Four species of Porpidia are newly reported from China, including one species new to science (Porpidia crystallina) and three records (Porpidia umbonifera, P. seakensis and P. cf. contraponenda) new to China. Porpidia crystallina is characterized by a macrocarpa-type exciple containing crystals, a Cinereorufa-green epihymenium, large ascospores and a lack of secondary metabolites. Morpho-anatomical, chemical and phylogenetic analyses were carried out to elucidate the placement of the species and to support the delimitation of the new taxon. Detailed taxonomic descriptions, ecological and chemical characters, and illustrations are provided for each species. A key to all known Chinese Porpidia species is also provided.

Can commitment to international human rights law promote human rights when the commitment is not yet legally binding? I argue that treaty signature can be used by non-governmental organizations and other rights actors to mobilize around rights standards and hold states accountable in the lead up to binding treaty ratification. Using the United Nations Convention on the Elimination of All Forms of Discrimination (CEDAW) as a case, I argue that CEDAW signature can have a positive impact on women’s rights. I find overall support for the argument that, following signature, states are significantly and positively associated with higher women’s rights. The findings hold across numerous robustness checks. Using an illustrative case of CEDAW signature and mobilization in the United States, I demonstrate that activists drew on the treaty following signature in the absence of ratification. The argument and results contribute to the study of international law and women’s rights mobilization, highlighting the importance of signature commitment as a tool for advancing women’s rights in advance of treaty ratification.

The Fueter-Sce theorem provides a procedure to obtain axially monogenic functions, which are in the kernel of generalized Cauchy–Riemann operator in ${\mathbb{R}}^{n+1}$. This result is obtained by using two operators. The first one is the slice operator, which extends holomorphic functions of one complex variable to slice monogenic functions in $ \mathbb{R}^{n+1}$. The second one is a suitable power of the Laplace operator in n + 1 variables. Another way to get axially monogenic functions is the generalized Cauchy–Kovalevskaya (CK) extension. This characterizes axial monogenic functions by their restriction to the real line. In this paper, using the connection between the Fueter-Sce map and the generalized CK-extension, we explicitly compute the actions $\Delta_{\mathbb{R}^{n+1}}^{\frac{n-1}{2}} x^k$, where $x \in \mathbb{R}^{n+1}$. The expressions obtained is related to a well-known class of Clifford–Appell polynomials. These are the building blocks to write a Taylor series for axially monogenic functions. By using the connections between the Fueter-Sce map and the generalized CK extension, we characterize the range and the kernel of the Fueter-Sce map. Furthermore, we focus on studying the Clifford–Appell–Fock space and the Clifford–Appell–Hardy space. Finally, using the polyanalytic Fueter-Sce theorems, we obtain a new family of polyanalytic monogenic polynomials, which extends to higher dimensions the Clifford–Appell polynomials.

We use the cobordism distance on the smooth knot concordance group $\mathcal {C}$ to measure how close two knots are to being linearly dependent. Our measure, $\Delta (\mathcal {K}, \mathcal {J})$, is built by minimizing the cobordism distance between all pairs of knots, $\mathcal {K}'$ and $\mathcal {J}'$, in cyclic subgroups containing $\mathcal {K}$ and $\mathcal {J}$. When made precise, this leads to the definition of the projective space of the concordance group, ${\mathbb P}(\mathcal {C})$, upon which $\Delta $ defines an integer-valued metric. We explore basic properties of ${\mathbb P}(\mathcal {C})$ by using torus knots $T_{2,2k+1}$. Twist knots are used to demonstrate that the natural simplicial complex $\overline {({\mathbb P}(\mathcal {C}), \Delta )}$ associated with the metric space ${\mathbb P}(\mathcal {C})$ is infinite-dimensional.

Selection of lines from segregating generations and breeding hybrids to exploit heterosis or heterobeltiosis is an effective tool for improving economically important traits in the genus Capsicum. The objective of this study was to identify high potential parents to obtain high-yielding F1 hybrids using a Line × Tester (8 × 2) mating design in the Habanero pepper improvement programme. Ten parents and 16 hybrids were evaluated in order to determine their values of general combining ability, specific combining ability, heterosis, and heterobeltiosis. Parent NKA-11 had the highest values of GCA for different quantitative variables of the fruit, which does it suitable for future improvement works, and tester RNJ-04 showed the highest value of GCA for fruit length. The quantitative variables evaluated confirm a significant genetic variability among the Habanero pepper genotypes studied. The best hybrids were NEK-03xRNJ-04, NBA-06xRNJ-04, AKN-07xRNJ-04, and RKI-10xRNJ-04, which showed their high productive potential with values between 3.13 and 4.92 Kg/Pta, a quality, that would open to them the national market for fresh consumption. Based on the GCA values of the parents and heterosis of the progenies, it is concluded hybridization would be the most appropriate genetic improvement method to increase both yield (YP) and the number of fruits for plant.

