Histidine is an essential limiting amino acid in piglet diets and plays a crucial role in pig production. Supplementing piglet diets with adequate histidine can enhance growth performance, promote protein synthesis, regulate lipid metabolism, and improve immune function in piglets. A large body of evidence indicates that histidine may improve digestion, nutrient absorption, and intestinal microbiota balance, thereby enhancing intestinal health. This review covers histidine’s physicochemical properties, metabolic pathways, its application in piglet diets, and the requirements and influencing factors of histidine in piglets. The aim is to provide a reference for the precise use of histidine in piglet production.

This study explores the development and scale-up of an emerging carbon capture technology using molten carbonate electrolysis, which converts CO2 into high-value graphene nanocarbons (GNCs) and oxygen in a single step, offering a scalable and economically incentivized pathway to address global greenhouse gas emissions. Paths to large-scale carbon capture using molten carbonate electrolysis that splits CO2 into GNCs and O2 are studied and advanced. GNCs include carbon nanotubes, carbon nano-onions and other zero-, one-, two- and three-dimensional graphene nanoallotropes. The CO2 to carbon nanotechnology (C2CNT) carbon capture utilization process directly removes the greenhouse gas CO2 over a wide range of concentrations (from 400 ppm to pure CO2), incentivizing the capture by providing a value-added product. Scale-up of the original lab-scale discovery of the transition metal nucleated electrolytic splitting of CO2 to an industrial process is documented. The scale-up includes a three-order-of-magnitude increase in the size of the electrolysis electrodes, an increase in the individual electrolysis modules to 100-tonne CO2 annually, and a new industrial-scale production extraction unit separating the molten electrolyte from the GNC product. The molten carbonate electrolyte has evolved from costly pure lithium carbonate to multicomponent carbonate electrolytes, predominantly based on 10-fold less expensive strontium carbonate. Other advances include the introduction of a new direct cathode press for separation and extraction of the GNC product, as well as specialized modifications of C2CNT for carbon capture, utilization and storage of industrial processes (Genesis CCUS), direct air capture (Genesis DAC) and the separate recovery of the oxygen product (Genesis O2).

While scholars of deliberative democracy have long conceded that good deliberation requires careful facilitation, little attention has been paid to the effects of different facilitation methods. This paper has three aims. First, it establishes the importance of facilitation. Second, it argues that facilitation may not be enough to counteract the imbalances in power and influence within deliberation. As such, this paper introduces two games that can be utilized in concert with facilitation: deliberative worth exercises and simulated representation. The former pushes participants to remain aware of their behavior patterns within deliberation by asking them to choose the best deliberator at the end of each round of deliberation; the latter enables empathy and perspective-taking by partnering participants and asking them to represent one another’s viewpoints for a portion of deliberation as if they were their own. Third, using proof-of-concept experiments, this paper demonstrates the efficacy of these games.

Pelmatozoa is an informal grouping of filter-feeding echinoderms including crinoids, paracrinoids, rhombiferans, and eocrinoids that possess a theca, an erect stalk, and feeding appendages. Although crinoids were major constituents of marine communities with high diversity and abundance throughout the Paleozoic, most other pelmatozoans had relatively low species diversity and/or short temporal durations. It has been proposed that these different diversification trajectories could have resulted from crinoids outcompeting other filter-feeding pelmatozoans during the early Paleozoic, although this hypothesis involving niche overlap has never been formally tested. Here, we tested this hypothesis using the incredibly diverse pelmatozoan fauna of the Late Ordovician (Sandbian) Bromide Formation of Oklahoma, which preserves a rich, ecologically complex fauna that developed as a result of the Great Ordovician Biodiversification Event. We developed a framework to quantitatively characterize pelmatozoan feeding ecology using multivariate analysis of ecomorphological traits and explored niche space occupation and potential competition between crinoids, rhombiferans, paracrinoids, eocrinoids, and diploporans from the Bromide fauna. Results revealed key ecological factors controlling niche differentiation and showed that crinoids, paracrinoids, and rhombiferans occupy nonoverlapping regions of niche space, indicating competition between groups was unlikely. Although the competition hypothesis was not supported, narrow niche space occupation suggests that paracrinoids and rhombiferans were more ecologically limited than crinoids, which might have played a role in their differential diversification dynamics. These results elucidate both the nature of interactions between pelmatozoan taxa and the potential mechanisms driving their evolutionary trajectories, as well as the complexity of ecological communities that arose during the Ordovician radiation.

