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Climate change stands as the paramount challenge confronting humanity in the contemporary era. Attempting to address the problem, the main sectors responsible for it have been subject to domestic or international policies and laws aimed at reducing greenhouse gas (GHG) emissions, except one: livestock. Given that animal-sourced food production contributes a large portion of GHG emissions, this Article aims to analyze the impacts that the exclusion of the livestock sector, in efforts to tackle climate change, would have on compliance with international treaties on the subject, especially the Paris Agreement. One conclusion reveals that state parties, by ignoring the sector, will violate several articles of the Agreement, which will likely lead to the failure of its main purpose of holding the increase in the global average temperature to well below 2°C.
Folate and vitamin B12 (cobalamin) are essential for growth and development. This cross-sectional study aims to describe folate and vitamin B12 status according to infant age and breastfeeding practices in Norwegian infants. Infants aged 0–12 months (n = 125) were recruited through public health clinics. We registered breastfeeding status and measured serum concentrations of folate, cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA). The associations between infant age, breastfeeding, and biomarker concentrations were estimated in regression models. The mean (SD) age was 24 (16) weeks, and 42% were exclusively breastfed, 38% were partially breastfed, and 21% were weaned. Overall, median (IQR) folate, cobalamin, tHcy, and MMA concentrations were 47 (35–66) nmol/L, 250 (178–368) pmol/L, 6.99 (5.69–9.27) µmol/L, and 0.35 (0.24–0.83) µmol/L, respectively. None of the infants were folate deficient, 15% were vitamin B12 deficient (< 148 pmol/L), and 23% had low vitamin B12 status (148–221 pmol/L). Elevated tHcy (> 6.5 μmol/L) and MMA (> 0.26 μmol/L) were found in 62% and 69% of the infants, respectively. Compared to weaned, exclusively or partially breastfed infants were younger and had 46% higher tHcy concentrations (P < 0.001), in addition to 47% and 39% lower cobalamin concentrations (P < 0.001), respectively. However, the observed biomarker concentrations appeared to be independent of infant age. In conclusion, low vitamin B12 status was prevalent and appeared to be more common in the younger exclusively breastfed compared to older weaned infants. The implications of low vitamin B12 status in infancy are unknown and require further investigation.
Autoimmune encephalidities (AIE) are becoming an increasingly recognized cause of encephalitis. While diagnosis and acute management are well described, information on long-term management and outcomes is limited. Given this, we reviewed 5 years of AIE patients, reporting on chronic management, relapse incidence and possible relapse predictors.
Methods:
We performed a chart review of all patients with non-paraneoplastic AIE presenting to Calgary Neuro-Immunology Clinic and Tom Baker Cancer Centre between 2015 and 2020. Severity of relapse was determined using the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Variables were assessed with descriptive analysis and/or t-test.
Results:
Patients were followed for a mean of 38.2 months. Outcome data were assessable in 37/38 patients. Relapse rate ranged from 0% (GFAP) to 67% (NMDA), with a mean of 46%. Most relapses (76%) occurred within 3 years. Time to treatment initiation at relapse was significantly shorter than initial presentation (p = 0.0015), and patients had less severe relapses compared to initial presentation (CASE score 5.18 vs 6.53; p = 0.040).
Use of chronic immunotherapy did not appear to impact overall relapse risk, although patients on any immunotherapy at relapse had milder relapses based on ΔCASE (p = 0.0035).
Conclusion:
Relapse was not uncommon (46%) for various AIE subtypes in our cohort, particularly within the first 3 years. Our data enforce the importance of long-term follow-up, which in our study allowed for earlier treatment and less severe relapses compared to initial presentation, as well as the need to further explore which patients would benefit from chronic immunotherapy.
