This meta-analysis assesses the relationship between vitamin D supplementation and incidence of major adverse cardiovascular events (MACE). PubMed, Web of science, Ovid, Cochrane Library and Clinical Trials were used to systematically search from their inception until July 2024. Hazard ratios (HR) and 95 % CI were employed to assess the association between vitamin D supplementation and MACE. This analysis included five randomised controlled trials (RCT). Pooled results showed no significant difference in the incidence of MACE (HR: 0·96; P = 0·77) and expanded MACE (HR: 0·96; P = 0·77) between the vitamin D intervention group and the control group. Further, the vitamin D intervention group had a lower incidence of myocardial infarction (MI), but the difference was not statistically significant (HR: 0·88, 95 % CI: 0·77, 1·01; P = 0·061); nevertheless, vitamin D supplementation had no effect on the reduced incidence of stroke (P = 0·675) or cardiovascular death (P = 0·422). Among males (P = 0·109) and females (P = 0·468), vitamin D supplementation had no effect on the reduced incidence of MACE. For participants with a BMI < 25 kg/m2, the difference was not statistically significant (P = 0·782); notably, the vitamin D intervention group had a lower incidence of MACE for those with BMI ≥ 25 kg/m2 (HR: 0·91, 95 % CI: 0·83, 1·00; P = 0·055). Vitamin D supplementation did not significantly contribute to the risk reduction of MACE, stroke and cardiovascular death in the general population, but may be helpful for MI. Notably, the effect of vitamin D supplementation for MACE was influenced by BMI. Overweight/obese people should be advised to take vitamin D to reduce the incidence of MACE.

Hydrothermal vents are known to host unique faunal assemblages supported by chemosynthetic production; however, the fauna associated with inactive sulphide ecosystems remain largely uncharacterised across the global seafloor. In November 2023, a six-rayed starfish was collected from the Semenov hydrothermal field on the Mid-Atlantic Ridge. A combination of morphological and molecular methods has confirmed the identity of this species as Paulasterias mcclaini Mah et al. 2015 (Forcipulatida: Paulasteriidae), providing the first validated record of this family in the Atlantic Ocean. We present an updated morphological description of the species, alongside phylogenetic analysis of the COI, 16S, 12S, and H3 genetic markers. The biogeography of the family is discussed, and previously published records amended.

In experimental social science, precise treatment effect estimation is of utmost importance, and researchers can make design choices to increase precision. Specifically, block-randomized and pre-post designs are promoted as effective means to increase precision. However, implementing these designs requires pre-treatment covariates, and collecting this information may decrease sample sizes, which in and of itself harms precision. Therefore, despite the literature’s recommendation to use block-randomized and pre-post designs, it remains unclear when to expect these designs to increase precision in applied settings. We use real-world data to demonstrate a counterintuitive result: precision gains from block-randomized or pre-post designs can withstand significant sample loss that may arise during implementation. Our findings underscore the importance of incorporating researchers’ practical concerns into existing experimental design advice.

This study examined whether supplementation with collagen peptides (CP) affects appetite and post-exercise energy intake in healthy active females. In this randomised, double-blind cross-over study, fifteen healthy females (23 (sd 3) years) consumed 15 g/d of CP or a taste matched non-energy control (CON) for 7 d. On day 7, participants cycled for 45 min at ∼55 % Wmax, before consuming the final supplement. Sixty-min post supplementation an ad libitum meal was provided, and energy intake recorded. Subjective appetite sensations were measured daily for 6 d (pre- and 30 min post-supplement) and pre (0 min) to 280 min post-exercise on day 7. Blood glucose and hormone concentrations (total ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY), cholecystokinin (CCK), dipeptidyl peptidase-4 (sDPP-4), leptin, and insulin) were measured fasted at baseline (day 0), then pre-breakfast (0 min), post-exercise (100 min), post-supplement (115, 130, 145, 160 min) and post-meal (220, 280 min) on day 7. Ad libitum energy intake was ∼10 % (∼41 kcal) lower in the CP trial (P = 0·037). There was no difference in gastrointestinal symptoms or subjective appetite sensations throughout the trial (P ≥ 0·412). Total plasma GLP-1 (AUC, CON: 6369 (sd 2330); CP: 9064 (sd 3021) pmol/l; P < 0·001) and insulin (+80 % at peak) were higher after CP (P < 0·001). Plasma ghrelin and leptin were lower in CP (condition effect; P ≤ 0·032). PYY, CCK and glucose were not different between CP and placebo (P ≥ 0·100). CP supplementation following exercise increased GLP-1 and insulin concentrations and reduced ad libitum energy intake at a subsequent meal in physically active females.

