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The advent of new technologies, particularly artificial intelligence (AI), has expanded the array of options and enhanced performance in addressing biothreats. This article provides a comprehensive overview of the specific applications of AI in addressing biothreats, aiming to inform and enhance future practices. Research indicates that AI has significantly contributed to infectious disease surveillance and emergency responses, as well as bioterrorism mitigation; despite its limitations, it merits ongoing attention for further study and exploration. The effective deployment of next-generation AI in mitigating biothreats will largely hinge on our ability to engage in continuous experiential learning, acquire high-quality data, refine algorithms, and iteratively update practices. Meanwhile, it is essential to assess the operational risks associated with AI in the context of biothreats and develop robust solutions to mitigate potential risks.
Existing evidence on the association between combined lifestyle and depressive symptoms is limited to the general population and is lacking in individuals with subthreshold depression, a high-risk group for depressive disorders. Furthermore, it remains unclear whether an overall healthy lifestyle can mitigate the association between childhood trauma (CT) and depressive symptoms, even in the general population. We aimed to explore the associations of combined lifestyle, and its interaction with CT, with depressive symptoms and their subtypes (i.e. cognitive-affective and somatic symptoms) among adults with subthreshold depression.
Methods
This dynamic cohort was initiated in Shenzhen, China in 2019, including adults aged 18–65 years with the Patient Health Questionnaire-9 (PHQ-9) score of ≥ 5 but not diagnosed with depressive disorders at baseline. CT (present or absent) was assessed with the Childhood Trauma Questionnaire-Short Form. Combined lifestyle, including no current drinking, no current smoking, regular physical exercise, optimal sleep duration and no obesity, was categorized into 0–2, 3 and 4–5 healthy lifestyles. Depressive symptoms were assessed using the PHQ-9 during follow-up. This cohort was followed every 6 months, and as of March 2023, had been followed for 3.5 years.
Findings
This study included 2298 participants (mean [SD] age, 40.3 [11.1] years; 37.7% male). After fully adjusting for confounders, compared with 0–2 healthy lifestyles, 3 (β coefficient, −0.619 [95% CI, −0.943, −0.294]) and 4–5 (β coefficient, −0.986 [95% CI, −1.302, −0.671]) healthy lifestyles were associated with milder depressive symptoms during follow-up. There exists a significant synergistic interaction between a healthy lifestyle and the absence of CT. The CT-stratified analysis showed that compared with 0–2 healthy lifestyles, 3 healthy lifestyles were associated with milder depressive symptoms in participants with CT, but not in those without CT, and 4–5 healthy lifestyles were associated with milder depressive symptoms in both participants with and without CT, with a stronger association in those with CT. The lifestyle-stratified analysis showed that CT was associated with more severe depressive symptoms in participants with 0–2 healthy lifestyles, but not in those with 3 or 4–5 healthy lifestyles. Cognitive-affective and somatic symptoms showed similar results.
Conclusions
In this 3.5-year longitudinal study of adults with subthreshold depression, an overall healthy lifestyle was associated with subsequent milder depressive symptoms and their subtypes, with a stronger association in adults with CT than those without CT. Moreover, an overall healthy lifestyle mitigated the association of CT with depressive symptoms and their subtypes.
The article examines the drivers of migrant atypical employment in the manufacturing sector of Emilia-Romagna, an Italian region that is well known for its high-quality manufacturing productions and industrial relations. By drawing on administrative data based on mandatory communications, we document that, even in such an institutional context, migrants have a disproportionately higher likelihood of being hired through either fixed-term or agency contracts than native workers. We interpret this evidence through a set of different theories, including human capital theory, dual labour market processes, the use of precarious contracts as screening devices, and institutional segmentation theories. The empirical analysis reveals that while migrant employment through fixed-term contracts is consistent with dual processes and screening practices, the hiring of migrants with agency contracts is driven by processes of institutional segmentation, through which employers shift the costs of flexibility to the most vulnerable and less organized segments within the labour force, such as migrants. Managerial and policy implications are discussed.
