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Half a century ago, Martin Shapiro discovered that European constitutional scholarship was stuck at a stage of ‘constitutional law without politics’, presenting the EU ‘as a juristic idea; the written constitution as a sacred text; the professional commentary as a legal truth; the case law as the inevitable working out of the … constitutional text; and the constitutional court as the disembodied voice of right reason’. Recent efforts to doctrinally construct the values in Article 2 TEU show that the mistakes identified by Shapiro persist to this day. This article examines the proposals for constructing Article 2 TEU by Armin von Bogdandy and Dimitri Spieker, and offers three criticisms: First, their doctrinal constructivism is ill-suited to constitutional reasoning. Second, their reasoning has evolved in a way that their work has become self-contradictory. Third and most importantly, especially due to the evolution of their thinking, their scholarship amounts to constitutionalism without principle. Not only does their work lack consistent principled foundations, it also neglects the principled choices underlying EU constitutional law. Moreover, as they do not maintain any critical distance to the CJEU, their work does not offer a principled basis for evaluating its case law. Finally, and most critically, the principles informing their arguments produce an increasingly undemocratic and unconstitutional view of EU law. To address these deficits, I revisit the call for a more contextualised study of European law made by its earliest proponents four decades ago, and demonstrate its continued relevance. Rather than pursuing institution building, EU constitutional scholarship should examine and critically interrogate the socio-political choices underlying the evolution of EU constitutional law.
Translating scientific discoveries in tissue engineering and regenerative medicine (TE/RM) into clinically adopted therapies is hindered by fragmented development pipelines, regulatory and manufacturing challenges, and limited funding. Despite substantial investment by the U.S. National Institutes of Health (NIH), few NIH-funded TE/RM projects achieve commercialization or regulatory approval by the US Food and Drug Administration. The gap between academic innovation and clinical implementation is particularly evident in the dental, oral, and craniofacial (DOC) domain, where market and reimbursement constraints further restrict translation. To address these barriers, the National Institute of Dental and Craniofacial Research established the Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC), comprising two nationwide Resource Centers tasked with guiding promising technologies from universities and small businesses through preclinical validation toward clinical adoption. This translational science case study outlines DOCTRC’s translational model, highlighting lessons learned from five cohorts of interdisciplinary translational project teams, strategies for navigating manufacturing and regulatory pathways, and approaches for aligning academic innovation with clinical and market needs. The unique impact of the DOCTRC framework demonstrates how disciplined product development activities, non-dilutive funding mechanisms, and a comprehensive support ecosystem can accelerate technology translation, offering a scalable model for other biomedical fields.
Sexual dimorphism, a widespread phenomenon, has been extensively researched in extant and fossil crustaceans. However, identifying sexual dimorphism in phyllocarid fossils preserved as isolated parts is often challenging, except in cases where the specimens are exceptionally well preserved, including those with soft tissues. This study proposes a novel approach by introducing the use of geometric morphometric techniques to identify sexual dimorphism in phyllocarid fossils based on carapace morphology. It presents a comprehensive re-analysis of Soomicaris ordosensis Liu et al., 2023a, carapaces from the Upper Ordovician in North China and Tarim Plates. Elliptic Fourier analysis was applied to quantify the size and shape variation in nearly 100 specimens. The results demonstrate the presence of significant sexual dimorphism in the length and shape of the S. ordosensis carapace. The carapace shape exhibited variation between the sexes: the posterodorsal margin of one group of carapaces gradually extends backward to form a posterodorsal spine; the carapaces of the other group have a convex posterior margin and lack a posterodorsal spine. Additionally, both types manifest an overall allometric growth pattern, albeit with distinct growth coefficients. Furthermore, the observed approximately 1:1 ratio between the two forms suggests that the population of S. ordosensis may have exhibited a dioecious mating system. Geometric morphometrics are a highly effective method for elucidating the subtle variations in the carapace morphology of S. ordosensis, thereby underscoring the cryptic dimorphism characteristics of fossil animals. This finding offers the first indirect evidence for egg-brooding behavior within the extinct order Archaeostraca.
