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Let a group Γ act on a paracompact, locally compact, Hausdorff space M by homeomorphisms and let 2M denote the set of closed subsets of M. We endow 2M with the Chabauty topology, which is compact and admits a natural Γ-action by homeomorphisms. We show that for every minimal Γ-invariant closed subset $\mathcal{Y}$ of 2M consisting of compact sets, the union $\bigcup \mathcal{Y}\subset M$ has compact closure.
As an application, we deduce that every compact uniformly recurrent subgroup of a locally compact group is contained in a compact normal subgroup. This generalizes a result of Ušakov on compact subgroups whose normalizer is compact.
This study discusses the intersection between Black/African Digital Humanities, and computational methods, including natural language processing (NLP) and generative artificial intelligence (AI). We have structured the narrative around four critical themes: biases in colonial archives; postcolonial digitization; linguistic and representational inequalities in Lusophone digital content; and technical limitations of AI models when applied to the archival records from Portuguese-colonized African territories (1640–1822). Through three case studies relating to the Africana Collection at the Arquivo Histórico Ultramarino, the Dembos Collection, and Sebestyén’s Caculo Cangola Collection, we demonstrate the infrastructural biases inherent in contemporary computational tools. This begins with the systematic underrepresentation of African archives in global digitization efforts and ends with biased AI models that have not been trained on African historical corpora.
Restaurant marketing to children may be associated with consumption. We examined whether and to what extent reported frequency of restaurant advertisements exposure was associated with consumption and money spent at all types of restaurants among children living in Canada. We also describe what children and youth report as appealing restaurant marketing techniques.
Design:
This study reports findings from a cross-sectional, online survey. The survey covered reported exposure to restaurant marketing, restaurant product consumption, money spent at restaurants and appealing features of restaurant advertisements. Descriptive statistics and adjusted and unadjusted linear and logistic regressions were constructed.
Setting:
Canadian provinces
Participants:
1500 children and youth aged 9–17 years.
Results:
A third (32 %) of participants reported restaurant advertisement exposure at least once per day. Overall, 43 % of participants consumed restaurant products more than twice per week, 61 % spent at least some money at a restaurant in the last 7 d, and of those who spent money, the mean expenditure in the last week was $20·70. Frequency of advertisement exposure was significantly associated with all outcomes. Several significant differences in outcomes emerged by region, age and race/ethnicity. Pictures were the most appealing marketing technique among both age groups; however, youth (aged 13–17 years) seemed to prioritise price and price promotions, while children (aged 9–12 years) prioritised toys, humour and winning prizes.
Conclusions:
A large proportion of Canadian children and youth consumed restaurant offerings more than twice a week. Reported restaurant advertising exposure was significantly positively associated with restaurant consumption frequency and money spent at restaurants.
Recent research on zoonotic diseases has increasingly focused on tick-borne illnesses due to their high prevalence in northwestern China. This study aimed to determine the prevalence of tick-borne pathogens in yaks (Bos grunniens) within Qinghai Province. A total of 299 blood samples were collected from yaks in Xining City of Qinghai Province and analysed using polymerase chain reaction. Results indicated the absence of several significant zoonotic pathogens, including Borrelia burgdorferi sensu lato, Anaplasma spp. and Coxiella burnetii. However, rickettsiae were detected in the sampled yaks. The overall prevalence of spotted fever group rickettsiae was 46·5%, with a significant difference between females (68·3%) and males (9·09%). Age was also identified as a significant factor influencing infection rates. Furthermore, sequencing analysis revealed that the obtained rickettsial sequences shared 99·04–100% nucleotide identity with Rickettsia raoultii, a species endemic to Qinghai, China. Phylogenetic analysis based on the ompA and gltA genes confirmed that these sequences clustered within the R. raoultii clade. This study demonstrates a high prevalence of R. raoultii infection in yaks from Qinghai. Consequently, the implementation of preventive and therapeutic measures for yaks is recommended to mitigate the risk of transmission. This study did not collect tick samples simultaneously, so the transmission vector cannot be identified. Additionally, uneven sample distribution across some age groups may affect the representativeness of the results.