Bubble–particle collisions in turbulence are key to the froth flotation process that is widely employed industrially to separate hydrophobic from hydrophilic materials. In our previous study (Chan et al., 2023 J. Fluid Mech.959, A6), we elucidated the collision mechanisms and critically reviewed the collision models in the no-gravity limit. In reality, gravity may play a role since, ultimately, separation is achieved through buoyancy-induced rising of the bubbles. This effect has been included in several collision models, which have remained without a proper validation thus far due to a scarcity of available data. We therefore conduct direct numerical simulations of bubbles and particles in homogeneous isotropic turbulence with various Stokes, Froude and Reynolds numbers, and particle density ratios using the point-particle approximation. Generally, turbulence enhances the collision rate compared with the pure relative settling case by increasing the collision velocity. Surprisingly, however, for certain parameters the collision rate is lower with turbulence compared with without, independent of the history force. This is due to turbulence-induced bubble–particle spatial segregation, which is most prevalent at weak relative gravity and decreases as gravitational effects become more dominant, and reduced bubble slip velocity in turbulence. The existing bubble–particle collision models only qualitatively capture the trends in our numerical data. To improve on this, we extend the model by Dodin & Elperin (2002 Phys. Fluids14, 2921–2924) to the bubble–particle case and found excellent quantitative agreement for small Stokes numbers when the history force is negligible and segregation is accounted for.
The fields of archaeology and museology are working to encourage and enforce research methodologies and policies that center reciprocity and respect among archaeologists, institutions, and Native Nations. This shift in approach is grounded in part by the inclusion of the Duty of Care clause in the revised NAGPRA regulations and partly by a revised awareness of ethical standards. Policy-level changes around research access are the most impactful but can also be the most challenging to initiate. In this article, we address shifts in both institutional research policies and researchers’ approaches and practices that actively incorporate Native perspectives. The framework presented was developed as a complement to the Indigenous Collections Care Guide and is grounded in case studies from three institutions that have changed their research policies. The resulting prompts, tips, examples, and challenges are provided for both researchers and institutions to evaluate research and access practices and how they intersect with Native perspectives. Seeking input and consent from Native Nations adds challenging layers to research, but the depth, quality, and impact of the research and the strengthening of relationships and trust with the communities significantly outweigh the extra time and effort.
Research informed by sociological neoinstitutionalism often frames organizational reactions to legal norms as either loose coupling, where formal legal commitments are only weakly aligned with actual practices, or tight coupling, where strong internal or external compliance pressures drive close alignment. This article introduces a third pattern – contentious coupling – where some organizational members attempt to realign practices with legal commitments, but these very efforts provoke pushback from others, resulting in substantive yet constrained success. This paradox is key to understanding the widespread yet limited effects of legal rights. I illustrate contentious coupling by examining how international human rights law has shaped solitary confinement reform in Taiwan. While hierarchical enforcement led by rights advocates and policymakers has successfully reduced prolonged solitary confinement, it has also alienated frontline correctional officers by triggering a sense of relative deprivation and perception of hypocrisy, encapsulated in their complaints of a “human rights upsurge.” In response, these officers engage in two forms of passive resistance – formalistic care and resistance spillover – both of which undermine the authority of human rights and hinder their capacity to transform correctional culture.
This study examined the motivational factors influencing African immigrants in New Zealand to become entrepreneurs and the factors that ensured their business success. Data were collected from 117 participants through survey questions employing the Qualtrics platform and its link was sent to participants in the Auckland region. Auckland was decided on for data collection, being the most populated city and the business nerve centre of New Zealand. The research was conducted using a descriptive and quantitative approach. From the analysis, the study found that passion for business entrepreneurship, flexibility, financial independence, generic independence, autonomy, and being one’s own boss are the most highly motivational factors for influencing African immigrants in New Zealand to opt for business ownership. The study also found that the six highest-rated reasons for African immigrants’ entrepreneurial business success in New Zealand were readiness to make sacrifices to succeed, always giving the best in everything that had to be done, the importance of action, a belief that everything is possible if the entrepreneur believes he/she can do it, the challenge of taking on new projects, and learning lessons from past failure. These findings are the most important factors helping African immigrant business owners in New Auckland Zealand to attain entrepreneurial and business success. This research maintains that the results shed light on why African migrants adopt business entrepreneurship and gear themselves up for success in New Zealand.
This work analyses the genetic potential of Stevia rebaudiana beyond its sweetening properties, aiming to reassess its conservation and utilization in breeding programmes. This focus is justified by the growing global demand for natural sweeteners and the challenges posed by extreme weather events and diseases affecting crop yield and quality. The relationship between the species’ genetic diversity and its response to biotic and abiotic stresses is explored, as well as the limitations of current conservation and breeding strategies. Findings reveal underutilized genetic resources, limited integration of genomic tools in breeding efforts and a lack of robust in situ conservation initiatives. Genotypic variability has been observed in response to diseases such as Septoria leaf spot, while abiotic factors, including salinity and drought, can significantly influence steviol glycoside content. It is concluded that an integrated approach, combining dynamic conservation, photoperiod‐informed breeding strategies, improvements in seed viability, omics‐based tools and coherent public policies, is essential to ensure crop resilience and genetic sovereignty, especially in regions of origin such as Paraguay. The sustainable use of Stevia’s genetic diversity could foster more sustainable, healthier and fairer production systems.
