This study evaluated the effect of green tea extract and metformin and its interaction on markers of oxidative stress and inflammation in overweight women with insulin resistance. After screening, 120 women were randomly allocated in 4 groups: Placebo (PC): 1g of microcrystalline cellulose/day; Green tea (GT): 1 g (558 mg polyphenols) of standardized dry extract of green tea/day and 1 g of placebo/day; Metformin (MF): 1 g of metformin/day and 1 g of placebo/day; Green Tea and Metformin (GTMF): 1 g (558 mg polyphenols) and 1 g of metformin/day. All groups were followed-up for 12 weeks with assessment of oxidative damage to lipids and proteins, specific activity of antioxidant enzymes and inflammatory cytokine serum levels. The association of green tea with metformin significantly reduced IL-6 (GTMF: –29.7((–62.6)–20.2))(p = 0.004). Green tea and metformin isolated reduced TNF-α (GT: –12.1((–18.0)–(–3.5)); MF: –24.5((–38.60)–(–4.4)) compared to placebo (PB: 13.8 (1.2–29.2))(P < 0.001). Also, isolated metformin reduced TGF-β (MF: –25.1((–64.4)–0.04)) in comparison to placebo (PB: 6.3((–1.0)–16.3))(p = 0.038). However, when combined, their effects were nullified either for TNF-α (GTMF: 6.0((–5.7)–23.9) and for TGF-β (GTMF: –1.8((–32.1)–8.5). This study showed that there is a drug-nutrient interaction between green tea and metformin that is dependent on the cytokine analyzed.

In the absence of a treaty protocol or verification regime, the Biological and Toxin Weapons Convention (BWC) instituted confidence-building measures (CBMs) as a mechanism to increase confidence in compliance by enhancing transparency and mitigating ambiguities regarding states parties’ biological activities. While a promising tool to support treaty compliance, low participation, concerns regarding the completeness and accuracy of CBM submissions, a dearth of analysis, and restricted access to many submissions have limited CBMs’ value. Through interviews with 53 international experts—38 from BWC delegations and 15 independent experts—we identified concrete opportunities to increase CBMs’ value while mitigating the burden on states parties. This study supports states parties’ efforts in the BWC Working Group on the Strengthening of the Convention, as part of a series of research on BWC assurance that aims to characterize challenges around BWC verification and increase certainty in BWC compliance.

In the aftermath of the atomic bombings of Hiroshima and Nagasaki and under the growing threat of planetary cataclysm, an array of prominent intellectuals grappled with the significance of nuclear war for the human condition and reflected upon the possibilities of escaping its peril. Following on the early interventions of Albert Camus and Jean-Paul Sartre, the collected thoughts of Karl Jaspers, Hans Morgenthau, and Günther Anders outline a philosophical current of ‘nuclear existentialism’ preoccupied with the nihilistic ‘being-towards-species-death’ entailed by the advent of the Bomb. Faced with the apparent negation of reason in bringing about the means of its own destruction through the scientific piercing of nature’s innermost workings, the nuclear existentialists end up reaffirming, however precariously, a teleological conception of history in which the apocalyptic fear of the Bomb figures as the necessary condition for the ultimate realisation of human freedom. In the light of the contemporary resurgence of nuclear anxiety, this article surveys and critically assesses the corpus of nuclear existentialism, drawing upon the distinctive existential phenomenology of Emmanuel Levinas to trace a potential alternative for thinking life and death under the Bomb.

Fostering employees’ innovative work behavior (EIB) has become one of the most important tasks of leaders. Although numerous studies have investigated the relationship between leadership and EIB, it is still unclear which specific leader behaviors promote EIB. Previous research has focused on leadership in terms of broad, non-innovation-specific leadership styles. Behavioral sub-factors have been neglected, and prioritization according to the importance of individual behaviors is still lacking. To address these issues, we identify innovation-specific leader behaviors and analyze which behaviors are best suited to increase EIB. To explain the relationship between the respective leader behaviors and EIB, we rely on the Ability–Motivation–Opportunity (AMO) framework and distinguish between ability-enhancing, motivation-enhancing, and opportunity-enhancing leadership behaviors. Our empirical analyzes are based on data from 1214 German employees. Our findings reveal that motivation- and opportunity-enhancing leadership behaviors foster EIB, with certain innovation-specific behaviors being particularly important for EIB. Building on our results, we provide guidelines for innovation-specific leadership.

