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We generalize Hopf’s theorem to thermostats: the total thermostat curvature of a thermostat without conjugate points is non-positive and vanishes only if the thermostat curvature is identically zero. We further show that, if the thermostat curvature is zero, then the flow has no conjugate points and the Green bundles collapse almost everywhere. Given a thermostat without conjugate points, we prove that the Green bundles are transverse everywhere if and only if it is projectively Anosov. Finally, we provide an example showing that Hopf’s rigidity theorem on the $2$-torus cannot be extended to thermostats. It is also the first example of a projectively Anosov thermostat which is not Anosov.
Waste management is one of the major environmental challenges of the twenty-first century. This Perspective examines how vegetation dynamics at composting facilities and landfills both reflect and influence anthropogenic environmental change. We define our use of the Anthropocene as a human-dominated epoch that is functionally and stratigraphically distinct from the Holocene, and we argue that waste-derived ecosystems constitute model systems for detecting its signals through technogenic substrates and synanthropic succession. Although composting reduces pressure on landfills, incomplete processing of biowaste can disseminate propagules of invasive plant species. Landfills, shaped by disturbance and altered edaphic regimes, support synanthropic plant assemblages dominated by neophytes that act as bioindicators of leachate stress and other pressures. At the same time, spontaneous vegetation provides functional benefits, including slope stabilization, organic matter accumulation and habitat provision during early successional stages. We bring together information on risks and functions, link ecological criteria to permitting, monitoring and post-closure management pathways, and outline practical considerations for integrating plant-based indicators with geochemical screening. These steps enable ecologically sensitive strategies to be implemented that mitigate biodiversity risks while leveraging succession to improve the resilience of waste-derived landscapes.
Despite years of efforts to combat disinformation, we remain far from a satisfactory set of solutions. The rise of generative AI, which enables the creation of highly credible fake content at scale, suggests that the problem is likely to grow even more severe. Lessons from the recent pandemic also call for a reconsideration of how disinformation should be addressed. This paper proposes a new approach that focuses not only on regulating everyone who spreads false information, but also on those who hold epistemic power – individuals with the capacity to shape what others know or believe. Such a strategy has the potential to move the debate forward, as it avoids the most common objection to disinformation regulation: the fear of widespread censorship. The paper argues that an individual’s epistemic position can justifiably differentiate their legal duties, and that those who possess epistemic power should bear corresponding legal – specifically, criminal – responsibility for the abuse of that power in spreading disinformation.
Cognitive symptoms are common in functional neurological disorder (FND), yet evidence of impaired neurocognitive test performance is variable. We aimed to assess self-reported cognitive symptoms, neurocognitive test performance, and metacognitive confidence in patients with functional seizures (FS) and functional motor symptoms (FMS).
Methods
Participants with FS (n = 50) and FMS (n = 50) were compared to age- and gender-matched healthy controls (HC, n = 50), and clinical controls with depression and/or anxiety disorders (CC, n = 50). The Cambridge Neuropsychological Test Automated Battery was used to examine response speed, working memory, executive functions, and social–emotional processing, with subjective confidence rated for each test. Intellectual functioning, performance validity, and self-reported cognitive symptoms were also assessed.
Results
The FND groups reported elevated cognitive symptoms compared to HC and CC (p-values<0.001). Impaired performance was demonstrated in both FND groups on tests of sustained attention (p-values = 0.03- < 0.001) and set-shifting (p-values = 0.01–0.001). Performance validity was comparable between groups (p = 0.64). The FND groups reported reduced post-diction confidence for sustained attention (p < 0.001). Executive performance deficits correlated with reduced test-specific confidence in FS/FMS (p-values = 0.02- < 0.001). In FMS, post-diction confidence for sustained attention performance correlated negatively with cognitive symptoms (p = 0.002). Cognitive symptoms were associated with psychological/physical symptom load, quality-of-life, and/or general functioning in FND and CC groups (p-values = 0.04- < 0.001).
Conclusions
Patients with FS and FMS displayed localized deficits on tests of executive functioning, with reduced domain-specific metacognitive confidence, alongside significant cognitive symptoms. These neurocognitive features were associated with poorer clinical status, warranting interventions targeting cognitive control and/or cognitive symptoms in everyday life.
In 1940, Serge Koussevitzky officially founded the Berkshire Music Center (later known as Tanglewood) and appointed Aaron Copland as head of the faculty. Copland actively participated in the US cultural diplomatic initiative of the Good Neighbor Policy by setting up the conditions for modern Latin American composers to attend the Center. By examining the contribution of modern Latin American art music, especially at Tanglewood, this article reflects on the relationship between music and politics, and shows that musical modernism encompasses a much broader artistic spectrum than previously thought.