Acoustic resonance is an important factor that contributes to aeroengine compressor failure. In this study, a plane cascade of compressor blades was designed to reproduce acoustic resonance via a low-speed wind tunnel test. A high-frequency hot-wire, microphone and strain gauge were used to synchronously measure the fluid, acoustic and structural parameters. We analysed the variation in the amplitude and frequency of the multi-field parameters with increasing mean flow velocity and explored the multi-field interaction mechanism that induces the acoustic resonance of the plane cascade. The plane cascade effectively reproduced the acoustic resonance phenomenon. The first-order acoustic-mode frequency of the plane cascade flow duct, second-order torsional vibration mode frequency of the blade and shedding mode frequency of the tip clearance leakage vortex were equal under acoustic resonance. The fluid, acoustic and structural fields showed a strong interaction effect, achieving the maximum blade vibration amplitude and causing fatigue cracks of torsional vibration at the blade root. The frequency lock-in region of the compressor plane cascade was divided into an ‘acoustic–structure’ interaction region, a ‘fluid–acoustic–structure’ interaction region and a first-order acoustic-mode dominant region with increasing mean flow velocity, which demonstrates an interesting phenomenon in which the fluid–acoustic–structure modes compete: acoustic mode > blade vibration mode > vortex shedding mode. The results demonstrate a unique approach to the study of acoustic resonance that provides insight into the acoustic resonance mechanism in a cascade of compressor blades.
In the past, Vietnam was impacted by numerous epidemics, particularly during the Nguyễn Dynasty from 1802 to 1883. Based on data from the Đại Nam Thực Lục (1961) (The Veritable Records of the Great South), this article investigates the frequency and nature of these epidemics, identifies the types of common diseases at that time, and explores the underlying causes of these outbreaks. The study further examines the Nguyễn Dynasty's strategies for managing these health crises. During these outbreaks, the dynasty faced significant challenges, with frequent epidemics leading to high death rates, widespread social disruption, and economic decline. The dynasty's primary preventive measures, heavily reliant on spiritual practices like prayer, highlight the limited medical understanding at the time and the constraints of its socio-political framework. However, there was a progressive shift towards the incorporation of Western medical innovations, particularly in the vaccine approach to treat diseases like smallpox. This transition not only marked a critical evolution in the local healthcare approach but also set the stage for more systematic medical advancements in Vietnam during the colonial period (1884–1945).
It is well documented that Andean bears (Tremarctos ornatus) feed extensively on plants and carrion, but their hunting habits remain understudied. Better understanding and documentation of Andean bear feeding ecology can improve conservation efforts for this vulnerable species. Here, we report an observation of an Andean bear hunting and capturing a wild guinea pig (Cavia aperea) in Chingaza National Natural Park, in Cundinamarca, Colombia. The sighting occurred in January 2023 by a team of conservationists, and we provided photographic evidence and details of the encounter. Our observation suggests that Andean bears are capable hunters of small rodents, indicating that hunting may play a more important role in the ecology of Andean bears than previously appreciated and highlighting the need for a better understanding of this feeding behaviour.
Childhood adversities have been linked to psychosocial outcomes, but it remains uncertain whether subtypes of adversity exert different effects on outcomes. Research is also needed to explore the dynamic interplay between adversity and psychosocial outcomes from childhood to mid-adolescence. This study aimed to investigate these relationships and their role in shaping adolescent wellbeing. Data were extracted from three timepoints of the UK Household Longitudinal Survey when participants (n = 646) were aged 10–15. Cross-lagged panel models were used to explore the relationship between cumulative adversities, and separately non-household (i.e., bullying victimization and adverse neighborhood) and household (i.e., sibling victimization, quarrelsome relationship with parents, financial struggles, and maternal psychological distress) adversities, and psychosocial outcomes (i.e., internalizing and externalizing problems, delinquency, and life satisfaction). Our results revealed that heightened cumulative adversity predicted psychosocial outcomes from childhood to mid-adolescence. Increased levels of household adversity predicted psychosocial outcomes throughout early to mid-adolescence, while non-household adversity only predicted psychosocial outcomes in early adolescence. Furthermore, worse psychosocial outcomes predicted higher levels of adversities during adolescence, highlighting bidirectionality between adversity and psychosocial outcomes. These findings underscore the varying impacts of adversity subtypes and the mutually reinforcing effects of adversities and psychosocial functioning from childhood to mid-adolescence.
Metabolic and bariatric surgery (MBS) is safe and efficacious for adolescents with severe obesity. Pairing MBS with behavioral lifestyle interventions may be effective for optimizing treatment outcomes. However, no standardized program exists. Adolescent perspectives are critical to understanding how to design interventions to enhance engagement, sustain motivation, and meet informational needs for pre- and post-MBS self-management behaviors. The aim of this study was to develop an MBS lifestyle support intervention built on evidence-based content with input from adolescents and their families.