This paper analyses some connectives introduced by Stephen Read, known as ‘Bullet connectives’. From the proof-theoretic semantics perspective, these connectives satisfy the requirement of harmony; however, they allow for the looping derivation of a contradiction. Namely, when the operation of detour reduction is applied to such a derivation, it leads to a non-terminating phenomenon. By appealing to Prawtiz’s notion of validity, we argue that such connectives cannot be considered as logical ones. Still, it is possible to assign a computational meaning to such connectives, as several useful computation properties are induced by their harmonious behaviour. In particular, we show that a fixed point operator can be defined by using the rules of a generalised version of the Bullet connectives. Such a generalisation is an instance of (non-terminating) recursive types. Finally, we show that type-free (i.e., untyped) lambda-calculus is interpretable in simply typed lambda-calculus extended with yet another variant of the Bullet connectives, and that the introduction rules of the Bullet connectives are interpretable by Nakano’s modality in typed lambda-calculus. We conclude that such a computational interpretation of the Bullet connectives is possible only if we separate the notion of types from that of propositions, which are meaningful and assertible linguistic entities (in fact, it is larger). Therefore, the computational interpretation we propose cannot be considered an instance of the Curry–Howard correspondence between propositions and types, and between proofs and programs.
Encouraging children’s sympathy (i.e., concern for others) across an array of social contexts is important for strengthening their prosocial responses to conflict and reducing aggression. We examined Canadian children’s (6, 9, and 12 years; N = 186; 50% girls and 50% boys) situational sympathetic responding following harm to victims, and how sympathy across contexts was linked to their aggressive behaviors (beyond dispositional sympathy). Children’s situational sympathy (sadness supported by moral reasoning) was measured in response to (un)provoked harm to hypothetical peers in vignettes. Parents reported on children’s proactive and reactive aggression. We also measured children’s dispositional sympathy via child- and parent-reports. Results showed that children felt stronger situational sympathy for victims of unprovoked harm than provoked harm, and only sympathy following unprovoked harm showed age-related increases. Above and beyond dispositional sympathy, lower situational sympathy in response to provoked harm was associated with higher reactive aggression. These findings demonstrate that children’s sympathy is dampened by a victim’s prior negative behavior – an emotional blunting effect that may have implications for their own retaliatory behavior.
The Radio Neutrino Observatory-Greenland (RNO-G, at Summit Station) experiment comprises an extensive fat-dipole antenna array deployed into ice boreholes over an eventual area of approximately 35 km2. Since the RNO-G experimental sensitivity depends on the radio-frequency properties of the firn, which are known to vary laterally on sub-km distance scales and vertically on sub-meter distance scales, a technique for quickly extracting information on firn ice properties with depth ($n(z)$) during drilling and deployment is desirable. Given that a dipole’s resonant wavelength is fixed by geometry, the resonant frequency $f_{res}$ (measured as an S-parameter reflection coefficient [‘$S_{11}$’] minimum) scales inversely with the local refractive index, allowing a translation of a depth-dependent $S_{11}$(z) profile into $n(z)$. $S_{11}$(z) data were initially taken in August 2024 using a dipole lowered into a newly drilled 98 ± 1 mm diameter, 350 m deep borehole at Summit Station, Greenland, approximately 1 km from the site of the original GISP-2 core; improved measurements were subsequently made in May 2025. We conclude that $S_{11}$(z) data can be used to estimate $n(z)$, on 50 cm vertical scales, at the per cent level of accuracy required by experiments such as RN0-G.
Psychiatric comorbidities are common in first-episode psychosis (FEP) and hinder recovery. Problem gambling (PBG), despite potentially serious clinical consequences, remains under-investigated in this population. This study aimed to estimate the incidence of PBG in FEP and identify predictive factors.
Methods
This prospective cohort study was conducted at two FEP programmes in Quebec, Canada. Individuals aged 18–35 years diagnosed with FEP between November-1-2019 and January-31-2023 were screened for PBG using the Problem Gambling Severity Index through May-1-2023. The primary outcome was incident PBG. Time-varying Cox regression models were used to estimate hazard ratios (HRs) for candidate predictors.
