Bioreactor scaffolds must be designed to facilitate adequate nutrient delivery to the growing tissue they support. For perfusion bioreactors, the dominant transport process is determined by the scale of fluid velocity relative to diffusion and the geometry of the scaffold. In this paper, models of nutrient transport in a fibrous bioreactor scaffold are developed using homogenisation via multiscale asymptotics. The scaffold is modelled as an ensemble of aligned strings surrounded by viscous, slowly flowing fluid. Multiple scales analysis is carried out for various parameter regimes which give rise to macroscale transport models that incorporate the effects of advection, reaction and diffusion. Multiple scales in both space and time are employed when macroscale advection balances macroscale diffusion. The microscale model is solved to obtain the effective diffusion coefficient and simple solutions to the macroscale problem are presented for each regime.

We show that the fundamental groups of smooth $4$-manifolds that admit geometric decompositions in the sense of Thurston have asymptotic dimension at most four, and equal to four when aspherical. We also show that closed $3$-manifold groups have asymptotic dimension at most three. Our proof method yields that the asymptotic dimension of closed $3$-dimensional Alexandrov spaces is at most three. Thus, we obtain that the Novikov conjecture holds for closed $4$-manifolds with such a geometric decomposition and for closed $3$-dimensional Alexandrov spaces. Consequences of these results include a vanishing result for the Yamabe invariant of certain $0$-surgered geometric $4$-manifolds and the existence of zero in the spectrum of aspherical smooth $4$-manifolds with a geometric decomposition.

We introduce and study the notion of hereditary frequent hypercyclicity, which is a reinforcement of the well-known concept of frequent hypercyclicity. This notion is useful for the study of the dynamical properties of direct sums of operators; in particular, a basic observation is that the direct sum of a hereditarily frequently hypercyclic operator with any frequently hypercyclic operator is frequently hypercyclic. Among other results, we show that operators satisfying the frequent hypercyclicity criterion are hereditarily frequently hypercyclic, as well as a large class of operators whose unimodular eigenvectors are spanning with respect to the Lebesgue measure. However, we exhibit two frequently hypercyclic weighted shifts $B_w,B_{w'}$ on $c_0(\mathbb {Z}_+)$ whose direct sum ${B_w\oplus B_{w'}}$ is not $\mathcal {U}$-frequently hypercyclic (so that neither of them is hereditarily frequently hypercyclic), and we construct a C-type operator on $\ell _p(\mathbb {Z}_+)$, $1\le p<\infty $, which is frequently hypercyclic but not hereditarily frequently hypercyclic. We also solve several problems concerning disjoint frequent hypercyclicity: we show that for every $N\in \mathbb {N}$, any disjoint frequently hypercyclic N-tuple of operators $(T_1,\ldots ,T_N)$ can be extended to a disjoint frequently hypercyclic $(N+1)$-tuple $(T_1,\ldots ,T_N, T_{N+1})$ as soon as the underlying space supports a hereditarily frequently hypercyclic operator; we construct a disjoint frequently hypercyclic pair which is not densely disjoint hypercyclic; and we show that the pair $(D,\tau _a)$ is disjoint frequently hypercyclic, where D is the derivation operator acting on the space of entire functions and $\tau _a$ is the operator of translation by $a\in \mathbb {C}\setminus \{ 0\}$. Part of our results are in fact obtained in the general setting of Furstenberg families.

Optimal transport tasks naturally arise in gas networks, which include a variety of constraints such as physical plausibility of the transport and the avoidance of extreme pressure fluctuations. To define feasible optimal transport plans, we utilize a $p$-Wasserstein metric and similar dynamic formulations minimizing the kinetic energy necessary for moving gas through the network, which we combine with suitable versions of Kirchhoff’s law as the coupling condition at nodes. In contrast to existing literature, we especially focus on the non-standard case $p \neq 2$ to derive an overdamped isothermal model for gases through $p$-Wasserstein gradient flows in order to uncover and analyze underlying dynamics. We introduce different options for modelling the gas network as an oriented graph including the possibility to store gas at interior vertices and to put in or take out gas at boundary vertices.