The Darband Wall in southern Uzbekistan marks an important political border in the Classical world, yet the dating of its construction is largely relative and contested. Presenting 10 new radiocarbon dates from the wall, the authors argue that construction began in the early or middle third century BC, likely under Seleucid or early Greco-Bactrian rule, while later reconstruction efforts coincide with Kushan expansion around the first and second centuries AD. Early Hellenistic-style fortifications reveal a defensive, and possibly an orientational, shift during Kushan rule that underscores both the strategic significance of the wall and the need for more extensive investigation.
This paper examines American public attitudes toward corrective measures against uncooperative security allies through a preregistered survey experiment on a nationally representative sample of 1,502 American citizens. The findings demonstrate strong public support for corrective measures, particularly coercive strategies such as economic sanctions and military aid reduction, against allies whose policies conflict with the dominant power’s interests. While alliance discord also triggers demands for reduced American contributions to the alliance, public response varies substantially based on the nature of the misalignment and the characteristics of the uncooperative ally. Notably, the ally regime type significantly moderates support for corrective measures, with Americans demonstrating marked reluctance to endorse punitive actions against democratic allies. However, neither the ally’s military capabilities nor the presence of formal treaty arrangements significantly moderates public preferences. These findings contribute to our understanding of alliance management and the domestic foundations of international cooperation while offering insights into the pressures leaders face when addressing alliance noncompliance.
Research finds genetic predisposition for depression is associated with increases in depression across adolescence and adulthood. In turn, depressive symptoms in adolescence are associated with substance use. However, there has been modest examination of genetic predisposition for depression, growth in depressive symptoms, and substance use from late childhood through adolescence, and mostly in White samples. Also, psychosocial interventions can attenuate associations between genetic predisposition and psychopathology, a genotype by intervention (GxI) effect. We examined associations among polygenic risk for depression, growth in depressive symptoms from age 7 to 16, and substance use at age 16, as well as moderation by a family-based preventive intervention. Participants were African-ancestry (n = 154) and European-ancestry (n = 219) youth from the Early Steps Multisite Study, half of whom participated in the Family Check-Up intervention. A small polygenic by intervention effect was found on reductions in depressive symptoms for African-ancestry youth, and growth in depressive symptoms was positively associated with substance use at age 16. In sensitivity analyses, a small GxI effect was detected in European-ancestry youth on reductions in depressive symptom slopes from age 10 to 16. These findings highlight how early intervention can buffer genetic effects on depressive symptoms over time.
Observed competitive market profit margins in property and casualty insurance have typically been higher than the capital assets pricing model adjustment for risky loss cashflows would suggest. Explanations for this difference include frictions from operating an insurance business and capital risks that are not adequately recognised and rewarded by the theory. It is proposed that the difference may instead be related to the consumption of insurance services and claim fulfilment with an additional fair profit margin evaluated using marginal utility pricing principles.
The treatment of asymptomatic bacteriuria (AB) has been associated with increased in antibiotic resistance and Clostridioides difficile infection, without clinical benefit. One strategy to improve management is to incorporate a recommendation in the microbiological report. The aim of the study was to assess the impact of this intervention on antibiotic prescribing for AB.
Methods:
Potential cases of AB were identified, and the following comment was included in the microbiology report: “Assess according to clinical findings. In AB, no treatment is recommended”. Patient demographics, sample characteristics, reason for request, isolated microorganism, resistance profile, time to clinician’s review of the report, initiation of treatment and its causes, and repeat urine culture were collected. Factors associated with adherence to the recommendations were evaluated.
