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The descriptive representation of stigmatized groups has numerous benefits both to group members and society at large. We study the extent to which LGB members of the US Congress provide increased support for LGBT rights. While LGBT substantive representation has been studied extensively, descriptive representation has been examined extensively at only the local and state levels. The absence of research at the federal level is important because federal policy is essential to expanding gay rights. We overcome issues related to the small number of openly LGBT Members of Congress and the few bills either introduced or receiving votes by examining LGB legislators over 24 years (i.e., 6,425 legislator–Congress pairs) using Human Rights Campaign scores. Using Coarsened Exact Matching, we find a substantively small but statistically significant and consistently positive effect: LGB members of Congress are more supportive of LGBT rights than other members with a similar background and from a similar district. The use of matching may provide a useful approach for scholars who are interested in studying the link between descriptive and substantive representation for other small groups.
The Publicity Department of the Austrian Fatherland Front served the Ständestaat regime (1933–38). An elaborate organization on paper, the Fatherland Front's actual work was bound up in the performance of para-fascism and the surveillance of opposing parties. Each of these modes of being mutually reinforced the need for the other and created a unique self-awareness of failure within the movement. As such, the Publicity Department offers a microcosm of the larger challenges of the Ständestaat, which faltered in the face of economic collapse, political violence, and a population largely indifferent to its attempt to secure Austrian sovereignty in the 1930s.
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response. Here, scanning and transmission electron microscopy were used to monitor the in vitro effects of sera (with, and without, complement depletion) on F. hepatica newly excysted juveniles (NEJs) and flukes recovered at 7, 35, 70 and 98 days post infection (dpi) from the liver and bile ducts of rats. Test sera were from these F. hepatica-infected rats. A F. hepatica NEJ-specific rabbit antiserum was also used. All fluke stages demonstrated release of the tegumental glycocalyx and microvesicles and intense activity within the tegumental syncytium characterized by eccrine secretion of T-0/T-1/T-2 secretory bodies with subsequent microvillar formation and shedding of microvesicles from the apical plasma membrane. Exposure of both NEJs and 35 dpi flukes to 35 and 70 dpi rat sera produced significant amounts of eccrine-derived secretory material and putative attached immunocomplex. Rabbit anti-F. hepatica NEJ-specific antiserum produced similar responses at the NEJ tegument, including binding of putative immunocomplex to the surface, but with additional blistering of some regions of the apical plasma membrane. Our data suggest that immune sera stimulates multiple interrelated secretory mechanisms to maintain the integrity of the tegumental barrier in response to immune attack. Concurrent release of microvesicles may also serve to both divert the immune response away from the fluke itself and permit delivery of immunomodulatory cargo to immune effector cells.
Through a series of example research studies, we illustrate processes in translating case report forms to increase language diversity in study populations while simultaneously highlighting implications for data collection and analyses. The Northwestern University Data Analysis and Coordinating Center manages the translation of participant-facing study documents into languages other than English through a process that has been refined over several years, adjusting for changes in technical capabilities in electronic case report forms. This approach to manage, examine for context, and implement certified case report form translations offers an efficient workflow to streamline data capture in multiple languages.
The fate of deformable buoyancy-driven bubbles rising near a vertical wall under highly inertial conditions is investigated numerically. In the absence of path instability, simulations reveal that, when the Galilei number, $Ga$, which represents the buoyancy-to-viscous force ratio, exceeds a critical value, bubbles escape from the near-wall region after one to two bounces, while at smaller $Ga$ they perform periodic bounces without escaping. The escape mechanism is rooted in the vigorous rotational flow that forms around a bubble during its bounce at high enough $Ga$, resulting in a Magnus-like repulsive force capable of driving it away from the wall. Path instability takes place with bubbles whose Bond number, the buoyancy-to-capillary force ratio, exceeds a critical $Ga$-dependent value. Such bubbles may or may not escape from the wall region, depending on the competition between the classical repulsive wake–wall interaction mechanism and a specific wall-ward trapping mechanism. The latter results from the reduction of the bubble oblateness caused by the abrupt drop of the rise speed when the bubble–wall gap becomes very thin. Owing to this transient shape variation, bubbles exhibiting zigzagging motions with a large enough amplitude experience larger transverse drag and virtual mass forces when departing from the wall than when returning to it. With moderately oblate bubbles, i.e. in an intermediate Bond number range, this effect is large enough to counteract the repulsive interaction force, forcing such bubbles to perform a periodic zigzagging-like motion at a constant distance from the wall.