Results
Among 520 individuals without prior PBG (mean age = 24.6±4.0 years; 28.8% women), 18 developed PBG during a mean follow-up of 478 days, yielding an incidence rate of 2.6 cases/ 100 person-years. In site-adjusted analyses, white ethnicity (HR = 9.7; 95%CI = 1.3–74.8), incomplete high school education (HR = 2.8; 95%CI = 1.1–7.2), stimulant use disorder (HR=2.8; 95%CI = 1.0–7.3), use of D2/D3-5-HT1A partial agonists (HR = 4.6; 95%CI = 1.5–14.1), and prior non-problematic gambling (HR = 3.1; 95%CI = 1.1–8.4) predicted increased risk. Thirteen cases occurred during aripiprazole treatment, which remained associated with increased PBG risk after multivariable adjustment (adjusted HR = 4.7; 95%CI = 1.6–13.9).
Conclusions
Despite the limited number of incident cases, these results suggest that PBG is relatively common PBG and is associated with potential risk factors, including white ethnicity, incomplete high school education, stimulant use disorder, prior non-problematic gambling, and treatment with D2/D3-5-HT1A partial agonists, particularly aripiprazole. These findings underscore the importance of routine screening for PBG and risk-informed antipsychotic prescribing in FEP.
We investigate turbulent Taylor–Couette flow between two concentric cylinders, where the inner cylinder of radius $r_i$ rotates while the outer one of radius $r_o$ remains stationary. Using direct numerical simulations, we examine how varying the radius ratio $\eta = r_i / r_o$ from $\eta = 0.714$ down to $0.0244$ affects the flow characteristics at low to moderate Reynolds numbers. Our results show significant changes in the flow structures and statistics in the limit of a vanishingly small inner radius. The turbulent kinetic energy, scaled with the friction velocity at the inner cylinder, does not exhibit a self-similar scaling; instead, it decreases with decreasing $\eta$. The turbulent kinetic energy budgets reveal that the locations of peak production and total dissipation are independent of $\eta$, whereas their amplitudes decrease as $\eta$ increases. The pressure–velocity correlation near the inner cylinder is large for small $\eta$ and its amplitude decreases with increasing $\eta$, while the turbulent transport term exhibits the opposite trend. Numerical simulations for $\eta \leqslant 0.5$ show that, for our specific set-up, a rather good collapse of the distribution of the normalised torque versus the Taylor number ($ \textit{Ta}$) is obtained when the latter is defined according to Chandrasekhar (Hydrodynamic and Hydromagnetic Stability, Oxford Univ. Press, 1961), with a tendency towards a $ \textit{Ta}^{1/3}$ regime at sufficiently large $ \textit{Ta}$.
Recent scholarship has emphasized methodological innovations to mitigate preference falsification in public opinion data, yet systematic scrutiny of bias in regression analyses remains limited. Drawing on analyses of political trust in China, we offer three key insights. First, determining the direction of social desirability bias in regression estimates—whether over- or underestimation—is challenging ex ante. Second, analyses of two nationally representative Chinese surveys, one incorporating a list experiment, cast doubt on the purported positive effect of social welfare expansion on political trust. Extending beyond social welfare and the Chinese case, we find similar biases when regressions rely on direct questions. Third, we show that certain identification strategies can partially mitigate regression bias when direct questions are unavoidable.
This study investigates the long-term associations between a childhood allowance (parental pocket money) and financial literacy, monetary attitudes, and time-discounting preferences in adulthood, with a specific focus on gender differences, using survey data from Japan. Gender factor analyses were conducted to identify common factors in psychological attitudes toward money. Subsequently, we estimated the relationship between childhood allowance and these factors, as well as the time-discounting preference and financial literacy by gender. Interaction terms between allowance types and gender were included to examine heterogeneous associations. Our findings reveal that regular monthly allowances are associated with good budgeting habits among males, whereas females receiving any form of allowance tend to have less negative attitudes toward money. Furthermore, the relationship between a childhood allowance and time-discounting preferences varies by gender, with females being more affected by the allowance. Additionally, the association between childhood allowance and financial literacy differs by gender and varies depending on how the allowance is received. Overall, this study underscores the importance of considering childhood financial experiences to understand financial behaviors and attitudes.
The transient response of an ice shelf to an incident wave packet from the open ocean is studied with a model that allows for extensional waves in the ice shelf, in addition to the standard flexural waves. Results are given for strains imposed on the ice shelf by the incident packet, over a range of peak periods in the swell regime and a range of packet widths. In spite of large differences in speeds of the extensional and flexural waves, it is shown that there is generally an interval of time during which they interact, and the coherent phases of the interactions generate the greatest ice shelf strain magnitudes. The findings indicate that incorporating extensional waves into models is potentially important for predicting the response of Antarctic ice shelves to swell, in support of previous findings based on frequency-domain analysis.