Using a behavioural intervention to target nutrition during pregnancy may be key in meeting recommendations for healthy eating. The aim was to assess the use of a short-term dietary intake measurement tool (3-day food intake record) to infer long-term habitual dietary intake during pregnancy (using a short-form FFQ). A convenience sample (n 90) between 12- and 18-weeks’ gestation was recruited from a larger randomised controlled trial for cross-sectional analysis. Participants completed a forty-four-item FFQ and 3-day food intake record. Using the participant food intake record, the investigator blindly completed a second frequency questionnaire. The frequency questionnaires were scored using dietary quality scores (DQS) and compared. Aggregate data were evaluated using a Wilcoxon signed rank test, and individual-level data were evaluated using a Bland–Altman plot. No significant difference was observed in the scores (Z = –1·88, P = 0·06), with small effect size (r= 0·19). The Bland–Altman plot showed that comparing the DQS derived from the two different dietary assessments underestimated scores by a mean difference of 0·4 points (95 % limits of agreement: −3·50 to 4·26). The data points were evenly spread suggesting no systematic variation for over- or underestimation of scores. Minimal difference was observed between the functionality of the two assessment instruments. However, the food intake record can be completed by pregnant individuals to estimate short-term nutrient intake and then scored by the investigator to estimate long-term dietary quality. Combining these two instruments may best capture the most accurate representation of dietary habits over time.
We propose CTREND, a new trend factor for cryptocurrency returns, which aggregates price and volume information across different time horizons. Using data on more than 3,000 coins, we employ machine learning methods to exploit information from various technical indicators. The resulting signal reliably predicts cryptocurrency returns. The effect cannot be subsumed by known factors and remains robust across different subperiods, market states, and alternative research designs. Moreover, it survives the impact of transaction costs and persists in big and liquid coins. Finally, an asset pricing model that incorporates CTREND outperforms competing factor models, providing a superior explanation of cryptocurrency returns.
Historical censuses have often served as valuable sources for understanding the past. Yet, their use as sources about women’s work has been highly debated. This article engages with the continuing debate regarding the reliability and validity of censuses by exploring significant potentials and issues of censuses’ information about women’s work. While recognizing a critical perspective on censuses’ information about women’s work, this article identifies the need for more careful and contextualized readings of censuses. To this end, it presents five novel analytical approaches that aim to enhance readings and interpretations of censuses. The approaches reveal the purposes, focuses, self-reflections, ambiguities, and evolving categorizations of censuses, respectively. Through analysis of Swedish census materials from 1910 to 1940, this article moreover demonstrates that historical census personnel engaged with women’s work in sophisticated ways and that censuses’ representations were complex. The article argues against dismissing censuses outright as a fruitful source about women’s work. Instead, it recommends leveraging their inherent qualities in new and creative ways. Though non-neutral by incorporating and disseminating ideas about gender, censuses can serve as rich historical sources about women’s work and societal roles when approached contextually in various ways. The article advocates for contextualized and historicized approaches to using census data, moving beyond simplistic labels to explore the complexities of these important historical sources.
Political professionals and scholars maintain that raising money early in the election season is critical to a successful campaign, having downstream consequences on a candidate’s future fundraising potential, the stiffness of competition she will face, and her likelihood of electoral victory. In spite of early money’s perceived importance, there is no common operationalization for money as “early.” Moreover, existing measures often fail to reflect definitional aspects of early money. In this paper, we first lay out a theoretical framework regarding the utility of early campaign fundraising for candidates. We argue that early fundraising can be expressed as two conceptually distinct quantities of interest centered on either a candidate’s own fundraising performance (candidate-centered) or her fundraising performance relative to her electoral competitors (election-centered). We next lay out steps for operationalizing candidate- and election-centered measures of early fundraising. Lastly, we demonstrate that both our proposed measures for early campaign fundraising are predictive of a candidate’s future fundraising and electoral success. By putting forward a set of best practices for early money measurement and, additionally, producing off-the-shelf measures for early fundraising in U.S. House elections, we fill an important gap in scholarly research on the measurement of money in politics.