Methods:
A mixed-methods design identified adolescent preferences for MBS lifestyle support. Data were collected from a racially and ethnically diverse sample of adolescents (N = 17, 76% females, 24% males 41.2% non-Hispanic Black, 41.2% Hispanic/Latino, 11.8% non-Hispanic White, 5.8% Other) and their mothers (N = 13, 38.4% Hispanic) recruited from an MBS clinic. Quantitative surveys and qualitative interviews assessed preferred types of pre-post MBS content, modality, frequency, and delivery platforms to inform the design of the intervention. Mixed methods data were triangulated to provide a comprehensive understanding of adolescent/parent preferences.
Results:
Adolescents prioritized eating well, managing stress, and maintaining motivation as desired support strategies. Parents identified parental support groups and nutrition guidance as priorities. Peer support and social media platforms were identified as key approaches for boosting motivation and engagement.
Conclusions:
The patient voice is an important first step in understanding how, and whether behavioral lifestyle programs combined with MBS for weight management can be optimized. Adolescent preferences may enhance program fit and identify health behavior supports needed to sustain behavior change.
We review and elaborate an account of consonantal strength that is founded on the model of speech as a modulated carrier signal. The stronger the consonant, the greater the modulation. Unlike approaches based on sonority or articulatory aperture, the account offers a uniform definition of the phonetic effect lenition has on consonants: All types of lenition (such as debuccalisation, spirantisation and vocalisation) reduce the extent to which a consonant modulates the carrier. To demonstrate the quantifiability of this account, we present an analysis of Ibibio, in which we investigate the effects of lenition on the amplitude, periodicity and temporal properties of consonants. We propose a method for integrating these different acoustic dimensions within an overall measure of modulation size. Not only does the modulated-carrier account cover all the classically recognised lenition types, but it also encompasses loss of plosive release in final stops – which, although not traditionally classed as lenition, is clearly related to processes that are.
A dearth of published archaeobotanical data from the Late Bronze Age of western Anatolia limits our understanding of agricultural production in this key area. Recent excavations at Çine-Tepecik provide insights into farming and the political economy in the kingdom of Mira within the lands of Arzawa. Archaeobotanical assemblages indicate that farming was structured to meet both domestic and institutional consumption; the former utilising a wide range of crop species while the latter focused on cereals. Plant remains provide further evidence for a ‘hybrid’ suite of farming practices across western Anatolia and contribute to debate around the spread of broomcorn millet cultivation.
This study provides data on the prevalence of mental health problems among adolescents in Ireland in 2021, toward the end of the COVID-19 pandemic. The importance of having recent, large-scale, mental health data for adolescents has been heightened by COVID-19, the increased demand for child and adolescent mental health services, and the rapidly changing adolescent environment.
Methods:
As part of the Planet Youth study, a cross-sectional survey of adolescents (N = 4,404), mostly aged 15–16, was conducted between September and December 2021. Participants were recruited from 40 schools and non-traditional educational centres across 3 regions in Ireland, one predominantly urban (North Dublin) and two predominantly rural (Cavan, Monaghan). A range of mental health outcomes were self-reported: a single-item question on mental health; the Strengths & Difficulties Questionnaire (SDQ); depressive and anxiety symptoms from the Symptom Check List 90; the Adolescent Psychotic-like Symptom Screener; and lifetime self-harm, suicidal ideation, and attempt.
Results:
Over a quarter of adolescents described their mental health as ‘bad’ or ‘very bad’ (29%), and had SDQ total problem scores over 20 (26%). Over a third (39%) reported self-harming, 42% reported suicidal ideation, and 11% reported attempting suicide, in their lifetime. Gender-diverse youth (non-binary, trans, and undisclosed) had higher rates of poor mental health outcomes compared to cis-gendered youth (male/female), and females had higher rates of most mental health outcomes compared to males.
Conclusions:
Many of these estimates suggest a deterioration from previous epidemiological studies. While our findings do not definitively prove youth mental health has worsened over time, these findings are highly concerning. We propose a close monitoring of mental health in future surveys of this population and encourage initiatives to improve the capacity and quality of youth mental health services.
