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Clinical translational research relies on clinical research professional staff, and efforts to stimulate a future workforce has included outreach to high schools.
Methods:
We assembled a multidisciplinary team from three institutions, leveraging expertise in education, clinical translational science, and team science to design and implement a summer camp for high school students to expose them to career opportunities in clinical research. Using backward design, we developed structured lesson plans and logistical operations. Recruitment targeted rising sophomores and juniors from Columbus, Ohio, metropolitan area high schools, with a blinded review process and no grade point averages requirement to encourage broad participation. Evaluation included pre/post assessments, facilitator feedback, and daily safety checks, with IRB exemption secured for toolkit development and dissemination.
Results:
Within one month, we received 100 applications from 14 schools, far exceeding expectations, and selected 34 students from 8 Columbus, Ohio, metropolitan area high schools. Of the 34 accepted, 33 participated in most elements of the program and 29 students completed all four days of camp and post-camp evaluations, with an average self-reported goal achievement score of 8.41 out of 10. Pre- and post-test results showed statistically significant increases in confidence across clinical research topics.
Discussion/conclusion:
The pilot summer camp for high school students, supported by in-kind contributions, successfully met its goals and led to the creation of a replicable summer camp toolkit. The camp laid a strong foundation for future offerings and collaborations, with ongoing efforts to secure funding and expand access and impact.
This article offers a response of hope to the metacrisis. Because of modernity’s philosophical premises, particularly Enlightenment concepts that separated humanity from nature, modern approaches to environmental challenges embrace a dualistic schism between culture and nature, fragmenting understanding through the compartmentalisation of knowledge. In our current situation, many feel bleak and too helpless to act. In response, we offer the experiences of Māori youth from a specific iwi (tribe) of Aotearoa New Zealand, Rongomaiwāhine. These young people speak of their holistic conceptualisation of humanity, the natural and the spiritual. Their values focus on taking responsibility for care in all realms, often through actions significant in community or land-sky-seascape settings. Their lives and ideas suggest the value of a framework grounded in Indigenous Māori philosophy from which others may learn. Thus, far from seeking new technological solutions we offer rememberings of how the ecology of relationships was and, for the rangatahi, remains. In this, the past, present and future are woven together in an understanding of the natural world of which humanity is merely a small part. The result is a hopeful framing of life in which relations of care protect ecological continuity.
Medical practitioners are among the people with a refugee or asylum seeker background to whom Australia has granted sanctuary. Yet, as the media has reported, refugee doctors (as we refer to them for convenience in this article) are often employed in low-skilled roles, rather than continuing their medical careers in Australia. Provided it is established that they are safe and competent to practise medicine, it would benefit refugee doctors, but also the community if they obtain legal entitlement to do so; Australia is presently facing major shortages of medical practitioners in certain geographical locations and fields of practice. The researchers in this study conducted semi-structured interviews with ten refugee doctors to explore their experiences in navigating the pathways for international medical graduates (‘IMGs’) to attain registration to practise medicine from the Medical Board of Australia. The study identified that refugee doctors encounter substantial challenges in this regard. A comparative analysis of the findings of this study with those of previous research reveals that, while IMGs frequently face barriers, certain obstacles appear to be unique to refugee doctors’ experiences. This article recommends specific reforms to address them.
Impaired autophagy has been implicated in the pathophysiology of neurodegenerative disorders, such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). Consistent and replicated evidence indicate that Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) exert treatment and preventative effects across disparate neurologic and mental disorders, potentially through mechanisms involving autophagy. This systematic review examined the effects of GLP-1RAs on autophagy in cell and animal models of AD and PD, as a proof of concept, to determine if these agents can be repurposed for the prevention and treatment of neurodegenerative and other mental disorders.
Methods:
A systematic search on PubMed, Web of Science, and OVID (Medline, Embase, and APA PsycInfo databases) was conducted from inception to June 17, 2025. Screening was performed independently by two reviewers (MCS and IH) using predefined inclusion and exclusion criteria. Subsequently, a quality assessment was conducted.
Results:
The search yielded 142 studies, of which 14 were included. Across studies, GLP-1RAs (e.g., liraglutide, semaglutide, and exendin-4) autophagy-specific markers, including beclin-1, LC3-II/LC3-I, ATG7, ATG3, and LAMP1, while normalising p62 levels.
Discussion:
In addition to promoting neurogenesis, neuroplasticity, and reducing inflammation, GLP-1RAs appear to modulate molecular and cellular systems contributing to autophagy, potentially mediating their broad therapeutic effects. Collectively, these studies present promising findings of GLP-1RAs for neurodegenerative and mental disorders; however, further studies are required to establish their translatability to human populations.