Results:
A total of 391 possible AB cases were identified. The majority of samples originated, from primary care (96%) and in women over 65 years of age (98%). Antibiotic treatment was initiated in 60% of cases, while the microbiological recommendation was followed in 40%. Factors associated with nonadherence to the recommendation included urine culture request prompted by foul-smelling or cloudy urine, and repeat culture. In contrast, urine cultures requested during routine health checks were more likely to be associate with adherence to the recommendation.
Conclusions:
The inclusion of a commentary in the microbiology report contributed to a reduction in antimicrobial prescription in AB. This intervention may be effective in optimising antibiotic prescribing practices and improving urine culture request management policies.
While increasing seafood consumption may help address micronutrient deficiencies and metabolic disorders, evidence supporting this recommendation in the Indian context remains limited and inconclusive. Using the nationally representative cross-sectional 2019–2021 National Family Health Survey dataset, we investigated the association of fish consumption frequency with anaemia and metabolic disorders (overweight/obesity, hypertension and hyperglycaemia) among adult men (aged 15–54 years) and women (aged 15–49 years) in India. A control function (CF) method was employed to examine the association in individuals who consumed fish daily and those who reported consuming fish daily/weekly. The analysis was restricted to non-vegetarians (who reported ever consuming egg, fish or meat). Overall, 86·9 % of men and 74·7 % of women were non-vegetarians. CF analysis revealed that both daily and daily/weekly fish consumption were associated with a reduced risk of anaemia among both men and women. Daily fish consumers exhibited increased likelihood of overweight/obesity (men: β: 0·405, 95 % CI: 0·074, 0·735, P: 0·017; women: β: 0·248, 95 % CI 0·125, 0·370, P < 0·001). Conversely, daily/weekly fish intake was associated with a reduced risk of overweight/obesity in men (β: −0·041, 95 % CI: −0·069, −0·013; P: 0·004). Daily/weekly fish consumption was associated with a reduced risk of hypertension and increased odds of hyperglycaemia among men. Fish consumption demonstrated a potentially protective relationship against hypertension in women, regardless of how often they consumed fish, while also being associated with a higher prevalence of hyperglycaemia. Indian adults can improve their health by eating more fish, which can help fight anaemia and may also reduce overweight/obesity and high blood pressure.
Psychotic symptoms in depression are linked to worse outcomes, and treatment options are limited. Ketamine and esketamine are effective antidepressants, yet most studies have excluded patients with a history of psychotic symptoms.
Aims
To evaluate by systematic review the efficacy and safety of ketamine and esketamine in treating patients with unipolar or bipolar depressive episodes with psychotic features.
Method
A comprehensive search of the PubMed, Ovid and Web of Science databases was conducted up to 2 November 2023. We included any study that reported the use of ketamine or esketamine in patients with depressive episodes with psychotic symptoms. The primary outcomes assessed were variations in depressive and psychotic symptoms and the incidence of adverse events. The protocol was preregistered in PROSPERO (CRD42023488524).
Results
Ten studies were included, encompassing 60 patients with unipolar depression with psychotic symptoms and 19 patients with bipolar depression with psychotic symptoms. Treatment with (es)ketamine showed mean score changes on the Montgomery–Åsberg Depression Rating Scale ranging from −13.7 to −18.2 points in open-label studies of patients with unipolar depression with psychotic symptoms. Up to 50% of participants achieved remission. The largest study with patients with bipolar depression with psychotic symptoms reported a mean Montgomery–Åsberg Depression Rating Scale score change of −14.9 points. Adverse events were mostly mild and transient. There were no reports of switches to (hypo)mania or deterioration of psychotic symptoms, and in six studies there was substantial improvement of the latter.
Conclusions
The available evidence suggests that (es)ketamine shows antidepressant effects in patients with depressive episodes with psychotic features and has a reasonable safety profile. However, the heterogeneity of the studies included in this review and the high risk of bias warrant caution in interpreting the findings and underscore the need for further trials to confirm these preliminary results.
