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A new resolvent-based method is developed to predict the space–time properties of the flow field. To overcome the deterioration of the prediction accuracy with increasing distance between the measurements and predictions in the resolvent-based estimation (RBE), the newly proposed method utilizes the RBE to estimate the relative energy distribution near the wall rather than the absolute energy directly estimated from the measurements. Using this extra information from RBE, the new method modifies the energy distribution of the spatially uniform and uncorrelated forcing that drives the flow system by minimizing the norm of the cross-spectral density tensor of the error matrix in the near-wall region in comparison with the RBE-estimated one, and therefore it is named as the resolvent-informed white-noise-based estimation (RWE) method. For validation, three time-resolved direct numerical simulation (DNS) datasets with the friction Reynolds numbers $Re_\tau = 180$, 550 and 950 are generated, with various locations of measurements ranging from the near-wall region ($y^+ = 40$) to the upper bound of the logarithmic region ($y/h \approx 0.2$, where h is the half-channel height) for the predictions. Besides the RWE, three existing methods, i.e. the RBE, the $\lambda$-model and the white-noise-based estimation (WBE), are also included for the validation. The performance of the RBE and scale-dependent model ($\lambda$-model) in predicting the energy spectra shows a strong dependence on the measurement locations. The newly proposed RWE shows a low sensitivity on $Re_{\tau }$ and the measurement locations, which may range from the near-wall region to the upper bound of the logarithmic region, and has a high accuracy in predicting the energy spectra. The RWE also performs well in predicting the space–time properties in terms of the correlation magnitude and the convection velocity. We further utilize the new method to reconstruct the instantaneous large-scale structures with measurements from the logarithmic region. Both the RWE and RBE perform well in estimating the instantaneous large-scale structure, and the RWE has smaller errors in the estimations near the wall. The structural inclination angles around $15^\circ$ are predicted by the RWE and WBE, which generally recover the DNS results.
The Seychelles Kestrel Falco araeus is an endemic species confined to the larger granitic islands in the Seychelles archipelago. It is classified as “Vulnerable” and became extinct on Praslin and La Digue islands in the 1970s, leading to an attempt of reintroduction in 1977. This reintroduction was not a success, with the last census reporting only four breeding pairs on Praslin Island. Studies on the Seychelles Kestrel are very limited and dated, and a lack of data on the biology and ecology of the species has made it difficult to make a thorough assessment of the cause of the current decline of the Praslin population. In order to determine the limiting factors on Praslin we investigated the following ecological parameters: nest-site availability, trophic availability, predatory pressure, and interspecific competition. Data were collected on Mahé and Praslin islands in three habitats (i.e. urban, suburban, and forest areas) and compared to determine if limiting factors differed among islands, habitats, and islands*habitat. We only found a significant difference in nest-site availability, with Praslin showing a marked lack of nesting cavities. Breeding pairs on Praslin are probably forced to nest in suboptimal sites. Indeed, the breeding success rate on Praslin is very low, and most of the nests there fail. The Seychelles Kestrel population on Praslin is in decline and cannot be sustained without human intervention. Such an intervention must take into account the ecological parameters highlighted in the present study.
Vitamin C-rich foods can improve mood; however, the timecourse of these benefits is unknown. This study utilised intensive longitudinal smartphone surveys from a three-armed placebo-controlled trial to determine mood-related changes following supplementation with vitamin C (250 mg tablet/d), kiwifruit (2 SunGold™ kiwifruit/d) or a placebo (1 tablet/d). Secondary data were analysed from the KiwiC for Vitality trial (Trial ID: ACTRN12617001031358). Adults (n 155, 63 % female, aged 18–35 years) with low plasma vitamin C (<40 μmol/l) completed a 14-d lead-in, 28-d intervention and 14-d washout. Participants self-reported vitality (SF-36), mood (POMS total mood disturbance), flourishing (flourishing scale), sleep quality, sleep quantity and physical activity every second day using smartphone surveys. Plasma vitamin C, measured fortnightly, reached saturation after 2 weeks of vitamin C or kiwifruit supplementation. Kiwifruit supplementation improved vitality and mood within 4 days, peaking around 14–16 days, and improved flourishing from day 14. Vitamin C marginally improved mood until day 12. Incremental AUC analyses revealed significant overall effects of kiwifruit consumption on vitality and mood compared with placebo, which were stronger than effects for vitamin C tablets, but attenuated when adjusting for covariates. Sensitivity analyses of participants with low baseline vitamin C status revealed improved mood (vitamin C and kiwifruit) and flourishing (kiwifruit only). This is the first study to use intensive smartphone surveys to model the day-to-day timecourse of mood-related states following vitamin C intervention and highlights the value of using smartphone surveys to reveal the temporal changes in mood-related outcomes following nutrient supplementation.
