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This article introduces the scope, content, and capabilities of a new born-digital archive. The Medieval Londoners Database (MLD) uses an online platform to collect from and connect to both documents (printed and archival) and digitized resources (such as British History Online and the History of Parliament Online). As a digital prosopography, MLD is a freely available resource that offers sophisticated search options to discover more about the lives of both the civic elite and ordinary individuals who resided in the city of London or its suburbs of Southwark and Westminster between ca. 1100 and 1520. MLD exemplifies how digitization and the semantic web enhance historical research by creating super-powered archival collections that are ever-expanding, accessible via multiple entry points, and able to facilitate highly analytical research.
In 1805, during a lull in hostilities between England and France, minor Warwickshire landowner and slaveholder Bertie Greatheed was on a European tour with his family when his son died, leaving behind an illegitimate child. Greatheed acquired his granddaughter from her Dresden-based mother and brought the child up as his own. This article revisits Steedman's earlier scholarship on Greatheed, which focused on questions of domestic service, through the lens of slavery. It uses the seventeen volumes of his diary-writing compiled between 1805 and 1825 to explore the connections between Greatheed's ownership of enslaved people on his St. Kitts estate and his possession and nurturing of his grandchild. It considers the contradiction between Greatheed's position as an abolitionist and his profit from slavery and slave ownership, which he used not only to sustain a way of life, but also to develop Leamington, Warwickshire, into a spa town and pleasure resort.
The Neptune Islands Group and Western Kangaroo Island Marine Parks were declared as part of South Australia’s representative system of Marine protected areas (MPAs) in 2009. Sanctuary zones, located within these MPAs, prohibited commercial fishing in the state’s Northern Zone Rock Lobster Fishery from 2014. In 2022, dedicated surveys were undertaken both inside and outside two of the sanctuary zones to estimate the relative abundance (catch per unit effort; CPUE) and size of southern rock lobster (Jasus edwardsii). Survey results were then compared to estimates of abundance obtained from long-term commercial fishery-dependent data within each area. The legal-size CPUE by weight of lobsters was 389% and 411% higher inside sanctuary zones of the Neptune Islands Group and Western Kangaroo Island, respectively, compared to outside, based on survey data. Survey catch rates inside the two sanctuary zones were also considerably higher than historical catch rates estimated from commercial fishing data. Lobsters inside both sanctuary zones were larger than those outside in terms of mean weight compared to historical estimates. However, surveys recorded similar mean size in lobsters both inside and outside the Neptune Islands Group sanctuary zone, indicating a possible spillover effect of MPA protection. The Northern Zone Rock Lobster Fishery is currently in a biomass rebuilding phase. The results highlight the productivity potential of temperate reef ecosystems within South Australia in terms of southern rock lobster abundances.
Motivational Interviewing (MI) has demonstrated significant effects in diverse areas of practice, with over 2,000 controlled clinical trials published. Some criticisms of MI have emerged along the way.
Aims:
We examine theoretical and methodological critiques of MI.
Method:
We discuss three significant theoretical and methodological criticisms of MI: (1) that MI lacks conceptual stability; (2) that MI lacks a theoretical foundation; and (3) that MI is just common factors in psychotherapy.
Results:
It is true that definitions and descriptions of MI have evolved over the years. Mastery of MI clearly varies across providers, and when the quality of an intervention is unmeasured, it is unclear what has been trained or delivered. Reliable and valid tools to assess MI fidelity are available but often unused in outcome studies. It remains unclear what levels of proficiency are necessary to improve client outcomes. Some attempts to minimize variability in the delivery of MI appear to have reduced its effectiveness. In respect of the second critique is that MI lacks a theoretical foundation. It is unclear whether and how this is a disadvantage in research and practice. Various theories have been proposed and specific causal chain predictions have been tested. A third critique is that MI is merely common factors found among psychotherapists. The contribution of such relational skills is testable. There are specific aspects of MI related to client language that influence client outcomes above and beyond its relational components.
Conclusions:
The critiques reflect important factors to consider when delivering, training, and evaluating MI research.
In recent decades, researchers have analyzed professional military education (PME) organizations to understand the characteristics and transformation of the core of military culture, the officer corps. Several historical studies have demonstrated the potential of this approach, but they were limited by both theoretical and methodological hurdles. This paper presents a new historical-institutionalist framework for analyzing officership and PME, integrating computational social science methods for large-scale data collection and analysis to overcome limited access to military environments and the intensive manual labor required for data collection and analysis. Furthermore, in an era where direct demographic data are increasingly being removed from the public domain, our indirect estimation methods provide one of the few viable alternatives for tracking institutional change. This approach will be demonstrated using web-scraping and a quantitative text analysis of the entire repository of theses from an elite American military school.