StopAsianHate protests arose in the West during the COVID-19 pandemic, opposing a perceived increase in hate incidents directed against Asians in general and Chinese people in particular. These events raise a question: what is the nature of attitudinal biases about Chinese people in the English-speaking world today? Here, we seek answers with AI and big data. Using BERT language models pre-trained on massive English-language corpora (books, news articles, Wikipedia, Reddit and Twitter) and a new method for measuring natural-language propositions (the Fill-Mask Association Test, FMAT), we examined three components of attitudinal biases about Chinese people: stereotypes (cognitive beliefs), prejudice (emotional feelings) and discrimination (behavioural tendencies). The FMAT uncovered relative semantic associations between Chinese people and (1) cognitive stereotypes of low warmth (less moral/trustworthy and less sociable/friendly) and somewhat low competence (less assertive/dominant but equally capable/intelligent); (2) affective prejudice of contempt (vs admiration); and (3) behavioural discrimination of active/passive harm (vs help/cooperation). These findings advance our understanding of attitudinal biases towards Chinese people in the English-speaking world.
Leopard seals (Hydrurga leptonyx) lead solitary lives, mainly associated with sea ice, and they are parasitized by the sucking louse Antarctophthirus ogmorhini, one of the few known marine insects and probably the only group adapted to survive in deep-ocean environments. A challenge for seal lice is that their eggs do not survive underwater, requiring them to complete their life cycle during the host’s reproductive or moulting season. We investigated the infestation parameters of A. ogmorhini in leopard seals on the Danco Coast, Antarctic Peninsula, estimating prevalence and mean abundance, comparing by sex, age class and interannual variability and determining the relationship between these parameters and the body condition of the seals. Over four field seasons (2014, 2015, 2019 and 2020), we collected data from 50 seals: 12 females and 38 males, including 47 adults and 3 juveniles. The overall prevalence (14%) was the lowest recorded for an Antarctic seal, with higher rates in juveniles (33.3%) than adults (12.8%) and in males (15.8%) compared with females (8.3%). Generalized linear models analysis, considering body condition and interannual variability, did not reveal a strong correlation between body condition and lice infestation. Although no strong correlation was found, there is some indication that seals in poorer condition may be more heavily infested.
Among the less considered ‘conversions’ of the Confessions is the conversion of grief. The Confessions traces how Augustine learns to grieve justly and with hope. Augustine’s grief in book four is presented in stark contrast to his grief in book nine. In many ways, these two books serve as a counter image of each other. The striking narrative similarities that Augustine presents between the death of his boyhood friend in book four and that of his mother in book nine serve, however, to highlight the significant differences that Augustine wants to accent between these two experiences of death and grief. Holding these two scenes next to each other allows us to witness another profound conversion of the Confessions, namely, how Augustine learns to grieve profound loss in hope.
What is persuasion and how does it differ from coercion, indoctrination, and manipulation? Which persuasive strategies are effective, and which contexts are they effective in? The aim of persuasion is attitude change, but when does a persuasive strategy yield a rational change of attitude? When is it permissible to engage in rational persuasion? In this paper, I address these questions, both in general and with reference to particular examples. The overall aims are (i) to sketch an integrated picture of the psychology, epistemology, and ethics of persuasion and (ii) to argue that there is often a tension between the aim we typically have as would-be persuaders, which is bringing about a rational change of mind, and the ethical constraints which partly distinguish persuasion from coercion, indoctrination, and manipulation.
Hydrogen, a deceptively simple element, plays crucial roles in regulating life on Earth. The concentration of hydrogen ions (H+) determines the pH of biological systems and dictates virtually all biochemical processes. The pH modulates the structure, physicochemical properties and function of most macromolecules. The plant cell surface is characterized by tremendous variations in apoplastic pH, serving as informative signals shaping plant development and its interaction with the environment. Here, we discuss the principles underlying cell surface H+ homeostasis, the molecular tipping points that regulate fast, controlled and informative changes in apoplastic pH, as well as open questions regarding the regulation of plasma membrane H+-ATPases.
This study aimed to assess the surgical and patient reported outcomes for monocanalicular and bicanalicular silicone stent insertion in endoscopic dacryocystorhinostomy for distal nasolacrimal duct obstruction.
Methods
A retrospective cohort study was undertaken for all endoscopic dacryocystorhinostomy cases performed collaboratively by ENT and ophthalmology at Royal Blackburn Hospital.
Results
A total of 60 patients were included in the study. Tubes were used in 95 per cent of cases; 92 per cent reported a positive outcome. Minor post-operative complications occurred in 30 per cent. When further broken down by tube type, success rates were 94 per cent for monocanalicular and 95.5 per cent for bicanalicular stents, however, the difference was not statistically significant. In contrast, the complication rates were 22 per cent for monocanalicular stents and 63.6 per cent for bicanalicular stents, with this difference being statistically significant.
Conclusion
Both monocanalicular and bicanalicular stents showed similar high surgical success rates. However, monocanalicular stents were better tolerated by patients and associated with fewer complications.
Ketamine exerts potent but transient antidepressant effects in treatment-resistant depression (TRD). Combinations of ketamine and psychotherapy have attracted interest, but no trial has investigated a psychedelic model of ketamine–psychotherapy for TRD to our knowledge.
