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Despite over 50 years of advocacy and policymaking toward deinstitutionalization, residential institutions for people labelled with intellectual and developmental disabilities (IDD) remain operational in six Canadian provinces. In addition, the lack of public, community-based housing has led to contemporary housing models that represent the re- or trans-institutionalization of labelled people. This article asks: why does the institutionalization of people labelled with IDD still occur in Canada? We argue that institutionalization is propelled by a policy legacy of systemic ableism that is manifested in three pervasive logics, which “haunt” the public provision of IDD housing: exclusion, elimination, and extraction. Empirical support is drawn from textual analysis and interviews with policymakers, advocates and people labelled with IDD in two Canadian provinces (Ontario and Nova Scotia). We conclude by discussing the interrelation of institutionalization and systemic ableism and presenting implications for counteracting ableism in Canadian IDD housing policy.
Maintaining high-complexity aircraft requires resilient and data-driven maintenance planning. This article presents the efficient task allocation and packing problem solver (ETTAPS), a novel framework that integrates predictive analytics and optimisation models to generate adaptive maintenance schedules. ETTAPS employs a trial-and-error approach to optimise maintenance intervals, leveraging a branch-and-cut solver combined with first-fit decreasing (FFD) task grouping to minimise costs and enhance aircraft availability. Additionally, a random forest model, retrained using a rolling 24-month data window, continuously refines predictions, leading to progressive cost reductions and improved system reliability over multiple maintenance cycles. Our results demonstrate that ETTAPS significantly reduces maintenance costs and increases aircraft availability by efficiently grouping tasks and incorporating real-world constraints, such as mechanic skill levels, task dependencies and resource limitations. The framework addresses key gaps in MSG-3 and certification analysis, improving task scheduling efficiency and ensuring long-term operational resilience. Furthermore, ETTAPS lays the groundwork for integration with digital twins, real-time anomaly detection and flight planning systems, supporting a more intelligent and proactive approach to aircraft maintenance. This research advances resilience and sustainable aviation maintenance planning by optimising costs, reducing downtime and proactively adapting to operational demands. By aligning with Industry 4.0 and aviation sustainability goals for 2050, ETTAPS contributes to the next generation of intelligent maintenance systems.
The settling of highly elastic non-Brownian closed fibres (called loops) under gravity in a viscous fluid is investigated numerically. The loops are represented using a bead–spring model with harmonic bending potential and finitely extensible nonlinear elastic stretching potential. Numerical solutions to the Stokes equations are obtained with the use of HYDROMULTIPOLE numerical codes, which are based on the multipole method corrected for lubrication to calculate hydrodynamic interactions between spherical particles with high precision. Depending on the elasto-gravitation number $B$, a ratio of gravitation to bending forces, the loop approaches different attracting dynamical modes, as described by Gruziel-Słomka et al. (2019 Soft Matt.15, 7262–7274) with the use of the Rotne–Prager mobility of the elastic loop made of beads. Here, using a more precise method, we find and characterise a new mode, analyse typical time scales, velocities and orientations of all the modes, compare them and investigate their coexistence. We analyse numerically the transitions (bifurcations) to a different mode at certain critical values of the elasto-gravitation number.
Using US quarterly data (1967–2023), including inflation’s post-pandemic surge and decline alongside monetary policies characterized by quantitative easing before refocusing on the 2% target, we utilize traditional and novel econometric tools to assess the stability of key macroeconomic variables’ responses to monetary shocks. Our findings confirm the relevance of a broad Divisia aggregate in understanding monetary policy transmission and highlight its empirical importance in explaining output and price dynamics across decades. Time-varying impulse response functions (IRFs) reveal consistent and puzzle-free price responses to Divisia-based monetary shocks throughout the sample, aligning with theory. Time-varying IRFs indicate that pandemic-related outliers in GDP (2020Q2) do not disrupt results. In contrast, Fed Funds rate or shadow policy interest rate shocks often yield puzzling outcomes across earlier and extended periods.
The fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), is a highly destructive polyvorous pest with a wide host range and the ability to feed continuously with seasonal changes. This destructive pest significantly damages crops and can also utilize non-agricultural plants, such as weeds, as alternative hosts. However, the adaptation mechanisms of S. frugiperda when switching between crop and non-crop hosts remain poorly understood, posing challenges for effective monitoring and integrated pest management strategies. Therefore, this study aims to elucidate the adaptability of S. frugiperda to different host plants. Results showed that corn (Zea mays L.) was more suitable for the growth and development of S. frugiperda than wheat (Triticum aestivum L.) and goosegrass (Eleusine indica). Transcriptome analysis identified 699 genes differentially expressed when fed on corn, wheat, and goosegrass. The analysis indicated that the detoxification metabolic pathway may be related to host adaptability. We identified only one SfGSTs2 gene within the GST family and investigated its functional role across different developmental stages and tissues by analysing its spatial and temporal expression patterns. The SfGSTs2 gene expression in the midgut of larvae significantly decreased following RNA interference. Further, the dsRNA-fed larvae exhibited a decreased detoxification ability, higher mortality, and reduced larval weight. The findings highlight the crucial role of SfGSTs2 in host plant adaptation. Evaluating the feeding preferences of S. frugiperda is significant for controlling important agricultural pests.
The settling dynamics of finite size, slightly heavier-than-fluid Kolmogorov-scale particles in homogeneous, isotropic turbulence at moderate volume loadings is investigated. A thoroughly validated two-way-coupled, point-particle model based on the complete Maxey–Riley–Gatignol equation of motion is used with closure models for all forces, including the history force, together with corrections for the self-disturbance field created by the particle using a novel zonal-advection-diffusion-reaction method. Settling dynamics is investigated by varying turbulence intensities relative to the particle settling speed in quiescent flow for multiple Stokes numbers. The length scales associated with the turbulence structures that strongly interact with and influence the settling dynamics are investigated using multiscale statistical analysis of the fluid velocity and second invariant of the velocity gradient tensors sampled by the particles. The time scales are investigated using trajectory curvature angle statistics of inertial and fluid particles. Low-to-moderate Stokes number particles tend to sample strain-rate dominated regions of the flow, tend to follow the curvature of the flow paths and show enhanced settling at higher turbulence intensities due to fast tracking and preferential sampling. Higher Stokes number particles, on the other hand, have a tendency to travel in straight lines relative to the flow and result in reduced settling speeds due to loitering. For the low mass loadings considered in this work, there is minimal global effect on the turbulent flow characteristics; however, it is found that the Kolmogorov-scale particles interact with and locally modify flow structures approximately twice their size, whereas they sample flow velocities from scales up to ten times the particle size, influencing preferential sampling and settling characteristics.
Since the 1979 Islamic Revolution, the Shiʿi theocratic state in Iran has occasionally prioritized state interests over traditional shariʿa rulings. This dynamic is best understood through the lens of the principle of maslahat (variously translated as “public good” or “the interests of the state), which has played a central role in guiding strategic state decisions. By invoking maslahat, the state has justified the modification or suspension of certain shariʿa prescriptions in pursuit of broader political and social objectives. These objectives, primarily safeguarding the Shiʿi theocratic order (hefz-e nezām) and protecting the religion from defamation (vahn-e din), were key tenets articulated by Ayatollah Khomeini and remain foundational to the state's governance. This pragmatic utilization of maslahat has enabled the Shiʿi theocratic state to adapt its legal framework to meet contemporary challenges while ostensibly adhering to shariʿa principles. Notable examples of this adaptability include reforms such as the equalization of blood money for religious minorities and the imposition of moratoriums on stoning executions. However, the inherently subjective nature of maslahat raises concerns about potential arbitrariness and misuse, prompting debates among Shiʿi jurists regarding its legitimacy and scope. This study offers a comprehensive analysis of maslahat within Iran's legal system, exploring its mechanisms, applications, and implications, and highlighting its complex role in both advancing and potentially challenging the principles of Islamic law.