In this work, we numerically investigate heat transfer in low-Prandtl-number drop-laden wall-bounded turbulence. These flows are characteristic of nuclear and fusion technologies, where liquid metals – known for their high thermal conductivity – are laden with drops or bubbles of another liquid or pressurised gas. To this end, we consider forced convection turbulence between two differentially heated parallel plates. The carrier phase (i.e. liquid metal) is characterised by a low Prandtl number $Pr_c=0.013$, while for the dispersed phase, we explore a range of Prandtl numbers from $Pr_d=0.013$ (matched case) to $Pr_d=7$ (super-unitary Prandtl number in the dispersed phase). Simulations are conducted at constant friction Reynolds number $Re_\tau =300$, and for each dispersed phase Prandtl number, two volume fractions are examined: $\alpha =5.4\,\%$ and $\alpha =10.6\,\%$. The simulation framework relies on direct numerical simulation of the Navier–Stokes equations, coupled with a phase-field method and the energy equation. Results show that an increase of the dispersed phase Prandtl number reduces heat transfer, leading to a lower Nusselt number for both volume fractions. To explain this behaviour, we analyse how the drops modify the temperature field, and demonstrate that the heat transfer reduction stems from a decreased diffusive heat flux within the dispersed phase. Finally, we propose a phenomenological model to predict the Nusselt number as a function of both the dispersed phase volume fraction and Prandtl number.
The urgency and scale of the COVID-19 pandemic demanded a coordinated response from public health agencies and the biomedical research community. The National COVID Cohort Collaborative (N3C) was established as a centralized enclave in 2020 to support the study of COVID-19 across the U.S. The Institutional Development Award for Clinical and Translational Research (IDeA-CTR) centers enhanced N3C’s national response by bringing representation from rural and medically underserved communities. This improved the representation of our diverse populations in the N3C Enclave and its use for research by IDeA-state investigators.
Methods:
We developed an organizational structure across the IDeA-CTRs to improve research productivity in resource-challenged areas of the U.S. This socio-technical ecosystem, informed by community input, included a governance committee and two workstreams. The operations workstream focused on data management and regulatory compliance, while the navigation, education, analysis, and training (NEAT) workstream supported educational and analytical activities for the N3C Enclave.
Results:
Our collaborative approach led to participation by 12 IDeA-CTRs, representing over 400 investigators from 23 sites. The shared governance, investigator engagement, and resource pooling enhanced research productivity and engagement with researchers across IDeA states. Participation in this IDeA-CTR N3C consortium enhanced informatics research capacity and collaboration across the IDeA-CTRs for participating networks.
Conclusions:
This collaborative model provides a roadmap and framework for future efforts among IDeA-CTRs and other academic partnerships. The socio-technical ecosystem fostered collectivism and team science, enabling the consortium to achieve far more than isolated efforts could, offering valuable insights for interdisciplinary research across geographically dispersed communities.
This article examines the measurement systems used in the built environment of Xochicalco, a significant Epiclassic archaeological site located in Central Mexico. Through careful analysis of the dimensions of the various structures, we identified two primary measurement units: U7 (1.47 m) and U8 (1.68 m). These units exhibit similarities to the Mayan zapal and Nahua maitl, which have been previously documented across diverse temporal contexts and other regions within Mesoamerica. The investigation revealed patterns in the application of these units related to orientation, functionality, and construction methods, indicating meticulous planning and potential symbolic importance. The frequent use of measurements that are multiples of three, four, nine, and twelve times the base units suggests the utilization of standardized measuring instruments. This study enhances our understanding of Mesoamerican measurement practices, particularly at Xochicalco, and provides insights into cultural interactions and construction traditions during the Epiclassic period.
Major depressive disorder (MDD) is a disabling psychiatric condition in which physical activity provides clinical benefits. While exercise effectively alleviates depressive symptoms, its biological mechanisms remain unclear.
Methods
This systematic review investigated the neurobiological effects of physical exercise on biomarkers in adults with MDD through randomized controlled trials, including studies assessing exercise interventions and reporting data on their biological effects.
Results
A total of 30 studies, including 2194 participants, were included, examining the effects of physical exercise on various biological systems in patients with MDD. Exercise interventions had mixed effects on inflammatory markers, including interleukins, C-reactive protein, and tumor necrosis factor-α, suggesting a potential but inconsistent anti-inflammatory role. Neurotrophic factors, such as brain-derived neurotrophic factor showed promise as biomarkers of treatment response, but their role in clinical improvements remained inconclusive. Findings for the stress-response system, including cortisol and monoaminergic systems, primarily involving serotonin and dopamine, were limited and variable. Exercise demonstrated potential benefits in reducing oxidative stress and enhancing β-endorphin levels, although these effects were not consistently observed.
