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This article presents the results of a contextual analysis of graffiti found in Substructure II-B at the Maya city of Calakmul. The final use of this space was for the burial of an important Kanu’l lord, whose identity—as shown by a recent analysis of the Long Count date inscribed as part of the graffiti—seems to be that of Yukno’m Ch’een II. My analysis of the frequency of appearance of different categories of graffiti within the structure, compared to the frequency of the same categories within the total set of graffiti recorded in the Maya area, suggests that the main objective of its creators was the ritual reconditioning of this space: they wished to make it more suitable for the entombment of the ruler, through its aesthetic modification, in what constitutes an example of placemaking. The inclusion of images of deities associated with death, rebirth, abundance, and kingship reconfigured the room and transformed it into a sacred space in which the burial process could be properly carried out. Analyzing the graffiti in the context in which they are located allows us to better understand the intentionality of its creators.
Rather than static traces of the past, ruins and ancient material objects represent dynamic and important generative components of communities. A relational ontology views objects and matter as animate; here we focus on their collaborative potential with humans to inspire memory practices that bring together ancestors and living humans, things, and landscapes in recursive relationships. Situated at Etlatongo in the Mixteca Alta of Oaxaca, Mexico, our research interrogates broader Mixtec and Mesoamerican perspectives on things, which indicates certain materials and ruined places could be especially potent, imbued with cosmogonic energy from previous eras. Such material had animating properties as well as inspiring memorial narratives. Continuously occupied for more than 3,500 years, Etlatongo illustrates dynamic and varied interactions with past places and things. We present two precontact archaeological case studies that highlight these persistent engagements with the past: the first focuses on the reuse and reincorporation of earlier public architecture while the second features the selection and generative power of ancient ceramic figurine heads in two later domestic settings.
This direct numerical simulation study analyses the transition-to-turbulence in plane Couette flow (PCF) with three-dimensional (3-D) roughness. Square ribs of height $k=0.2h$ (where $h$ is the half-channel height) and a streamwise pitch separation of $\lambda =10k$, classified as k-type roughness, are mounted on the stationary wall. This configuration features alternating rough and smooth zones in the spanwise direction and is referred to as 3-D k-type roughness. We compare the behaviour of 3-D k-type roughness in the transitional regime with that of two-dimensional (2-D) k-type roughness (Gokul & Narasimhamurthy 2024 J. Fluid Mech. vol. 1000, p. A40). The route-to-transition in 3-D k-type roughness confirms the formation of laminar–turbulent patterns, which exist in the transitional Reynolds number range $\textit{Re} \in [325, 350]$. This range interestingly overlaps with those for smooth PCF ($\textit{Re} \in [325, 400]$) and 2-D k-type roughness ($\textit{Re} \in [300, 325]$), thereby indicating that 3-D k-type roughness amalgamates the characteristics of both the rough and smooth zones. In striking contrast to the 2-D k-type roughness, the laminar–turbulent bands in the 3-D k-type configuration are of non-uniform bandwidth. The 3-D k-type roughness surprisingly introduces continuous competition among bands of opposite orientations, a characteristic unique in this case. Due to this competition, the large-scale flow associated with the oblique bands is never fully aligned with the diagonal direction. The smooth zones in the 3-D k-type roughness exhibit complex interactions, evident from oscillatory velocity signals and multiple high-energy peaks in the frequency spectra, which likely contribute to the competing patterns with opposite orientations.
High-amylose maize starch (HAMS) can lead to succinate accumulation in the rat colon depending on the colonic microbiota. Since succinate is primarily produced via the vitamin B12 (VB12)-dependent succinate pathway, limited VB12 availability in the colon may impair fermentation. While a portion of dietary VB12 may reach the colon, most of it is absorbed in the upper gastrointestinal tract, potentially resulting in an insufficient supply for colonic bacteria. This study aimed to determine the minimum caecal VB12 concentration required to prevent succinate accumulation and to assess whether dietary cobalt (Co), a structural component of VB12 and its analogues, promotes microbial VB12 analogue synthesis. Sprague-Dawley male rats were used in three experiments. In Experiment 1, HAMS-fed rats were given diets with increasing VB12 doses. Caecal succinate concentrations decreased dose-dependently, with a predicted threshold of 74 pmol/g VB12 required to prevent accumulation. In Experiment 2, rats were fed HAMS diets with varying Co levels. Co supplementation significantly increased VB12-equivalent concentrations, measured by microbiological assay, from 27 to 915 pmol/g without altering cobalamin concentrations, suggesting enhanced microbial synthesis of VB12 analogues. Caecal succinate levels decreased with increasing Co intake, mimicking the effects of dietary VB12. In Experiment 3, rats were fed HAMS diets with or without high-dose Co to confirm these effects and assess microbiota changes. Co supplementation restored the abundance of Akkermansia, which utilises VB12 and its analogues. These findings suggest that maintaining sufficient colonic VB12 – through direct supplementation or Co-stimulated microbial production – may help mitigate HAMS-induced succinate accumulation and support balanced colonic fermentation.