The offshoring-fuelled growth of the Central and Eastern European business services sector gave rise to shared service centres (SSCs) – quasi-autonomous entities providing routine-intensive tasks for the central organisation. The advent of technologies such as intelligent process automation, robotic process automation, and artificial intelligence jeopardises SSCs’ employment model, necessitating workers’ skills adaptation. The study challenges the deskilling hypothesis and reveals that automation in the Polish SSCs is conducive to upskilling and worker autonomy. Drawing on 31 in-depth interviews, we highlight the negotiated nature of automation processes shaped by interactions between headquarters, SSCs, and their workers. Workers actively participated in automation processes, eliminating the most mundane tasks. This resulted in upskilling, higher job satisfaction, and empowerment. Yet, this phenomenon heavily depends upon the fact that automation is triggered by labour shortages, which limit the expansion of SSCs. This situation encourages companies to leverage the specific expertise entrenched in their existing workforce. The study underscores the importance of fostering employee-driven automation and upskilling initiatives for overall job satisfaction and quality.
The Making Care Primary (MCP) model represents a sharp shift in Medicare’s approach to primary care, yet its current design risks duplicating failures from prior alternative payment models. Our editorial suggests refinements to address these gaps. To prevent early provider dropout from MCP’s rigid track-based system, we propose a sliding-scale infrastructure payment model that adjusts based on practice needs rather than abrupt phase-outs. Given MCP’s reliance on community-based organisations (CBOs) for social determinants of health interventions, we also advocate for direct, outcomes-based contracts between providers and CBOs, ensuring accountability for patient outcomes rather than passive referrals. We recommend that MCP enforce data-sharing mandates for commercial insurers and Medicaid agencies, drawing from Washington State’s successful Multi-Payer Collaborative, to avoid payer disengagement that plagued previous multi-payer models. To expand beyond conventional quality measures, we propose integrating patient-centred outcomes from the International Consortium for Health Outcomes Measurement, making sure MCP captures meaningful clinical impact. Finally, we propose programme adjustments frequently at two- to three-year intervals to refine risk adjustment methodologies. These approaches could enhance MCP’s sustainability, preventing the financial instability and misaligned incentives that undermined past value-based care initiatives.
Plastic chemicals are numerous and ubiquitous in modern life and pose significant risks to human health. Observational epidemiological studies have been instrumental in identifying consistent and statistically significant associations between exposure to certain chemicals and adverse health outcomes. However, these studies often fail to establish causality due to the complexity of real-world chemical mixtures, confounding factors, reverse causation, and study designs that lack measures reflecting underlying genetic and cellular mechanisms indicating causal pathways to harm. Addressing these limitations requires moving beyond traditional ‘black-box’ epidemiology, which mainly focuses on the strength of associations. We propose adopting hybrid epidemiological methodologies that incorporate genetic susceptibility and molecular mechanisms to uncover biological pathways, combined with machine learning and statistical analysis of chemical mixtures, to strengthen the causal evidence linking exposure to harm. By integrating observational multi-omics data with experimental and mechanistic models, hybrid epidemiology offers a transformative path to improve causal evidence and public health interventions. In addition, machine learning and statistical methods provide a more nuanced understanding of the health effects of exposures to plastic chemical mixtures, facilitating the identification of interactions within chemical mixtures and the influence of biological pathways. This paradigm shift is critical addressing the complex challenges of plastic exposure and protecting human health.
Iron oxide-apatite (IOA) deposits and the related iron oxide-copper-gold (IOCG) deposits, are major repositories of base metals (Fe, Cu). However, the genesis of IOA deposits remains a topic of debate, with both magmatic and hydrothermal models. Close parallels exist between IOA deposits and some skarns, which exhibit sodic alteration in silicic host rocks, but are unequivocally metasomatic in origin. In this study we compared the trace element composition of magnetite from IOA deposits in the Kiruna District, Sweden, with magnetite skarns from the Turgai district, Kazakhstan. Comparison with published discrimination diagrams for deposit types shows poor correspondence with defined fields. The two districts correspond closely in terms of Sn and Ga contents, with close correspondence to previous analyses of porphyry and skarn deposits. When estimates of temperature (T) from Mg in magnetite are considered Sn and Ga show little correlation with T, whereas Ni increases and Mn decreases with decreasing T. Rare earth element distribution patterns correspond to local igneous rocks, albeit at lower absolute concentration. Tin and Ga, as high valence ions in tetrahedral sites in magnetite are potentially more resistant to re-equilibration and preserve a high temperature magmatic-hydrothermal signature comparable to Fe skarns and the early magmatic stages of some IOA deposits in the Kiruna district. Overall, these data are consistent with an early high-temperature mineralisation stage, potentially resulting from hypersaline brines or salt melts interacting with volcanic rocks (Kiruna district) or limestone and volcanic rocks (Turgai district), followed by subsequent hydrothermal magnetite mineralisation to relative low T. The high-temperature stage is better represented in the Turgai skarns compared to the Kiruna district IOA deposits. Overprint of sulfide mineralisation on magnetite results in an increase in Ni content which may be an effective tracer for IOCG mineralisation related to IOA deposits, or sulfide mineralisation in skarns, whilst metamorphism may homogenise and reduce trace element concentrations.