Conclusion
This systematic review adopted a broader perspective than prior studies, exploring less-studied biological systems and identifying several limitations in the included studies, including small sample sizes, varying methodologies, and a predominant focus on biochemical markers. Future research should prioritize larger, standardized trials and particularly employ omics approaches to better understand the biological mechanisms underlying the effects of exercise in MDD. The findings highlight the complexity of exercise’s biological effects and emphasize the need for further research to clarify its mechanisms.
To present a tool and examine the minimum cost of a healthy and diverse diet that meets the daily requirements of essential nutrients for the people of India, using interactive web-based tools.
Design:
Linear-programming algorithms were adapted into two web-based tools: a Food Optimisation for Population (FOP) tool and a Diet Optimisation Tool (DOT). The FOP optimises daily food choices at a population level, considering local food consumption patterns. The DOT focuses on household or individual food selection.
Setting:
India, with consideration of locally produced and consumed foods.
Participants:
The two optimisation tools are demonstrated for the state of Bihar: the FOP tool at the population level, exemplified by diet optimisation for children aged 1–3 years, and DOT at the household level, demonstrated through diet optimisation for a household of four members.
Results:
Both tools provide cost-effective, optimised food plans, respecting cultural preferences. Based on food prices from June 2022, the FOP tool generated optimised diets for 1–3-year-old Bihari children priced at INR 26·8 (USD 0·32 converted as of January 2024 rate)/child/day. By applying a milk subsidy, this cost could drop to INR 23·7 (USD 0·28). The DOT was able to formulate a vegetarian diet for a family of four at INR 204 (USD 2·45)/day.
Conclusions:
These web-based tools offer diet plans optimised to meet macro- and micronutrient requirements at population and/or individual/household levels, at minimum cost. This tool can be used by policymakers to design food-focused strategies that can meet nutritional needs at local price points, while considering food preferences.
People with functional disorders often receive high levels of healthcare resource use yet have poor outcomes. The health service costs and productivity losses of functional cognitive disorders (FCD) is unknown.
Aims
This study aims to report the cost to health services and productivity losses of FCD.
Method
Examination of healthcare service use and productivity losses in a sample of individuals with FCD who had attended a specialist out-patient clinic in south London.
Results
The findings revealed high rates of healthcare use, including frequent contact with general practitioners, psychologists and hospital services, as well as work absences. The total estimated cost of healthcare and productivity losses per individual over 6 months was £1114.
Conclusions
These results highlight the need for effective and efficient diagnostic pathways, targeted and effective interventions, and improved support for individuals with FCD.
The macro-social and environmental conditions in which people live, such as the level of a country’s development or inequality, are associated with brain-related disorders. However, the relationship between these systemic environmental factors and the brain remains unclear. We aimed to determine the association between the level of development and inequality of a country and the brain structure of healthy adults.
Methods
We conducted a cross-sectional study pooling brain imaging (T1-based) data from 145 magnetic resonance imaging (MRI) studies in 7,962 healthy adults (4,110 women) in 29 different countries. We used a meta-regression approach to relate the brain structure to the country’s level of development and inequality.
Results
Higher human development was consistently associated with larger hippocampi and more expanded global cortical surface area, particularly in frontal areas. Increased inequality was most consistently associated with smaller hippocampal volume and thinner cortical thickness across the brain.
Conclusions
Our results suggest that the macro-economic conditions of a country are reflected in its inhabitants’ brains and may explain the different incidence of brain disorders across the world. The observed variability of brain structure in health across countries should be considered when developing tools in the field of personalized or precision medicine that are intended to be used across the world.
This article takes a micro-history approach, focusing on the life of a man identified only in the British records as “Ned” in order to illuminate the complexity and slipperiness of categories of “race.” Ned had lived in the Zulu Kingdom and, after fleeing a civil war there, became employed in Natal by an English colonist-settler, Thomas Handley. Ned traveled with the Handley family to England in 1859, and during this time, unexpectedly “disappeared” from the Handley's residence near Sheffield. A manhunt ensued and, as locals ruminated on Ned's possible status as a “slave,” the case attracted the interest of the British and Foreign Anti-Slavery Society. Ned was eventually taken to London and housed in the Strangers’ Home for Asiatics, Africans and South Sea Islanders before his tragic death a few months later. His repeated escapes transfixed the public and resulted in detailed press coverage. Numerous parties became interested in his case, and complex and changing processes of racialization were key to the shifting ways in which he was represented. In this article, we both search for Ned's agency and volition, and demonstrate how the case also speaks to major issues in British history, including race, humanitarianism, and enslavement.