High dose rate (HDR) intracavitary brachytherapy (ICBT) plays a crucial role in cervix cancer treatment, with variations in fractionation schedules across different radiation societies. This study aims to assess the effectiveness and tolerability of a 7 Gy per fraction twice daily schedule over two successive weeks versus an 8 Gy per fraction once weekly schedule over three successive weeks.
Patients and Methods:
From 2020 to 2022, 87 patients with uterine cervix cancer (Stages II and III) underwent concomitant external beam radiotherapy (EBRT) and chemotherapy, followed by HDR-ICBT. Patients were randomised into two arms: Arm A (8 Gy per fraction once weekly for 3 fractions) and Arm B (7 Gy per fraction twice daily once a week for 4 fractions). Local control is defined as any patient free from local progression (CR + PR + SD) in the first year after ending brachytherapy (BTH).
Results:
The median follow-up was 16·5 months. Local control at 1 year was 78·7% in Arm A and 89·2% in Arm B (p = 0·24). No clinically significant differences in rectal and bladder toxicities were observed between the two arms (p = 0·40).
Conclusion:
There were limited treatment machines and other BTH challenges in Egypt, and the HDR BTH schedule of 7 Gy per fraction twice daily over 2 successive weeks presents an acceptable alternative to the current national standard of 8 Gy per fraction once weekly over 3 weeks. Both schedules demonstrate comparable local control, late toxicity and progression-free survival. Notably, the 7 Gy per fraction twice daily per week for 4 fractions offers the advantage of a reduced total treatment time.
In 1912, the Italian parliament approved the extension of male suffrage, making it ‘almost’ universal. This process of revising representation transformed the very idea of the relationship between citizens and the state and shaped a profoundly different Italy. The aim of this article is to trace both the process leading to the approval of universal suffrage and its impact on the party system. With a compilation and analysis of data developed from scratch for the elections of 1909 and 1913, it was possible to analyse the main dimensions of the two rounds in a disaggregated manner. Three aspects make 1913 a year of transition. First, the degree of competition in the electoral process, especially in the South, increased considerably. Second, the decline of liberal formations was not transformed into defeat, thanks only to the Catholic vote. Third, the birth of the Popular Party and the failure to create a mass party of conservatives were causes of the imbalance in the party structure.
We aimed to compare and link the total scores of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), two common global cognitive screeners.
Methods:
2,325 memory clinic patients (63.2 ± 8.6 years; 43% female) with a variety of diagnoses, including subjective cognitive decline, mild cognitive impairment, and dementia due to various etiologies completed the MMSE and MoCA concurrently. We described both screeners, including at the item level. Then, using linear regressions, we investigated how age, sex, education, and diagnosis affected total scores on both instruments. Next, in linear mixed models, we treated the two screeners as repeated measures and analyzed the influence of these characteristics on the relationship between the instruments’ total scores. Finally, we linked total scores using equipercentile equating, accounting for relevant patient characteristics.
Results:
MMSE scores (mean ± standard deviation: 25.0 ± 4.6) were higher than MoCA scores (21.2 ± 5.4), and MMSE items generally showed less variation than MoCA items. Both instruments’ scores were individually influenced by age, sex, education, and diagnosis. The relationship between the screeners was moderated by age (estimate = −0.01, 95% confidence interval = [−0.03, −0.00]), education (0.14 [0.10, 0.18]), and diagnosis. These were accounted for when producing crosswalk tables based on equipercentile equating.
Conclusions:
Accounting for the influence of patient characteristics, we created crosswalk tables to convert MMSE scores to MoCA scores, and vice versa. These tables may facilitate collaboration between clinicians and researchers and could allow larger, pooled analyses of global cognitive functioning in older adults.
Declining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
This study explores the economics of culling decisions in cow-calf operations in the Southern U.S. with a novel application of a dynamic mathematical programing model. The results provide an optimal culling strategy under the base model and a range of optimal strategies that vary with respect to different components such as fertility probabilities, prices, replacement costs, and pregnancy checking. The results suggest that producers should cull all cows that are older than age 10 and cows that fail to calve once they reach the age of 7. The sensitivity analysis underlines the impact of market conditions, replacement costs, and pregnancy check use on the optimal culling decisions.
