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A patient post-Fontan palliation with a venous collateral unusually arising from the renal vein. Since renal vein oxygen saturations are relatively high, there was not systemic desaturation despite a right-to-left shunt.
In 1968 the inhabitants of the Chagos Islands were forcibly displaced by the British to set up a US military base on Diego Garcia, in an act which Chagossians have contested for over 50 years. At the time, and to the present, the UK Foreign and Commonwealth Office (FCO) attempted to legitimise the displacement by disingenuously claiming that the Chagossians were a mobile population of contract workers. Through archival analysis, this paper addresses the FCO representation of the islanders as a mobile ‘floating population’ of ‘contract workers’, linked to the figure of the ‘migrant’. At the same time, it problematises the legal contestation of the islanders’ displacement through a politicisation of stasis, linked to claims to ‘indigenous’ status based on long-held ties with the islands, as well as a discrete ‘Ilois’ or ‘Chagossian’ identity category. It argues that these debates reproduce distinctions between ‘migrants’ and ‘natives’ which obscure mobile political relations, including the imperial mobilities that constitute ‘national’ polities, as well as the histories of enforced mobility of enslaved and indentured labourers. Drawing on Glissant’s concept of errantry, the paper highlights the need to multiply conceptual and legal frameworks and create additional frameworks that can recognise mobile forms of rootedness.
The study is the first to examine the effects of children’s and therapists’ in-session behaviors on later therapeutic alliance (TA; i.e., relational bond, task collaboration) as rated by children and therapists in an intervention for children with aggressive behavior. One hundred eighty children (ages 9.3–11.8; 69% male; 78% Black), screened as having aggressive behavior by teacher and parent ratings, received a 32-session group-based cognitive-behavioral intervention (Coping Power) at their schools. TA ratings were collected from children and therapists at mid- and end-of-intervention using the Therapeutic Alliance Scale for Children. Children’s and therapists’ behaviors during the first 16 sessions were coded by independent observers. Children’s negative in-session behaviors predicted lower child- and therapist-rated TA (averaged across mid- and end-of-intervention). Children’s in-session positive behaviors, at both the individual and group-wide level, predicted higher later TA. Therapists’ efforts to manage deviant behavior predicted stronger child-reported ratings of the relational bond and of child- and therapist-rated task collaboration. Exploratory analyses indicate that the effect of children’s in-session behaviors on later TA is moderated by therapists’ skills in managing the group and in managing deviant talk and behavior in sessions. Clinical and research implications of the findings are discussed.
Language impairments are common in affective and psychotic disorders, yet their patterns and underlying pathomechanisms remain insufficiently understood. A transdiagnostic perspective provides a framework for identifying shared and disorder-specific language alterations across diagnostic boundaries. Combining natural language processing (NLP) with network analysis enables the investigation of complex associations between linguistic, cognitive, and psychopathological features.
Methods
Spontaneous speech from N = 372 participants (119 MDD, 27 BD, 48 SSD and 178 HC) was elicited using four Thematic Apperception Test pictures (~12 min per participant). NLP models were applied to extract latent linguistic variables across various levels, including lexical diversity, syntactic complexity, semantic coherence, and disfluencies. Network analysis was used to relate linguistic variables, psychopathology (SAPS, SANS, HAM-A, HAM-D, YMRS, TLI, GAF), and cognitive performance (attention, verbal memory, recognition, and verbal fluency).
Results
Linguistic variables formed the densest network cluster, with type–token ratio, mean length of utterance, and syntactic complexity emerging as central nodes. Psychopathology variables were less cohesive, while TLI “Impoverishment”, coherence mean, and executive functioning bridged linguistic, cognitive, and psychopathological domains. Network comparison tests revealed no significant differences in linguistic–cognitive network structure across HC, MDD, BD, and SSD.
Conclusions
Linguistic networks show high structural consistency across healthy individuals and patients, whereas psychopathological symptom networks reflect transdiagnostic profiles. These findings support a dimensional and transdiagnostic framework underscore shared language–cognition mechanisms, and highlight executive functioning as key cross-domain connection, which opens up new avenues for dimensional research into the pathophysiological and etiological mechanisms underlying language dysfunctions.