We analyze the effects of limited investor attention on the stock market reaction to innovation announcements and develop a new measure of patents’ economic value. We hypothesize that, when some investors pay delayed attention to innovation announcements, there will be a post-announcement drift in addition to the announcement effect, with the former decreasing and the latter increasing in investor attention. Using media coverage and abnormal Google search volume as investor attention proxies, we find consistent evidence. Our new attention-weighted measure of patents’ economic value has greater predictive power for future firm performance than measures based on the announcement effect alone.

In this article, we study the Johnson homomorphisms of basis-conjugating automorphism groups of free groups. We construct obstructions for the surjectivity of the Johnson homomorphisms. By using it, we determine their cokernels of degree up to four and give further observations for degree greater than four. As applications, we give the affirmative answer to the Andreadakis problem for the basis-conjugating automorphism groups of free groups at degree four. Moreover, we calculate twisted first cohomology groups of the braid-permutation automorphism groups of free groups.

This study explores the relationships between board internationalization, board size, and strategic change of firms from emerging markets. Building upon resource dependency theory (RDT), this study proposes that board internationalization has a positive impact on strategic change. A higher level of nationality heterogeneity on the board of directors, an organization receives more diverse perspectives and experiences from foreign directors. This, in turn, influences firms to identify areas of improvement and engage in strategic change. In addition, conventional wisdom suggests that board size per se has a negative relationship with strategic change. However, this study proposes that large board sizes together with board internationalization can foster strategic change. In other words, board size and board internationalization can jointly counteract the inertial nature of a large board, resulting in strategic change. The analyses of 255 publicly listed firms from nine emerging countries for the 2013–2018 financial years confirm these predictions.

This paper tests for the cyclical implications of the external constraint in Argentina from 1930 to 2018, and investigates the responses of GDP, real wages, trade balance, and external debt to external trade shocks using a recursive vector-autoregressive model. Moreover, considering the shift in development strategy in 1976, marked by the transition from state-led industrialization to deregulation and trade openness, changes in external vulnerability are analyzed.

Results confirm a trade balance bottleneck hindering future growth, and that external debt fails to spur short-term growth or improve the purchasing power of the population, thereby confirming the vicious cyclical dynamics of stop-and-go and go-and-crash for the entire period. Also, real external vulnerability grew significantly after 1976, as evidenced by the fact that the cumulative impact of movements in the terms of trade and external demand rose from explaining 30% to 43% of GDP variation.

Given any finite collection $\mathcal {G}$ of translation-invariant linear equations of the form

$$ \begin{align*} \sum_{i=1}^{v} m_i x_i = m_0 x_0, \end{align*} $$

where $(m_0, m_1, \ldots , m_v) \in \mathbb {N}^{v+1}$, $m_0 = \sum _{i=1}^{v} m_i$ and $v \ge 2$, we estimate lower and upper bounds of the supremum of the Hausdorff dimension of sets on the real line that uniformly avoid nontrivial zeros of any f in $\mathcal {G}$.

People from different ethnic minorities in the UK are experiencing a steeper increase in dementia diagnosis compared to their white counterparts but are more likely to have a higher risk of dementia, to be diagnosed at a younger age and to die earlier from the condition. These disparities suggest the need for urgent interventions to prevent and reduce dementia risk. Despite the significant presence of Chinese people in the UK, there has been little dementia research involving them, so this study is the first in the UK to focus on Chinese communities living in five major cities. Using a cultural adaptation theoretical framework, we adapted Alzheimer’s Research UK’s virtual dementia prevention campaign Think Brain Health to meet the needs of Chinese people. We used a mixed methods approach to evaluate knowledge of dementia and brain health activities, and intention regarding help-seeking. We performed descriptive, chi-square and thematic analysis; 54 Chinese people completed the intervention, with 85 per cent aged over 60 years. Over half (56%) could not speak, read or write in English. Our results showed significant improvements in knowledge of dementia and brain health, and an improved intention to seek help and information. All participants reported a positive experience of the culturally tailored intervention and valued working with dementia researchers who were able to deliver the intervention in Chinese languages. Future work involving Chinese communities in the UK will need to identify an appropriate but non-stigmatizing Chinese term for dementia.