This article discusses the grammatical role played by the interpretation of an action as either intentional or accidental. It focuses on two grammatical restrictions that exhibit sensitivity to such interpretation. The first concerns so-called subject obviation, whereby, in many European languages, the subject of the subjunctive clause cannot refer to the same individual as the subject of the matrix clause. For the purpose of this article, an important property of subject obviation is that it is weakened in the case of accidental actions. The second restriction pertains to an aspectual restriction in negative imperatives and desire statements in Slavic, which disallows the perfective aspect in these constructions. As is the case with subject obviation, the aspectual restriction in Slavic is lifted when the action is interpreted as accidental. This article argues for a unified semantic-pragmatic account of the weakening of subject obviation and aspectual restriction. It also shows that this weakening of obviation and of aspectual restriction is part of a larger picture where the interpretation of an action as intentional versus accidental plays a central role.
The political participation of Black women has important consequences for electoral outcomes in the US, yet little is known about whether and how affect (both negative and positive) influences this group’s engagement in American politics. Despite the prevalent stereotype that Black women are “angry,” scholarly exploration of the effects of the emotions of these women is rare. In this paper, we highlight a gap in theories that center on Black women and argue that survey question wording about affect may impact how Black women express positive or negative emotions in relation to their political behavior. Using 2016 and 2020 CMPS data, we find support for our expectations. This project highlights the importance of group-specific, intersectional theories and the potential limitations to our understanding of how affect influences political participation.
The propagation of high-energy X-rays or hot electrons have the potential to alter the initial conditions in experimental target designs, especially at material interfaces, for laser-driven inertial confinement fusion (ICF) and high-energy density (HED) experimental platforms. Hot-electron preheat can drastically modify the initial conditions of experimental targets used to study the deceleration-stage Rayleigh–Taylor instability (RTI) both with and without applied magnetic fields. Therefore, it is necessary to understand and quantify the impact of hot-electron preheat. The hydrodynamic (HD) capabilities in the Ares code are used to study the effects varying levels of preheat can have on RTI evolution. The experimental and computational studies presented in this work demonstrate that at high laser intensities of around or greater than $10^{15} \,\textrm {W}\, \textrm {cm}^{-2}$, there is hot-electron generation from laser plasma instabilities which induces substantial preheat and impacts the morphology of RTI evolution and even inhibits the intended RTI growth such that it is not observable experimentally. The necessity of better quantifying hot-electron induced preheat and mitigating its impact on such high-intensity direct-drive laser experiments in the future is discussed.
Schizophrenia (SZ) is a debilitating psychiatric disorder where patients experience cognitive decline. Antipsychotic drugs alleviate positive symptoms but do not improve cognitive performance. We previously demonstrated that Toll-like receptors (TLRs), involved in cytokine production, can predict cognitive deficits in SZ patients. In this study, we aim to investigate the potential moderating effects of antipsychotic drugs on the associations between cytokines, TLRs, and cognition.
Methods
In total, 280 participants (201 controls and 79 cases of SZ) were recruited in Ireland. Venous blood from the participants was stimulated with TLR ligands. Levels of cytokines were measured from plasma and post-blood stimulation. The participants were administered a battery of cognitive tasks using the Cambridge Neuropsychological Test Automated Battery and Wechsler Adult Intelligence Scale-IIIR. Olanzapine equivalents were calculated using the defined daily dose method.
Results
The results indicate that antipsychotic drug dose does not predict TLR activity or cognition, indicating that antipsychotic drug dose does not have a direct effect on cognition or TLR activity. However, the relationship between TLR4 activity and visual learning and memory is moderated by the antipsychotic drug dose (B = −0.065; p < 0.001), where increasing doses have a decreasing impact on their relationship.
Conclusions
Our data indicate that the dose of antipsychotic drugs alone cannot predict changes in cognitive performance and TLR4-activity. It also suggests that antipsychotic drug doses significantly affect TLR activity and its relationship with cognition. These effects are more pronounced on some domains than others. These findings open up new avenues for understanding the complex interplay between antipsychotic drugs, TLRs, and cognitive deficits in SZ.
