionally, we derive a moderate deviation inequality for noncommutative successively independent sequences, and extend this result together with the Baum–Katz theorem to noncommutative martingales. Finally, we conclude the article by applying our results to derive a noncommutative Marcinkiewicz–Zygmund-type strong laws of large numbers theorem, which extends the result of Łuczak [37] in some aspects.