Over the past two decades, there has been growing interest in analyzing the effects of educational programs on outcomes using process data from computer-based testing and learning environments. However, most analyses focus on final outcomes at the end of a test or session, overlooking their functional nature over time and neglecting causal mechanisms. To address this gap, this article proposes a novel causal mediation framework for identifying and estimating functional natural direct effects, functional natural indirect effects, and functional total effects, along with their subgroup effects. We define these effects using potential outcomes and provide nonparametric identification strategies depending on whether post-treatment covariates are present or not. We then develop estimation methods using generalized additive models, a flexible and robust tool for analyzing functional data. Through a simulation study, we assess the finite-sample performance of the proposed approach by comparing it to parametric regression methods. We also demonstrate our approach by examining the effects of extended time accommodations on two functional outcomes using process data from the National Assessment of Educational Progress. Our mediation approach with functional outcomes effectively captures dynamic causal mechanisms underlying the program’s effects and pinpoints when and for whom each effect manifests throughout the testing period.
The current study presents an HPSG analysis for deliminative verbal reduplication in Mandarin Chinese. We provide a detailed description of the phenomenon. After discussing reduplication’s interaction with verb classes and aspect markers, we argue that it is better analyzed as a morphological rather than a syntactic process. We put forward a lexical rule for verbal reduplication in Mandarin Chinese, and the different forms of reduplication are captured in an inheritance hierarchy. The interaction between verbal reduplication and aspect marking is handled by multiple inheritance. This analysis covers all forms of deliminative verbal reduplication in Mandarin Chinese and has none of the shortcomings of previous analyses.
The Latent Position Model (LPM) is a popular approach for the statistical analysis of network data. A central aspect of this model is that it assigns nodes to random positions in a latent space, such that the probability of an interaction between each pair of individuals or nodes is determined by their distance in this latent space. A key feature of this model is that it allows one to visualize nuanced structures via the latent space representation. The LPM can be further extended to the Latent Position Cluster Model (LPCM), to accommodate the clustering of nodes by assuming that the latent positions are distributed following a finite mixture distribution. In this paper, we extend the LPCM to accommodate missing network data and apply this to non-negative discrete weighted social networks. By treating missing data as “unusual” zero interactions, we propose a combination of the LPCM with the zero-inflated Poisson distribution. Statistical inference is based on a novel partially collapsed Markov chain Monte Carlo algorithm, where a Mixture-of-Finite-Mixtures (MFM) model is adopted to automatically determine the number of clusters and optimal group partitioning. Our algorithm features a truncated absorb-eject move, which is a novel adaptation of an idea commonly used in collapsed samplers, within the context of MFMs. Another aspect of our work is that we illustrate our results on 3-dimensional latent spaces, maintaining clear visualizations while achieving more flexibility than 2-dimensional models. The performance of this approach is illustrated via three carefully designed simulation studies, as well as four different publicly available real networks, where some interesting new perspectives are uncovered.
We analyse the monetary-fiscal policy mix in post-war Europe, focusing on France and Italy, to trace the historical dynamics of debt and inflation. Using a Markov-switching DSGE model, we identify distinct policy regimes: a Passive Monetary-Active Fiscal (PM/AF) regime before the late 1980s/early 1990s, an Active Monetary-Passive Fiscal (AM/PF) regime associated with central bank independence and EMU convergence, and a third regime marked by the ELB and active fiscal measures aimed at recovery. Simulations reveal that the PM/AF regime in France led to price volatility but stabilised debt, while AM/PF curbed inflation at the cost of rising debt. In contrast, Italy’s procyclical fiscal policy in downturns exacerbated imbalances, aggregate volatility, and low growth. We further assess the implications of policy credibility and uncertainty.
Previous literature has shown that the introduction of homogeneous perforation on plates and cylinders decreases aerodynamic drag. Here, it is shown that the opposite is true for a sphere; drag can increase with porosity. Hollow porous spheres exposed to a uniform free stream are studied experimentally using force and flow field measurements. The parameter space encompasses moderate to high Reynolds numbers ($5 \times 10^4 \leq \textit{Re} \leq 4 \times 10^5$) and porosities ranging from $0\,\%$ to $80\,\%$. The main conclusion is that drag increases with porosity, at super-critical Reynolds numbers, for all studied porosities. At low porosities (less than $9\,\%$), the effect of porosity on drag can be explained by shifts in the separation point. At higher porosities the drag increase cannot be explained by separation shifts, and instead is explained by two competing forms of kinetic energy dissipation: (i) shear on the macro-scale of the body, and (ii) hole losses from flow through the pores. The former generally decreases with porosity, as bleeding flow passing through the body decreases the characteristic velocity difference in the body-scale wake. In a sphere, hole losses increase with porosity sufficiently fast to overcome decreasing body-scale shear losses, in contrast to plates and cylinders where this is not the case. Relatively weak wake vortex structures, and associated low drag coefficient at zero porosity, for a sphere reduce the impact of wake bleeding. Moreover, fluid entering the fore of a sphere can exit perpendicular to the free stream, further reducing wake bleeding while still contributing to hole losses.