The intensification of production systems raises concerns about animal welfare. In egg production, the use of cages is the main reason for discussion. The current transition from the production system to cage-free systems raises questions about consumer perception. The objective of this study was to typify, characterize and differentiate the profile of Brazilian consumers regarding animal welfare in laying poultry. For this, a questionnaire with 28 questions, addressing questions about sociodemographic indicators (SOC), eating habits (HAB), knowledge about the production chain (CON), general perception of animal welfare in egg production (HPW) and about eggs with an animal welfare guarantee (PEAWG) was answered by 1415 consumers. Machine learning techniques were applied to characterize; typify and holistic perception. Three groups of consumers were defined: interested, emerging and indifferent. All indicators under study showed discriminatory power (P < 0.001). The indicators that showed the greatest importance for the classification of the three profiles were HPW < EHAB < COM < PEAWG < SOC. The results indicate the potential of interested and emerging groups to become consumers of cage-free eggs and also indicate the need to inform the population about animal welfare in egg production. The results reinforce the need to create specific public policies for the production chain, in order to value egg production and reaffirm interest in the area, especially in specific niches such as production in cage-free systems.
The Hoffman ratio bound, Lovász theta function, and Schrijver theta function are classical upper bounds for the independence number of graphs, which are useful in graph theory, extremal combinatorics, and information theory. By using generalized inverses and eigenvalues of graph matrices, we give bounds for independence sets and the independence number of graphs. Our bounds unify the Lovász theta function, Schrijver theta function, and Hoffman-type bounds, and we obtain the necessary and sufficient conditions of graphs attaining these bounds. Our work leads to some simple structural and spectral conditions for determining a maximum independent set, the independence number, the Shannon capacity, and the Lovász theta function of a graph.
The United Nations General Assembly adopted the United Nations Convention on the International Effects of Judicial Sales of Ships at its 47th plenary meeting on December 7, 2022 (the Convention). Known as the “Beijing Convention on the Judicial Sale of Ships,” the Convention opened for signature at a ceremony held in Beijing, PRC, on September 5, 2023. By its terms, the Convention will enter into force 180 days after the date that it is ratified, accepted, approved, or otherwise acceded to by at least three states. With strong backing from the maritime community, it is expected that the Convention will enter into force by 2024.
Adrenal gland-induced hypertension, also known as secondary hypertension, is a medical condition caused by an underlying adrenal pathology, most typically adrenocortical adenomas. Current clinical practices involve pharmacotherapy or surgical resection to treat adrenal gland diseases that cause hypertension. However, due to the limitations of these treatment options, microwave ablation (MWA) has emerged as a promising minimally invasive alternative. An accurate understanding of the dielectric properties of adrenal glands would support the further development and optimization of MWA technology for treating adrenal tumors. Only a few studies have examined the dielectric properties of both human and animal adrenal glands, and the sample sizes of these studies have been relatively small. Therefore, further dielectric data of human and animal adrenal glands are warranted. This paper presents the ex vivo dielectric properties of the ovine adrenal glands (medulla and cortex) and summarizes the published literature on dielectric data of adrenal glands from porcine, bovine, ovine, and human samples in the microwave frequency range to analyze the consistency and reliability of the reported data. The dielectric properties of the ovine adrenal glands (N = 8) were measured using an open-ended coaxial probe measurement technique at frequencies ranging from 0.5 to 8.5 GHz. This study also investigated the temperature-dependent dielectric properties of the ovine adrenal medulla ranging from 37 to 64°C at frequencies ranging from 0.5 to 8.5 GHz. The dielectric properties of the ovine adrenal medulla measured in this study were found to be consistent with the literature. Moreover, the review suggests that variations exist in the dielectric properties of the adrenal medulla and cortex among species. The study also found that the dielectric properties of the adrenal medulla decrease with increasing temperature, similar to other tissues for which temperature-dependent dielectric data have been reported. This summary of dielectric data of adrenal glands and the temperature-dependent dielectric properties of the ovine adrenal medulla will accelerate the development of MWA technologies for hypertension treatment.