This article examines how Latina Republican Congressional candidates frame themselves as both embodying and representing the “real Latino electorate,” who they claim has been ignored in the U.S. political arena. In this article, I engage in an in-depth analysis of these candidates — including content analyses of their public interviews, speeches, advertisements, websites, newspaper coverage, and social media presences — in four border districts in Texas. I find that the ways in which these candidates strategically reframe Latinidad and the immigrant experience to align with Republican ideology allow these candidates to advocate for comprehensive immigration reform while simultaneously engaging in the Latino threat narrative that dehumanizes the very community they claim to represent. More specifically, these candidates articulate an alternate, intersectional vision of Latinidad which presents Latino immigrant women and children as victims, Latino immigrant men as criminals, and themselves as unique authorities on immigration given their status as border patrol wives. These candidates’ race-gender consciousness also allows these candidates to express political anger, which has generally been denied to women of color in the Republican Party. In so doing, they offer a pointed critique claiming that Latinos are a captured group in American political parties.
In this article, we reformulate LXYZ’s $L^p$ affine Sobolev inequality chain (including Lutwak–Yang–Zhang’s $L^p$ affine Sobolev inequality and Xiao’s p-affine capacity inequality) in the setting of Grassmann manifolds. For this purpose, the Grassmannian $ p $-affine capacity is introduced.
This article reframes the traditional view of Persian rhetoric as merely a derivative of Arabic tradition by examining its development through four key manuals: Muhammad ibn ʿUmar Rādūyānī’s Tarjumān al-Balāgha, Rashīd al-Dīn Vatvāt’s Hadāʾiq al-Sihr, Shams-i Qays-i Rāzī’s al-Muʿjam, and Sayf-i Jām-i Hiravī’s Jāmiʿ al-Sanāyiʿ. It is an exploration of the historical and cultural contexts in which these works were composed, highlighting how Persian rhetoricians adapted and reshaped Arabic models as part of a broader movement toward literary autonomy. By foregrounding these dynamics, the article offers a fresh perspective on the reciprocal relationship between Arabic and Persian rhetorical traditions. Particular attention is given to Tarjumān al-Balāgha as a seminal effort to Persianize rhetorical tradition, in which Rādūyānī adapts and reconfigures Arabic concepts to lay the groundwork for a distinct Persian literary identity, and to Jāmiʿ al-Sanāyiʿ, which subsequently consolidates this project into a coherent and comprehensive Persian framework. Together, these works mark pivotal moments in the trajectory of Persian rhetorical thought and reflect broader cultural and intellectual currents in the medieval Islamicate world.
We study the decay properties of non-negative solutions to the one-dimensional defocusing damped wave equation in the Fujita subcritical case under a specific initial condition. Specifically, we assume that the initial data are positive, satisfy a condition ensuring the positiveness of solutions, and exhibit polynomial decay at infinity. To show the decay properties of the solution, we construct suitable supersolutions composed of an explicit function satisfying an ordinary differential inequality and the solution of the linear damped wave equation. Our estimates correspond to the optimal ones inferred from the analysis of the heat equation.