Pulsar timing arrays (PTAs) are Galactic-scale nanohertz-frequency gravitational wave (GW) detectors. Recently, several PTAs have found evidence for the presence of GWs in their datasets, but none of them have achieved a community-defined definitive ($\gt 5\sigma$) detection. Here, we identify limiting noise sources for PTAs and quantify their impact on sensitivity to GWs under different observing and noise modelling strategies. First, we search for intrinsic pulse jitter in a sample of 89 millisecond pulsars (MSPs) observed by the MeerKAT Pulsar Timing Array (MPTA) and obtain new jitter measurements for 20 MSPs. We then forecast jitter noise in pulsars for the future SKA-Mid telescope, finding that the timing precision of many of the best-timed MSPs would be dominated by jitter noise. We then consider dispersion measure variations from the interstellar medium and find that their effects are best mitigated by modelling them as a stationary Gaussian process with a power law spectrum. Improving upon the established hasasia code for PTA sensitivity analysis, we assess the timing potential of the lower frequency UHF-band (544$-$1088 MHz) of MeerKAT and find a potential increase in GW background sensitivity by $\approx 8$%, relative to observing at L-band. We show that this improvement relies on assumptions on the propagation through the interstellar medium and highlight that if observing frequency-dependent propagation effects, such as scattering noise, are present, where noise is not completely correlated across observing frequency, then the improvement is significantly diminished. Using the multi-frequency receivers and sub-arraying flexibility of MeerKAT, we find that focused, high-cadence observations of the best MSPs can enhance the sensitivity of the array for both the continuous GWs and stochastic GW background. These results highlight the role of MeerKAT and the MPTA in the context of international GW search efforts.

A seminal result of Komlós, Sárközy, and Szemerédi states that any $n$-vertex graph $G$ with minimum degree at least $(1/2+\alpha )n$ contains every $n$-vertex tree $T$ of bounded degree. Recently, Pham, Sah, Sawhney, and Simkin extended this result to show that such graphs $G$ in fact support an optimally spread distribution on copies of a given $T$, which implies, using the recent breakthroughs on the Kahn-Kalai conjecture, the robustness result that $T$ is a subgraph of sparse random subgraphs of $G$ as well. Pham, Sah, Sawhney, and Simkin construct their optimally spread distribution by following closely the original proof of the Komlós-Sárközy-Szemerédi theorem which uses the blow-up lemma and the Szemerédi regularity lemma. We give an alternative, regularity-free construction that instead uses the Komlós-Sárközy-Szemerédi theorem (which has a regularity-free proof due to Kathapurkar and Montgomery) as a black box. Our proof is based on the simple and general insight that, if $G$ has linear minimum degree, almost all constant-sized subgraphs of $G$ inherit the same minimum degree condition that $G$ has.

In a retrospective cohort of 6363 neonates admitted to three NICUs, there was no reduction in Staphylococcus aureus acquisition when comparing pre- and post-pandemic incidence rates. While additional infection prevention practices introduced during the pandemic helped prevent SARS-CoV-2 transmission, these practices may not have reduced S. aureus transmission to infants.

We explore how honesty-humility and the other HEXACO personality traits relate to citizens’ nascent ambition and their recruitment to run for office. We extend previous work on virtue-related personality traits and political recruitment in two important ways: we go beyond North America and conduct a five-country cross-national study with nationally representative samples. More importantly, going beyond individual-level differences in nascent ambition, we also address how honesty-humility predicts the likelihood of being asked to and actually running for office. Based on data from Canada, Denmark, Israel, the Netherlands, and Switzerland, we demonstrate that citizens with lower levels of honesty-humility are more likely to have considered running, to deem themselves qualified to run, to have been asked to run, and to actually have run for a political office. From a ‘virtue ethics’ perspective, this is highly concerning: low honesty-humility predisposes individuals to engage in unethical behavior and decision-making. We discuss implications for the quality of political representation.