This article examines Israeli juvenile courts as sites where poverty is present yet systematically denied as a cause of child neglect. Drawing on focused ethnographic observations, I show how factual reports routinely document material deprivation—housing shortages, lack of food, utilities cutoffs—yet court actors reject poverty as a legitimate explanation for neglect. Instead, they insist that “good parents” should be able to cope with scarcity, thereby displacing structural conditions onto individualized parental failure. I frame this configuration as part of “criministrative law”: an administrative forum that adopts criminal-style rituals of blame and correction while deferring to welfare agencies, leaving families without the protections of either criminal or administrative law. This criministrative denial of poverty produces epistemic marginalization of parents and legitimates punitive interventions. As a normative remedy, I propose adapting the poverty-aware paradigm from social work to law, reframing protection as solidarity rather than surveillance.
In 2019 we published the extensive review paper ‘Petawatt and exawatt class lasers worldwide’ in High Power Laser Science and Engineering. We are delighted that the review has achieved over 1000 citations on Google Scholar and over 750 on Web of Science. We take this opportunity to reflect on the current state of the field.
The objective of this study was to develop, implement and refine a food environment survey to capture people’s perceptions of their food environments in low-and middle-income countries: the Food Environment Perceptions Survey (FEPS).
Design:
Identifying aspects of food environment to include drawing from existing survey instruments, a Delphi survey with food environment experts working globally, workshops with local experts in India and Cambodia, cognitive testing of the survey items and piloting the tools in diverse field settings in India and Cambodia.
Setting:
Rural, peri-urban and urban communities in India and Cambodia.
Participants:
Global food environment experts for the Delphi survey, food environment experts in India and Cambodia for workshops and a convenience sample of participants in India (n 44) and Cambodia (n 60) for FEPS piloting.
Results:
The FEPS underwent many iterations prior to piloting. The initial versions of the survey were long, leading us to remove questions and reconfigure the survey to streamline it. The workshop participants rated the revised survey versions relatively favourably. The final survey consists of 109 questions covering six sections: accessibility and availability (forty-eight questions); affordability (five questions), convenience (seventeen questions); quality and safety (three questions); information, promotion and labelling (sixteen questions); and an optional sustainability section (twenty questions). Based on pilot data, we found significant differences in how participants interacted with different food environment types across rural, peri-urban and urban transects.
Conclusions:
The finalised FEPS is a newly developed survey instrument that can be incorporated by other researchers to characterise diverse perceptions of food environments in low-and middle-income countries.
This article derives analytical expressions fully describing laminar flow through concentric pipe-within-pipe set-ups, focusing on scenarios where one tube is pressure driven, and the other serves as a lubricant. Both fluid zones are axially unbounded, therefore excluding recirculation, and are connected along longitudinal infinite slits situated on the inner pipe wall, representing fluid–fluid interfaces. Crucially, the viscous interaction along these interfaces is captured by means of a local slip length, for which explicit formulae are provided, allowing a straightforward evaluation. With that, these models provide a full description of the velocity field for slippery concentric pipes, taking into account the viscosity ratio of both fluids and the overall geometry, therefore extending beyond the common assumption of perfect slip applied to superhydrophobic surfaces. Thereby, they enable a precise analysis of the flow, offering important tools to decipher the intricate dynamics of the two coupled fluids within such set-ups. As a result, the insights acquired contribute to the design and optimisation of superhydrophobic and liquid-infused surfaces, with implications for numerous engineering applications such as microfluidic contactors or drag reduction. The analytical models are in excellent agreement with numerical simulations, thus confirming the selected approach. Therefore, our study further illustrates an effective methodology to derive additional analytical models through the presented mathematical techniques, which can serve as a useful template for modelling such surfaces.