Pulsed gravity currents are generated by the sequential release of dense material into a lighter ambient. We investigate the dynamics of pulsed gravity currents using physical scale experiments, two-dimensional depth-averaged shallow water equation (SWE) based models and three-dimensional lattice Boltzmann method (LBM) simulations. Integrating these results we show for the first time that short duration pulsed releases generate intrusive layers, which accelerate front propagation relative to an instantaneously released current of the same total volume. Conversely, a long delay time between pulses produces a current that propagates slower than an equivalent instantaneous release. This finding is supported by physical experiments and depth-resolving LBM simulations. The depth-resolving simulations show that intrusions in pulsed flows experience less drag resistance than those generated by instantaneous releases. The depth-averaged model considered in the present study does not accurately capture the intrusive flow dynamics of pulsed currents. However, the limitations of the finite-depth SWE model may be mitigated by extensions to incorporate entrainment and density stratification. The results also motivate further research into the impact of buoyancy Reynolds number and channel slope on the propagation of pulsed currents.
Eating duration and shift work can both influence metabolic regulation, but their joint associations with diabetes are unknown. We aimed to examine the independent and joint associations of eating duration and shift work with diabetes in a cross-sectional study using a nationally representative sample of US workers. We included 14852 eligible participants from the National Health and Nutrition Examination Survey, 2005–2010 and 2017–2020. Eating duration was calculated based on first and last eating occasions from 24-h dietary recalls. Long eating duration (LED: ≥ 13 h) v. short eating duration (SED: < 13 h) was defined based on the median. Workers were classified as engaging in shift work (SW, n 5140) v. non-shift work (NSW, n 8945) based on self-report. Logistic regressions were used to examine the associations of LED and SW with diabetes, independently and jointly with stratification by age. LED was associated with higher odds of diabetes among workers aged < 45 years (OR, 1·51; 95 % CI, 1·05–2·19) but not among workers aged ≥ 45 years (OR, 0·98; 95 % CI, 0·79–1·20). SW was associated with higher odds of diabetes among both younger (OR, 1·28; 95 % CI, 0·88–1·85) and older workers (OR, 1·28; 95 % CI, 1·04–1·58). There was suggestive evidence that workers with both LED and SW had higher odds of diabetes compared with those with SED and NSW, but the association was stronger among younger (OR, 1·40; 95 % CI, 0·85–2·28) than older workers (OR, 1·28; 95 % CI, 0·99–1·66). LED and SW were independently associated with increased odds of diabetes with suggestive evidence on their joint associations, but associations varied by workers’ age.
Bystander cardiopulmonary resuscitation (CPR) has been shown to be associated with increased rates of survival from non-traumatic out-of-hospital cardiac arrest (OHCA). GoodSAM is a platform integrated into the computer-assisted dispatch system. The software allows the telecommunicator to send a link to the caller’s smart phone. Once activated, the telecommunicator can see and hear the patient, and obtain breathing and heart rates using the camera and microphone on the caller’s phone. The telecommunicator can use the platform to identify cardiac arrest and provide real-time compression feedback. It was hypothesized that telecommunicator use of video telecommunication would be associated with increased rates of pre-arrival CPR.
Methods:
This was a retrospective review of all cardiac arrest resuscitations performed from July 2021 through February 2022 in the San Antonio Fire Department (SAFD) Emergency Medical Services (EMS) system – the seventh largest city in the United States. Data source was the Office of the EMS Medical Director (OMD) Cardiac Arrest Registry. Inclusion criteria included cardiac arrests for which resuscitation was attempted. Exclusion criteria were cardiac arrest was witnessed by EMS personnel, or missing data. Dataset included: location of arrest, presumed etiology of the arrest, if dispatch CPR instructions were given; caller compliance; type of CPR performed; who witnessed the arrest; and who performed the CPR prior to EMS. Patients were dichotomized as to whether video telecommunication was used by the paramedic telecommunicator. A case was recorded as having received pre-arrival CPR if the initial CPR was performed by anyone other than the responding unit.
Results:
A total of 779 cases were included in the study. Primary outcome, in the cases where video telecommunication was utilized, 46/74 (62%) received pre-arrival CPR, versus 324/705 (46%) without the use of video telecommunication, with an overall difference of 16.2% (95% CI, 4.6% to 27.9%; P = .008). When using video telecommunication, a larger proportion of the persons performing pre-arrival CPR were family members when compared to the cases where video telecommunication was not used (35% versus 17%).
Conclusion:
Using video telecommunication to perform paramedic clinical dispatch telemedicine was associated with an increased rate of pre-arrival CPR. Further research will be required to show outcome-related results to determine if dispatch video and audio telemedicine can be used to increase survival in patients suffering OHCA.
The aim of this study was to investigate the effects of central vestibular dysfunction on physical functionality and cognitive function in individuals with multiple sclerosis (MS).