Although studies had suggested that monosodium glutamate (MSG) may serve as a salt substitute in processed foods, its market impact remains unclear. This study was aimed to: (1) identify MSG in ingredient lists, (2) compare sodium levels in products with and without MSG, (3) examine the association between MSG and other umami enhancers, and (4) assess manufacturers’ adherence to the Food Regulation 1985 for MSG declaration. An observational cross-sectional market survey was conducted during the Movement Control Order (June to September 2021) on 1076 processed foods from selected Malaysian hypermarkets, that were located within 10 km of the researcher’s residence to ensure accessibility amid the COVID-19 pandemic movement restrictions. Additionally, online platforms were used to supplement any missing data. Nutritional and ingredient information were collected from packaging, and foods were classified by using the FAO/WHO Food Standards CODEX Alimentarius. Over half (50.8%) of the surveyed products contained MSG. Results found that MSG-containing products had a significantly higher sodium levels (2812.2 ± 5191.4 mg/100 g) than those without (1372.2 ± 1541.4 mg/100 g) (p < 0.001). Additionally, 14.4% of MSG-free products were labelled as ‘No Added MSG’, while products with MSG were more likely to contain other umami enhancers (p < 0.001). Compliance with MSG declaration regulations was 61%. In conclusion, MSG was present in half of the surveyed products. MSG-containing products were more likely to have higher sodium content and include other flavour enhancers. Future research should analyse the actual MSG as well as sodium content and explore alternative sodium reduction strategies.

We define a new class of plane billiards – the “pensive billiard” – in which the billiard ball travels along the boundary for some distance depending on the incidence angle before reflecting, while preserving the billiard rule of equality of the angles of incidence and reflection. This generalizes so-called “puck billiards” proposed by M. Bialy, as well as a “vortex billiard,” that is, the motion of a point vortex dipole in two-dimensional hydrodynamics on domains with boundary. We prove the variational origin and invariance of a symplectic structure for pensive billiards, as well as study their properties including conditions for a twist map, the existence of periodic orbits, etc. We also demonstrate the appearance of both the golden and silver ratios in the corresponding hydrodynamical vortex setting. Finally, we introduce and describe basic properties of pensive outer billiards.

We establish a polynomial ergodic theorem for actions of the affine group of a countable field K. As an application, we deduce—via a variant of Furstenberg’s correspondence principle—that for fields of characteristic zero, any ‘large’ set $E\subset K$ contains ‘many’ patterns of the form $\{p(u)+v,uv\}$, for every non-constant polynomial $p(x)\in K[x]$. Our methods are flexible enough that they allow us to recover analogous density results in the setting of finite fields and, with the aid of a finitistic variant of Bergelson’s ‘colouring trick’, show that for $r\in \mathbb N$ fixed, any r-colouring of a large enough finite field will contain monochromatic patterns of the form $\{u,p(u)+v,uv\}$. In a different direction, we obtain a double ergodic theorem for actions of the affine group of a countable field. An adaptation of the argument for affine actions of finite fields leads to a generalization of a theorem of Shkredov. Finally, to highlight the utility of the aforementioned finitistic ‘colouring trick’, we provide a conditional, elementary generalization of Green and Sanders’ $\{u,v,u+v,uv\}$ theorem.