Given historical and contemporary hegemonic discourse that portrays the UnitedStates as a monolingual nation, a critical perspective is needed to counter thissocietal erasure of bi/multilingualism. The present study reports on anintroductory linguistics course about bilingualism in the US that adoptedcritical language awareness as its pedagogical framework. Results from anend-of-semester survey show that students from diverse linguistic backgrounds(monolingual English, heritage language, L2 world language, and L2 Englishspeakers) demonstrated critical awareness about language, albeit with somedifferences that were mediated by their linguistic backgrounds. Implications forlinguistics and world language programs, as well as adaptations for futureiterations of the course, are also discussed.
Identifying confidence in recovering balance following destabilizing events is essential for helping older adults prevent falls. However, existing measures primarily assess balance confidence. The Balance Recovery Confidence (BRC) scale was developed to address this gap, but its length may limit clinical feasibility. This study aimed to develop and validate a Short-Form Balance Recovery Confidence (SF-BRC) scale that retains the psychometric integrity of the original version while improving practicality.
Methods:
A cross-sectional dataset comprising 309 older adults (≥ 65 years) was analyzed. Exploratory factor analysis using unweighted least squares extraction on polychoric correlations was conducted to determine the underlying factor structure. Confirmatory factor analysis using the weighted least squares mean and variance adjusted (WLSMV) estimator evaluated model fit. Rasch modeling assessed item fit, item difficulty, and person separation reliability. Criterion and convergent validity were examined through correlations with the original BRC, Activities-specific Balance Confidence (ABC), and Falls Efficacy Scale–International (FES-I) scales.
Results:
The final 7-item SF-BRC demonstrated a unidimensional structure with excellent model fit (CFI = 0.99, TLI = 0.99, RMSEA = 0.06, SRMR = 0.02). Internal consistency was high (α = 0.94), and Rasch person separation reliability was 0.93. Criterion validity with the full BRC was strong (r = 0.99), while convergent validity with ABC and FES-I scales was moderate, supporting theoretical distinctiveness of the construct.
Conclusions:
The SF-BRC is a psychometrically robust instrument for assessing BRC. Its strong reliability and practical utility support its use in rehabilitation, fall prevention, and community-based settings.
Post-traumatic stress disorder (PTSD) may shorten life expectancy, but evidence for Asian populations and cause-specific mortality remains limited. The aim of this study is to investigate the association between PTSD and mortality risk in an Asian population.
Methods
We used Taiwan’s National Health Insurance Research Database (2000–2022) to assemble a cohort of 28,777 individuals with incident PTSD and 115,108 age- and sex-matched unexposed individuals, plus a sibling cohort of 13,305 affected patients and 22,030 unaffected siblings. Cox models estimated adjusted hazard ratios (AHRs) for all-cause, unnatural-cause (suicide and accidents) and natural-cause mortality, with progressive adjustment for sociodemographic factors, comorbidity and familial confounding. Subgroup analyses addressed five psychiatric comorbidities, sex and age (youth, adulthood and older adults).
Results
Over a mean follow-up of 8 years, PTSD was associated with excess all-cause mortality (AHR = 1.32, 95% CI 1.24–1.41) driven by markedly increased unnatural deaths (AHR = 5.93, 5.13–6.85), especially suicide (AHR = 10.36, 8.41–12.76) and accidental deaths (AHR = 2.18, 1.67–2.86). Natural-cause mortality showed no consistent increase (AHR = 0.91, 0.85–0.98). In sibling analyses, excess risks persisted for all-cause (AHR = 2.48, 2.04–3.01), unnatural deaths (AHR = 4.76, 3.58–6.34) and suicide mortality (AHR = 7.90, 5.21–11.97), but not for accidents or natural causes. The risk patterns were similar across different psychiatric comorbidity strata and genders; suicide and unnatural-cause excess remained evident in all age groups.
Conclusions
PTSD was associated with elevated premature death risk in Taiwan, primarily through suicide and unnatural causes. Integrating targeted suicide-prevention into PTSD care pathways may be essential to reducing this avoidable mortality burden.
Outpatient parenteral antimicrobial therapy (OPAT) reduces hospitalization, yet poor standardization and implementation contribute to readmission rates near 25%. The Infectious Diseases Society of America recommends structured and multidisciplinary OPAT programs. Twelve quality indicators, spanning organization, initiation, continuation, and outcome domains, have been proposed to improve OPAT delivery. Our scoping review assessed associations between reported OPAT quality indicators and patient readmission.
Methods:
We searched PubMed, Embase, Cochrane CENTRAL, Web of Science, and Google Scholar from database inception through May 1, 2025, for studies of adults discharged on OPAT, managed by multidisciplinary teams, and reporting readmission rates. Data included presence of each quality indicator, team composition, and readmission rates. Readmission was categorized as low (<10%) or high (≥10%).