Studies have found that women’s representation is more likely to spike after corruption scandals. However, the mechanism underlying this increase remains unclear: are parties more likely to nominate women after corruption scandals, are voters more likely to support women candidates, or is it a combination of both? Using an original dataset of audit results and the gender of 47,000 candidates running in over 10,000 mayoral elections in Mexico (2000–2019), we find that voters drive the effect. While political parties are not more likely to nominate women as candidates in municipalities with recent revelations of spending irregularities, women candidates are more likely to win elections after corruption is uncovered. In contrast to previous studies, which expect strategic parties to be behind the increases in women’s representation following corruption scandals, our findings underscore that increases in women’s representation can happen despite parties and not because of parties.
During stroke reversals, insect wings interact with their own wake flow from the preceding half-stroke, resulting in an unsteady aerodynamic mechanism known as ‘wing–wake interaction’ or ‘wake capture’. To better elucidate this mechanism, we numerically solved the incompressible Navier–Stokes equations at Reynolds numbers $10^2$ and $10^3$. Simulations were conducted for wing planforms defined using the beta function distribution with varying aspect ratios ($AR=2\unicode{x2013}6$) and radial centroid locations ($\hat {r}_1=0.4\unicode{x2013}0.6$), whilst employing representative normal hovering kinematics. The wake development from the considered flapping wing planforms was investigated, and the wake capture contribution to aerodynamic force production was quantified by comparing the force generation between the fifth and first stroke cycles at multiple sections along the wingspan. Our results revealed that on the inboard wing region experiencing an attached leading-edge vortex (LEV) structure, wing–wake interaction is dominated by an unsteady downwash effect, resulting in a reduction in local force production. However, in regions closer to the wingtip experiencing detachment of the LEV, wing–wake interaction is dominated by an unsteady upwash effect, leading to an increase in local force production. Consequently, the global wake capture force production is controlled by the extent of LEV detachment, which primarily increases with the increase of wing aspect ratio. This suggests that for normal hovering flapping wings, the typical loss in translational force production due to wingtip stall is partially mitigated by wake capture effects.
During national emergencies, democratically elected leaders have sought to expand executive power in ways that violate democratic norms, ostensibly to guide their nation through crisis. Drawing from research on democratic backsliding, we anticipate support for such executive privileges may stem from different ideological and contextual factors, but primarily from inclinations toward ethno-nationalistic and authoritarian populism. We propose American Christian nationalism represent such inclinations. Analyses of nationally representative data reveal Christian nationalism is the strongest predictor Americans believe unspecified “national emergencies” might require leaders to suspend elections, suppress political opponents, and disregard checks and balances. However, political disinterest, stronger Democratic partisanship, and being Black (vs. White) are also positively associated with support for violating democratic norms, and these associations are amplified by Christian nationalism. Ancillary analyses suggest the interactions with race and party may be contextual, due to a Democratic President in office at the time of the survey. Findings suggest populist impulses characteristic of Christian nationalism may combine with political disinterest (perhaps reflecting disillusionment) and threats to in-group power to increase support for leaders suspending democratic norms during national crises.
Mine closure can be approached by several points of view, from the technical, engineering, ecological, up to social and governance aspects. The definition of a good mine closure should cover most, if not all, of these aspects. This article provides a review of technical and engineering-oriented research work as a partial answer to the question ‘what is good mine closure’. The article presents a ten-year research program realized in the framework of a Canada Research Chair in integration of environment in the mine life cycle. Research projects aimed at better planning mine closure and mine site reclamation from the early stages of a mining project life cycle are exposed as possible steps to strive for optimal mine waste management. At the exploration stage, geo-environmental characterization and modeling are proposed as tools to improve mine waste management planification. During mine operations, environmental desulfurization is suggested as a method to reduce environmental risks associated with sulfidic tailings and waste rock. Indeed, research has shown that acid mine drainage and metal leaching can be significantly limited via desulfurization. At the closure stage, desulfurized tailings can be used to replace at least part of natural materials used for reclamation cover systems. Research work done on other types of mine waste, such as waste rock and water treatment sludge, also show good potential for their reuse as closure material. All these tools can be integrated into the mine life cycle to better plan for closure, which ultimately will make mine closure more sustainable.