The oversight of Chinese feminist traditions in transnational feminist discourse is remarkable given China’s historical importance and vast population. Despite historical suppression by Confucianism, Chinese feminisms emerged at the turn of the last century, drawing from Marxist, anarchist, and liberal movements. While scholars increasingly recognize overlooked female thinkers like Ban Zhao, contemporary discussions of China often revolve around reconciling Confucianism and feminism. This tendency underscores the perception of Chinese feminism as a derivative of Western feminism, where modern thinkers reject local culture for transnational movements. This paper contends that Chinese feminists, including Kang Youwei and He-Yin Zhen, remained deeply rooted in their traditions. While Kang incorporated foreign ideas to advocate for feminist goals and modernize society, he predominantly engaged with traditional philosophy to address its sexist elements. Similarly, He-Yin’s anarcho-feminist approach integrated Western influences to engage with traditional Chinese thought rather than rejecting it outright. By examining prevalent gender and selfhood concepts in traditional Chinese thought, this paper elucidates the notion of “correlative sexism,” and argues that women were not primarily regarded as a “second sex” as described by Simone de Beauvoir. The paper then demonstrates how Kang and He-Yin responded to this sexist discourse, offering novel perspectives on women’s liberation and societal reform.

Delirium frequently occurs among hospital in-patients, with significant attributable healthcare costs. It is associated with long-term adverse outcomes, including an eightfold increased risk of subsequent dementia. The purpose of this article is to inform clinicians of the best practices for spotting, stopping and treating delirium and provide guidance on common challenging clinical dilemmas. For spotting delirium, suggested screening tools are the 4 ‘A's Test (in general medical settings) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Prevention is best achieved with multicomponent interventions and targeted strategies focusing on: (a) avoiding iatrogenic causes; (b) brain optimisation by ensuring smooth bodily functioning; (c) maintaining social interactions and normality. Non-pharmacological approaches are the first line for treatment; they largely mirror prevention strategies, but the focus of empirical evidence is on prevention. Although sufficient evidence is lacking for most pharmacological approaches, an antipsychotic at low doses for short durations may be of utility for highly distressing or high-risk situations, particularly in hyperactive delirium, but only as a last resort.

This research challenges the conventional wisdom that value-driven protests in China are exceedingly rare and face harsh state repression. Drawing on a hand-coded, multi-source dataset of over 3,100 protests in three Chinese megacities from 2014 to 2016, we identify 67 protests that reveal a hitherto unknown underbelly of everyday, value-driven contention. Qualitatively, we identify three main forms of contentious performances. Quantitatively, we show how value-driven protesters combine non-disruptive tactics with ambitious targets and virtually never extract concessions. Surprisingly, we find that such protests are less often policed and repressed than other protests. They are also never met with violence from non-state actors. We provide three interpretations for the counter-intuitive finding on repression. This study shows that the Chinese state coexists with a non-negligible amount of explicitly regime-critical contention. It adopts a containment strategy, tolerating a certain extent of value-driven performances when the risk of spill-over into wider society is limited.

Rectifying the imbalance of theorisation of education expansion focusing on its benefits, this study examines the relationship between education expansion and income inequality by turning our attention to its risky aspects. We investigate how expanding education might not effectively mitigate income inequality, because it brings about costly and risky competition for the positional value of education. We consider welfare regimes as relevant institutional factors associated with educational positionality based on the similarities between two environmental conditions that make education positional and two underlying dimensions of welfare regimes (de-stratification and commodification). We analysed higher education cases in twenty-four to twenty-five developed countries from 2000 to 2020. Our results show that higher education expansion initially reduced income inequality, but the reducing effect was attenuated, and eventually, it increased income inequality when higher education was positional, corresponding to the countries with a liberal regime and two East Asian countries such as Japan and Korea.

Saccharin is a widely used sugar substitute, but little is known about the long-term health effects of saccharin intake. Our study aimed to examine the association between saccharin intake and mortality in diabetic and pre-diabetic population and overweight population from NHANES 1988–1994. Cox proportional hazard models were used to evaluate the association between saccharin intake and CVD, cancer and all-cause mortality. After multivariable adjustment, increased absolute saccharin intake was associated with the risk of all-cause mortality (hazard ratio (HR): 1·41, 95 % CI: 1·05, 1·90), CVD mortality (HR: 1·93, 95 % CI: 1·15, 3·25) and cancer mortality (HR: 2·26, 95 % CI: 1·10, 4·45) in diabetic and pre-diabetic population. Among overweight population, higher absolute saccharin intake was associated with the risk of cancer mortality (HR: 7·369, 95 % CI: 2·122, 25·592). Replacing absolute saccharin intake with total sugar significantly reduced all-cause mortality by 12·5 % and CVD mortality by 49·7 % in an equivalent substitution analysis in the diabetic and pre-diabetic population. Aspartame substitution reduced all-cause mortality by 29·2 % and cancer mortality by 30·2 %. Notably, the relative daily intake of saccharin also had similar effects as the absolute intake on all-cause, cardiovascular and cancer mortality in all analyses. This was despite the fact that the relative daily intake in our study was below the Food and Drug Administration limit of 15 mg/kg. In conclusion, our study showed a considerable risk of increased saccharin intake on the all-cause, CVD mortality and cancer mortality.