Results:
Of 2,610 studies screened, 18 (5,027 patients) met criteria. The median readmission rate was 11.3 (IQR 8–20). All studies reported a structured OPAT program and formal OPAT team. Initial patient assessment by a competent team member was more common in studies with lower readmissions. Reporting more indicators (range 4–11) did not significantly correlate with fewer readmissions. Organization and initiation indicators were reported more frequently than continuation and outcome indicators. All programs included an infectious diseases physician; 94% included nurses, 55% pharmacists, 28% social workers, and 11% hospitalists.
Conclusions:
Higher quantity of reported indicators did not predict fewer readmissions. Future research should explore team engagement, including potential roles of hospitalists and social workers to strengthen care transitions, and the impact of continuation and outcome indicators on readmissions.
John Dewey holds that uncertainty is a central feature of the concrete interaction between organism and environment, and he mobilizes this diagnosis to explain both the emergence of inquiry and the persistence of speculative and abstract philosophies. However, we show that material reality is not uncertain and that the quest for certainty cannot explain the flight from the concrete, but should explain a return to it. Drawing on historical, philosophical, and sociological sources (most notably Edgar Zilsel’s thesis and the embodied knowledge of artisans) we invert Dewey’s interpretative framework: epistemic uncertainty arises not from material reality, but from theoretical abstraction. This reinterpretation enables a reformulation of Dewey’s critique of dualism and provides the basis for a pragmatist epistemology grounded in the relative stability of practical experience. Finally, it opens the way for a reconsideration of the foundations of democracy from a non-relativistic perspective.
Adults exhibit different acoustic characteristics in infant-directed speech (IDS) compared to adult-directed speech (ADS). We investigate differences in voice quality between IDS and ADS in sentences read aloud by Hungarian mothers, using longitudinal data gathered at various child ages (4, 8, 18 months). Vowels in IDS are found to be breathier than those in ADS, regardless of the infant’s age. Possible motivations for this difference may include emotional expressions, as breathiness relates to positive emotions, and speech entrainment, since the speech of children is breathier than that of adults.
This article demonstrates how political science, particularly the emerging field of American Political Economy (APE), can more robustly theorize and study the political economy of systemic racism by drawing on insights from critical race theories, including intersectionality and racial capitalism, and post/anti-colonial theory. A paired case study of the foreclosure “noncrisis” of the 1990s and the coerced sterilization of incarcerated women in California during the early 2000s highlights three key contributions of critical race theories: (1) intersectionality reveals nonuniformity, unintended consequences of purportedly progressive policy, and underscores the importance of margins-to-center resistance; (2) feudal-colonial roots illuminate how racialized hierarchies become institutionalized in law and policy, often without explicit racial language; and (3) racial capitalist logics explain how administrative tools, such as risk assessment and cost-benefit analysis, reproduce racial hierarchy through markets. This framework offers APE a more historically grounded, power-conscious, and theoretically expansive approach to systemic racism and underscores the urgency of resisting efforts to suppress such scholarship.
The division of cognitive labor leads to what Barry has recently called epistemic alienation: a problematic separation of individuals from epistemic goods. According to Barry, individuals are alienated from epistemic virtues because an efficient division of cognitive labor requires them to manifest a lack of virtues. I argue that this is a mistaken diagnosis of the source of epistemic alienation. Participating in high-functioning collectives does not prevent individuals from being robustly virtuous; rather, our cognitive limitations make it impossible for us to live up to the highest standards of epistemic conduct. Collectives transcend these cognitive limitations to achieve what individuals cannot by harnessing those same limitations in their members. Furthermore, I argue that we should distinguish the epistemic weaknesses that facilitate the division of cognitive labor from those that result from the division of labor. Only the latter are aspects of epistemic alienation. By dividing our cognitive labor over larger populations of agents and artifacts, we have massively accelerated our rate of epistemic productivity but have thereby created conditions that are variously inhospitable for the thinking of individuals by alienating them from the products, processes, and environments of inquiry. These forms of separation are problematic insofar as they amplify intellectual vices, incapacitate reason, and induce cognitive biases.
We are self-conscious creatures thrown into a world, which is not of our making. What is the connection between being self-conscious and being related to an objective world? The Practical Self argues that self-consciousness requires faith in ourselves as the agents of our thinking and that this faith is sustained by a set of practices which relate us to a world of others.