This comment examines the rapidly evolving ecosystem of historical research data in the United Kingdom, where cultural heritage collections are increasingly digitised, commercialised and fragmented. Historians face growing challenges in discovering, accessing and reusing data as resources move behind paywalls, and repositories remain scattered, without a national infrastructure to ensure long-term preservation or discoverability. Drawing on examples from major digital initiatives, we analyse the life cycle of historical research data and highlight the complex interplay of commercial, institutional and scholarly interests that shape access. We distinguish three types of data that emerge from historians’ typical engagements with digitised collections: derived, enhanced and aggregated data. We argue that historians must actively participate in the practices relating to the creation, maintenance and reuse of such data. This will involve new forms of citation, favouring open datasets, improving digital skills and building communities around shared resources. The comment concludes with proposals to improve discoverability, sustainability and reuse, urging the discipline to establish common standards and infrastructures to secure an equitable data commons for future research.
Clinical and Translational Science Awards (CTSAs) are positioned to enhance the integration of rigorous implementation research methods into projects across their networks, but lack a systematic, standardized process to do so. This study introduces the Dissemination and Implementation Research Capability Self Survey (DIRC-SS), a pragmatic instrument to evaluate and integrate implementation science methods in traditional research activities.
Methods:
We developed the 15-item DIRC-SS to assess researchers’ use of implementation research methods across five key constructs. Its reliability (inter-rater agreement and internal consistency) and sensitivity (change over time) were examined in 10 NIH-funded research projects via ratings assigned by the research teams and by implementation science experts at baseline and one year later.
Results:
The DIRC-SS total score demonstrated good internal consistency and inter-rater reliability increased over one year. Although the research team ratings did not change significantly over time, the expert ratings significantly increased, and effect sizes across research teams and expert raters were large in this small sample study.
Conclusions:
The DIRC-SS demonstrated good internal consistency reliability and moderate inter-rater reliability. It effectively distinguished between different levels of implementation research methods integration. Unlike tools focused on grant proposals or final reports, the DIRC-SS can be used at any point in the research process by a research team as a self-survey, by implementation science experts in a consultation process, or across a CTSA program to characterize the implementation science methods employed across projects and highlight targeted areas for researcher education and training.
Distributed ledgers, including blockchain and other decentralized databases, are designed to store information online where all trusted network members can update the data with transparency. The dynamics of a ledger’s development can be mathematically represented by a directed acyclic graph (DAG). In this paper, we study a DAG model that considers batch arrivals and random delay of attachment. We analyze the asymptotic behavior of this model by letting the arrival rate go to infinity and the inter-arrival time go to zero. We establish that the number of leaves in the DAG, as well as various random variables characterizing the vertices in the DAG, can be approximated by its fluid limit, represented as the solution to a set of delayed partial differential equations. Furthermore, we establish the stable state of this fluid limit and validate our findings through simulations.
Self-regulation is central to adolescent emotional and cognitive development, and deficits in self-regulation may associate with depression and anxiety. This scoping review maps the use of the Emotional Go/No-Go (EGNG), Delay Discounting Task (DDT), and Balloon Analogue Risk Task and Youth version (BART) in studies of adolescent depression and anxiety, examines consistency of task implementation, and identifies methodological and geographic gaps.
Methods:
A PRISMA-ScR–compliant search was conducted in MEDLINE (PubMed), Scopus, and PsycINFO from database inception to 15 December 2025 (initial search: 1 December 2023; updated: 15 December 2025). Data were charted using a standardised form. Eligible studies included adolescents, employed EGNG, DDT, or BART, and assessed depressive or anxiety symptoms.
Results:
Thirty reports were included (EGNG n = 21; DDT n = 3; BART n = 6). Twenty-six studies (87%) were conducted in high-income countries and 24 (80%) were English language. Twenty-two studies were cross-sectional (EGNG n = 18/21; DDT n = 2/3; BART n = 2/6); five employed longitudinal designs, and two employed experimental manipulations. Fourteen studies (47%) reported significant task performance associations with depression or anxiety (EGNG n = 8/21; DDT n = 2/3; BART n = 4/6); the remaining studies reported no significant associations. The directionality of associations differed across study populations and methodologies.
Conclusion:
The current literature is concentrated in English-speaking higher-income contexts and has yielded few and inconsistent associations with adolescent depression and anxiety. Future research should harmonise protocols, expand evidence from low- and middle-income settings, and increase longitudinal and intervention-based studies to assess sensitivity to change and clinical utility.