Complete exploration of design spaces is often computationally prohibitive. Classical search methods offer a solution but are limited by challenges like local optima and an inability to traverse dislocated design spaces. Quantum computing (QC) offers a potential solution by leveraging quantum phenomena to achieve computational speed-ups. However, the practical capability of current QC platforms to deliver these advantages remains unclear. To investigate this, we apply and compare two quantum approaches – the Gate-Based Grover’s algorithm and quantum annealing (QA) – to a generic tile placement problem. We benchmark their performance on real quantum hardware (IBM and D-Wave, respectively) against a classical brute-force search. QA on D-Wave’s hardware successfully produced usable results, significantly outperforming a classical brute-force approach (0.137 s vs 14.8 s) at the largest scale tested. Conversely, Grover’s algorithm on IBM’s gate-based hardware was dominated by noise and failed to yield solutions. While successful, the QA results exhibited a hardware-induced bias, where equally optimal solutions were not returned with the same probability (coefficient of variation: 0.248–0.463). These findings suggest that for near-term engineering applications, QA shows more immediate promise than current gate-based systems. This study’s contribution is a direct comparison of two physically implemented quantum approaches, offering practical insights, reformulation examples and clear recommendations on the utilisation of QC in engineering design.
Understanding the formation and evolution of fast flowing ice streams is essential to projecting the response of ice sheets to climate forcings. Slow-flowing or stagnant ice streams can slide at low velocities over a bed that is below the bulk melting point of ice, dissipating small amounts of frictional heat. This subtemperate sliding complicates the assumed dichotomy between frozen and thawed beds embedded in many large-scale ice sheet models. In this study, we allow for subtemperate sliding in a simple ice stream box model. This leads to non-negligible frictional heat dissipation, which can accelerate sliding and lead to runaway acceleration of stagnant ice streams. These results suggest that subtemperate sliding and the associated thermo-frictional feedback are important control on ice stream temporal variability over longer timescales characterizing Heinrich events. In addition, subtemperate sliding is likely an important physical process to consider in modeling the potential reactivation of stagnant ice streams like Kamb Ice Stream, which evolve on shorter centennial timescales.
Like many newer EU Free Trade Agreements, the Trade and Cooperation Agreement (TCA) includes commitments concerning labour and social standards and environment and climate policy under the title the ‘Level Playing Field’. This title includes non-regression provisions, which prohibit reducing or weakening certain standards ‘in a manner affecting trade’, and novel rebalancing provisions, which allow the parties to take unilateral measures if material impacts on trade are arising as a result of significant divergences in levels of protection in specific areas of regulation. Although terminology linking trade to labour and environmental issues is becoming reasonably common in trade agreements, there has only been limited consideration as to what trade effects or impacts actually need to be demonstrated. This paper argues that the language of ‘manner affecting trade’ and ‘material impact on trade’ in the TCA denotes a ‘conditions of competition’ test as opposed to a stricter, and relatively more difficult to satisfy, trade remedies model. It further considers the possible application of the provisions in the context of the UK’s 2022 strikes measures, highlighting that even if a conditions of competition test is used, there are serious questions as to whether the non-regression and rebalancing provisions in the TCA are efficacious in achieving values-based objectives.
We give a construction of integral local Shimura varieties which are formal schemes that generalise the well-known integral models of the Drinfeld p-adic upper half spaces. The construction applies to all classical groups, at least for odd p. These formal schemes also generalise the formal schemes defined by Rapoport-Zink via moduli of p-divisible groups, and are characterised purely in group-theoretic terms.
More precisely, for a local p-adic Shimura datum $(G, b, \mu)$ and a quasi-parahoric group scheme ${\mathcal {G}} $ for G, Scholze has defined a functor on perfectoid spaces which parametrises p-adic shtukas. He conjectured that this functor is representable by a normal formal scheme which is locally formally of finite type and flat over $O_{\breve E}$. Scholze-Weinstein proved this conjecture when $(G, b, \mu)$ is of (P)EL type by using Rapoport-Zink formal schemes. We prove this conjecture for any $(G, \mu)$ of abelian type when $p\neq 2$, and when $p=2$ and G is of type A or C. We also relate the generic fibre of this formal scheme to the local Shimura variety, a rigid-analytic space attached by Scholze to $(G, b, \mu , {\mathcal {G}})$.