Capsules are widely used in bioengineering, chemical engineering and industry. The development of drug delivery systems using deformable capsules is progressing, yet the regulation of drug release within a capsule remains a challenge. Meanwhile, a microswimmer enclosed in a capsule can generate a large lubrication force on the capsule membrane, which could result in deformation and mechanical damage to the membrane. In this study, we numerically investigate how a capsule can be damaged by an enclosed microswimmer. The capsule membrane is modelled as a two-dimensional neo-Hookean material, with its deformability parametrised by capillary number. An isotropic brittle damage model is applied to express membrane rupture, with the Lighthill–Blake squirmer serving as the microswimmer model. In a sufficiently small capillary number regime, pusher-type squirmers exhibit stable swimming along the capsule membrane, while neutral-type and puller-type squirmers exhibit swimming towards the membrane and remain stationary. As capillary number increases, the damage to the membrane increases and rupture occurs in all swimming modes. For pusher-type squirmers, the critical capillary number leading to rupture is dependent on the initial incidence angle, whereas neutral-type and puller-type squirmers are independent of the initial value. Furthermore, we present methods for controlling membrane damage by magnetically orienting the microswimmer. The findings reveal that a static magnetic field can orient the microswimmer, leading to membrane damage and rupture even for a capsule that cannot be damaged by free swimming, while controlling the swimming path with a rotating magnetic field enables soft membranes to maintain deformation without rupture.
Plague and famine are two of the worst killers in human history. Both struck the Czech lands in the Middle Ages not long after each other (the famine of 1318 CE and the plague of 1348–1350 CE). The aim of our study was to try to relate the mass graves found in the vicinity of the Chapel of All Saints with an ossuary in the Kutná Hora–Sedlec site to these two specific events. For this purpose, we used stratigraphic and archaeological data, radiocarbon dating, and Bayesian modeling of 172 calibrated AMS ages obtained from teeth and bones of 86 individuals buried in the mass graves. Based on the stratigraphic and archaeological data, five mass graves were interpreted as famine graves and eight mass graves were interpreted as plague graves. Using these data and the calibration of the radiocarbon results of the tooth-bone pairs of each individual, we constructed the Bayesian model to interpret the remaining mass graves for which no contextual information was available (eight mass graves). In terms of Bayesian model results, the model fits stratigraphic data in 23 out of 34 cases and in all seven cases based on calibration data. To validate the model results on archaeologically and stratigraphically uninterpreted data, ancient DNA analysis is required to identify Yersinia pestis.
Regret risk is not consistently part of information sharing within informed consent. Yet two kinds of decisions that often invoke concerns about future regret, abortion and sterilization, raise considerations for the role of regret in clinical decision-making and informed consent, particularly regarding decisions about potentially transformative experiences. We distinguish between first-personal and second-personal anticipatory regret and argue that first-personal anticipatory regret can play a productive role, but second-personal anticipatory regret can function in ways that are pernicious. Introducing second-personal anticipatory regret into medical informed consent processes is, we argue, not only not required for informed medical decision-making, but impermissible within the clinical encounter. This view has broader implications for medical decision-making about potentially transformative experiences, and for empirical research on regret regarding healthcare decisions.
Human language is increasingly written rather than just spoken, primarily due to the proliferation of digital technology in modern life. This trend has enabled the creation of generative artificial intelligence (AI) trained on corpora containing trillions of words extracted from text on the internet. However, current language theory inadequately addresses digital text communication’s unique characteristics and constraints. This paper systematically analyzes and synthesizes existing literature to map the theoretical landscape of digitized language. The evidence demonstrates that, parallel to spoken language, features of written communication are frequently correlated with the socially constructed demographic identities of writers, a phenomenon we refer to as “digital accents.” This conceptualization raises complex ontological questions about the nature of digital text and its relationship to social identity. The same line of questioning, in conjunction with recent research, shows how generative AI systematically fails to capture the breadth of expression observed in human writing, an outcome we call “homogeneity-by-design.” By approaching text-based language from this theoretical framework while acknowledging its inherent limitations, social scientists studying language can strengthen their critical analysis of AI systems and contribute meaningful insights to their development and improvement.