Although the incidence of hospital-associated respiratory virus infection (HARVI) is well recognized, the risk factors for infection and impact on patient outcomes are not well characterized.
Methods:
We identified a cohort of all inpatient admissions ≥24 hours duration at a single academic medical center from 2017 to 2020. HARVI were defined as respiratory virus detected in a test ordered after the 95th percentile of the virus-specific incubation period. Risk factors for HARVI were assessed using Cox proportional hazards models of the competing outcomes of HARVI and discharge. The associations between time-varying HARVI status and the rates of ICU admission, discharge, and in-hospital death were estimated using Cox-proportional hazards models in a competing risk framework.
Results:
HARVI incidences were 8.8 and 3.0 per 10,000 admission days for pediatric and adult patients, respectively. For adults, congestive heart failure, renal disease, and cancer increased HARVI risk independent of their associations with length of stay. HARVI risk was also elevated for patients admitted in September–June relative to July admissions. For pediatric patients, cardiovascular and respiratory conditions, cancer, medical device dependence, and admission in December increased HARVI risk. Lengths of stay were longer for adults with HARVI compared to those without, and hospital-associated influenza A was associated with increased risk of death. Rates of ICU admission were increased in the 5 days after HARVI identification for adult and pediatric patients. HARVI was not associated with length of stay or death among pediatric patients.
Conclusions:
HARVI is associated chronic health conditions and increases morbidity and mortality.
Data on trends in the epidemiological burden of bipolar disorder are scarce.
Aims
To provide an overview of trends in bipolar disorder burden from 1990 to 2019.
Method
Revisiting the Global Burden of Disease Study 2019, we analysed the number of cases, calculated the age-standardised rate (per 100 000 population) and estimated annual percentage change (EAPC) of incidence, prevalence and years lived with disability (YLDs) for bipolar disorder from 1990 to 2019. The independent effects of age, period and cohort were estimated by the age–period–cohort modelling.
Results
Globally, the bipolar disorder-related prevalent cases, incident cases and number of YLDs all increased from 1990 to 2019. Regionally, the World Health Organization Region of the Americas accounted for the highest estimated YLD number and rate, with the highest age-standardised prevalence rate in 1990 and 2019 and highest EAPC of prevalence. By sociodemographic index (SDI) quintiles, all five SDI regions saw an increase in estimated incident cases. Nationally, New Zealand reported the highest age-standardised rate of incidence, prevalence and YLDs in 1990 and 2019. The most prominent age effect on incidence rate was in those aged 15–19 years. Decreased effects of period on incidence, prevalence and YLD rates was observed overall and in females, not in males. The incidence, prevalence and YLD rates showed an unfavourable trend in the younger cohorts born after 1990, with males reporting a higher cohort risk than females.
Conclusions
From 1990 to 2019, the overall trend of bipolar disorder burden presents regional and national variations and differs by age, sex, period and cohort.
Cyril of Alexandria's Festal Letters are an underutilised source of his theology. Through them one can trace the development of his thought throughout the tumultuous years of his episcopacy. In this article, I draw attention to Cyril's ‘unitive’ Christology and the way he explains the incarnation to those under his pastoral care. Cyril employs key strategies informed by strong theological convictions to describe Christ as one subject who is fully divine and human.