Major depression (MDD) is linked to neuro-immune, metabolic, and oxidative stress (NIMETOX) pathways. The gut microbiome may contribute to these pathways via leaky gut and immune–metabolic processes.
Aims:
To identify gut microbial alterations in MDD and to quantify functional pathways and enzyme gene families and integrate these with the clinical phenome and immune–metabolic biomarkers of MDD.
Methods:
Shotgun metagenomics with taxonomic profiling was performed in MDD versus controls using MetaPhlAn v4.0.6, and functional profiling was conducted using HUMAnN v3.9, aligning microbial reads to species-specific pangenomes (Bowtie2 v2.5.4) followed by alignment to the UniRef90 v201901 protein database (DIAMOND v2.1.9).
Results:
Gut microbiome diversity, both species richness and evenness, is quite similar between MDD and controls. The top enriched taxa in the multivariate discriminant profile of MDD reflect gut dysbiosis associated with leaky gut and NIMETOX mechanisms, that is, Ruminococcus gnavus, Veillonella rogosaem, and Anaerobutyricum hallii. The top four protective taxa enriched in controls indicate an anti-inflammatory ecosystem and microbiome resilience, that is, Vescimonas coprocola, Coprococcus, Faecalibacterium prausnitzii, and Faecalibacterium parasitized. Pathway analysis indicates loss of barrier protection, antioxidants, and short-chain fatty acids, and activation of NIMETOX pathways. The differential abundance of gene families suggests that there are metabolic distinctions between both groups, indicating aberrations in purine, sugar, and protein metabolism. The gene and pathway scores explain a larger part of the variance in suicidal ideation, recurrence of illness, neurocognitive impairments, immune functions, and atherogenicity.
Conclusion:
The gut microbiome changes might contribute to activated peripheral NIMETOX pathways in MDD.
To investigate the extent to which the associations of socio-economic position (SEP) with stunting and wasting are mediated by minimum acceptable diet (MAD) and a family care indicator (FCI) in Sri Lanka.
Design:
Secondary data analysis of children from the 2016 Sri Lanka Demographic and Health Survey. The outcomes were stunting and wasting, the exposure was a composite measure combining maternal education and household wealth, and the mediators were binary MAD and FCI variables (adequate v. inadequate). Analyses were performed using counterfactual mediation models adjusted for age, sex and place of residence.
Setting:
A nationally representative sample of children from Sri Lanka.
Participants:
Mothers/caregivers of children under 36 months (4325).
Results:
Twenty per cent of children were stunted, and 14 % were wasted. Lower SEP was associated with higher odds of stunting and wasting and inadequate MAD and FCI. Inadequate FCI was associated with higher odds of stunting (OR = 1·47, 95 % CI = 1·24, 1·74) but not wasting (OR = 1·14, 95 % CI = 0·94, 1·38), whereas MAD was not associated with stunting or wasting. Neither MAD nor FCI significantly mediated the relationship between SEP and stunting and wasting. All mediation estimates were statistically non-significant at the 5 % level. For example, the proportion mediated by FCI on the association between the lowest composite SEP and stunting was 13 % (mean difference = 0·13, 95 % CI = < 0·00, 0·26).
Conclusion:
We did not find consistent or strong evidence that the associations of SEP with childhood stunting and wasting in Sri Lanka are mediated by MAD and FCI. Research with larger samples is needed for more precise estimates.
This work aims to complement the description of the atomisation process in a typical commercial pressure-swirl atomiser. Conventional characterisation focuses on the final spray, where established experimental techniques allow for measuring spherical droplets in a dilute regime. However, the early stages of atomisation involve distorted liquid structures with complex interface morphology that challenge both experimental and numerical approaches. While numerical simulations with interface-capturing methods have provided access to this region, they currently remain computationally prohibitive to follow the atomisation process until the formation of the final spherical droplets. To characterise the evolving interface morphology, we propose analysing the curvature distribution obtained from both simulations and two-photon laser-induced fluorescence (2P-LIF) imaging. This curvature-based methodology, recently developed to characterise numerical sprays (Palanti et al. Intl J. Multiphase Flow 147, 2022, 103879; Ferrando et al. Atomiz. Sprays 33, 2023, 1–28), is here extended to experimental data. Both approaches are compared with available phase Doppler anemometry (PDA) measurements performed further downstream on spherical droplets. The morphological evolution of the atomising spray is interpreted through curvature statistics, which provide a unified framework applicable to all atomisation stages. When applied to spherical droplets, the curvature distribution recovers the conventional drop size distribution, linking early interface deformation to the final spray structure. The birth of this final drop size distribution can thus be observed by comparing the three approaches – numerical simulation limited to the early stage of atomisation, curvature derived from 2P-LIF images limited to two-dimensional (2-D) contour analysis, and PDA measurements of the dilute spray. The results show that curvature properties evolve in a way that can be directly representative of the final spray even at early atomisation stages.