The flow-induced oscillations of a clamped flexible ring in a uniform flow were explored using the penalty immersed boundary method. Both inverted and conventional ring configurations were examined, with systematic analysis focused on the effects of bending rigidity and eccentricity. Four distinct oscillation modes were identified across parameter variations: flapping (F), deflected oscillation (DO), transverse oscillation (TO) and equilibrium (E) modes. Each mode exhibited a 2S wake pattern. The inverted ring sustained the DO mode under low bending rigidity with a deflected shape, transitioning to the TO mode at higher bending rigidity. In the TO mode, a lock-in phenomenon emerged, enabling the inverted ring to achieve a high power coefficient due to a simultaneous rise in both oscillation amplitude and frequency. By contrast, the conventional ring exhibited the F mode at low bending rigidity and transitioned to the E mode as rigidity increased, although its power coefficient remained lower because of reduced critical bending rigidity. For the inverted ring, low eccentricity enhanced oscillation intensity but limited the operational range of the TO mode. In contrast, for the conventional ring, reducing eccentricity led to an increase in oscillation amplitude. Among the investigated configurations, the inverted-clamped ring achieved the highest energy-harvesting efficiency, surpassing those of the conventional clamped ring and a buckled filament.
The work investigates the response dynamics of non-premixed jet flames to blast waves that are incident along the jet axis. In the present study, blast waves, generated using the wire-explosion technique, are forced to sweep across a non-premixed jet flame that is stabilised over a nozzle rim positioned at a distance of 264 mm from the source of the blast waves. The work spans a wide range of fuel-jet Reynolds numbers ($Re$; ranging from 267 to 800) and incident blast-wave Mach numbers ($M_{s,r}$; ranging from 1.025 to 1.075). The interaction imposes a characteristic flow field over the jet flame marked by a sharp discontinuity followed by a decaying profile and a delayed second spike. The second spike in the flow field profile corresponds to the induced flow that follows the blast front. While the response of the flame to the blast front was minimal, it was found to detach from the nozzle rim and lift off following the interaction with the induced flow. Subsequently, the lifted flame was found to reattach back at the nozzle or extinguish, contingent on the operating $Re$ and $M_{s,r}$. Alongside flame lift-off, flame-tip flickering was aggravated under the influence of the induced flow. A simplified theoretical model extending the vorticity transport equation was developed to estimate the change in flickering time scales and length scales owing to the interaction with the induced flow. The observed experimental trends were further compared against theoretical predictions from the model.
In 1921 the international Red Cross movement passed a series of resolutions declaring they had a right and duty to intervene in civil wars, ‘social and revolutionary troubles’. This article focuses on the specific historical origins of the resolutions. It argues that these resolutions were a direct response to the Russian Civil War and designed to enable humanitarian interventions against Soviet Russia and other communist revolutionaries. The ICRC followed through on these intentions with robust efforts to access political prisoners in Soviet Russia. However, other parties embraced these resolutions and applied them to nationalist and anti-colonial struggles, such as the Third Silesian Uprising, Irish Civil War and Rif War. These conflicts did not fit the template of the Russian Civil War, leading to reluctant, cautious and often ineffective interventions by the ICRC. The open-ended language of the resolutions hid a much more direct historical context that restricted its viable application.
Obesity pathophysiological conditions and obesogenic diet compounds may influence brain function and structure and, ultimately, cognitive processes. Animal models of diet-induced obesity suggest that long-term dietary high fat and/or high sugar may compromise cognitive performance through concomitant peripheral and central disturbances. Some indicated mechanisms underlying this relationship are discussed here: adiposity, dyslipidaemia, inflammatory and oxidative status, insulin resistance, hormonal imbalance, altered gut microbiota and integrity, blood–brain barrier dysfunction, apoptosis/autophagy dysregulation, mitochondrial dysfunction, vascular disturbances, cerebral protein aggregates, impaired neuroplasticity, abnormal neuronal network activity and neuronal loss. Mechanistic insights are vital for identifying potential preventive and therapeutic targets. In this sense, flavonoids have gained attention due to their abundant presence in vegetable and other natural sources, their comparatively negligible adverse effects and their capacity to cross the blood–brain barrier promptly. In recent years, interventions with flavonoid sources have proven to be efficient in restoring cognitive impairment related to obesity. Its modulatory effects occur directly and indirectly into the brain, and three fronts of action are highlighted here: (1) restoring physiological processes altered in obesity; (2) promoting additional neuroprotection to the endogenous system; and (3) improving neuroplasticity mechanisms that improve cognitive performance itself. Therefore, flavonoid consumption is a promising alternative tool for managing brain health and obesity-related cognitive impairment.