In recent years, a group of influential authoritarian states has emerged that fall between the ranks of great powers and small states. These authoritarian middle-powers – such as Türkiye and the United Arab Emirates – exert considerable influence, particularly in their region. Yet this development has been overlooked in favor of a focus on superpowers, especially China and Russia. We therefore lack a framework for understanding their behavior and impact. This Element offers the first comprehensive analysis of how non-democratic middle-powers engage abroad. Drawing on critical case studies, it shows how the combination of authoritarian politics and mid-level status leads to distinctive foreign policies. In particular, these strategies erode global democratic norms and institutions through a combination of hard power and transnational repression tempered by hedging and legitimation strategies. In this way, authoritarian middle-powers are helping to unravel the liberal rules-based order. This title is available as Open Access on Cambridge Core.
The Great Depression in 1929 had a transformative impact on Turkey. The institutions established to minimize the effects of the crisis propagated a set of statist measures. The National Economy and Savings Association and Public Press Directorate utilized photography and painting in the beginning of the 1930s to propagate those measures. In their efforts, these institutions constructed a new conception of landscape with a moral agenda: citizens and artists should travel in Anatolia to learn about the country, love it, and create art accordingly. Key to this conception was the productivity of the land. The most comprehensive cultural program during World War II, Homeland Tours, mimicked this new conception of a landscape. This article analyzes the conception of productive landscapes up until the end of World War II by drawing attention to the overlooked photography collection in the State Archives, which comprises paintings made during the Homeland Tours. One of the many tools that the statist economic institutions devised was agricultural statistics. The comparison between the paintings and actual land use statistics demonstrates that the artists collectively followed the statist economic agenda.
Strategies to improve accrual and reduce barriers to cancer clinical trials participation are critical for the advancement and implementation of new treatments and processes to improve cancer patient outcomes. While researchers have identified several barriers to accrual from the perspective of health care providers and patients, mechanisms to address and alleviate these concerns are needed to increase participation and interest in clinical trials.
Methods:
A focus group of 9 people with lived experience of a cancer diagnosis were accrued randomly and provided with a hands-on research experience and educational resources about clinical trials, followed by a focused group discussion to capture perspectives and/or experiences with clinical trials. Focus groups were transcribed and analyzed via Braun & Clarke’s 6-phase reflexive thematic analysis.
Results:
Five key themes were identified as important to increase clinical trial accrual. These included a patient-centered approach, easily digestible educational resources, a personalized understanding of motivating factors, local outreach, and transparency on outcomes and progress of the work. Qualitative input also identified methods that could positively influence accrual rates.
Conclusions:
Providing participants with opportunities to see first-hand how research works and data are used was noted as an overwhelmingly positive experience that could improve clinical trial accrual rates. This work confirms several previous findings with respect to patient identified barriers to participation in clinical trials and provides support and a framework for development of knowledge translation strategies to increase awareness and knowledge of the importance of clinical research to improve health outcomes for cancer patients.
From 2023–2024, the Maryland Statewide Prevention & Reduction Collaborative (SPARC) led an intervention targeting broad-spectrum antibiotic use for sepsis, aiming to identify the factors that influence the success of collaborative quality improvement (QI) programs.
Design:
Evaluation of a state collaborative run QI intervention.
Participants:
Acute-care facilities in Maryland.
Methods:
Participating sites developed and implemented sepsis-focused interventions with SPARC support, including tailored guidance and bimonthly office hours. Following the implementation of site-level interventions, sites participated in a mixed-methods assessment guided by the RE-AIM framework including brief qualitative interviews and a 6-month follow-up.
Results:
Eight hospitals implemented multi-component, multi-disciplinary sepsis-focused interventions. Facilities involved staff from up to six departments in the implementation of interventions. All sites noted the effectiveness of SPARC in supporting sites’ intervention activities, as well as the effectiveness of the site’s interventions in creating change. Sites identified barriers impacting the implementation of their interventions including lack of resources, administrative red-tape, and challenges changing culture. Facilitators included leadership support, having a structured intervention plan, and opportunities for peer-to-peer learning. Most sites were positive about SPARC’s role identifying interventions and support, utilized information from SPARC as part of their interventions, and found it useful to hear how other institutions implement antibiotic stewardship. Six months post-assessment, all sites were continuing intervention activities.
Conclusions:
This evaluation highlights how statewide QI collaboratives can be effective in promoting hospital-based antibiotic stewardship. Sites identified several facilitators and challenges that contributed to intervention implementation and highlighted the contributions of the SPARC team.