Methods:
Fifty-two fully ambulatory individuals with MS (Expanded Disability Status Scale [EDSS] ≤ 4) were included and divided into two groups: those with central vestibular involvement (Group 1; n = 25) and those without (Group 2; n = 27). Central vestibular involvement was assessed using videonystagmography. Physical and cognitive functions were evaluated in all participants using the Glittre Activities of Daily Living (ADL) test, Godin Leisure-Time Exercise Questionnaire (GLTEQ), and the physical dimension of the MSQoL-54 for physical functionality, and the BICAMS, Trail Making Test (TMT), Word List Generation test and the cognitive dimension of the MSQoL-54 for cognitive function.
Results:
According to the physical functionality assessment results, the time required to complete the Glittre ADL test was longer in group 1 than in group 2 (p = 0.01). The score for the physical dimension of the MSQoL-54 was lower in group 1 (p = 0.045). In the BICAMS Symbol Digit Modalities Test, Group 1 scored lower than Group 2 (p = 0.013). A significant difference between the groups was also observed in the time taken to complete the TMT (p = 0.017). Additionally, Group 1 exhibited lower scores on the cognitive dimension of the MSQoL-54 (p = 0.012).
Conclusion:
Physical functionality and specific cognitive domains differed between MS participants with and without central vestibular involvement. It should be considered that vestibular dysfunction may adversely impact cognitive and physical functionality, even in low-moderate disability level.
A short FFQ was developed for online assessment of adherence to the Dutch Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND-NL) diet, a culturally adapted version of the original American MIND diet. This study aimed to evaluate the relative validity of this short FFQ for assessing adherence to the MIND-NL diet, as scored by the MIND-NL score, compared with 3-d food records among community-dwelling older adults at risk of cognitive decline (n 1078; 67·4 (sd 4·6) years; 64 % female). A combination of statistical methods was used to assess the relative validity: presence of bias by Bland–Altman analysis; strength of association with Kendall’s Tau-b and Spearman correlation coefficients and levels of agreement with Wilcoxon signed rank test, cross-classification and weighted Kappa (κ) statistics. The Kendall’s Tau-b correlation for the MIND-NL score was 0·33 (95 % CI: 0·29, 0·37; de-attenuated Tau-b: 0·45). Individual MIND-NL diet component score correlations ranged from 0·05 to 0·56, with 12 out of 15 of the MIND-NL diet components adequately correlated (> 0·20). The average MIND-NL scores for the short FFQ (8·4 (sd 1·8) points) and food records (6·7 (sd 1·7) points) showed to be significantly different (P < 0·001). The Kappa (κ) coefficient for tertile classification of the MIND-NL score was 0·29 (95 % CI: 0·25, 0·33), indicating an acceptable level of agreement in ranking participants beyond chance. Acceptable agreements (κ > 0·20) were observed for 10 out of 15 MIND-NL diet components. Taking all analyses together, the short FFQ showed acceptable validity for ranking older adults at risk of cognitive decline according to their adherence to the MIND-NL diet.
We investigate the role of slippery boundaries, quantified by the Navier boundary friction coefficient $\beta$, in regulating heat transport and flow structures in rotating Rayleigh–Bénard convection. Owing to the Ekman pumping effect arising from viscous boundary layers that is intensified with increasing boundary friction, it is found that the properties of global heat transport exhibit two distinct parameter regimes separated by a transitional Rayleigh number ($ \textit{Ra}_t$). In the rotation-dominated regime ($ \textit{Ra} \lt \textit{Ra}_t$), enhanced viscous friction increases the efficiency of Ekman pumping, significantly elevating the Nusselt number and lowering the convection onset threshold. Conversely, in the buoyancy-dominated regime ($ \textit{Ra} \gt \textit{Ra}_t$), boundary-induced viscous dissipation suppresses convective motions, thereby reducing heat transport. Large-scale vortices (LSVs), prevalent under free-slip conditions, progressively dissipate as $\beta$ increases, revealing that viscous friction disrupts the inverse energy cascade from baroclinic to barotropic modes. Through kinetic energy partitioning analysis, the transition between quasi-two-dimensional and three-dimensional turbulent states is identified, with the parameter $\beta _{\textit{cr}}$ following a generic scaling relation on the Prandtl (Pr) and Ekman (Ek) numbers $\beta _{\textit{cr}}\sim \textit{Pr}^{-0.67}\textit{Ek}^{-1.18}$. This relation enables us to predict LSV emergence across different parameter spaces. Furthermore, it is reported that the heat-transport scaling exponent, the convection onset and the partitioning of kinetic energy between barotropic and baroclinic components undergo a smooth flow transition at $\beta _{\textit{cr}}$. These results also indicate a direct correlation between Ekman pumping efficacy and the friction coefficient $\beta$, demonstrating that controlling boundary friction can modulate global transport properties and reshape flow structures.