Aims
This secondary analysis of a randomised clinical trial (RCT) explores the therapeutic effects and experiential mechanisms of the Montreal Model of ketamine–psychotherapy for TRD, with or without music.
Method
A two-centre, single-blinded, RCT conducted in Montreal, Canada, between January 2021 and August 2022 (NCT04701866). Participants received ketamine–psychotherapy for TRD – six subanaesthetic infusions over 4 weeks and psychological support – with either music or matched non-music support during ketamine doses, as per random group assignments. The primary therapeutic outcome was the Montgomery–Åsberg Depression Rating Scale, assessed by blinded raters. Psychedelic-like experiences, evaluated by the Mystical Experience Questionnaire and Emotional Breakthrough Inventory, and their session-by-session relationships with depression were explored with multilevel, time-lagged covariate models with autoregressive residuals.
Results
Thirty-two participants with severe and highly comorbid TRD, including high rates of personality disorder and suicidality, received 181 ketamine infusions. Therapeutic outcomes and psychedelic experiences did not differ between music (n = 15) and non-music (n = 17) interventions. Both groups experienced significant reductions in clinician-rated and self-reported depression (d = 1.2 and d = 0.87, respectively; p < 0.001), anxiety (d = 0.8, p < 0.001) and suicidality (d = 0.4, p < 0.05) at 4 weeks, fully maintained at 8-week follow-up. Ketamine experiences were highly emotional and mystical. Converging analyses supported mystical-like ketamine experiences as mechanisms of its antidepressant effects.
Conclusions
This trial found large and notably sustained benefits of ketamine–psychotherapy for severe TRD, with or without music, and psychedelic experiences of comparable intensity to those observed with psilocybin. Mystical-like experiences may particularly contribute to ketamine’s immediate and persistent psychiatric benefits.
Submarine melting is one of the major mechanisms of ice loss from marine-terminating glaciers and ice shelves, but its contribution is yet to be fully understood. Here, we demonstrate the feasibility of monitoring melting using passive underwater acoustics, by sensing the loud crackling sound produced during melting due to the release of pressurised ice-trapped bubbles. We profile the acoustic field in glacial bays in Svalbard using a hydrophone array and show that the sound level in the bay contains clues on the melt activity. The sound level’s interpretation is hindered by its spatial variability, which we suppress using a model of melt-induced acoustic activity. Thereby, we show that the sound generated at the glacier terminus is correlated with the ablation rate at the calving glacier front and the water temperature and thus linked to the melt rate. This marks a step forward in using passive acoustics to monitor submarine melt, paving the way for an autonomous, long-term, large-scale monitoring tool providing data that can inform assessments and simulations of ice sheet loss and sea level rise.
In Nairobi, water rights emerge not through legal recognition alone but through relationships with infrastructurally powerful actors. Residents must engage with specific individuals across institutional levels who control urban water distribution. This explains neighborhood disparities in water access and why some residents secure better supplies than others. The fragmentation of water control challenges traditional legal and normative frameworks of water rights. Understanding how rights are embedded in everyday socio-material relationships is crucial for comprehending how people establish water access and thereby concretize their right to water in practice.
In survey experiments, should all covariates be administered before the experimental treatment? Some scholars argue that post-treatment items should never be used as covariates because the treatment could bias the measurement of those items and disrupt experimental randomization. Other scholars argue certain items—specifically sensitive questions measuring prejudice—should not be administered pre-treatment. They argue if asked pre-treatment, these items may prime respondents in ways that will influence how they engage with the experiment treatment, thereby affecting the overall outcome of the experiment. Using evidence from four studies (two original collections) that vary the placement of sensitive items—pre-treatment, post-treatment, or in a separate wave—we find little evidence that the placement of sensitive items influences the measurement of those items, the experimental outcomes, nor heterogeneously affects the outcome conditional on the treatment. However, we find the placement of sensitive items inconsistently affects the experimental outcome by interacting with both the measurement of the items and the experimental treatment condition. Overall, we find these measures to be robust to where they are administered. It may be best to place items pre-treatment to preserve randomization. If researchers have reason to include sensitive moderators post-treatment, they should transparently discuss this choice and the anticipated trade-offs.
The literature on user trust in social welfare systems appropriately highlights the quality of relationships with frontline workers and the perception of their skills and human qualities, which develop and evolve over time. However, it tends to place less emphasis on users’ perceptions of and experiences with the formal procedures within which these relational processes unfold. With this paper, we aim to contribute to knowledge on user (dis)trust-building by focusing on the microdynamics of its development, which equally considers citizens’ interactions with frontline workers and institutional procedures at various organisational levels. Drawing on empirical research conducted among disadvantaged families seeking support from social services and assistance institutions in the Czech Republic and Serbia, we analyse the narrated experiences and perception-based mechanisms that shape users’ (dis)trust within the dual context of institutional procedures governing access to services, and the relationship with frontline workers.