Multilevel modeling accounts for outcome dependence across lower-level units due to unobserved group effects, while spatial modeling accounts for outcome dependence across units in the same level of analysis due to diffusion. Outcome dependence can occur simultaneously due to both spatial diffusion in the lower-level units and spatial diffusion in the unobserved group effects. For example, counties are nested within states and diffusion processes might take place at both levels of analysis. Building on recent research from the spatial econometrics and multilevel modeling literature, we propose a class of spatial hierarchical models with binary outcomes. One method accounts for spatially independent, unobserved group effects and the other method accounts for spatially dependent unobserved group effects. We propose a Bayesian approach to estimate such effects while also accounting for lower-level diffusion in the outcome, and provide software to estimate these models. Our Monte Carlo results demonstrate that failing to correctly account for diffusion and/or the nested structure of data can lead to bias in both parameter estimates and substantive effects. We apply these models to analyze the causes of civil rights protests in the United States in the 1960s.
Social support is a key coping resource; its specific role for refugees from sub-Saharan Africa in high-income settings remains poorly understood. This systematic review synthesises existing evidence on the sources of social support and how these networks aid coping during resettlement. We applied an optimised search strategy to identify studies examining social support among sub-Saharan African refugees across six academic indexing databases. We then undertook a meta-synthesis of the identified studies. This involved the use of meta-thematic analysis of the interpretations and quotes presented in each study, combining thematic analysis through the reviewer’s reflexivity. The PRISMA framework guided the review process to ensure methodological rigour. A total of 22 articles were included in the qualitative meta-synthesis. The synthesis revealed four key sources of social support: 1) family, 2) friends, 3) ethnic and community groups, and 4) cultural and religious supports. These support sources played multiple roles, including enhancing community engagement and reciprocity, providing practical and emotional assistance, offering relief from distress and cultivating cultural continuity and adaptation. However, some individuals distanced themselves from their ethnic community and preferred self-driven coping. Access to social support systems remains a crucial coping resource for many sub-Saharan African refugees in high-income settings, alleviating distress and enhancing resilience. Programs that strengthen informal social support networks through community-driven initiatives can enhance the relevance of social support. Future research should investigate the role of social support across various phases of resettlement in relation to psychosocial well-being.
One-dependent first passage percolation is a spreading process on a graph where the transmission time through each edge depends on the direct surroundings of the edge. In particular, the classical i.i.d. transmission time $L_{xy}$ is multiplied by $(W_xW_y)^\mu $, a polynomial of the expected degrees $W_x, W_y$ of the endpoints of the edge $xy$, which we call the penalty function. Beyond the Markov case, we also allow any distribution for $L_{xy}$ with regularly varying distribution near $0$. We then run this process on three spatial scale-free random graph models: finite and infinite Geometric Inhomogeneous Random Graphs, including Hyperbolic Random Graphs, and Scale-Free Percolation. In these spatial models, the connection probability between two vertices depends on their spatial distance and on their expected degrees.
We show that as the penalty function, that is, $\mu $ increases, the transmission time between two far away vertices sweeps through four universal phases: explosive (with tight transmission times), polylogarithmic, polynomial but strictly sublinear, and linear in the Euclidean distance. The strictly polynomial growth phase is a new phenomenon that so far was extremely rare in spatial graph models. All four growth phases are robust in the model parameters and are not restricted to phase boundaries. Further, the transition points between the phases depend nontrivially on the main model parameters: the tail of the degree distribution, a long-range parameter governing the presence of long edges, and the behaviour of the distribution L near $0$. In this paper we develop new methods to prove the upper bounds in all sub-explosive phases. Our companion paper complements these results by providing matching lower bounds in the polynomial and linear regimes.
D-band waveguide transitions that combine a resonant patch on the printed circuit board with multiple waveguide irises are presented and shown to achieve a relative bandwidth of up to 35%. The irises implement an impedance-matching network that is described by a lumped-element circuit model. Parametric sweeps and Monte Carlo simulations quantify the influence of iris dimensions and manufacturing tolerances. The transitions’ group delay is characterized, and its influence on time-domain signals is demonstrated. As an application example, a transition design with six irises is integrated into a multichannel radar frontend with $40\,\mathrm{GHz}$ bandwidth, and measured range profiles are presented. The derived design guidelines enable straightforward customization of iris-based transitions for various applications and frequency bands.
The framing of the 2015 Rachel Dolezal transracialism scandal as a new kind of “trans moment” relies on a peculiar understanding of transness and Blackness, and the relationship they share. In this article, I analyze the “trans grammar” that structures this post-Dolezalian transracialism discourse, seeking to understand its points of reference in, and implications for, theories of transness and Blackness. I argue the post-Dolezalian transracialism discourse evidences a concern amongst Black trans feminists that the institutionalization of a “trans” concept that indexes always and only a normative figuration of “transgender” is reliant on the abstraction of the racialization of gendered space, and the erasure of Black trans feminist genealogies. I analyze the debate’s use of “trans” as a prefix for descriptors of the phenomenon Dolezal has come to represent and find the most prevalent usages create “trans” as a qualifier that is emptied of conceptual significance and political investments. This grammar, I argue, captures both Blackness and transness as fixed and knowable. Ultimately, the analysis builds an argument that the discourses’ dominant trans grammars rely on and reproduce a deficient theorization of racialized and gendered identities that depoliticizes transness and recreates gendered and Black identities as a priori and immutable.