To investigate the associations between dietary patterns and biological ageing, identify the most recommended dietary pattern for ageing and explore the potential mediating role of gut microbiota in less-developed ethnic minority regions (LEMRs). This prospective cohort study included 8288 participants aged 30–79 years from the China Multi-Ethnic Cohort study. Anthropometric measurements and clinical biomarkers were utilised to construct biological age based on Klemera and Doubal’s method (KDM-BA) and KDM-BA acceleration (KDM-AA). Dietary information was obtained through the baseline FFQ. Six dietary patterns were constructed: plant-based diet index, healthful plant-based diet index, unhealthful plant-based diet index, healthy diet score, Dietary Approaches to Stop Hypertension (DASH), and alternative Mediterranean diets. Follow-up adjusted for baseline analysis assessed the associations between dietary patterns and KDM-AA. Additionally, quantile G-computation identified significant beneficial and harmful food groups. In the subsample of 764 participants, we used causal mediation model to explore the mediating role of gut microbiota in these associations. The results showed that all dietary patterns were associated with KDM-AA, with DASH exhibiting the strongest negative association (β = −0·91, 95 % CI (–1·19, −0·63)). The component analyses revealed that beneficial food groups primarily included tea and soy products, whereas harmful groups mainly comprised salt and processed vegetables. In mediation analysis, the Synergistetes and Pyramidobacter possibly mediated the negative associations between plant-based diets and KDM-AA (5·61–9·19 %). Overall, healthy dietary patterns, especially DASH, are negatively associated with biological ageing in LEMRs, indicating that Synergistetes and Pyramidobacter may be potential mediators. Developing appropriate strategies may promote healthy ageing in LEMRs.

This paper examines the identity and origins of Swedish inventors prior to WWI, drawing on the universe of patent records linked to census data. We document that the rise of innovation during Sweden’s industrialization can largely be attributed to a small industrial elite belonging to the upper-tail of the economic, educational, and social status distribution. Analyzing children’s opportunities to become inventors, we show that inventors were disproportionately drawn from privileged family backgrounds. However, innovation was a path to upward mobility for the middle- and working-class children that managed to overcome the barriers to entry.

While divestments and decisions to exit commercial fossil fuel ventures are not new, the imperatives of the energy transition are catalysing such moves at a global industry-wide level, as oil companies position themselves for the future. The international normative framework for business and human rights provides clear guidance on how responsible divestment from fossil fuels should occur; however, in the absence of intergovernmental coordination and regulation, individual business divestment decisions create severe human rights risks. The case of Shell’s divestment from onshore Niger Delta oil production illustrates business and human rights issues relevant to the energy transition.

Given a probability space $(X,\mu )$, a square integrable function f on such space and a (unilateral or bilateral) shift operator T, we prove under suitable assumptions that the ergodic means $N^{-1}\sum _{n=0}^{N-1} T^nf$ converge pointwise almost everywhere to zero with a speed of convergence which, up to a small logarithmic transgression, is essentially of the order of $N^{-1/2}$. We also provide a few applications of our results, especially in the case of shifts associated with toral endomorphisms.

This paper presents the radio frequency (RF) design and experimental validation of a multifunctional bandpass filtering (BPF) concept with center frequency tunability and RF codesigned isolator and impedance matching functionality. The multifunctional bandpass filter/isolator (BPFI) concept combines frequency-tunable reciprocal resonators and nonreciprocal frequency-selective stages (NFSs) to realize center frequency tunability and fully directional transfer characteristics. The NFS, as the core component of the BPFI concept, exhibits frequency-selective transmission response in the forward direction and signal cancellation in the reverse direction. Its tunability is achieved by combining a transistor-based network with a tunable capacitively loaded coupled-line section. Furthermore, the NFS facilitates matching of different source loads allowing for the BPFIs to be used as reconfigurable matching networks. For experimental validation, an NFS and two BPFIs were designed, manufactured, and measured at L band. Their features include (i) NFS: center frequency tuning from 1.55 to 1.9 GHz with maximum directivity from 20 to 52 dB and gain from 0.3 to 1.3 dB. (ii) BPFI (topology A): center frequency tuning from 1.52 to 1.9 GHz with maximum directivity from 20 to 44 dB and gain from −1.5 to −0.5 dB. (iii) BPFI (topology C): ability to match complex loads with 26 + j18 Ω and 26 − j14 Ω.