Sheath-ends are poorly represented in works regarding weaponry of the Cimmerian period (10th–7th century BC), despite forming an important component, particularly among the melee weapons of the time. There are several reasons for this neglect: until recently, the number of known sheath-ends was quite small, thus making it impossible to speak of types, variants or cultural affiliations; also, most of the previously published sheath-ends are spread over a large territory and were published many decades ago. Therefore, some of them may be unknown to researchers due to the age of publications, as well as linguistic and cultural barriers. Over the past few years, a larger number of new sheath-ends has emerged. Some of them belong to previously known types, others are completely new. Their analysis is here conducted using the comparative method. The total number of sheath-ends now known makes it possible to begin a discussion about their types, chronology and origins, which will undoubtedly develop as new finds appear.
This study demonstrated the incidences of hospital-acquired colonization by extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), and vancomycin-resistant enterococci (VRE) of 22%, 8%, and 8% among hematologic malignancy patients. Difference in time to colonization detection between VRE (14 d) and ESBL-E and CRE (7 d) may inform appropriate surveillance measures.
In p-adic Hodge theory and the p-adic Langlands program, Banach spaces with $\mathbf {Q}_p$-coefficients and p-adic Lie group actions are central. Studying the subrepresentation of G-locally analytic vectors, $W^{\mathrm {la}}$, is useful because $W^{\mathrm {la}}$ can be studied via the Lie algebra $\mathrm {Lie}(G)$, which simplifies the action of G. Additionally, $W^{\mathrm {la}}$ often behaves as a decompletion of W, making it closer to an algebraic or geometric object.
This article introduces a notion of locally analytic vectors for W in a mixed characteristic setting, specifically for $\mathbf {Z}_p$-Tate algebras. This generalization encompasses the classical definition and also specializes to super-Hölder vectors in characteristic p. Using binomial expansions instead of Taylor series, this new definition bridges locally analytic vectors in characteristic $0$ and characteristic p.
Our main theorem shows that under certain conditions, the map $W \mapsto W^{\mathrm {la}}$ acts as a descent, and the derived locally analytic vectors $\mathrm {R}_{\mathrm {la}}^i(W)$ vanish for $i \geq 1$. This result extends Theorem C of [Por24], providing new tools for propagating information about locally analytic vectors from characteristic $0$ to characteristic p.
We provide three applications: a new proof of Berger-Rozensztajn’s main result using characteristic $0$ methods, the introduction of an integral multivariable ring $\widetilde {\mathbf {A}}_{\mathrm {LT}}^{\dagger ,\mathrm {la}}$ in the Lubin-Tate setting, and a novel interpretation of the classical Cohen ring $\mathbf {{A}}_{\mathbf {Q}_p}$ from the theory of $(\varphi ,\Gamma )$-modules in terms of locally analytic vectors.
Recently, autonomous aerial systems have received unparalleled popularity and applications as varied as they are innovative in the civil domain. The unmanned aerial vehicle (UAV) is now the subject of intensive research in both aeronautical and automotive engineering.
This paper presents a new, robust gain-scheduled adaptive control strategy for a class of UAV with linear parameter varying (LPV) models. The proposed controller synthesis involves a set of pre-tuned linear quadratic regulator (LQR) combined with fractional-order PID controllers supervised with an adaptive switching law. The main innovation in this work is the enhancement of the classical gain-scheduling adaptive control robustness for systems with LPV models by combining a set of robust LQR + fractional-order PID compensators. The stability of the resulting controller is demonstrated and its efficiency is validated using a numerical simulation example on a civilian UAV system airspeed and altitude control to illustrate its practical efficiency and achieved robustness.