Skilled and impaired language users can fail to understand sentences with noncanonical thematic role ordering. To advance understanding of the cause of the difficulty, we compared noncanonically ordered, object-experiencer-verb (OE) sentences to canonical agentive sentences in otherwise comparable syntactic structures. However, the field has neglected to consider that OE thematic roles may be altered by the comprehender’s interpretation; the aim of the investigation reported here was to address this research gap. We collected participants’ thematic role interpretations for sentences while measuring incremental processing speed as they read the sentences in a self-paced reading paradigm. Fluent English speakers rated the intent of the subjects of OE and agentive active sentences and of the objects of OE and agentive passive sentences. Consistently high ratings of intent identified a cluster containing agentives and an OE eventive subtype with an agent. In contrast, a spread of ratings in a second cluster suggested labile interpretation for a second OE subtype. Splitting the labile group at its active and passive mean, we compared reading time of OE and agentive sentences with a higher-intent, agent interpretation with OE sentences with a low-intent causer/theme interpretation. Whether active or passive, canonicity as determined by the relative prominence ordering of the rated role compared to the necessary OE experiencer or agentive theme, accounted for reading speed at the verb, second noun, and prepositional phrase. We propose that the results support an agent > experiencer > (causer)/theme thematic role hierarchy, suggesting refinements to event structure theory and little v/CAUS morphology.

The global use of antimicrobial chemicals drastically increased during and after the COVID-19 pandemic owing to heightened awareness of personal and surface hygiene needs. Disinfectants, especially chlorine-based disinfectants (CBDs), were extensively used for surface and equipment decontamination in the domestic, industrial, veterinary and healthcare sectors during the heights of the pandemic. The increased use of disinfectants has resulted in their increased discharge into municipal wastewater systems and surface waters. Our Perspective article considers the One Health challenges associated with the increased discharge of disinfectants into wastewater. One Health is a collaborative approach that ensures the well-being of people, animals and the environment. Wastewater is a common endpoint to the many interactions between people, animals and their environment. The potential One Health challenges and knowledge gaps associated with the constant discharge of low but sublethal concentrations of CBDs into wastewater are discussed. The data gaps point to the risks associated with the unregulated use of CBDs and need for their judicial use.

This study investigates the gut microbiota of newly emerged adult females and males of five economically important Anastrepha species (Tephritidae) – A. ludens, A. obliqua, A. serpentina, A. striata, and A. fraterculus – by analyzing 16S rRNA amplicon sequences from 36 samples collected from ecologically relevant fruit hosts and locations in Mexico. We chose to concentrate only on newly emerged adults to identify bacteria that females could potentially transmit vertically to progeny via oviposition, a topic that remains poorly studied. Results revealed that Proteobacteria dominated the microbiota in all species, but substantial variation was observed in genus-level composition. Differentially abundant genera included Enterobacter, Gluconobacter, Tatumella, Providencia, Ochrobactrum, Siccibacter, Sphingobacterium, and Sphingobium. Significant differences in alpha diversity were observed between species, particularly between A. obliqua and A. striata, and between A. obliqua and A. serpentina based on the Shannon index. Anastrepha ludens, A. obliqua, and A. striata males exhibited higher species richness than females, although these differences were not statistically significant within individual species likely due to limited sample size. Interestingly, across all species, significant differences in microbiota composition were observed between males and females. Our findings suggest that morphological, physiological (i.e., metamorphosis) and ecological factors, such as possible gut structural differences and host fruit preferences, may influence the composition of the gut microbiota, potentially affecting the ecological adaptability and pest behavior of these flies.

We introduce a new family of coalescent mean-field interacting particle systems by producing a pinning property that acts over a chosen sequence of multiple time segments. Throughout their evolution, these stochastic particles converge in time (i.e. get pinned) to their random ensemble average at the termination point of any one of the given time segments, only to burst back into life and repeat the underlying principle of convergence in each of the successive time segments, until they are fully exhausted. Although the architecture is represented by a system of piecewise stochastic differential equations, we prove that the conditions generating the pinning property enable every particle to preserve their continuity over their entire lifetime almost surely. As the number of particles in the system increases asymptotically, the system decouples into mutually independent diffusions, which, albeit displaying progressively uncorrelated behaviour, still close in on, and recouple at, a deterministic value at each termination point. Finally, we provide additional analytics including a universality statement for our framework, a study of what we call adjourned coalescent mean-field interacting particles, a set of results on commutativity of double limits, and a proposal of what we call covariance waves.