The generalized Gompertz distribution—an extension of the standard Gompertz distribution as well as the exponential distribution and the generalized exponential distribution—offers more flexibility in modeling survival or failure times as it introduces an additional parameter, which can account for different shapes of hazard functions. This enhances its applicability in various fields such as actuarial science, reliability engineering and survival analysis, where more complex survival models are needed to accurately capture the underlying processes. The effect of heterogeneity has generated increased interest in recent times. In this article, multivariate chain majorization methods are exploited to develop stochastic ordering results for extreme-order statistics arising from independent heterogeneous generalized Gompertz random variables with increased degree of heterogeneity.
Large biobanks offer unprecedented data for psychiatric genomic research, but concerns exist about representativeness and generalizability. This study examined depression prevalence and polygenic risk score (PRS) associations in the All of Us data to assess potential impacts of nonrepresentative sampling.
Methods
Depression prevalence and correlates were analyzed in two subsamples: those with self-reported personal medical history (PMH) data (N = 185,232 overall; N = 114,739 with genetic data) and those with electronic health record (EHR) data (N = 287,015 overall; N = 206,175 with genetic data). PRS weights were estimated across ancestry groups. Associations of PRS with depression were examined by state and ancestry.
Results
Depression prevalence varied across states in both PMH (16.7–35.9%) and EHR (0.2–45.8%) data. Concordance between PMH and EHR diagnoses was low (kappa: 0.29, 95% CI: 0.30–0.30). Overall, one standard deviation increase in depression PRS was associated with lifetime depression based on PMH (odds ratio [OR] = 1.05, 95% confidence interval [CI]: 1.04–1.07) and EHR (OR = 1.05, 95% CI: 1.04–1.07). Results were generally consistent by ancestry, with the strongest signal for European ancestry (PMH: OR = 1.10, 95% CI: 1.08–1.12; EHR: OR = 1.07, 95% CI: 1.05–1.10). Associations between PRS and lifetime depression were largely consistent and significant associations varied minimally (ORs = 1.06–1.45) by state of residence in both subsamples.
Conclusions
Recorded depression prevalence by state in All of Us demonstrates a wide range, likely reflecting recruitment differences, EHR data completeness, and true geographic variation; yet PRS associations remained relatively stable. As studies like All of Us expand, accounting for sample composition and measurement approaches will be crucial for generating actionable findings.
A lattice Boltzmann method is adopted to investigate the breakup of surfactant-free and surfactant-laden droplets in both regular and irregular T-junction microchannels. During droplet neck contraction, the neck thinning shifts from inertia dominated to interfacial tension dominated, causing spontaneous rapid neck collapse due to Rayleigh–Plateau instability. For the regular rectangular microchannels, we find that the prerequisite for the spontaneous breakup of a surfactant-free droplet is that the local capillary pressure in the triggering area exceeds the Laplace pressure difference between the inside and outside of the droplet neck. Results show that the critical neck thickness $\delta _\textit{cr}^{*}$ for the droplet spontaneous breakup increases with increasing height-to-width ratio $\chi$ of the microchannel in both surfactant-free and surfactant-laden systems. The presence of surfactants decreases $\delta _\textit{cr}^{*}$ at the identified $\chi$, while the surfactant effects are gradually enhanced as $\chi$ increases. Subsequently, a constriction section is incorporated into the upper microchannel wall to establish an irregular microchannel. As constriction depth (length) increases, $\delta _\textit{cr}^{*}$ linearly decreases (increases) in the surfactant-free system, while $\delta _\textit{cr}^{*}$ exponentially decreases (linearly increases) in the surfactant-laden system. Four empirical formulas are proposed to predict the values of $\delta _\textit{cr}^{*}$ under varying constriction depths and lengths in the two systems.