The period after 1850 is often assumed to have witnessed some amelioration in the operation of the game code. This article highlights the origins of a little-researched statute, the 1862 Poaching Prevention Act, which conversely augmented the existing game laws and, most significantly, bestowed new responsibilities and powers on the police to tackle poachers at a critical point in the development of the new county constabularies. This controversial measure owed much to the particular circumstances of the 1850s and early 1860s when the violence and criminality associated with the activities of poaching gangs in Midland and northern counties threatened both game preservation and the authority of the new police. In these circumstances, an alliance of magistrates, police leaders and parliamentary advocates successfully lobbied for new measures to deal with this specific class of offenders who were increasingly held as representative of a wider urban criminal class.
Plasmodium simium, a parasite of platyrrhine monkeys, is known to cause human malaria outbreaks in Southeast Brazil. It has been hypothesized that, upon the introduction of Plasmodium vivax into the Americas at the time of the European colonization, the human parasite adapted to neotropical anophelines of the Kerteszia subgenus and to local monkeys, along the Atlantic coast of Brazil, to give rise to a sister species, P. simium. Here, to obtain new insights into the origins and adaptation of P. simium to new hosts, we analysed whole-genome sequence (WGS) data from 31 P. simium isolates together with a global sequence dataset of 1086 P. vivax isolates. Population genomic analyses revealed that P. simium comprises a discrete parasite lineage with greatest genetic similarity to P. vivax populations from Latin America – especially those from the Amazon Basin of Brazil – and to ancient European P. vivax isolates, consistent with Brazil as the most likely birthplace of the species. We show that P. simium displays half the amount of nucleotide diversity of P. vivax from Latin America, as expected from its recent origin. We identified pairs of sympatric P. simium isolates from monkeys and from humans as closely related as meiotic half-siblings, revealing ongoing zoonotic transmission of P. simium. Most critically, we show that P. simium currently causes most, and possibly all, malarial infections usually attributed to P. vivax along the Serra do Mar Mountain Range of Southeast Brazil.
How do counterterrorism policies enable terrorist groups to thrive and survive? This article examines the relationship and how counterterrorism policies and political structures impact terrorist group success. While studies of terrorism have tended to separate the two phenomena, there is considerable complexity in the interactions between violent action and coercive state response. To demonstrate the complexity of these interactions, this article examines the persistence of three transnational terrorist groups from 1989 to 2022 – the Lashkar-e-Taiba, Jaish-e-Mohammad, and the Hizbul Mujahideen – that operate in the Kashmir region despite India’s coercive counterterrorism policies. While existing research emphasises macro-level factors in transnational terrorism, this article, based on original qualitative data, demonstrates the critical importance of granular, localised opportunities for terrorist groups to carry on. We show how these structures interact with civilian perceptions of state legitimacy and security to create nuanced patterns of support. In doing so, we challenge simplistic explanations of terrorist recruitment and resilience. The article dispels existing misconceptions about the efficacy of coercive counterterrorism to end militant groups and further suggests that softer, non-coercive approaches might not necessarily generate public sympathy. In fact, select counterterrorism policies might inadvertently legitimise violence by extremist groups to their constituency and increase sympathy in the process.
Heath forests, or known locally as kerangas, in Indonesia and Malaysia form a distinct and understudied ecoregion. We document the distribution and ecological significance of the largest extent of kerangas in Kalimantan, Indonesian Borneo. We mapped 16,586 km2 of kerangas to the nearest one square kilometre across Kalimantan, showing a significant reduction from previous estimates. About 19% of this area exists as a poorly documented mosaic landscape in Central Kalimantan’s Rungan-Kahayan region. Here, peat-based forests transition to heath and dipterocarp forests, making it difficult to reliably classify these forests for conservation planning. Using remote sensing and tree plot data, we identified three forest types—kerangas, low pole, and mixed swamp. Vegetation structure is influenced by soil, topography, and hydrology, while peat depth and elevation affect species diversity. Our findings indicate that these forests are dynamic ecosystems with diverse vegetation communities adapted to peat as well as sandy soils. Lowland heath forests in Rungan-Kahayan exhibits higher tree densities compared to other Bornean heath forests, reflecting unique ecological adaptations to challenging environments. Despite covering just 3% of Kalimantan’s forest area, these ecosystems remain largely unprotected, facing threats from land conversion and fire. Our study highlights the ecological complexity of kerangas and underscores the urgent need for targeted conservation and further research on these forests.