To advance understanding of the influence hill-slope and hill-shape have on neutrally stratified turbulent air flow over isolated forested hills, we interrogate four turbulence-resolving simulations. A spectrally friendly fringe technique enables the use of periodic boundary conditions to simulate flow over isolated two-dimensional (2D) and three-dimensional (3D) hills of cosine shape. The simulations target recently conducted wind tunnel (WT) experiments that are configured to fall outside the regimes for which current theory applies. Simulation skill for flow over isolated 3D hills is demonstrated through matching the canopy and hill configuration with the recently conducted WT experiments and comparing results. The response of the mean and turbulent flow components to 2D versus 3D hills along the hill-centreline are discussed. The phase and amplitude of spatially varying flow perturbations over forested hills are evaluated for flows outside the regime valid for current theory. Flow over isolated 2D forested hills produces larger amplitude vertical motions on a hill’s windward and leeward faces and the speed-up of the mean wind compared with that over isolated 3D forested hills at the hill-centreline. The 3D hills generate surface pressure minima over hill-crests that are only half the magnitude of those over 2D hills. The spatial region over which hill-induced negative pressure drag acts increases with increasing hill steepness. Assumptions in partitioning the flow into an upper layer with an inviscid response to the hill’s pressure field are robust and lead to solid predictions of hill-induced perturbations to the mean flow; however, applying those assumptions to predict the evolution of the turbulent moments only provides approximate explanations at best.
Noonan syndrome is characterised by typical facial features, short stature, CHDs, and other comorbidities, which are caused by germline mutations in genes coding for components of the Ras-mitogen-activated protein kinase pathway. Noonan syndrome is an inherited disease involving multiple systems, but ventricular arrhythmia in Noonan syndrome is rarely reported.
Case summary:
Here we report a 15-year-old patient with leucine zipperlike transcription regulator 1-associated Noonan syndrome, who has CHD (left ventricular hypertrophy with left ventricular outflow tract obstruction), ventricular arrhythmia, bundle branch block, pectus excavatum, costal eversion, scoliosis, myopia, growth retardation, hearing loss, chest tightness, and fatigue. Chest tightness and fatigue are the main reasons for admission of the patient. The patient was treated with spironolactone, empagliflozin, tolasemide, potassium chloride, and bisoprolol. One month after treatment, the patient has no more chest tightness or fatigue. Genetic testing revealed that the patient had a novel heterozygous variant c.313delT (p.trp105Glyfs * 42) mutation in the leucine zipperlike transcription regulator 1. We provide a review of the literature of leucine zipperlike transcription regulator 1 mutations and find that ventricular arrhythmias have been reported in leucine zipperlike transcription regulator 1-related Noonan syndrome.
Discussion:
Our findings expand on the Noonan syndrome phenotype and suggest that mutations in the leucine zipperlike transcription regulator 1 gene are involved in ventricular arrhythmia.
The sourcing of exotic raw materials provides a window into the social networks of ancient peoples. Here we source copper from four archaeological contexts at the Mound City Group, a UNESCO World Heritage site and major Hopewell ceremonial site in south-central Ohio, USA. Results of laser ablation–inductively coupled plasma–mass spectrometry indicate the use of copper at Mound City from both the Great Lakes Copper District and the southern Appalachians. Forty-two percent of the Mound City sample was classified as southern Appalachian copper, a higher percentage than for any other large Ohio Hopewell site tested. The use of Appalachian copper has not been documented in earlier, pre-Hopewell contexts in the central Ohio Valley. This new pattern correlates with both an increased demand for copper and the development of broader-based social networks connecting the central Ohio River Valley with the Southeast. This context is different from and complementary to that of the “copper trail” to the north established hundreds of years earlier.