This article examines the challenges Indigenous communities face in safeguarding their intangible cultural heritage (ICH) in the digital age, using two case studies. Referring to the Te Hiku Media case, it analyzes the threat of data colonialism posed by corporate digitization projects. The article argues that existing legal frameworks provide limited protection for Indigenous ICH, prompting Indigenous communities to develop the innovative theory of Indigenous data sovereignty (ID-SOV). The Government of Nunavut–Microsoft partnership case highlights the benefits and drawbacks of public–private partnerships (PPPs) for Indigenous ICH. Key takeaways from both cases’ analysis lead to our proposal of integrating ID-SOV principles into PPPs to limit data colonialism risks and improve the sustainability of Indigenous ICH digitization projects. The article contends that implementing ID-SOV principles by design and by default in PPPs can empower Indigenous communities while leveraging the oversight of public actors and resources of private partners to safeguard Indigenous ICH through digital tools.
Healthcare-prescribed opioids are a known contributor to the opioid epidemic. Locally, there was an identified opportunity to improve opioid prescribing practices in cardiac surgical patients. The cardiac surgical team sought to standardise prescribing practices in postoperative patients and reduce opioid prescriptions at discharge. The improvement was undertaken at a large midwestern freestanding children’s hospital with over 400 beds and 120 cardiac surgeries annually. A multidisciplinary team was formed, using the model for Improvement to guide the improvement work. The key improvement interventions included standardised evidence-based prescribing guidelines based patient age and surgical approach, enhanced pain management with non-opioid medications, and integration of prescribing guidelines into the electronic health record. The primary outcome measure was rate of compliance with the prescribing guidelines and secondary measures included morphine equivalent dosing at discharge, opioid-free discharge, and length of stay. A balancing measure of opioid re-prescriptions was tracked. There were 289 patients included in the primary study period (January 2019 through December 2021). Sustainability of key outcomes was tracked though December 2022. The guideline compliance increased from 24% to 100%. The morphine equivalent dosing decreased to 22.5 in 2021 then 0 in 2022, from baseline of 36.25 in 2019. Opioid-free discharges decreased from 8% (2019) to 1.5% (2021) and 0% in 2022. Establishment and compliance with standardised guidelines for post-operative cardiac surgical pain management yielded a reduction in morphine equivalent dosing, an increase opioid-free discharges, and no increase in length of stay or opioid re-prescriptions.
When unexploded ordnance (UXO) is embedded in the body, the effect of explosive weapons used in conflict is amplified. Though relatively rare, such events present potentially devastating consequences for the patient and medical providers as routine diagnostic and therapeutic procedures hold potential to initiate detonation of the embedded UXO (eUXO). The objective is to identify and synthesize available literature relating to the management of eUXO in low resource settings.
Methods
A scoping review was conducted using PRISMA-ScR methodology to evaluate literature in all languages from all date ranges until January 31, 2024, discussing the management of casualties with eUXO, including types of ordnance, injury patterns, diagnostics, resource utilization, surgical interventions, and outcomes.
Results
Search strings identified 3,425 records. After title and abstract screening 3,397 were excluded yielding 18 for full text screening of which 5 were excluded. Therefore 13 reports were included in analysis. Data variable reporting was heterogeneous but themes and subthemes regarding safety, planning and communication emerged.
Conclusions
A scoping review was conducted to identify gaps in existing literature on the management of eUXO in low resource settings. Coordinated engagement from personnel representing a variety of clinical and non-clinical specialties is required to safely manage eUXO.