Social scientists often compare survey responses before and after important events to test how those events impact respondent beliefs, attitudes, and preferences. This article offers a formal analysis of such pre-event/post-event survey comparisons, including designs that seek to reduce bias using quota sampling, rolling cross-sections, and panels. Our analysis distinguishes major sources of bias and clarifies the comparative strengths and weaknesses of each approach. We then introduce a modified panel design—the dual randomized survey—to reduce bias in cases where asking respondents to complete the same survey twice could impact their Wave 2 responses. Our formalization of bias and novel research design improve scholars’ ability to study the causal impact of events through surveys.
Vicarious learning helps small and medium-sized enterprises (SMEs) acquire foreign market knowledge by observing and interpreting other firms’ actions and outcomes in international markets. We searched Scopus, ProQuest, and EBSCOhost (2000–2025) and retained 27 studies (2007–2025). The synthesis organizes prior studies into four analytically derived categories that summarize how vicarious learning is conceptualized and operationalized in SME internationalization research: (T1) peer performance benchmarking, (T2) imitation and leader-following, (T3) institutional mimetic pressures, and (T4) network-, cluster-, and advisor-enabled vicarious learning. Across themes, a subset of studies suggests that absorptive capacity may condition whether external experience is recognized, assimilated, and exploited, although direct tests remain uneven and in some cases the contingency is inferred rather than explicitly tested. We translate these insights into an organizing framework and a future agenda on boundary conditions, measurement, and multi-level designs, positioning the review as mechanism clarification that imposes conceptual order on a fragmented literature, rather than as field-level consolidation.
We aimed to examine the association between team functioning in primary care and patients’ self-efficacy and quality of life. We also examined the moderation effect of multimorbidity and social vulnerability on this association.
Background:
Team-based care has been adopted as an appropriate model to deliver comprehensive primary care services to meet the complex needs of patients. Little is known about the association between team functioning and patients’ self-efficacy for managing chronic conditions (SEMCD) and quality of life.
Methods:
We used mixed-random effect modelling to analyse secondary cross-sectional data. Data were collected in primary care practices in three Canadian regions. Dependent variables included patients’ SEMCD and quality of life. The independent variable was team functioning measured using the Team Climate Inventory scale (TCI). We also included two interaction terms: social vulnerability and TCI, and multimorbidity and TCI. Control variables included patient characteristics, patients’ experience with care and practice characteristics.
Findings:
Eighty-seven practices and 1,929 patients participated in the study. Of these, 67% were female, 5% had two or more social vulnerabilities and 65% had multimorbidity. Regression analyses failed to find an association between team functioning and patients’ self-efficacy or quality of life. There was a strong positive association between team functioning and self-efficacy for people with multimorbidity (p = .005) compared to those without multimorbidity. There was also a strong positive association between team functioning and quality of life for those with two or more vulnerabilities (p < .001) but not for those with fewer vulnerabilities. The findings showed people with multimorbidity and increased vulnerabilities could benefit from well-functioning teams. Supporting better team functioning through effective communication (e.g., team meetings) and care coordination; encouraging full participation of all team members in service delivery; and establishing clear team objectives, roles and responsibilities can better meet the needs of complex patients.
This paper discusses the 2024 Tokyo gubernatorial election in the context of past contests. It shows how this election manifested the trends since the 1990s: an increasing distrust of the existing political parties, including those created in that decade and the growing support for independent candidates. Such candidates follow their own line of thinking, free from party ties, and appeal to voters in ways that resonate with public skepticism toward party politics. The analysis highlights both continuity and change in Tokyo elections and underscores broader patterns in Japanese political development.
This article re-evaluates the late seventeenth-century operatic culture of the Savoy court in Turin through the lens of newly examined archival material, the Avvisi di Torino preserved in the Medici archive in Florence. These handwritten newsletters, covering the years 1688–99, offer unprecedented insights into the musical and theatrical life of the Savoy capital, a court that stood at the crossroads of the Italian and French traditions. Previous scholarship has often overlooked this period or has relied primarily on printed librettos that provide only a partial view of operatic production. By integrating the avvisi with other sources, this study reconstructs the repertory, organization, and sociopolitical function of operatic spectacles under Victor Amadeus II of Savoy.