Spaceflight associated neuro-ocular syndrome (SANS) is one of the potential barriers to human long-duration spaceflight (LDSF), including a manned mission to Mars. While a large barrier, the pathophysiology of SANS is not well understood, and functional and structural findings from SANS continue to be further characterized. Currently on the International Space Station (ISS), scheduled visual assessments are static visual acuity, Amsler grid, and a self-reported survey. Additional visual assessments may help the understanding of this neuro-ophthalmic phenomenon, as well as the effects of spaceflight of overall ocular health. In this paper, a case is made for expanding scheduled visual assessments to include dynamic visual, contrast sensitivity (CS), visual field testing, and virtual reality-based metamorphopsia assessment during spaceflight. These further assessments may play a key role in helping to determine the structural and functional changes associated with SANS, which are crucial to maintain astronaut vision during LDSF, as well as for developing countermeasures. Finally, a brief discussion is provided about current challenges to expanding visual testing during spaceflight and potential solutions to these barriers, specifically head-mounted visual assessment technology.

It took nearly two thousand years for society to recognize the Hippocratic insistence that “the doctor knows best”1 was an inadequate approach to medical decisionmaking. Today, patient-centered medicine has come to understand that the individual patient has a significant role in the decisionmaking process.2

Sustainability, properly understood, is an existential moral ideal. The United Nations, however, defines it in terms of 17 indivisible sustainable development goals. This definition changes the core idea of the concept. It turns sustainability from a moral ideal into a set of economy-based political aspirations. The European Union’s bioeconomy strategy demonstrates the shift aptly and reveals its main problem. When economy is prioritized, social and ecological concerns become secondary. This has been the United Nations line since the Brundtland Commission’s report, Our Common Future in 1987. Considerations of justice illustrate the inadequacy of the approach. Equality and justice require that all those affected by decisions are heard in making them. Under the current operationalization, decisions related to the natural environment and climate change are currently being made without hearing voices that advocate deeper social and ecological equality. After an explication of the problem and the state of the art as outlined above, a new notion of justainability is introduced and it is argued that assuming it would be a step in the right direction in taking also noneconomic values properly into account in international decision making.

Melatonin supplementation to obese mothers during gestation and lactation might benefit the pancreatic islet cellular composition and beta-cell function in male offspring adulthood. C57BL/6 females (mothers) were assigned to two groups (n = 20/each) based on their consumption in control (C 17% kJ as fat) or high-fat diet (HF 49% kJ as fat). Mothers were supplemented with melatonin (Mel) (10 mg/kg daily) during gestation and lactation, or vehicle, forming the groups (n = 10/each): C, CMel, HF, and HFMel. The male offspring were studied, considering they only received the C diet after weaning until three months old. The HF mothers and their offspring showed higher body weight, glucose intolerance, insulin resistance, and low insulin sensitivity than the C ones. However, HFMel mothers and their offspring showed improved glucose metabolism and weight loss than the HF ones. Also, the offspring’s higher expressions of pro-inflammatory markers and endoplasmic reticulum (ER) stress were observed in HF but reduced in HFMel. Contrarily, antioxidant enzymes were less expressed in HF but improved in HFMel. In addition, HF showed increased beta-cell mass and hyperinsulinemia but diminished in HFMel. Besides, the beta-cell maturity and identity gene expressions diminished in HF but enhanced in HFMel. In conclusion, obese mothers supplemented with melatonin benefit their offspring’s islet cell remodeling and function. In addition, improving pro-inflammatory markers, oxidative stress, and ER stress resulted in better glucose and insulin levels control. Consequently, pancreatic islets and functioning beta cells were preserved in the offspring of obese mothers supplemented with melatonin.

In the debate on the (de-)judicialisation of international affairs and the International Criminal Court (ICC) specifically, the distinctions between legality and politics and between state sovereignty and the international remain contested. While realist and legalist approaches discuss the transformation of international politics by international criminal law, sociological and critical-legal perspectives instead highlight the politics of international criminal law. In this contribution, we focus on how the distinctions between (international) law and politics matter, not as substantively opposed spheres, but as boundaries that the ICC itself contingently and flexibly draws when considering particular situations. These meta-politics of invoking and reproducing key boundaries in seemingly technical elaborations of the interest of justice, the scope of its jurisdiction, or the application of complementarity reflect the Court’s particular authority but also its predicament of pushing for an international criminal law serving humanity, rather than states, while reproducing the distinctions between (international) law and politics. We illustrate the Court’s meta-politics by revisiting three recent decisions of the ICC to (not) investigate alleged international crimes committed by British forces in Iraq, by the Taliban, governmental, and US forces in Afghanistan, and by Israeli authorities and Palestinian groups in the West Bank, East Jerusalem, and Gaza.

This qualitative study draws attention to the symbolic value of driving or having a valid driver’s licence among older adults as part of their impression management. While several studies have focused on driving behaviour, safety, risk factors and not least the consequences of driving cessation, the present study from the Faroe Islands contributes to the body of knowledge concerning older adults and driving by bringing an impression management lens to this issue. Social constructionism formed both the theoretical and methodological approach and data came from interviews with three couples and eight individuals in their eighties. All the male participants still had their driver’s licence and were active drivers except for one. Among the women, four had driver’s licences and three were active drivers. Our findings point to the necessity of understanding the reluctance to give up driving as being not only related to quality of life, mobility and independence, but also being highly related to preserving one’s identity as a competent and ‘not that old’ person. Contrary to common prejudices against older drivers, the findings also showed that these participants reported self-regulation adjustments to continue driving safely. The study indicates a need to support older drivers to continue driving if they wish to do so. It is not only a question of mobility or being independent, but also related to preserving one’s social identity in later life.