In this paper, we prove that if a three-dimensional quasi-projective variety X over an algebraically closed field of characteristic $p>3$ has only log canonical singularities, then so does a general hyperplane section H of X. We also show that the same is true for klt singularities, which is a slight extension of [15]. In the course of the proof, we provide a sufficient condition for log canonical (resp. klt) surface singularities to be geometrically log canonical (resp. geometrically klt) over a field.

In this paper, we consider an optimal distributed control problem for a reaction-diffusion-based SIR epidemic model with human behavioural effects. We develop a model wherein non-pharmaceutical intervention methods are implemented, but a portion of the population does not comply with them, and this non-compliance affects the spread of the disease. Drawing from social contagion theory, our model allows for the spread of non-compliance parallel to the spread of the disease. The quantities of interest for control are the reduction in infection rate among the compliant population, the rate of spread of non-compliance and the rate at which non-compliant individuals become compliant after, e.g., receiving more or better information about the underlying disease. We prove the existence of global-in-time solutions for fixed controls and study the regularity properties of the resulting control-to-state map. The existence of optimal control is then established in an abstract framework for a fairly general class of objective functions. Necessary first–order optimality conditions are obtained via a Lagrangian-based stationarity system. We conclude with a discussion regarding minimisation of the size of infected and non-compliant populations and present simulations with various parameters values to demonstrate the behaviour of the model.

We characterize hyperbolic groups in terms of quasigeodesics in the Cayley graph forming regular languages. We also obtain a quantitative characterization of hyperbolicity of geodesic metric spaces by the non-existence of certain local $(3,0)$-quasigeodesic loops. As an application, we make progress towards a question of Shapiro regarding groups admitting a uniquely geodesic Cayley graph.

Inspired by Nakamura’s work [36] on $\epsilon $-isomorphisms for $(\varphi ,\Gamma )$-modules over (relative) Robba rings with respect to the cyclotomic theory, we formulate an analogous conjecture for L-analytic Lubin-Tate $(\varphi _L,\Gamma _L)$-modules over (relative) Robba rings for any finite extension L of $\mathbb {Q}_p.$ In contrast to Kato’s and Nakamura’s setting, our conjecture involves L-analytic cohomology instead of continuous cohomology within the generalized Herr complex. Similarly, we restrict to the identity components of $D_{cris}$ and $D_{dR},$ respectively. For rank one modules of the above type or slightly more generally for trianguline ones, we construct $\epsilon $-isomorphisms for their Lubin-Tate deformations satisfying the desired interpolation property.

This paper is focused on the existence and uniqueness of nonconstant steady states in a reaction–diffusion–ODE system, which models the predator–prey interaction with Holling-II functional response. Firstly, we aim to study the occurrence of regular stationary solutions through the application of bifurcation theory. Subsequently, by a generalized mountain pass lemma, we successfully demonstrate the existence of steady states with jump discontinuity. Furthermore, the structure of stationary solutions within a one-dimensional domain is investigated and a variety of steady-state solutions are built, which may exhibit monotonicity or symmetry. In the end, we create heterogeneous equilibrium states close to a constant equilibrium state using bifurcation theory and examine their stability.

We study the existence and regularity of minimizers of the neo-Hookean energy in the closure of classes of deformations without cavitation. The exclusion of cavitation is imposed in the form of the divergence identities, which is equivalent to the well-known condition (INV) with $\operatorname{Det} = \operatorname{det}$. We show that the neo-Hookean energy admits minimizers in classes of maps that are one-to-one a.e. with positive Jacobians, provided that these maps are the weak limits of sequences of maps that satisfy the divergence identities. In particular, these classes include the weak closure of diffeomorphisms and the weak closure of homeomorphisms satisfying Lusin’s condition N. Moreover, if the minimizers satisfy condition (INV), then their inverses have Sobolev regularity. This extends a recent result by Doležalová, Hencl, and Molchanova by showing that the minimizers they obtained enjoy extra regularity properties and that the existence of minimizers can still be obtained even when their coercivity assumption is relaxed.