This article explores the constitutional regulation of birthright ius soli citizenship in two Latin American countries which restrict access to citizenship for the children of foreigners deemed to be passing through the countries. Access to citizenship is a significant marker of membership, setting the boundaries of inclusion and exclusion within and across States. Choosing the cases of Chile and Colombia, this article uses historical, institutional and comparative analysis in order to excavate the evolving conceptions of citizenship in those two countries, with particular reference to the concepts of the ‘transient foreigner’ and of ‘domicile’. The case studies provide an excellent laboratory within which to examine the evolution of constitutional ideas of citizenship and ‘the people’. In Colombia, the outcome of the investigation shows that there is unlikely to be significant long-term change in the citizenship regime towards a more generalised acceptance of unconditional ius soli, notwithstanding the substantial shorter-term measures taken to accommodate the children of undocumented migrants from Venezuela and to respond to international pressure. In Chile, combined with other ongoing constitutional work in the citizenship space as part of a wider reform process, there may be a slow journey towards a different constitutional future for so-called ‘transient foreigners’ and others excluded within the State, but this is currently stalled. Chile has, however, introduced legislation cementing a more limited concept of ‘transient foreigner’, linking this work on citizenship to the wider domain of migration governance.
The turbulent external flow around a three-dimensional stepped cylinder is studied by means of direct numerical simulations with the adaptive mesh refinement technique. We give a broad perspective of the flow regimes from laminar to turbulent wake at $Re_D=5000$, which is the highest ever considered for this flow case. In particular, we focus on the intermediate Reynolds number $Re_D=1000$ that reveals a turbulent wake coupled with a stable cylinder shear layer (subcritical regime). This flow shows a junction dynamics similar to the laminar $Re_D=150$, where no hairpin vortex appears around the edges, and just two horseshoe vortices are visible. A new stable vortex in the form of a ring, which coils around the rear area, is also identified. In the turbulent wake, the presence of three wake cells is pointed out: the large and small cylinder cells together with the modulation region. However, the modulation dynamics varies between the subcritical and turbulent regimes. A time-averaged, three-dimensional set of statistics is computed, and spatially coherent structures are extracted via proper orthogonal decomposition (POD). The POD identifies the (long-debated) connection between the N-cell and the downwash behind the junction. Furthermore, as the Reynolds number increases, the downwash phenomenon becomes less prominent. Eventually, a reduced-order reconstruction with the most energetically relevant modes is defined to explain the wake vortex interactions. This also serves as a valuable starting point for simulating the stepped cylinder wake behaviour within complex frameworks, e.g. fluid–structure interaction.
Suppose $\mathfrak {g}=\mathfrak {g}_{\bar 0}+\mathfrak {g}_{\bar 1}$ is a finite-dimensional restricted Lie superalgebra over an algebraically closed field $\mathbf {k}$ of characteristic $p>2$. In this article, we propose a conjecture for maximal dimensions of irreducible modules over the universal enveloping algebra $U(\mathfrak {g})$ of $\mathfrak {g}$, as a super generalization of the celebrated first Kac–Weisfeiler conjecture. It is demonstrated that the conjecture holds for all basic classical Lie superalgebras and all completely solvable restricted Lie superalgebras. In this process, we investigate irreducible representations of solvable Lie superalgebras.
This article analyses the little-studied thirteenth-century Arabic inscriptions of the monastery of Santa María la Real de Las Huelgas in Burgos, Spain. Despite their creation during an intensifying Christian–Muslim conflict, they were part of a decorative programme that relied on shared religious ideas and iconography. Their incorporation reinforced daily, funerary and commemorative monastic liturgies. While the article explores the Islamic provenance of these inscriptions, it also reveals the overlooked Arabic New Testament as a source. The inscriptions’ provenance, however, was deliberately obscured first and foremost by the nature of their visual display. Examining the relationship of the Latin to the Arabic inscriptions illustrates an unusual symbiosis between the meaning of the inscriptions, the iconography and the monastery's ritual. This symbiosis was formulated through a highly selective editorial process on the part of the Christian patrons, and predicated on their knowledge of the finer points of Islamic doctrine and cultural practices.
In 2021, an Italian-Peruvian archaeological team began a research project in the Ancash Sierra to investigate the origins of early monumental architecture in the northern-central Andes. The large complex of Tumshukayko—located in the northern part of the town of Caraz in Ancash, Peru—was immediately found to be the most suitable site for this project. This report presents an initial description of the current state of the remains, topographical data, and test pit results. Preliminary data suggest that Tumshukayko is a multicomponent site comprising at least two mounds that were built during the Initial Formative period (2500–1500 BC).