Characterizing the structure and composition of clay minerals on the surface of Mars is important for reconstructing past aqueous processes and environments. Data from the CheMin X-ray diffraction (XRD) instrument on the Mars Science Laboratory Curiosity rover demonstrate a ubiquitous presence of collapsed smectite (basal spacing of 10 Å) in ~3.6-billion-year-old lacustrine mudstone in Gale crater, except for expanded smectite (basal spacing of 13.5 Å) at the base of the stratigraphic section in a location called Yellowknife Bay. Hypotheses to explain expanded smectite include partial chloritization by Mg(OH)2 or solvation-shell H2O molecules associated with interlayer Mg2+. The objective of this work is to test these hypotheses by measuring partially chloritized and Mg-saturated smectite using laboratory instruments that are analogous to those on Mars rovers and orbiters. This work presents Mars-analog XRD, evolved gas analysis (EGA), and visible/shortwave-infrared (VSWIR) data from three smectite standards that were Mg-saturated and partially and fully chloritized with Mg(OH)2. Laboratory data are compared with XRD and EGA data collected from Yellowknife Bay by the Curiosity rover to examine whether the expanded smectite can be explained by partial chloritization and what this implies about the diagenetic history of Gale crater. Spectral signatures of partial chloritization by hydroxy-Mg are investigated that may allow the identification of partially chloritized smectite in Martian VSWIR reflectance spectra collected from orbit or in situ by the SuperCam instrument suite on the Mars 2020 Perseverance rover. Laboratory XRD and EGA data of partially chloritized saponite are consistent with data collected from Curiosity. The presence of partially chloritized (with Mg(OH)2) saponite in Gale crater suggests brief interactions between diagenetic alkaline Mg2+-bearing fluids and some of the mudstone exposed at Yellowknife Bay, but not in other parts of the stratigraphic section. The location of Yellowknife Bay at the base of the stratigraphic section may explain the presence of alkaline Mg2+-bearing fluids here but not in other areas of Gale crater investigated by Curiosity. Early diagenetic fluids may have had a sufficiently long residence time in a closed system to equilibrate with basaltic minerals, creating an elevated pH, whereas diagenetic environments higher in the section may have been in an open system, therefore preventing fluid pH from becoming alkaline.
With China’s economy transitioning into a post-industrial phase focused on knowledge and technology, there has been a notable shift in the patterns of Chinese Outward foreign direct investment (OFDI). This change has led to the emergence of new research perspectives, underscoring the importance of organizing them systematically. To address this, our research presents a thorough analysis of eighty-eight publications examining Chinese OFDI in natural resource-rich (NRR) and technology-intensive (TI) locations across various global regions and countries. Based on the geographical scope and comprehensive coverage of studies published between 1998 and 2023, we summarize the major themes, theories, and methodologies used in this research area. Identifying three elements related to Chinese investment (antecedents and motives, operational strategies, and investment outcomes), we develop a matrix based on the discussion of Chinese firms’ investment behavior in the foreign environment in which they operate. We describe the theoretical distinctions between investments in NRR global regions, such as Africa and Central Asia, and TI regions, such as Europe and North America, with regard to technology acquisition, creation, co-creation, and transfer. We identify several research sub-themes (e.g., control and learning mechanisms, technology transfer, intellectual property, etc.) that remain under-investigated and suggest future research opportunities.
Over the twentieth century, the Vienna Philharmonic—Austria’s flagship musical institution—became a leading player in global musical life through intercontinental touring, the distribution of recordings, and the establishment of “Austrianness” as a global brand. By framing the mobility of musicians as “world practices,” this article investigates the driving forces behind an Austrian ensemble going global. It understands the Philharmonic’s relation to the music world as an entangled history of globalizing tour destinations, cultural diplomacy, non-European audiences, the agents and interests in the music market, and musical branding. The attitudes that become visible in relation to the musicians’ global mobility and their reluctance to admit non-European players bear witness to the disruptive dimensions of world practices. In conclusion, this article proposes the Philharmonic’s entanglements with Europe, the Americas, East Asia, and the Middle East as an entry point for writing a global history of twentieth-century Austrian culture.