In this article, we study the effect of the Hardy potential on existence, uniqueness, and optimal summability of solutions of the mixed local–nonlocal elliptic problem

\begin{equation*}-\Delta u + (-\Delta)^s u - \gamma \frac{u}{|x|^2}=f \,\text{in } \Omega, \ u=0 \,\text{in } {\mathbb R}^n \setminus \Omega,\end{equation*}

${\mathbb R}^n$

Quorum sensing governs bacterial communication, playing a crucial role in regulating population behaviour. We propose a mathematical model that uncovers chaotic dynamics within quorum sensing networks, highlighting challenges to predictability. The model explores interactions between autoinducers and two bacterial subtypes, revealing oscillatory dynamics in both a constant autoinducer submodel and the full three-component model. In the latter case, we find that the complicated dynamics can be explained by the presence of homoclinic Shilnikov bifurcations. We employ a combination of normal-form analysis and numerical continuation methods to analyse the system.

We study the planar FitzHugh–Nagumo system with an attracting periodic orbit that surrounds a repelling focus equilibrium. When the associated oscillation of the system is perturbed, in a given direction and with a given amplitude, there will generally be a change in phase of the perturbed oscillation with respect to the unperturbed one. This is recorded by the phase transition curve (PTC), which relates the old phase (along the periodic orbit) to the new phase (after perturbation). We take a geometric point of view and consider the phase-resetting surface comprising all PTCs as a function of the perturbation amplitude. This surface has a singularity when the perturbation maps a point on the periodic orbit exactly onto the repelling focus, which is the only point that does not return to stable oscillation. We also consider the PTC as a function of the direction of the perturbation and present how the corresponding phase-resetting surface changes with increasing perturbation amplitude. In this way, we provide a complete geometric interpretation of how the PTC changes for any perturbation direction. Unlike other examples discussed in the literature so far, the FitzHugh–Nagumo system is a generic example and, hence, representative for planar vector fields.

Using a perturbation result established by Galatolo and Lucena [Spectral gap and quantitative statistical stability for systems with contracting fibers and Lorenz-like maps. Discrete Contin. Dyn. Syst. 40(3) (2020), 1309–1360], we obtain quantitative estimates on the continuity of the invariant densities and entropies of the physical measures for some families of piecewise expanding maps. We apply these results to a family of two-dimensional tent maps.

For a finite group G, let $\operatorname { {AD}}(G)$ denote the Fourier norm of the antidiagonal in $G\times G$. The author showed recently in [‘An explicit minorant for the amenability constant of the Fourier algebra’, Int. Math. Res. Not. IMRN 2023 (2023), 19390–19430] that $\operatorname { {AD}}(G)$ coincides with the amenability constant of the Fourier algebra of G and is equal to the normalized sum of the cubes of the character degrees of G. Motivated by a gap result for amenability constants from Johnson [‘Non-amenability of the Fourier algebra of a compact group’, J. Lond. Math. Soc. (2) 50 (1994), 361–374], we determine exactly which numbers in the interval $[1,2]$ arise as values of $\operatorname { {AD}}(G)$. As a by-product, we show that the set of values of $\operatorname { {AD}}(G)$ does not contain all its limit points. Some other calculations or bounds for $\operatorname { {AD}}(G)$ are given for familiar classes of finite groups. We also indicate a connection between $\operatorname { {AD}}(G)$ and the commuting probability of G, and use this to show that every finite group G satisfying $\operatorname { {AD}}(G)< {61}/{15}$ must be solvable; here, the value ${61}/{15}$ is the best possible.

We address the inverse problem for holomorphic germs of a mapping of the complex line near a fixed point which is tangent to the identity. We provide a preferred parabolic map $\Delta $ realizing a given Birkhoff–Écalle–Voronin modulus $\psi $ and prove its uniqueness in the functional class we introduce. The germ is the time-$1$ map of a Gevrey formal vector field admitting meromorphic sums on a pair of infinite sectors covering the Riemann sphere. For that reason, the analytic continuation of $\Delta $ is a multivalued map admitting finitely many branch points with finite monodromy. In particular, $\Delta $ is holomorphic and injective on an open slit sphere containing $0$ (the initial fixed point) and $\infty $, where the companion parabolic point is situated under the involution ${-1}/{\mathrm {Id}}$. One finds that the Birkhoff–Écalle–Voronin modulus of the parabolic germ at $\infty $ is the inverse $\psi ^{\circ -1}$ of that at $0$.